JP2000290189A - Anti-allergic agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject medicine having a release-suppressing effect of leucotriene and histamine from mastcyte, and a stimulation-moderating effect for an allergen by containing a plant body of plants belonging to the genuses Curcuma, Crataegus and Artemisia or their extracts. SOLUTION: This anti-allergic agent contains at least one kind of a plant body and/or an extract selected from a group consisting of (A) a plant belonging to the genus Curcurma [e.g.; Curcurma rhizoma (turmeric)], (B) a plant belonging to the genus Crataegus [e.g.; Crataegus cuneata, Crataegus pinnatifida (hawthorn))] and (C) a plant belonging to the genus Artemisia [e.g.; Artemisia princeps (mugwort), Artemisia montana, Artemisia argyl (moxa), Artemisia vulgaris. The amount of administration is usually approximately 3-30 g in the case of oral administration and approximately 10-50 mg in the case of local administration for an adult daily based on dried weight of the plant material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antiallergic agent.

[0002]

2. Description of the Related Art In an allergic reaction, pollen and dietary components (or feed components) become allergens, and when sensitized to a living body, IgE antibodies are produced in the living body, and the IgE antibodies bound to the allergen bind to mast cells. Histamine and leukotriene (LTB ₄ ) that cause allergy from the mast cells
Substances that cause inflammation such as inflammation are released. Among them, the bronchoconstrictive action of leukotriene (LTB ₄ ) is said to be about 1000 times stronger than histamine (Dahlen SE, H
edqvist P, Hammarstrom S, Samuelsson
B. Leukotrienes are potent constrictors of human
bronchi. Nature 1980; 288; 484-6)

[0003] For this reason, in the field of foods, research and development have been progressing in the direction of allergen removal, that is, de-allergenization. That is, since most foods can be allergens to humans, in the case of rice, buckwheat, soybeans, and other foods that are particularly important for humans, the allergens contained therein are treated by a physicochemical method such as heating or enzymatic treatment to obtain allergens. Is decomposed / removed to obtain a food with reduced allergen, and the food is provided in a form that does not affect humans who are allergic to the food.

[0004] However, when a protease treatment is carried out as a de-allergenization treatment, the protein contained in the food becomes a peptide, so that even if the allergen is decomposed, bitterness peculiar to the peptide is generated. , And as a result, require more specialized processing,
There was a disadvantage that the product cost was high. De-allergenizing all foods and food ingredients is
It is practically impossible because it is necessary to find those allergen parts and to make enzymes act on specific parts.In addition, these low allergen foods do not improve the allergic constitution of humans and are highly processed. -There are drawbacks such that the processed food must be ingested all the time.

[0005] In the field of medicines and quasi-drugs for allergic diseases, antihistamines, steroid hormones and the like are usually used for histamine control. However, they have the problem of side effects when used for a long period of time, and there has been a demand for the development of materials that can be used for quasi-drugs, such as creams, that are safe and effective without side effects.

[0006] In view of the above, the most ideal treatment method for allergies at present is that the consumption of highly processed foods and the administration of pharmaceuticals such as hormonal drugs as symptomatic treatments are more effective than daily dietary contents. Improvement is the best method, and there is a need for a dietary ingredient material that is less likely to cause allergies and a drug / quasi-drug ingredient that has a mild effect and has no side effects for the purpose of improving the constitution.

[0007]

SUMMARY OF THE INVENTION The present invention relates to histamine or leukotriene (LT) produced by allergen sensitization.
B ₄₎ in raw materials and components and mixtures thereof having a release-inhibiting effect of the mast cell chemical mediators such as, also be possible to use as a material for such food or food additives materials and soaps and creams to alleviate the effects of allergens Another object of the present invention is to provide an antiallergic agent having an allergen irritation alleviating effect.

[0008]

Means for Solving the Problems As a result of earnest studies, the inventors of the present invention have found that plants of the genus Kirkuma, Clataegas and Artemissia and their extracts are obtained from leukotriene (LTB ₄ ) from mast cells and The present invention has been found to have an effect of suppressing the release of histamine and / or has completed the present invention.

That is, the present invention relates to the genus Curcuma (Curcum
a) To foods and quasi-drugs containing as an active ingredient at least one plant selected from the group consisting of plants, plants of the genus Crataegus and plants of the genus Artemissia and / or extracts thereof Provide an antiallergic agent that can be used.

