JP5775059B2 - Pipette tip - Google Patents

Description

  The present invention relates to pipette tips.

  Pipette tips are used to measure liquids with pipettes and other metering devices. In the following, pipettes and metering devices are summarized as “pipette devices”. The pipette tip has an elongated tubular body. The pipette tip has an opening for transferring the liquid with a pipette and an opening for upper connection for connection to an attachment portion of the pipetting device. Standardized cone mounting parts with standard connection structures are known. It is used uniformly by many manufacturers and is characterized for each pipette tip by a specific average diameter and a specific cone angle of the cone mounting portion.

  The pipetting device is equipped with a gas exclusion element. The gas discharge element is a piston having a cylinder movable in the axial direction. The gas exclusion element communicates with the tube hole of the mounting portion. The pipette tip is hermetically fixed to the attachment portion by pressing the attachment portion of the pipette against its upper opening.

  The air column is similarly displaced by the gas discharge element in order to draw liquid into or discharge liquid from the pipette tip seated on the mounting part. When the air column is moved away from the pipette tip, a certain amount of liquid is drawn into the pipette tip through the lower opening. By moving the air column towards the pipette tip, an amount of liquid is released from the pipette tip through the lower opening.

  Most pipetting devices have an ejector. A force acts on the upper end of the pipette tip to push and remove the ejector from the attachment. At this time, in order to remove the pipette tip from the mounting portion, the user is avoided from touching the contaminated pipette tip.

  The pipette device is a manual pipette that can be held and operated only by the user's hand. The pipetting device can be a measuring station or can be built into the workstation. In all cases, the gas exclusion element can be actuated manually or by a motor. Connection and removal of pipette tips can also be done manually or by motor.

  In order to avoid mishandling of the pipette, the pipette tip must be hermetically attached to the attachment. Furthermore, the force to connect and remove the pipette tip from the mounting part should not be too high. In a conventional pipette tip, the contact area between the pipette tip and the cone mounting portion is like a truncated cone. When connecting the pipette tip, the pipette tip is elastically enlarged around its circumference by the mounting portion. Since the spring characteristics are steep, a high connection force must be used. After connection, correspondingly high static friction acts between the mounting part and the pipette tip. This static friction must be overcome when the pipette tip is removed. The user is burdened by high forces to connect or remove the pipette tip. As long as the connection and disconnection are made by the motor drive, these must be correspondingly powerful and require high energy consumption.

  Document US Pat. No. 6,197,259 B1 discloses a pipette tip that allows easy and reliable mounting and dismounting to and from the pipette attachment with a small axial force of 6 pounds and 3 pounds (26.7 N and 13.3 N). Is described. The pipette tip has a tubular pipette portion. The tubular pipette part has a conical upper part with an inner diameter at its upper part that is larger than the diameter of the pipette mounting part where the pipette tip is blocked. Furthermore, the pipette tip has a hollow central portion and an annular sealing region at the connection between the upper end and the central portion. When the pipette tip is inserted into the mounting part, the annular sealing area has an inner diameter smaller than the value “x” and is engaged with the lower end of the sealing zone of the mounting part so that it expands radially outward Designed to be. Thereby, a liquid-impermeable sealing occurs between the sealing zone of the attachment part and the sealing area of the pipette tip. Furthermore, the pipette tip has lateral stabilization means next to the sealing area. The lateral stabilization means engages the outer surface of the mounting portion to stabilize the pipette tip on the mounting portion. These lateral stabilizing means having at least three contacts are circumferentially spaced and extend inwardly from the inner surface of the pipette tip. The contact diameter is easily sized to easily engage the free end of the mounting portion and to allow the mounting portion to slide along the mounting portion without expanding the side of the pipette tip at the contact placement portion. Is done. To prevent the pipette tip from moving laterally when a laterally outward force is applied to the pipette tip so that the liquid is stripped off by the wall, the contacts are arranged laterally of the pipette tip at the mounting part. Bring support. When the lower end of the mounting zone sealing zone engages the sealing area of the pipette tip, the pipette tip expands in the sealing area and immediately adjoins the lower end of the sealing zone. When the contact guides the tip of the attachment portion and is stably and safely disposed on the attachment portion, the side wall of the pipette tip that supports the contact is deformed inward and is not expanded. Thereby, only minimal force is exerted on the mounting part during insertion.

