CN103170386B - pipette tip - Google Patents
pipette tip Download PDFInfo
- Publication number
- CN103170386B CN103170386B CN201210559958.5A CN201210559958A CN103170386B CN 103170386 B CN103170386 B CN 103170386B CN 201210559958 A CN201210559958 A CN 201210559958A CN 103170386 B CN103170386 B CN 103170386B
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- China
- Prior art keywords
- pipette tip
- axially extending
- extending ribs
- pipette
- adnexa
- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/08—Ergonomic or safety aspects of handling devices
- B01L2200/087—Ergonomic aspects
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
nullThe present invention provides a kind of pipette tip，It has the shape of elongated tubule，Have in lower end for by the under shed of fluid，With the upper shed in upper end，Wherein pocket area is present on the inner periphery of adjacent described upper shed and for pipette tip is plugged into the standardized cone shape adnexa of pipette device，Wherein said pocket area has the holding region with the axially extending ribs prominent towards inner radial，With the sealing area under described holding region，And it is configured so that when its pocket area of described pipette tip is by ensureing that the holding of described pipette tip and the mating force being sealed on described standardized cone shape adnexa are plugged on described standardized cone shape adnexa，The partly plastic deformation of described axially extending ribs，And elastic deformation occurs in the described pocket area of the outside of described axially extending ribs.
Description
Technical field
The present invention relates to a kind of pipette tip.
Background technology
Together with pipet and other metering device, pipette tip is used for metering liquid.Hereinafter, pipet and meter
Amount device is generically and collectively referred to as " pipette device ".Pipette tip has elongate tubular body, and described main body has the pipette in lower end
Opening and for the grafting opening that is plugged on the adnexa of pipette device.There is the standardized cone shape adnexa of standard geometrical shapes
Being known, it is as one man used by many manufacturers and average by conical attachment for each pipette tip
Diameter is characterized than with cone angle ratio.
Pipette device includes that gas discharges element, and described gas is discharged element and is typically to have the most moveable
Cylindrical piston.Gas is discharged element and is connected to the access opening of adnexa.By the adnexa of pipet is pressed into pipette tip
In upper shed, pipette tip is clamped to adnexa hermetically.
By means of gas discharge element move air column in case for the pipette tip pumping liquid that is positioned on adnexa or from
It releases liquid.When air column moves away from pipette tip, a certain amount of liquid is drawn into pipet point by under shed
In end.By moving air column towards pipette tip, outside a certain amount of liquid is discharged to pipette tip by under shed.
Pipette device is generally of pushing piece, and described pushing piece acts on the upper limb of pipette tip to push open from adnexa
It.By so, it is to avoid user must reach over to contaminated pipette tip it to be departed from from adnexa.
Pipette device can be that user can be by a grasped and the hand-held pipette of operation.Pipette device can also
It is measuring station or is incorporated in work station.In all cases, gas discharge element can manually or be operated by motor.Move liquid
Grafting or the release of tip end can also manually or be carried out by motor.
In order to avoid the pipette action of mistake, pipette tip must be sealingly fixed on adnexa.It addition, be used for moving liquid
Tip end must be the highest from the power of adnexa grafting and release.In conventional pipette tip, pipette tip and cone are attached
Contact area between part is similar to frustum of a cone.When grafting pipette tip, pipette tip at its circumference by adnexa bullet
Property ground expand.Spring performance is uprushed so that must use high mating force.After grafting, corresponding high static friction acts on adnexa
And between pipette tip.This static friction is must pull against when releasing pipette tip.User is moved by for grafting and release
The noticeable effort of liquid tip end is perplexed.As long as being carried out grafting and release by motor driver, these must correspondingly strength
And they have high energy consumption.