[0010]

DETAILED DESCRIPTION OF THE INVENTION As described above, the antiallergic agent of the present invention comprises a plant of the genus Curcuma,
ataegus) and at least one plant selected from the group consisting of Artemissia plants and / or
Or the extract is contained as an active ingredient.

Here, a preferred example of a plant of the genus Kirkuma is Curcuma rhizoma (turmeric)
However, the present invention is not limited to this. Turmeric (Curcuma rhizoma) belongs to the ginger family,
It is commonly known as spring turmeric and autumn turmeric. Spring turmeric is mainly used for medicinal purposes, and autumn turmeric is used as a turmeric as a coloring material for curry powder, turkey, pickles and the like. It is native to tropical Asia and is widely cultivated in India, southern China, Indonesia, Vietnam, Taiwan, Okinawa, etc., and its tubers or rhizomes are dried and used. The pharmacological effects of turmeric are known to be mainly bile, and prevent and prevent hepatitis, cholangitis and cholelithiasis.
Used for treatment.

The turmeric used in the present invention may be either spring turmeric or autumn turmeric, or may be a mixture of spring turmeric and autumn turmeric. In the present invention, a plant of the genus Kirkuma such as turmeric or an extract thereof is used, and the plant part is preferably a tuberous root or a rhizome. In addition, a residue obtained by drying a residue of a turmeric rhizome bark or a tuberous root of a tuberous root or an extract thereof can also be used.

A preferred example of the plant belonging to the genus Clataegus used in the present invention is Crataegus crueta (Crataegus).
cuneata) (Noyama) and Crataegus pinnatifida (Yama), but are not limited thereto. Noyama and Sanken are rose plants native to China, and their mature fruits are called Yamashiko. This is generally called "red fruit" in China and is used for dried sweets, yokan or juice. The pharmacological effect of Yamashiko is known to be stomach and digestive, and is mainly used for treatment of indigestion and diarrhea.

The plant part of the plant belonging to the genus Clataegas used in the present invention is not particularly limited, but fruits (pulp and seeds), particularly mature fruits are preferred. Pulverized dried fruit, extract or squeezed juice, and dried dried fruit can also be preferably used.

Preferred examples of the Artemissia genus (Artemissia princeps) plant used in the present invention include Artemissia princeps (Artemissia princeps), Artemissia montana (Artemissia montana) and Artemissia argyi (Artemissia argyi).
(Aoi) and Artemissia vu
lgaris) (field mushroom), but is not limited thereto. Artemisia belongs to the Asteraceae family and is a perennial plant native to various parts of Japan, and there are many species of Artemisia. In Japan, mugwort or artemisia is the main species, and in China, Aga or field mite closely related to mugwort is well known. Its use is used as a moxa for moxibustion or as a mochigusa in mochi. The pharmacological effect of mugwort is said to be effective in stopping or stopping blood in Chinese medicine, and is used for treatment of diarrhea, nosebleeds, blood discharge, swelling and the like.

The part of the plant of the genus Artemisia used in the present invention is not particularly limited, but is preferably a leaf or a stem, and preferably a whole plant.

The antiallergic agent of the present invention may further comprise at least one plant of the above three genera and / or an extract thereof, and further, a plant of an Aloe plant and / or an extract thereof. May be included.

Aloe belongs to the lily family and is distributed in warm and dry areas, and there are more than 100 species. Aloe arborescene (Aloe arborescene) (Aloe arborescene Mill), aloe saponaria (Aloe saponaria) (jumbo aloe (Aloe saponari)) are preferable examples of aloe plants that can be used in the present invention.
aMill)), Aloe ferox (Aloe ferox) (Aloe ferox Mill), Aloe barbadensis (Aloe barbaden)
sis Mill)) and Aloe africana
(Aloe africana Mill), but is not limited thereto. These aloe plants are adopted as pharmacopoeias in each country. The pharmacological effect of aloe is used as a stomachic when taking small doses and as a laxative when taking large amounts.
In addition, for burns, wounds, insect bites, eczema,
Aloe peeled leaves or mucus are applied to the affected area.

The part of the plant of the genus Aloe used in the present invention is not particularly limited, but leaves are preferred.
A gel-like part in a leaf can also be preferably used. When a plant of the genus Aloe is used, it is preferable to use a plant that has been treated and processed so as not to contain anthraquinone-based substances such as aloin.