  Document US 7,339,373 B1 describes an ergonomically designed pipette tip. The pipette tip can be securely connected to the shaft to the pipette, and the axial force spent on connecting and disconnecting is simultaneously greatly reduced. An ergonomic pipette tip is provided with a thin expansion gap made by injection molding. In order to reduce the force required to expand the upper end of the pipette tip by means of a bending spring principle when the pipette shaft is inserted into the sealing area of the pipette tip, the extension part has a thick wall part on both sides and / or The second elastic body is in contact. Further, the pipette tip has one or a plurality of protrusions on the inside thereof. The protrusion is intended to limit the depth of the insertion port for inserting the pipette shaft into the pipette tip as a stopper.

  The literature describes a plastic pipette tip with an elongated tubular body. The pipette tip has an opening for taking in with a pipette at the lower end and an insertion opening for connecting to a fixed shaft of the pipetting device at the upper end. Near the upper end, the pipette tip circulates along a closed curve and has a first zone at different circumferential positions and at different distances from the lower end. The circulation zone has a contact area on the inner side and extends in a plane of rotation. The second band extends to the upper end. The second zone starts from the position of the circulation zone farthest from the lower end. In the contact area inside the circulation zone, the pipette tip enters the sealing portion of the pipetting device. When removing the pipette tip, the ejector of the pipette device pushes the second band at the upper end of the pipette tip. The force removed by the second zone is transmitted to the position of the circulation zone that is farthest away from the lower end. These positions of the circulation zone are thereby pressed somewhat towards the lower end. In contrast to a plane that is adapted to be perpendicular to the pipette tip tubular body, the circulation zone is pressed somewhat and flattened. The second zone forms a hard region and undergoes only a relatively weak deformation during force transmission. Since the circulation zone is adapted to the second zone in the lateral direction, the circulation zone can be deformed relatively easily by the force guided in the direction of the second zone. As a result, the circulation zone is somewhat enlarged and the static friction between the inside of the circulation zone or the contact area and each of the mounting parts is reduced accordingly. Accordingly, the force required to separate the pipette tip from the mounting shaft is reduced. Furthermore, the pipette tip is easier to bend in the region of the circulation zone. As a result, the force of connecting the pipette tip to the mounting part is also reduced, which is advantageous for connecting to mounting shafts having different dimensions.

US Application Publication US 6,197,259 B1 US Application Publication US 7,339,373 B1 European Application Publication EP1 520 624 B1

  In the pipette tips of each of the above documents, variations in the dimensions of the pipette tip and the mounting portion are compensated by the elastic expansion of the pipette tip. For each case where the inner diameter of the pipette tip in the seat area is significantly less than the standard size or the outer diameter of the mounting part exceeds the standard size, a high force of connection and removal results.

  In view of this situation, the present invention is based on the problem of providing a pipette tip that reduces the force required for removal from the pipetting device, and the outer diameter tolerance has little effect on the removal force.

  This object is achieved by a pipette tip having the features of claim 1. Advantageous embodiments of pipette tips are indicated in the subclaims.

The pipette tip of the present invention is
Having an elongated tubule shape with a lower opening at the lower end and an upper opening at the upper end for liquid passage;
A seat region on the inner periphery adjacent to the upper opening;
The seat area is used to connect to the standardized cone mounting part of the pipetting device,
The seat region has a holding region with a first rib extending in the axial direction projecting radially inward,
When the pipette tip is connected to the seat region by a connection force that secures holding and sealing of the pipette tip to the attachment portion, the first rib is partially elastically deformed in the sealing region below the holding region, And it is comprised so that the said elastic deformation may arise in the seat part area | region outside a 1st rib.

  When the pipette tip of the present invention is connected to the standardized cone mounting portion of the pipetting device, the surface pressure in the region of the axial first rib causes plastic deformation of the axial first rib. Further, the pipette tip is deformed with an elastic force in a seat region outside the first rib having an elastic force. A part of the connecting force is consumed for plastic deformation of the first rib, and the other part of the connecting force is accumulated by elastic deformation. As a result, the pipette tip is held on the mounting portion by biasing. Since the first rib supports the pipette tip in the lateral direction, the pipette tip does not vibrate under the influence of the lateral force. In order to remove the pipette tip, only the force accumulated by the elastic deformation must be overcome. When the pipette tip is removed, part of the connection force assigned to plastic deformation of the first rib need not be overcome as newly accumulated stress. The removal force must overcome the frictional force created by the elastic bias between the pipette tip and the mounting part. The tolerance of the outer diameter of the pipette tip and the mounting portion is compensated by the plastic deformation of the first rib, and has less effect on the elastic deformation of the seat region than the elastic deformation of the conventional pipette tip. The influence of the outer diameter tolerance on the removal force is thereby reduced.