Document US6,197,259B1 describes one can be by applying six pounds and three pounds (respectively 26.7N and 13.3N)
Relatively small axial grafting and release power easily and be fixedly secured to the adnexa of pipet or from described standardized cone shape
The pipette tip that adnexa is released.This pipette tip has tubulose pipet part, and described tubulose pipet part has circle
Tapered upper end, holds the internal diameter having will to be plugged on the diameter of the adnexa of pipet thereon more than pipette tip thereon.This
Outward, pipette tip has hollow central part and the annular seal zones of the junction between upper end and middle body.Ring
The internal diameter that shape sealing area has is less than value " x " and is designed such that it engages with the lower end of the band of adnexa, thus
When inserting adnexa towards radially outside expanding, thus produce between the band of adnexa and the sealing area of pipette tip
Impenetrable liquid seal.Additionally, pipette tip has a lateral stabilizer at the inner side of sealing area, described laterally
Stabilising arrangement engages with the outer surface of adnexa in order to stabilize pipette tip on adnexa.These lateral stabilizers have to be justified
At least three contact spaced apart in circumferential direction, described contact extends towards inside from the inner surface of pipette tip.Connect
Being sized to of the diametral distance of contact element easily engages with the free end of adnexa so that them and makes adnexa
Lower end can not expand described sidewall along the side walls of the pipette tip that contact is disposed thereon.When lateral external force
When acting on pipette tip, such as, when liquid landing on wall, contact realizes the lateral of the pipette tip on adnexa
Support, in order to prevent pipette tip from moving to side.When the lower end of the band of adnexa engages the seal area of pipette tip
During territory, pipette tip expands at sealing area with in being close to its region.When contact guides pipet point on adnexa
End and when stably and being directed at it safely on adnexa, the sidewall of the bearing contact part of pipette tip be deformed inward and
Not expanding, thus only slight in insertion power puts on adnexa.
Document US7,339,373B1 describe a kind of ergonomic designs pipette tip, and it can be plugged into safely
On the axle of pipet, the axial force used by grafting simultaneously and release is obviously reduced.This ergonomics pipette tip is included in note
Moulding the thin expansion clearance of middle manufacture, described thin expansion clearance is connected by thicker wall section and/or the second elastomeric material side, in order to
Reduce according to flexural spring principle when pipet axle introduces in the sealing area of pipette tip and expand the upper of pipette tip
Power necessary to edge.And, pipette tip has one or several projections within it, and described projection is intended to limit moves
Liquid pipe axle enters the insertion depth of the pipette tip as obturator.
Document EP1520624B1 describes a kind of plastic suction pipet tip with elongate tubular body, described tubulose master
Body has the opening in lower end and the grafting opening on the fixing axle being plugged into pipette device in upper end.Pipette tip
There is tie near upper end, described tie along closed curve around and have at different circumferential positions from lower end
Different distance.Around tie, there is the contact area in inner side, the cincture on Plane of rotation of described contact area.Other tie
Start to extend to upper end from the position around tie farthest from lower end.Use the contact area on the inner side of tie
Territory, pipette tip is in sealing contact with the adnexa of pipette device.When releasing, the pushing piece of pipette device presses against pipet point
The other tie of the upper end of end.By other tie, release power is delivered to the position around tie farthest from lower end.Around knob
These positions of band are thus extruded somewhat towards lower end.Relative to the tubular body of pipette tip, orientation at a right angle is flat
Face, is squeezed into the most flat around tie.Additionally tie formed rigid region, described rigid region in the transmission of power only
By relatively small deformation.Owing to orienting across with other tie around tie, therefore can be drawn by the direction of other tie
The power entered relatively easily deforms it.Therefore, somewhat expand around tie, and the inner side of cincture tie or contact area are with attached
Static friction between part respectively reduces.Therefore, it is used for making pipette tip depart from necessary power from fixing axle to reduce.
And, pipette tip is bigger in flexibility in the region of tie so that the power for it being plugged on adnexa even subtracts
Little, and contribute to being plugged into and have on various sizes of fixing axle.
In the pipette tip of document above, the change in size of pipette tip and adnexa is by the elasticity of pipette tip
Expansion compensation.When the internal diameter of the pipette tip in pocket area is well below standard size, or when the external diameter of adnexa is remote
When exceeding well over standard size, generation is used for the more high-tensile strength of grafting and release.
Summary of the invention
Thus, the present invention based on task be to provide a kind of pipette tip, wherein reduce for from pipette device
Adnexa release release power necessary to pipette tip, and dimensional tolerance is less on the impact of the power of release.
This task is realized by the pipette tip of the feature with claim 1.Indicate shifting in the dependent claims
The advantageous embodiment of liquid tip end.