In the present invention, the above-mentioned plants of each genus can be used either raw or dried. Furthermore, it can be pulverized into a powder form, or can be made into any form. Further, an extract of a plant can also be used.
The extraction is preferably performed using water or an aqueous medium or a mixed solution thereof. Here, the “aqueous medium” includes an organic solvent that is freely miscible with water, such as ethanol. The extraction temperature is not particularly limited. Usually, the extraction is performed in a range from room temperature to the boiling point of the medium.
It is preferably carried out at 0 ° C. or higher, more preferably at 90 ° C. or higher, more preferably at the boiling point of the medium. Further, it is also preferable to perform the extraction treatment by using an autoclave or a pressure cooker to raise the boiling point above the boiling point of 1 atm, for example, to about 125 ° C. Extraction time depends on the type of plant,
Although it can be appropriately set according to the amount, the amount of the medium, the extraction temperature and the like, it is usually performed for about 5 minutes to 48 hours. In addition, when performing extraction at high temperature, the extraction time may be short, and when performing at relatively low temperature such as room temperature, it is preferable to increase the extraction time. The amount of the medium used for extraction is not particularly limited, but is usually 2% of the weight of the plant.
It is about 1 to 100 times, preferably about 5 to 20 times. Further, the extract may be in the form of an extract, or may be a powder obtained by drying the extract, or a form obtained by molding the extract into an arbitrary form.

Suppression of release of either leukotriene (LTB ₄ ) or histamine alone is effective in significantly reducing allergy, but it is more effective if the release of both can be suppressed simultaneously. . As specifically shown in the examples below, the plants of the genus Kirkuma have an extremely excellent effect of inhibiting the release of leukotriene (LTB ₄ ), but the effect of inhibiting the release of histamine is not as high as that of the plants of the genus Krataegus or Artemisia. When a genus plant is used, it is preferably used in combination with a Krataegas plant and / or an Artemisia plant. In addition, aloe plants have excellent leukotriene (LTB ₄ ) release inhibitory effect, but do not have histamine release inhibitory effect. Therefore, Aloe plants may be used in combination with Krataegas plants and / or Artemisia plants having excellent histamine release inhibitory effect. preferable. That is,
It is preferable that the antiallergic agent of the present invention contains at least one plant of a Krataegas plant and an artemisia plant having an excellent histamine release inhibitory effect, or an extract thereof. The combination of plants is not limited to these, and the above-described plants can be arbitrarily combined.

When a plurality of kinds of plants or extracts thereof are used in combination, the compounding ratio thereof is not limited at all, and may be mixed at an arbitrary ratio according to the intended antiallergic effect. it can. For example, when combining a plant of the genus Karkuma or a plant of the genus Aloe with a plant of the genus Clataegus or an artemisia plant, the compounding ratio is, for example, about 2: 8 to 8: 2, preferably about 4: 6 to 6: 4 on a weight basis. .

The antiallergic agent of the present invention preferably further contains fish oil and / or fish oil components in addition to the above-mentioned plant or its extract. By adding fish oil, a further improved antiallergic effect is obtained. In the arachidonic acid cascade of lipid metabolism, leukotrienes (LTB ₄ ) related to allergy are produced from ω6 oils and fats, and become powerful inflammatory substances. On the other hand, in the case of fish oil, it is known that ω3-based highly unsaturated fatty acids (such as DHA and EPA), which are the main fatty acids, are metabolized in vivo to non-inflammatory leukotrienes (LTB ₅ ). LTB ₅ has only 1/30 the efficacy of LTB4. Therefore, by ingesting fish oil and / or fish oil components, the amount of production of strongly inflammatory leukotriene (LTB ₄ ) is reduced, and non-inflammatory leukotriene (LTB ₅ ) is increased. For this reason, the antiallergic effect is further enhanced by the above-mentioned plant raw materials and additives' leukotriene (LTB ₄ ) release inhibitory effect and fish oil leukotriene (LTB ₄ ) production reducing effect.

As the fish oil, any fish oil containing unsaturated fatty acids such as DHA and EPA can be preferably used. Preferred examples of the fish oil supply source include skipjack, tuna, squid, and sardine. , Horse mackerel and other fish and shellfish, but are not limited thereto.

When the antiallergic agent of the present invention contains fish oil, the mixing ratio of the plant and / or its extract to the fish oil is not particularly limited, but is usually 2: 1 to 1 on a weight basis.
The ratio is about 1: 5, preferably about 1: 2 to 1: 4.