  Therefore, only a small removal force is spent to remove the pipette tip of the present invention from the attachment part. This is released when the user of a manual pipette with an ejector applies the removal force with the thumb. The user can easily exert the necessary removal force with the forearm and hand. Similarly, the motor driven ejector is also opened by the pipette tip of the present invention.

  Elastic deformation of the seat area may occur in the sealing area and / or in the holding area between the ribs. The elastic deformation can be limited to the sealing region or the region between the ribs, or can occur in the sealing region as well as in the region between the ribs. The plastic deformation of the ribs and the elastic deformation of the seat region are determined by the shape of the seat region and the material of the pipette tip. The plastic deformation of the rib is determined in particular by the rib contour. The wall thickness of the pipette tip in the area of the rib determines the amount of elastic deformation in this area. The wall thickness in the region of the rib can be selected as the size that the pipette tip functions securely there, resulting in only plastic deformation of the rib. The elastic rubber or plastic deformation of the sealing area can be determined in particular by the wall thickness of the pipette tip in the sealing area. In this case, it is determined by the shape of the sealing nose that spreads in the internal sealing region.

  The normalized cone mounting portion is determined by the specific average diameter and the specific cone angle for each pipette tip dimension. This is summarized in the table below:

  The tolerance for the diameter specification is +/− 0.05 mm and the tolerance for the angle specification is +/− 0.3 °.

  According to one embodiment, the ribs are uniformly distributed on the circumference. A uniform deformation and support of the pipette tip in the seat area is thereby favored.

  According to a further embodiment, the pipette tip comprises 3-12 ribs, preferably 5-7 first ribs, more preferably 6 first ribs. Uniform support is thereby achieved. The above-mentioned first number of ribs having a plastically deformable rib shape can be easily manufactured.

  According to a further embodiment, when the pipette tip is connected to the mounting portion by a connection force for ensuring the holding and sealing of the pipette tip at the mounting portion, the ribs are in accordance with the position occupied by the mounting portion. Having an outer shape that overlaps with the conical mounting portion, which is at least 0.1 mm, preferably at least 0.2 mm and / or most effectively 0.5 mm, and most preferably 0.3 mm It is. This overlapping shape supports partial plastic deformation of the ribs.

  According to a further embodiment, the pipette tip has an axially extending second rib adjacent to the top opening and projecting radially inwardly inside the top opening, the second rib comprising two pieces It arrange | positions for every 1st rib. The second rib can function as an additional guide for the pipette tip at the mounting portion, and when the pipette tip is connected to the mounting portion, the second rib is not deformed or is more than the first rib. It only makes a small deformation. According to a preferred embodiment, when the pipette tip is connected to the attachment portion by a connection force for ensuring the holding and sealing of the pipette tip at the attachment portion, the second rib is sized so as not to be deformed. .

  According to a further embodiment, the first rib and / or the second rib have a radially inwardly tapered profile. The plastic deformation of the axial rib at the inner end of the contour is thereby supported. According to a further embodiment, the first rib and / or the second rib have a triangular, trapezoidal or parabolic contour.

  According to a preferred embodiment, the pipette tip has a grooving on the outer periphery, the grooving overlapping the first rib and / or the second rib. The grooving serves, for example, to fix the pipette tip in the rib area or to give properties to the pipette tip. If the grooving is useful to characterize the pipette tip, the grooving arrangement above the first rib and / or the second rib supports the perception of the grooving of the transparent pipette tip. Otherwise, the first rib and / or the second rib can be perceived as grooving.

  According to a further embodiment, the pipette tip expands conically towards the upper opening of the region where the ribs are arranged and / or in the sealing region. The insertion of the attachment part of the pipetting device is thereby supported. In principle, the aforementioned region can have a cylindrical shape instead of a conical shape. However, the rib is adapted to a conical mounting part normalized by plastic deformation and has a circulating sealing nose in the sealing region. Thereby, the sealing area compresses the mounting part.

  According to a further embodiment, the sealing region has a sealing nose projecting inwardly on the inner circumference thereof. The sealing nose is, for example, a sealing bead or a sealing lip.