The pipette tip of the present invention has elongated shape of small, and has opening under by fluid in lower end
Mouth and the upper shed in upper end, wherein pocket area is positioned on the inner periphery of adjacent described upper shed and for by pipet point
End is plugged on the standardized cone shape adnexa of pipette device, and wherein said pocket area has with prominent towards inner radial
Axially extending ribs keep region and the sealing area under described holding region, and be configured so that when described shifting
Liquid tip end is plugged on described standardized cone shape adnexa to ensure described pipet point by mating force with its pocket area
When end keeps and is sealed on described standardized cone shape adnexa, the partly plastic deformation of described axially extending ribs and elasticity
Deformation occurs in the described pocket area of the outside of described axially extending ribs.
When the pipette tip of the present invention is plugged on the standardized cone shape adnexa of pipette device, the region of axial rib
In surface pressing cause the part plastic deformation of axial rib.Additionally, pipette tip is at the pocket area of the outside of elastic rib
Elastic deforms.A part for mating force is by the plastic deformation consumption of rib, and another part of mating force is stored in elastic change
In shape.Therefore, pipette tip is maintained on adnexa under bias.Rib laterally supports pipette tip so that it is laterally
Do not shake under the influence of power.In order to release pipette tip, only have to overcome the power stored by elastic deformation.When pipet point
Rectify when being pushed out, it is not necessary to overcome the part of the plastic deformation being assigned to axial rib of mating force as the power that again stores.
Release power must pull against the frictional force existed due to the fexible bias pressure between pipette tip and adnexa.Pipette tip and adnexa
Dimensional tolerance compensated by the plastic deformation of rib and on the impact of the elastic deformation in pocket area than with conventional pipette point
Hold less.By so reducing the dimensional tolerance impact on the power of release.
Therefore, only have to expend little release power and release the pipette tip of the present invention from adnexa.This relieves and make apparatus
There is the burden of hand-held pipette by the pushing piece of thumb-actuated.User can easily apply inserting of necessity with forearm and hands
Relay.Similarly, the pipette tip of the present invention also relieves motor and drives the burden of pushing piece.
Elastic deformation in pocket area can occur in the holding region in sealing area and/or between rib.Elastic
Deformation can be limited to the region between sealing area or rib, or it can occur in sealing area and between rib
In region.The elastic deformation in the plastic deformation of rib and the pocket area geometry by pocket area and the material of pipette tip
Material determines.The plastic deformation of rib is determined by rib profile especially.The wall thickness of the pipette tip in the region of rib determines this region
In the size of elastic deformation.Wall thickness in the region of rib can be selected as the big pipette tip that makes and be presented with rigidity,
And only there is the plastic deformation of rib.Elasticity or plastic deformation in sealing area can be especially by the shiftings in sealing area
The wall thickness of liquid tip end determines, and the geometry sealing protuberance by cincture in internal sealing area that depends on the circumstances
Shape.
For each size of pipette tip, standardized cone shape adnexa is limited by certain average diameter and certain cone angle
Fixed.This sums up in the following table:
| The size (microlitre) of pipette tip | Average diameter (mm) | Cone angle (is spent) |
| 0.1-10 | 2.95 | 4.77 |
| 0.1-20 | 2.95 | 4.77 |
| 0.5-20 | 3.3 | 6.68 |
| 2-20 | 4.4 | 6.99 |
| 20-30 | 4.4 | 6.99 |
| 50-1000 | 7.1 | 2.71 |
| 50-1250 | 7.1 | 2.48 |
| 500-2500 | 9.3 | 3.78 |
| 100-5000 | 12.4 | 4.00 |
| 1000-10000 | 14.3 | 4.35 |
| 10-10000 | 14.3 | 4.35 |
The tolerance of +/-0.05mm is applicable to diameter specification, and +/-0.3 ° is applicable to angle gauge model.
According to an embodiment, described axially extending ribs is circumferentially evenly distributed.By so contributing to holder district
The homogeneous deformation of the pipette tip in territory and support.
According to another embodiment, described pipette tip has 3 to 12 ribs, preferably 5 to 7 ribs, and more preferably 6
Individual rib.By being achieved in that uniform support.It is variable that the quantity of described axially extending ribs has the plasticity that can easily produce
Shape rib geometry.