The antiallergic agent of the present invention exerts its effects by parenteral administration such as oral administration and topical administration. In the case of oral administration, the dosage varies depending on the symptoms and the like, but is usually about 3 to 30 g, preferably about 9 to 15 g, per adult per day in terms of dry weight of the plant. In the case of topical administration, the dose varies depending on the symptoms and the like, but is usually 10 to 50 in terms of dry weight of a plant per day.
It is about 0 mg, preferably about 100-200 mg.

The antiallergic agent of the present invention can be used as such as the plant or its extract as it is, or can be used in a conventional manner together with other excipients and additives usually used in pharmaceutical preparations. It can also be formulated in a dosage form. Furthermore, as long as the effects of the present invention are not hindered, other medicines and other active ingredients may be contained. Usually, it is preferable to add the plant, its extract, or its dried product as it is to food or the like, or to soap or cream as an additive. In these cases, the amount of the antiallergic agent of the present invention is not particularly limited, and is appropriately set so as to achieve the above-mentioned dose in consideration of the amount of food consumed or the amount of soap or cream used. can do.

Since the raw materials of the antiallergic agent of the present invention have been used for a long time as foods and Chinese medicines, there are no side effects such as steroid hormones conventionally used for treating allergic diseases.

[0029]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below more specifically based on embodiments. However, the present invention is not limited to the following examples.

Example 1 In order to confirm the antiallergic effects of turmeric, Yamako, mugwort and aloe, a test was conducted using mast cells of rats to see the effect of inhibiting the release of leukotriene (LTB ₄ ).

Specifically, each of the above-mentioned raw materials (turmeric is a tuberous root, Yamakoko is a fruit including seeds, mugwort is a whole plant (leaves and stems), aloe is a leaf) is added to a phosphate buffer (PBS) at 10% by weight. The mixture was added and mixed, heated and extracted in an autoclave at 121 ° C. for 15 minutes, and centrifuged at 3,000 rpm for 10 minutes at 5 ° C., and the supernatant was used as a sample. Rats were Splague Dawr with an average weight of 200 g
A male y-rat (7 weeks old) was killed under ether anesthesia, 30 ml of Tyrode solution was injected into the abdominal cavity, the abdomen was massaged for 2 minutes, and the abdomen was opened to collect the Tyrode solution. The recovered solution was centrifuged at 200 G for 5 minutes, and the supernatant was removed to obtain peritoneal cells (hereinafter referred to as PEC) containing mast cells. PEC is Tyrod
The cell number was adjusted to 2 × 10 ⁶ cells / ml with the solution e.

Leukotriene (LTB ₄ ) was measured using Tyrode's solution.
854 μl, extraction sample solution (10% solution) 10 μl, 50 μM Ca
A mixture of 100 μl of ionophore and 36 μl of 25 mM CaCl ₂ solution was used as a culture solution. 2 × 10 previously prepared
Centrifuge 1 ml of ⁶ cells / ml PEC at 200G for 5 minutes.
After removing the supernatant, 50 μl of the reaction solution was added, and the cells were cultured with shaking at 37 ° C. for 20 minutes. Add 50 μl of acetonitrile / methanol mixture (6: 5) to the culture and add 10 μl as internal standard
PGB ₂ are added, and allowed to stand for 30 minutes at -20 ° C., after centrifugation 10 minutes at 12000 rpm, was measured LTB ₄ in the supernatant by HPLC.

As a result, the amount of leukotriene (LTB ₄ ) released from turmeric, mugwort, Yamako and aloe was lower than that of the negative control.
It became 4-36%, and the release inhibitory effect of 64-96% was recognized (Table 1). These results indicate that Shiso (Masatoshi Yamazaki et al., The anti-allergic activity of perilla extract, which is considered to have anti-allergic effects, summarizes the Japanese Society of Pediatric Dermatology (1992), Masatoshi Yamazaki et al. Control, Fragrance Journal VoL.21, No.9, 75-81 (1993))
The effect was better than that.

[0034]

[Table 1]

Example 2 Another factor of allergy is histamine.
Therefore, a test was conducted to confirm the effect of suppressing the release of histamine from rat mast cells using turmeric, Yamako, mugwort and aloe. In addition, Shiso, which has an antiallergic effect, was used as a positive control.