  According to a further embodiment, the pipette tip has a region in which the ribs are arranged and the wall thickness is greater than the wall thickness of the sealing region. The pipette tip is stiffer in the area of the axial rib. Thereby, the plastic deformation of the rib is supported.

  According to a further embodiment, the pipette tip has means for restricting the connection at the standardized cone mounting part. The means stops the connection at the attachment portion when the connecting force ensures that the attachment portion retains and seals the pipette tip and plastic deformation of the ribs. The plastic deformation of the axial ribs can be limited to an appropriate range through this. The limiting means is formed by contact, and the means is formed by one or a plurality of protrusions protruding inward from the inner periphery of the pipette tip.

  According to a further embodiment, the means for limiting the connection is a braking area that extends conically from the lower sealing area towards the upper opening. When the standardized conical mounting part connection is carried out, the lower end of the mounting part hits the braking area and the insertion movement of the mounting part is gradually stopped by the conical shape of the braking area. As a result, the user is not burdened by the conventional contact member. Moreover, the conventional contact member stops connection movement rapidly.

  The pipette tip is preferably formed of a plastic material. More preferably, the pipette tip is made of polyolefin, preferably polypropylene or polyethylene. According to a further embodiment, the pipette tip is light transmissive and is preferably transparent. More preferably, the pipette tip is manufactured by injection molding. The inner and / or outer diameter of the pipette tip is preferably increased from the lower opening toward the upper opening.

  In the following, the present invention will be described in further detail with reference to the accompanying drawings.

FIG. 6 is a side view of a pipette tip having an axial rib and an annular sealing nose. 1 b is a longitudinal sectional view of the pipette tip shown in FIG. 1b is an enlarged bottom view of the pipette tip shown in FIG. 1b is an enlarged plan view of the pipette tip shown in FIG. 1b is a cutaway perspective view of the pipette tip shown in FIG. FIG. 2 is a side view of an attachment portion and a pipette tip when the pipette tip of FIG. 1 is connected. It is a fragmentary longitudinal cross-sectional view of the attachment part inserted in the sealing area | region of the pipette tip of FIG. It is a figure which shows the comparison of the connection and removal of the pipette tip (a) of this invention, and the conventional pipette tip (b). Figure 3 shows the average diameter and cone angle of a standardized cone attachment for connecting pipette tips of different sizes. Figure 3 shows the average diameter and cone angle of a standardized cone attachment for connecting pipette tips of different sizes.

  In this application, they are referred to as “up” and “down” based on the direction of the pipette tip when handling the pipette. That is, the pipette tip is placed in the correct vertical position, the lower opening is located on the lower side, and the upper opening is located on the upper side.

  In the following description of different possible embodiments, corresponding features are denoted by the same reference signs.

  According to FIG. 1, the pipette tip 1 comprises an elongated tubular body 2. The pipette tip 1 has a lower opening 4 at the lower end 3 and an upper opening 6 for connection at the upper end 5. The lower opening 4 is smaller than the upper opening 6.

  The inner diameter and / or outer diameter of the tubular body 2 increases from the lower opening 4 toward the upper opening 6. In this embodiment, the tubular body 2 has a conical tip portion 7 on the lower side, a conical center portion 8 having a smaller inclination than the tip portion, and a head portion 9 above the center portion. The pipette tip 1 according to the invention may in particular extend partially or continuously from the lower opening 4 to the upper opening 6.

  The head portion 9 directly adjacent to the upper opening 6 has an insertion area 10 with an enlarged diameter. The insertion region 10 extends only through a short portion of the head portion 9. The lower side of the insertion area 10 is connected to the holding area 11, and the ribs 12 and 13 protrude inward from the inner periphery of the head portion 9 in the holding area 11. They have first ribs 12 extending in the axial direction, and the first ribs 12 protrude longer inward than the second ribs 13. That is, the second rib 13 extending in the axial direction does not protrude beyond the inward first rib 12. In FIG. 1 d and FIG. 1 e, it can be recognized that one first rib 12 protrudes from the inner periphery of the pipette tip 1 farther than the second rib 13. One second rib 13 is always arranged between the two first ribs 12.

  At the top, the first rib 12 and the second rib 13 each have a short chamfer 14, 15 following the insertion region 10.

  At its upper part, the head part 9 has a cylinder area 16 protruding outward. The cylinder area 16 is regulated by an outer step 17 below it. Inside it, the head region has an inner step 18. The first rib 12 and the second rib 13 extend across the inner step 18. Below it, they have reached the sealing area 19. Therefore, the bead-shaped annular sealing nose 20 protrudes from the outer periphery of the head portion 9 inside. The first rib 12 and the second rib 13 extend to the sealing nose 20. The second rib 13 has a jump position 21 in the area of the inner step 18.