According to another embodiment, described axially extending ribs be sized to so that: when described pipette tip by
Mating force is plugged on described standardized cone shape adnexa to ensure that described pipette tip keeps and is sealed in described standard
When changing on conical attachment, for the position occupied by described standardized cone shape adnexa, described size and described standardization circle
The overlap of taper attachment is at least 0.1mm, preferably at least 0.2mm and/or maximum 0.5mm, preferably at most 0.3mm.This size
Overlap with the part plastic deformation helping rib.
According to another embodiment, described pipette tip has towards internal footpath at the most described upper shed in inside
To prominent other axially extending ribs, described other axially extending ribs does not has described axially extending ribs to extend towards inner radial
Far, described other axially extending ribs is arranged between two described axially extending ribss.Additionally rib may be used for pipet point
End is additionally directed on adnexa, and wherein when pipette tip is plugged on adnexa, additionally rib can be not subjected to deformation, or
Only by the deformation less than rib.According to preferred embodiment, additionally rib be sized to so that: when described pipette tip
It is plugged on described standardized cone shape adnexa to ensure that described pipette tip keeps and is sealed in described by mating force
Time on standardized cone shape adnexa, additionally rib does not deform.
Have in radially court according to another embodiment, described axially extending ribs and/or described other axially extending ribs
Profile tapered on internal direction.By so contributing to the inner axial rib plastic deformation at profile.According to another
Individual embodiment, described axially extending ribs and/or described other axially extending ribs have that triangle is trapezoidal or parabolical profile.
According to preferred embodiment, described pipette tip has the groove on outside circumference, and described groove is with described
Axially extending ribs and/or described other axially extending ribs are overlapping.Groove is such as used for making pipette tip have in rib region
Rigidity, or be used for characterizing pipette tip.In the case of they are used for characterizing pipette tip, groove arrangement rib and/
Or additionally layout on rib contributes to the recognizability of the groove on transparent pipette tip.Otherwise, rib and/or additionally rib meeting
It it is considered as groove.
According to another embodiment, described pipette tip is in the region arranging described axially extending ribs and/or in institute
State in sealing area towards described upper shed conical expand.By so contributing to the insertion of the adnexa of pipette device.Former
Then go up, if rib is fitted on standardized cone shape adnexa mutually by plastic deformation, and have around sealing prominent in sealing area
Portion, sealing area abuts against described sealing protuberance and is bearing on adnexa, the most described region can have cylindrical shape rather than
Cone shape.
According to another embodiment, described sealing area has and therein circumference on cincture prominent towards inside
Seal protuberance.Seal protuberance such as sealing bead or sealing lip.
According to another embodiment, the wall thickness that described pipette tip has in arranging the region of described axially extending ribs
More than the wall thickness in described sealing area.Pipette tip is harder in the region of axial rib, thereby assists in the plasticity of rib
Deformation.
According to another embodiment, described pipette tip have for limit be plugged into described standardized cone shape adnexa
On restriction device, when obtaining mating force to ensure that described pipette tip keeps and to be sealed in described standardized cone shape attached
On part and during the part plastic deformation of described axially extending ribs, described restriction device stops and is plugged into described standardized cone shape
On adnexa.Suitable degree can be limited to by the plastic deformation of such axial rib.Restriction device for limiting is permissible
Being formed by butting section, described butting section is by one or several projection shapes highlighted from the inner periphery of pipette tip towards inside
Become.
According to another embodiment, the described restriction device for limiting grafting is towards institute under described sealing area
State the brake area that upper shed is expanded conically.When performing to be plugged on standardized cone shape adnexa, the lower edge of adnexa hits
Hit brake area, and the motion that introduces of adnexa is gradually stoped by the cone shape of brake area.By so, and with stopping suddenly
Only the conventional butting section of grafting campaign is compared, and burden for users is less.
Described pipette tip is preferably made from a plastic material.It is highly preferred that described pipette tip is by polyolefin, excellent
Choosing is by polypropylene or polyethylene manufacture.According to another embodiment, pipette tip is light-permeable, preferably clear.More excellent
Selection of land, pipette tip is made up of injection mo(u)lding.The internal diameter of pipette tip and/or external diameter preferably under shed towards open
Mouth increases.