Specifically, each of the same raw materials as in Example 1 was added to a phosphate buffer (PBS) at 10% by weight and mixed, and the mixture was heated at 121 ° C.
After heating and extracting in an autoclave for 15 minutes, the mixture was centrifuged and the supernatant was used as a sample. Rats were Splagu with an average weight of 200 g
e Dawry male rats (7 weeks old) were killed under ether anesthesia, 30 ml of Tyrode solution was injected into the abdominal cavity, the abdomen was massaged for 2 minutes, and the abdomen was opened to collect the Tyrode solution. The recovered solution was centrifuged at 200 G for 5 minutes, and the supernatant was removed to obtain peritoneal cells (hereinafter referred to as PEC) containing mast cells. In addition, PEC
The cell number was adjusted to 1 × 10 ⁶ cells / ml with Tyrode solution.

Histamine was measured using Tyrode solution at 10 ⁶ cells.
1 ml of PEC adjusted to s / ml, extraction sample solution (10% solution) 25
0 μl, 50 μM Ca ionophore 250 μl, 25 mM CaCl ₂ solution 9
0 μl and 910 μl of the Tyrode solution were mixed, cultured at 37 ° C. for 20 minutes, and cooled with ice to stop the reaction. After stopping the reaction, 200
G, centrifuged for 5 minutes, and histamine in the supernatant was measured with a fluorescence spectrophotometer.

As a result, as shown in Table 2 below, the amount of histamine released by mugwort and mountain sprout was 35-39 of the negative control.
%, And a histamine release inhibitory effect of about 70% was observed. The effect was almost the same as that of Shiso used as a positive control. On the other hand, aloe had no histamine release inhibitory effect.

[0039]

[Table 2]

REFERENCE EXAMPLE 1 It is said that when fish oil and its component polyunsaturated fatty acids are taken, leukotriene (LTB ₄ ), which is a chemical mediator of allergy, decreases and leukotriene (LTB ₅ ), which is non-inflammatory, increases. I have. Therefore, the embodiment
Tests were conducted to confirm the effects of fish oil as further enhancing the effect of suppressing the release of leukotriene (LTB ₄ ) and histamine, which are the plant materials shown in 1 and 2.

That is, first, in order to confirm the degree of antiallergic effect of fish oil, rats were fed a diet mixed with fish oil, and leukotriene (LTB ₄ ), which is an allergenic substance from rat mast cells, was fed. The effect of suppressing histamine release was examined.

Specifically, male rats of Splague Dawley strain (3 weeks old) were fed a diet containing 5% of fish oil derived from skipjack.
The rats were fed for 4 weeks, and after 4 weeks from the feeding, peritoneal cells (PEC) containing rat mast cells were collected and used for the experiment by the method described in Examples 1 and 2. The measurement of leukotriene (LTB ₄ ) and histamine was similarly performed under the conditions shown in Examples 1 and 2.

As a result, in the rats fed the diet containing 5% fish oil, as shown in Table 3 below, the amount of leukotriene (LTB4) released from the mast cells was about 60% of the rats fed the control diet. Somewhat less results were obtained. On the other hand, as shown in Table 4 below, the difference in histamine release from the control was small. These results confirmed that administration of fish oil reduced the release of leukotriene (LTB ₄ ), one of the allergic chemical mediators.

[0044]

[Table 3]

[0045]

[Table 4]

Example 3 In Example 1, the effect of inhibiting the release of leukotriene (LTB ₄ ) from rat mast cells was observed in turmeric, mugwort, mountain sprout and aloe, and in Example 2, the effect of suppressing the release of histamine in mugwort and mountain sprout. Was observed, so that a mixture of those combinations was trial-produced at the ratio shown in Table 5 below. The raw materials used were turmeric obtained by mixing dry crushed spring turmeric and autumn turmeric in equal amounts. The mugwort was made from dried and ground whole mugwort (including leaves and stems). Yamako used as a raw material what was dried and pulverized fruits (including seeds). The aloe was obtained by drying and pulverizing a substance containing the gel-like part in the leaf and the entire leaf epidermis as a raw material. The numbers in Table 5 indicate the weight percentage of each raw material in the mixture.

[0047]

[Table 5]

Example 4 The addition ratio of fish oil to 1 of each mixture prepared in Example 3 was set so that the ratio of fish oil was 3 on a weight basis, and the total amount of oil and fat was 6% by weight including lard. A feed having the composition shown in Table 6 below was prepared. That is, each of the mixtures (A to E) experimentally prepared in Example 3 was added to 3 kg of bonito-derived fish oil.
kg, and the mixture was stirred in a warm bath at 40 ° C., and the suspended oily mixture was mixed with other raw materials.

[0049]

[Table 6] Note: Feeds AE indicate that the type of mixture (AE) is added.