  The first rib 12 and the second rib 13 have first and second parabolic contours 22 and 23 in a region above the inner step 18. The contour has first and second flat portions 24, 25 in that region and projects inwardly farthest away. The contour of the radiation shape first widens from top to bottom up to the maximum width positions 26, 27 and then becomes narrower again from the positions 26, 27 to the inner step 18.

  Furthermore, the head part 9 has a waterdrop-shaped sculpture 28 projecting on the surface at the outer periphery of the cylinder region 16 on the outside. Above the inner step 18, the edge of the groove 28 overlaps the edge of the first rib 12 and the edge of the second rib 13.

  At the bottom of the sealing nose 20, the conical braking region 29 is joined to the sealing region 19, and tapers downward and expands upward in each of the lower and upper regions.

  In the first and second ribs 12 and 13, the head portion 9 has a slightly conical shape above the inner step 18 and below the inner step 18, similar to the sealing region 19. In the braking region 29, the shape is a conical shape with an acute angle than the head portion 9.

  Both the second rib 13, the sealing region 19, and the braking region 29 are grouped as a “seat region 30”.

  Below the braking area 29, the central part 8 restricts the tubular body 2.

  According to FIG. 2, the manual pipette 31 comprises a handgrip-shaped housing 32. The housing 32 includes a displacement element 33 for displacing air. The displacement device 33 is provided with an actuating member 36 to be actuated, and an ejector 35 associated with the further actuating member 36 is similarly arranged. On the lower side, a standardized cone mounting part 37 is arranged on the lower side of the housing 32.

  The pipette tip 1 can block the attachment part 37.

  According to FIG. 3, when the pipette tip 1 closes the conical attachment part 37 standardized in the seat region 30, it is partially plastically deformed. This is a case where the outer shape of the attachment portion 37 and the first rib 12 shown in FIG. The wall of the pipette tip 1 is slightly elastically deformed between the first rib 12 and the second rib 13. In the sealing nose 20, the seat region 30 is elastically deformed so that the wall of the pipette tip 1 is somewhat distorted outward with respect to the indicated position where the outer shapes of the sealing nose 20 and the attachment portion 37 overlap each other. The outer shapes of the stop nose 20 and the attachment portion 37 overlap each other.

  The braking area 29 is plastically deformed at the lower end 38 of the mounting portion 37 (left side in FIG. 3). This is a case where the end 38 of the lower mounting portion and the outer shape of the braking region 29 overlap.

  According to FIG. 4 a, some of the connecting force is required for plastic deformation of the pipette tip 1. The other part of the connecting force is assigned to the elastic part of the deformation of the pipette tip 1. Therefore, part of the connecting force is irreversibly consumed due to plastic deformation of the pipette tip 1. The force required to remove the pipette tip 1 from the mounting part only overcomes part of the connecting force assigned to elastically deform the pipette tip 1.

  Therefore, in using the pipette tip 1 of the present invention, the force to be removed is smaller than that of the conventional pipette tip 1 and only elastically deformed by the connecting force. In a conventional pipette tip, the connecting force and the removing force are the same. This is shown in FIG. 4b.

  FIG. 5 shows the respective average diameter and cone angle of the upper standardized cone mounting part 37 for a pipette tip 1 having a certain syringe size. Average diameter is given in millimeters and cone angle in degrees. As the extent of the pipette tip size, the respective ranges of the filling amount that can be filled by the pipette tip 1 are indicated in microml and milliliter, respectively. The average diameter of the attachment portion 37 corresponds to the diameter between the lower end and the upper end of the attachment portion 37. It does not have to be strictly distributed by a diameter that is necessarily arranged centrally between the lower and upper ends of the mounting part. However, the average diameter can also be accurately centered between the lower and upper ends of the mounting portion.

  Furthermore, the tolerances of the average diameter (+/− 0.05 mm) and the angle display (+/− 0.3 °) are shown in FIG. The mounting part 37 is manufactured with corresponding tolerances.