Accompanying drawing explanation
Hereinafter, the present invention is explained in greater detail by the accompanying drawing of embodiments of the invention.In the drawings:
Fig. 1 a-e (Fig. 1 a) in side view, in longitudinal section (Fig. 1 b), in looking up enlarged drawing (Fig. 1 c), put in vertical view
In big figure (Fig. 1 d) and in sectional perspective view (Fig. 1 e) show there is axial rib and around the pipet point sealing protuberance
End；
Fig. 2 shows the pipette tip when the pipette tip of Fig. 1 is by grafting and adnexa in side view；
Fig. 3 shows the adnexa in the pocket area of the pipette tip being inserted into Fig. 1 in partial longitudinal section；
Fig. 4 shows the grafting of the pipette tip of the present invention and release power (Fig. 4 a) and conventional pipette tip (Fig. 4 b)
Comparison；
Fig. 5 shows the flat of the standardized cone shape adnexa for the various sizes of pipette tip of grafting in total view
All diameter and cone angles.
Detailed description of the invention
In this application, deictic word "up" and "down" refers to the orientation of the pipette tip in pipette, wherein pipet
Most advanced and sophisticated vertically oriented, and under shed in bottom side and upper shed in top side.
In the following description of different embodiments, same characteristic features is represented by same reference numerals.
According to Fig. 1, pipette tip 1 has elongate tubular body 2, and this main body has at the under shed 4 of lower end 3 with upper
The grafting opening 6 of end 5.Under shed 4 is less than upper shed 6.
The internal diameter of tubular body 2 and/or external diameter generally increase towards upper end 6 from lower end 4.In this example, tubular body 2
There is the conical forepart in bottom side and divide 7, middle body 8 that cone above is less and on middle body 8
Head part 9.The pipette tip 1 of the present invention can also in another manner, particularly in part or continuously under shed 4 court
Upper shed 6 to expand.
Head part 9 has the introducing region 10 of band enlarged diameter at next-door neighbour's upper shed 6, and described enlarged area is only at head
Extend in the short part of part 9.Keep region 11 to be connected to introduce under region 10, its middle rib 12,13 towards inside from head
The inner periphery divided highlights.They are towards the prominent axially extending ribs 12 farther out of inner radial and prominent nearer another towards inside
Outer axially extending ribs 13.In Fig. 1 d and 1e, it may be clearly seen that rib 12 than other rib 13 from the inner circle of pipette tip 1
Week is prominent farther.One other rib 13 is always arranged between two ribs 12.
Rib 12 and other rib 13 all have in top side against the short chamfering 14,15 introducing region 10.
Head part 9 side thereon has the cylindrical region 16 prominent towards outside.Cylindrical region 16 is by outside its bottom side
Step 17 limits.Head zone has interior step 18 in inside.Rib 12 and other rib 13 extend through interior step 18.They are the end of at
Terminate at side in sealing area 19.There, the cincture in weld shape seals protuberance 20 in inside from the circle of head part 9
Week is prominent.Rib 12 and other rib 13 extend to seal protuberance 20.Additionally rib 13 has in the region of interior step 18
Step position 21.
Rib 12 and other rib 13 have the parabolic outlines 22,23 in the region on interior step 18.This profile has
Farthest evener 24,25 is highlighted in this region towards inside.First, parabolic outlines 22,23 is in direction from the top down
Upper expansion is until the position 26,27 of Breadth Maximum, and it narrows again therefrom, until interior step 18.
Additionally, head zone has the water-drop-shaped in the exterior periphery of cylindrical region 16 and groove outwardly 28.
On interior step 18, the edge of groove 28 and the edge of rib 12 and the imbricate of other rib 13.
Sealing under protuberance 20, cone brake area 29 connects sealing area 19, and the most tapered and
Upwards expand.
In the region of rib 12,13, head part 9 is on interior step 18 and under interior step 18 and at sealing area 19
In inside slightly conical.In brake area 29, it is in bigger taper.
Additionally the region of rib 13, sealing area 19 and brake area 29 will be generically and collectively referred to as " pocket area " 30.
Under brake area 29, middle body 8 limits main body 2.
According to Fig. 2, hand-held pipette 31 has the shell 32 in handle shapes, and described shell comprises for air-out
Discharge element 33, and arrange on element and discharge activating element 34 and having connected of element 33 discharging for activating
Additionally activate the pushing piece 35 of element 36.In bottom side, standardized cone shape adnexa 37 is arranged on the bottom side of shell 32.