Example 5 In order to confirm the antiallergic effect of the mixture prepared in Example 3, the method described in Examples 1 and 2 was applied to the leukotriene (LT), a chemical mediator of allergy.
B ₄ ) and histamine were tested for their inhibitory effect on rat mast cell release. The mixture was added to phosphate buffer (PBS) for 10 minutes.
% By weight, and extracted by heating in an autoclave at 125 ° C. for 15 minutes. After centrifugation, the supernatant was used as a sample.

The results are shown in Table 7 below. Leukotriene (LTB ₄ ) (Dahlen SE, Hedqvist P, Hammarstro), which is said to exhibit a bronchoconstriction effect 1000 times that of histamine.
m S, Samuelsson B. Leukotrienes are potent constric
The release inhibitory effect of tors of human bronchi. Nature 1980; 288; 484-6) was superior to that of the positive control Shiso, in which mixtures A to E are said to have antiallergic effects. Shiso was superior in suppressing histamine, but the effect of Additive C was equivalent to that of Shiso.

[0052]

[Table 7] Note: Additives AE indicate extracts of mixtures AE, respectively.

Example 6 Six kinds of feeds produced in Example 4 were fed to Splague Dawley male rats (3 weeks of age) for 4 weeks, and 4 weeks after feeding the feed (at 7 weeks of age), Examples 1 and 2 were fed. The release amount of leukotriene (LTB ₄ ), a chemical mediator of allergy, from the test rat peritoneal cells (PEC) was measured according to the method described in (1).

As a result, as shown in Table 8 below,
The groups fed the diets A to E containing A to E showed a 20 to 30% decrease in the release of leukotriene (LTB4) compared to the group fed the control diet containing the same amount of fish oil. Allergic effects were confirmed.

[0055]

[Table 8]

[0056]

As described above, according to the present invention, the present invention has an effect of suppressing the release of leukotriene (LTB ₄ ) and histamine, which are allergic mediators from mast cells, and is useful for alleviating various symptoms caused by allergens. Antiallergic drugs were provided. Since the antiallergic agent of the present invention is highly safe, it can be used as an effective material such as food and cream on a daily basis.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 37/08 A61K 31/00 637E 43/00 643D F-term (Reference) 4C088 AB29 AB51 AB81 AB86 AC01 AC04 AC05 AC11 AC13 AD11 BA03 BA06 BA08 BA09 BA18 MA07 MA08 NA14 ZB13 ZC02 ZC13

Claims (13)

[Claims] 1. An anti-allergic agent comprising, as an active ingredient, at least one plant selected from the group consisting of a plant of the genus Karkuma, a plant of the genus Krataegus and a plant of the genus Artemisia and / or an extract thereof. 2. The antiallergic agent according to claim 1, further comprising a plant of the genus Aloe and / or an extract thereof as an active ingredient. 3. The antiallergic agent according to claim 1 or 2, comprising a plant of the genus Krataegas and / or a plant of the genus Artemisia or an extract thereof as an active ingredient. 4. The antiallergic agent according to any one of claims 1 to 3, wherein the plant of the genus Karkuma is a tuber and / or a rhizome. 5. The antiallergic agent according to claim 1, wherein the plant body of the genus Clataegas is a fruit. 6. The plant of the artemisia genus plant,
The antiallergic agent according to any one of claims 1 to 5, which is a leaf and / or a stem. 7. The antiallergic agent according to claim 2, wherein the plant of the Aloe plant is a leaf. 8. The antiallergic agent according to any one of claims 1 to 7, wherein the plant of the genus Kirkuma is Curcuma rhizoma. 9. The antiallergic agent according to any one of claims 1 to 8, wherein the Clataegas plant is Crataegus cuneata and / or Crataegus pinnatifida. 10. The plant of the genus Artemisia, wherein the plant of the genus Artemisia is Artemissia princeps, Artemissia montana, Artemissia argyi and / or Artemissia vulgaris. 10. The anti-allergic agent according to any one of 9 above. 11. The plant of the genus Aloe, which is selected from the group consisting of Aloe arborescene and Aloe saponaria.
e saponaria), Aloe ferox, Aloe barbadensis and / or Aloe africana. The antiallergic agent according to any one of claims 2 to 10. 12. The antiallergic agent according to claim 1, wherein the extract is obtained by extracting a plant with water or an aqueous medium. 13. The method according to claim 1, further comprising a fish oil.
The antiallergic agent according to any one of the above.