DESCRIPTION OF SYMBOLS 1 ... Pipette tip 2 ... Tubular body 3 ... Lower end 4 ... Lower opening 5 ... Upper end 6 ... Upper opening 7 ... Conical tip part 8 ... Conical center part 9 ... Head part 10 ... Insertion area 11 ... Holding area 12 ... Axial direction 1st Rib 13 ... Second axial rib 14 ... First short chamfer 15 ... Second short chamfer 16 ... Cylinder area 17 ... Outer step 18 ... Inner step 19 ... Sealing area 20 ... Sealing nose 21 ... Jump position 22 ... First Parabolic shape 23 ... Second parabolic shape 24 ... First flat portion 25 ... Second flat portion 26 ... Maximum width position 27 ... Maximum width position 28 ... Waterdrop-shaped groove carving 29 ... Conical braking region 30 ... Seat Region 31 ... Manual pipette 32 ... Housing 33 ... Discharge element 34 ... Actuating member 35 ... Ejector 36 ... Second actuating member 37 ... Conical attachment portion 38 ... Installation Part lower end

Claims (15)

A pipette tip having an elongated tube shape with a lower opening (4) at the lower end (3) and an upper opening (6) at the upper end for liquid passage;
A seat region (30) on the inner periphery adjacent to the upper opening (6);
The seat area is used to connect to a standardized cone mounting part (37) of the pipetting device (3 1 ),
The seat region (30) has a holding region (11) with a first rib (12) extending in the axial direction projecting radially inward,
Below the holding area (11), the sealing area (19) is pipetted into the seat area (30) by a connection force that ensures the holding and sealing of the pipette tip (1) on the mounting part (37). The first rib (12) is partially plastically deformed when (1) is connected, and the elastic deformation is generated in the seat region (30) outside the first rib (12). Pipette tips that are. The pipette tip according to claim 1,
Pipette tips in which the first ribs (12) are evenly distributed on the circumference. The pipette tip according to claim 1 or 2,
Pipette tip with 3-12 first ribs (12 ) . The pipette tip according to any one of claims 1 to 3,
When the pipette tip (1) is connected to the attachment portion (37) by the connection force for securing the pipette tip (1) to be held and sealed by the attachment portion (37), the first rib (12) Has an outer shape that overlaps with the conical mounting part (37) normalized according to the position occupied by the mounting part (37);
The outline is at least 0.1 mm
Pipette tip characterized by that . The pipette tip according to any one of claims 1 to 4,
Adjacent to the upper opening (6), projecting radially inwardly inside the upper opening, and having a second rib (13) extending in the axial direction,
A pipette tip in which the second rib (13) extends smaller in the axial direction inward than the first rib (12) and is disposed between the two first ribs (12). The pipette tip according to claim 5,
When the pipette tip (1) is connected to the mounting portion (37) by a connecting force for securing the pipette tip (1) and sealing at the mounting portion (37), the second rib (13) Pipette tips that are configured to the required size without deformation. The pipette tip according to claim 5 or 6 ,
A pipette tip in which the first rib (12) and / or the second rib (13) are configured to have a radially inwardly tapered contour. The pipette tip according to claim 7,
Pipette tip, wherein the first rib (12) and / or the second rib (13) are configured to have a triangular, trapezoidal or parabolic contour. The pipette tip according to any one of claims 5 to 8 ,
The pipette tip has a groove (28) on the outer periphery, and the groove (28) is configured to overlap the first rib (12) and / or the second rib (13). The pipette tip according to any one of claims 1 to 9,
The pipette tip is configured to expand conically toward the upper opening in the region where the first rib (12) is arranged and / or in the sealing region (19). The pipette tip according to any one of claims 1 to 10,
Pipette tip configured to have a sealing nose (20) projecting inwardly in the sealing region (19). The pipette tip according to any one of claims 1 to 11,
The wall thickness of the holding area (11), a pipette tip that is configured to size than Kunar wall thickness of the sealing region (19). The pipette tip according to any one of claims 1 to 12,
The pipette tip has means for restricting the bayonet connection at the standardized cone mounting part (37);
When the connection force ensures that the pipette tip (1) is retained, sealed and partially plastically deformed in the first rib (12) at the attachment portion (37), the limiting means is the attachment Pipette tip configured to stop plugging connection at part (37). 14. Pipette tip according to claim 13,
The means (29) for limiting the connection area is a braking area (29) that extends conically from the lower sealing area (19) towards the upper opening.
Pipette tip characterized by that . The pipette tip according to any one of claims 1 to 14,
The pipette tip is made of plastic material, the pipette tip is configured with one of polyolefins, polypropylene and polyethylene.

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