Pipette tip 1 can be plugged on adnexa 37.
According to Fig. 3, when pipette tip 1 is plugged on standardized cone shape adnexa 37 at its pocket area 30, rib 12
Partly plastic deformation.Adnexa 37 in figure 3 and rib 12 profile overlapping region in so is exactly.Pipette tip 1
Wall in rib 12 and additionally somewhat plastic deformation between rib 13.In the region sealing protuberance 20, pocket area 30 is flexibly
Deformation, reason is that wall deflects somewhat towards outside relative to shown position, seals protuberance 20 and adnexa in described position
The profile of 37 overlaps each other.
Brake area 29 plastic deformation in the region of the lower end 38 of adnexa 37 (left side in figure 3).Lower attachment end
38 and the profile overlapping of brake area 29 so is exactly.
According to Fig. 4 a, a part for mating force needs the plastic deformation for pipette tip.The other part of mating force
It is assigned to the elastic part of the deformation of pipette tip 1.Therefore, a part for mating force irreversibly consumes for moving liquid
The plastic deformation of tip end 1.Release power needed for adnexa ejects pipette tip 1 only have to overcome distributes to pipet point
The part of the mating force of the elastic deformation of end 1.
Therefore, compared to only by the conventional pipette tip 1 of mating force elastic deformation, the pipet of the present invention is used
In the case of most advanced and sophisticated 1, release power less.In conventional pipette tip, mating force and release power are identical.This is in fig. 4b
Display.
Fig. 5 shows have the standardized cone shape adnexa on the association pipette tip 1 of certain syringe size
The corresponding average diameter of 37 and cone angle.Average diameter millimeter represents and cone angle expenditure represents.As pipette tip size
Degree, the respective range of the packing volume that pipette tip 1 can be filled represents with microlitre and milliliter respectively.Putting down of adnexa 37
All diameters between diameter to the lower end of adnexa 37 and upper end are relevant.Must not force to process lower end and the upper end being exactly in adnexa
Between the diameter of centre.But, average diameter can also be exactly in the centre between the lower end of adnexa and upper end.
It addition, the tolerance (+/-that the tolerance (+/-0.05mm) that expression average diameter represents in Figure 5 and angle represent
0.3 °).Adnexa 37 produces with corresponding tolerance.
The list of reference
1 pipette tip
2 tubular bodies
3 lower ends
4 under sheds
5 upper ends
6 upper sheds
7 conical forepart divide
8 conical central parts
9 head part
10 introduce region
11 keep region
12 axially extending ribss
13 other axially extending ribss
14 short chamferings
15 other short chamferings
16 cylindrical regions
17 outer step
Step in 18
19 sealing areas
20 seal protuberance
21 step position
22 parabolic outlines
23 other parabolic outlines
24 eveners
25 eveners
The position of 26 Breadth Maximums
The position of 27 Breadth Maximums
28 water-drop-shaped grooves
29 cone brake area
30 pocket area
31 hand-held pipette
32 shells
33 discharge element
34 activate element
35 pushing pieces
36 other actuating elements
37 conical attachments
The lower end of 38 adnexaes
Claims (16)
1. a pipette tip, described pipette tip has an elongated tubular shape, and have in lower end (3) for liquid
The under shed (4) passed through and the upper shed (6) in upper end, wherein pocket area (30) is proximally located at described upper shed (6)
On inner periphery and for described pipette tip being plugged into the conical attachment (37) of pipette device, wherein said holder
Region (30) have with from described inner periphery towards the holding region (11) of the prominent axially extending ribs (12) of inner radial and
Sealing area (19) under described holding region (11), and be configured so that when by mating force by described pipet
Most advanced and sophisticated (1) is plugged on described conical attachment (37) to ensure described pipette tip (1) by described pocket area (30)
When keeping and be sealed on described conical attachment (37), described axially extending ribs (12) partly plastic deformation, and in institute
Elastic deformation occurs in the described pocket area (30) of the outside stating axially extending ribs (12), and described pipette tip is described guarantor
Hold the wall thickness in region (11) and be more than the wall thickness in described sealing area (19),
Wherein said pipette tip has in internal other axially extending ribs (13) abutted to described upper shed (6) place,
Described other axially extending ribs axially extends from described inner periphery, and highlights towards inner radial from described inner periphery, described
Additionally axially extending ribs does not has described axially extending ribs to extend far from described inner periphery towards inner radial, described the most axial
Extending rib is arranged between two described axially extending ribss.
Pipette tip the most according to claim 1, wherein said axially extending ribs (12) is circumferentially evenly distributed.
Pipette tip the most according to claim 1, described pipette tip has 3 to 12 axially extending ribss (12).
Pipette tip the most according to claim 1, wherein said axially extending ribs (12) be sized to so that:
It is plugged on described conical attachment (37) to ensure described pipette tip (1) by mating force at described pipette tip (1)
When keeping and be sealed on described conical attachment (37), for the position occupied by described conical attachment (37), described chi
The size of very little and described conical attachment (37) is overlapping is at least 0.1mm and maximum 0.5mm.
Pipette tip the most according to claim 1, being sized to of wherein said other axially extending ribs (13)
Make: when described pipette tip (1) is plugged on described conical attachment (37) to ensure described pipet by mating force
When most advanced and sophisticated (1) keeps and is sealed on described conical attachment (37), described other axially extending ribs does not deform.
Pipette tip the most according to claim 1, wherein said axially extending ribs (12) has towards internal footpath
Profile tapered on direction.
Pipette tip the most according to claim 1, wherein said axially extending ribs (12) has triangle, trapezoidal or throwing
The profile of thing line.
Pipette tip the most according to claim 1, described pipette tip has the groove on outside circumference
(28), described groove is overlapping with described axially extending ribs (12).
Pipette tip the most according to claim 1, described pipette tip is arranging described axially extending ribs (12)
In region and/or in described sealing area (19) towards described upper shed conical expand.
Pipette tip the most according to claim 1, described pipette tip has from described inner periphery prominent towards inside
Go out and the sealing protuberance (20) of cincture on the circumference of described sealing area (19).
11. pipette tips according to claim 1, described pipette tip have for limit be plugged into described circular cone
Restriction device on shape adnexa (37), keeps with the described pipette tip of guarantee (1) when obtaining mating force and is sealed in described
Conical attachment (37) is upper and during the part plastic deformation of described axially extending ribs (12), and described restriction device stops and is plugged into
On described conical attachment (37).
12. pipette tips according to claim 11, the described restriction device being wherein used for limiting grafting is described
Towards the brake area (29) expanded of the conical ground of described upper shed under sealing area (19).
13. pipette tips according to claim 1, described pipette tip is made up of plastic material.
14. pipette tips according to claim 1, wherein said other axially extending ribs (13) has towards inside
The most tapered profile.
15. pipette tips according to claim 1, wherein said other axially extending ribs (13) has triangle, ladder
Shape or parabolical profile.
16. pipette tips according to claim 1, described pipette tip has the groove on outside circumference
(28), described groove is overlapping with described other axially extending ribs (13).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11010189.6 | 2011-12-23 | ||
| EP11010189.6A EP2606977B1 (en) | 2011-12-23 | 2011-12-23 | Pipette tip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103170386A CN103170386A (en) | 2013-06-26 |
| CN103170386B true CN103170386B (en) | 2016-10-26 |
Family
ID=45476260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210559958.5A Active CN103170386B (en) | 2011-12-23 | 2012-12-21 | pipette tip |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2606977B1 (en) |
| JP (1) | JP5775059B2 (en) |
| CN (1) | CN103170386B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486803B2 (en) | 2010-01-22 | 2016-11-08 | Biotix, Inc. | Pipette tips |
| US8795606B2 (en) | 2012-05-30 | 2014-08-05 | Biotix, Inc. | Integrated pipette tip devices |
| US9844777B2 (en) | 2014-06-27 | 2017-12-19 | A&D Company, Limited | Pipette tip |
| EP3115110B1 (en) | 2015-07-07 | 2019-03-27 | Eppendorf Ag | Pipette tip |
| CN105136515B (en) * | 2015-07-29 | 2017-09-29 | 俞雄飞 | The liquid flowing tube of bath trough on plating line |
| EP3471878B1 (en) * | 2016-06-15 | 2024-01-03 | Hamilton Company | Pipette tip |
| CN107398310A (en) * | 2017-02-22 | 2017-11-28 | 佛山市工芯精密机械有限公司 | A kind of pipettor is interrupted |
| EP3624946A1 (en) * | 2017-05-17 | 2020-03-25 | Biotix, Inc. | Ergonomic pipette tips |
| USD905865S1 (en) | 2018-05-11 | 2020-12-22 | Biotix, Inc. | Pipette tip |
| JP6539774B1 (en) | 2018-05-11 | 2019-07-03 | バイオティクス， インコーポレイテッド | Pipette tip |
| EP3575000A1 (en) * | 2018-05-31 | 2019-12-04 | Eppendorf AG | Pipette tips |
| US20220001376A1 (en) * | 2018-12-20 | 2022-01-06 | Tecan Trading Ag | Pipette tip extension, pipette tip, assembly of pipette tip and pipette tip extension, and method of use |
| JP7568631B2 (en) * | 2019-01-28 | 2024-10-16 | フォーミュラトリクス・インターナショナル・ホールディング・リミテッド | Positive Displacement Pipette Tips for Motorized Controlled Automation or Instrument Systems |
| EP3831485A1 (en) | 2019-12-03 | 2021-06-09 | Eppendorf AG | Pipette tips |
| EP3888791A1 (en) * | 2020-04-03 | 2021-10-06 | Eppendorf AG | Pipette tip |
| EP4063013A1 (en) | 2021-03-26 | 2022-09-28 | Eppendorf AG | Pipette tip |
| EP4140588A1 (en) | 2021-08-30 | 2023-03-01 | Tecan Trading AG | Pipette tip with two positive angle steps |
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| US6197259B1 (en) * | 1998-11-06 | 2001-03-06 | Rainin Instrument Co., Inc. | Easy eject pipette tip |
| CN1330573A (en) * | 1998-11-06 | 2002-01-09 | 瑞宁器材公司 | Pipette with improved pipette tip and mounting shaft |
| CN1984717A (en) * | 2004-02-11 | 2007-06-20 | 马特里克斯技术公司 | Pipette tip mounting and ejection assembly and associated pipette tip |
| EP2138234A1 (en) * | 2008-06-24 | 2009-12-30 | F. Hoffmann-Roche AG | Flexible disposable tip interface |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE7518809U (en) * | 1975-06-12 | 1978-09-14 | Eppendorf Geraetebau Netheler & Hinz Gmbh, 2000 Hamburg | PIPETTE TIP |
| US5200151A (en) * | 1990-05-21 | 1993-04-06 | P B Diagnostic Systems, Inc. | Fluid dispensing system having a pipette assembly with preset tip locator |
| US7335337B1 (en) * | 2001-09-11 | 2008-02-26 | Smith James C | Ergonomic pipette tip and adapters |
| DE10345324B3 (en) | 2003-09-30 | 2004-08-19 | Eppendorf Ag | Pipette tip, in one-piece plastics structure, has projecting ring near upper end with wave-shaped contour giving points at different gaps from bottom end to reduce ejection forces on removal from pipetting shaft |
| JP4521239B2 (en) | 2004-09-10 | 2010-08-11 | 株式会社日立ハイテクノロジーズ | Magnetic field shielding device and biomagnetic field measuring device |
-
2011
- 2011-12-23 EP EP11010189.6A patent/EP2606977B1/en active Active
-
2012
- 2012-12-18 JP JP2012275879A patent/JP5775059B2/en active Active
- 2012-12-21 CN CN201210559958.5A patent/CN103170386B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197259B1 (en) * | 1998-11-06 | 2001-03-06 | Rainin Instrument Co., Inc. | Easy eject pipette tip |
| CN1330573A (en) * | 1998-11-06 | 2002-01-09 | 瑞宁器材公司 | Pipette with improved pipette tip and mounting shaft |
| CN1984717A (en) * | 2004-02-11 | 2007-06-20 | 马特里克斯技术公司 | Pipette tip mounting and ejection assembly and associated pipette tip |
| EP2138234A1 (en) * | 2008-06-24 | 2009-12-30 | F. Hoffmann-Roche AG | Flexible disposable tip interface |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5775059B2 (en) | 2015-09-09 |
| CN103170386A (en) | 2013-06-26 |
| EP2606977A1 (en) | 2013-06-26 |
| JP2013136052A (en) | 2013-07-11 |
| EP2606977B1 (en) | 2019-07-03 |
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