IS2734B - Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum - Google Patents

Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum

Info

Publication number: IS2734B
Authority: IS; Iceland
Prior art keywords: pyrazole derivatives; compounds; preparation; reverse transcriptase; derivatives
Prior art date: 2001-04-10

Application number

IS6939A

Other languages

English (en)

Other versions

IS6939A (is

Inventor

Charles Eric Mowbray

David Anthony Price

Lyn Howard Jones

Matthew Duncan Selby

Paul Anthony Stupple

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-10

Filing date

2003-09-04

Publication date

2011-04-15

2001-04-10 Priority claimed from GB0108999A external-priority patent/GB0108999D0/en

2001-11-15 Priority claimed from GB0127426A external-priority patent/GB0127426D0/en

2003-09-04 Application filed by Pfizer filed Critical Pfizer

2003-09-04 Publication of IS6939A publication Critical patent/IS6939A/is

2011-04-15 Publication of IS2734B publication Critical patent/IS2734B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IS6939A 2001-04-10 2003-09-04 Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum IS2734B (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0108999A GB0108999D0 (en)	2001-04-10	2001-04-10	Pyrazole derivatives
GB0127426A GB0127426D0 (en)	2001-11-15	2001-11-15	Pyrazole derivatives
PCT/IB2002/001234 WO2002085860A1 (en)	2001-04-10	2002-04-04	Pyrazole derivatives for treating hiv

Publications (2)

Publication Number	Publication Date
IS6939A IS6939A (is)	2003-09-04
IS2734B true IS2734B (is)	2011-04-15

Family

ID=26245955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6939A IS2734B (is)	2001-04-10	2003-09-04	Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum

Country Status (43)

Country	Link
US (4)	US7109228B2 (is)
EP (2)	EP1377556B1 (is)
JP (1)	JP3806090B2 (is)
KR (1)	KR100569324B1 (is)
CN (1)	CN100408564C (is)
AR (2)	AR037319A1 (is)
AT (2)	ATE556059T1 (is)
AU (1)	AU2002242926B2 (is)
BG (1)	BG66349B1 (is)
BR (1)	BRPI0208811B8 (is)
CA (1)	CA2443449C (is)
CR (1)	CR7069A (is)
CY (2)	CY1107626T1 (is)
CZ (1)	CZ305099B6 (is)
DE (1)	DE60219292T2 (is)
DK (2)	DK1762567T3 (is)
DO (1)	DOP2002000378A (is)
EA (1)	EA007184B1 (is)
EE (1)	EE05400B1 (is)
ES (2)	ES2385659T3 (is)
GE (1)	GEP20053619B (is)
HK (1)	HK1063781A1 (is)
HR (1)	HRP20030783B1 (is)
HU (1)	HU229025B1 (is)
IL (2)	IL157875A0 (is)
IS (1)	IS2734B (is)
MA (1)	MA27009A1 (is)
ME (1)	ME00558A (is)
MX (1)	MXPA03009380A (is)
MY (1)	MY146669A (is)
NO (1)	NO326518B1 (is)
NZ (1)	NZ529403A (is)
OA (1)	OA12501A (is)
PA (1)	PA8543601A1 (is)
PE (1)	PE20021056A1 (is)
PL (3)	PL216985B1 (is)
PT (2)	PT1377556E (is)
RS (1)	RS51166B (is)
SI (2)	SI1762567T1 (is)
SK (1)	SK287858B6 (is)
TW (1)	TWI333488B (is)
UY (1)	UY27248A1 (is)
WO (1)	WO2002085860A1 (is)

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JP5524071B2 (ja)	2007-10-24	2014-06-18	メルク・シャープ・アンド・ドーム・コーポレーション	複素環フェニルアミドｔ型カルシウムチャネルアンタゴニスト
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AU2008340422B2 (en)	2007-12-21	2014-06-19	F. Hoffmann-La Roche Ag	Heterocyclic antiviral compounds
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WO2013057593A1 (en)	2011-10-07	2013-04-25	Phivco Uk Limited	Process for the preparation of lersivirine
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US9695127B2 (en)	2012-11-08	2017-07-04	University of Pittsburgh—of the Commonwealth System of Higher Education	Compounds for treating HIV and methods for using the compounds
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JOP20180092A1 (ar) *	2017-10-13	2019-04-13	Gilead Sciences Inc	مثبطات hiv بروتياز
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KR102114389B1 (ko) *	2018-05-02	2020-05-25	이화여자대학교 산학협력단	신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물
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2002
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Also Published As

Publication number	Publication date
MXPA03009380A (es)	2004-04-21
KR20040007496A (ko)	2004-01-24
DK1377556T3 (da)	2007-07-16
ME00558A (en)	2011-12-20
CR7069A (es)	2007-12-17
SK12442003A3 (sk)	2004-12-01
CA2443449C (en)	2008-11-04
US20060020012A1 (en)	2006-01-26
ES2283532T3 (es)	2007-11-01
US8063044B2 (en)	2011-11-22
NZ529403A (en)	2005-06-24
HRP20030783B1 (en)	2011-11-30
ATE556059T1 (de)	2012-05-15
DE60219292D1 (de)	2007-05-16
EP1377556B1 (en)	2007-04-04
EA200300943A1 (ru)	2004-08-26
CY1107626T1 (el)	2013-04-18
EP1762567A1 (en)	2007-03-14
PL398536A1 (pl)	2012-06-04
PE20021056A1 (es)	2002-12-03
IS6939A (is)	2003-09-04
US20120029192A1 (en)	2012-02-02
ES2385659T3 (es)	2012-07-27
CN1514828A (zh)	2004-07-21
PL216985B1 (pl)	2014-06-30
UY27248A1 (es)	2002-11-29
SK287858B6 (sk)	2012-01-04
BRPI0208811B1 (pt)	2018-03-13
MY146669A (en)	2012-09-14
NO326518B1 (no)	2008-12-22
PL396946A1 (pl)	2012-01-02
WO2002085860A1 (en)	2002-10-31
NO20034523L (no)	2003-12-09
PL217629B1 (pl)	2014-08-29
YU77503A (sh)	2006-05-25
NO20034523D0 (no)	2003-10-09
EE05400B1 (et)	2011-04-15
US7435728B2 (en)	2008-10-14
PT1377556E (pt)	2007-06-06
TWI333488B (en)	2010-11-21
SI1762567T1 (sl)	2012-08-31
HUP0303735A2 (hu)	2004-03-01
US20030100554A1 (en)	2003-05-29
PA8543601A1 (es)	2002-10-31
EA007184B1 (ru)	2006-08-25
SI1377556T1 (sl)	2007-08-31
BR0208811A (pt)	2004-03-09
BRPI0208811B8 (pt)	2021-05-25
PT1762567E (pt)	2012-07-16
HU229025B1 (en)	2013-07-29
CA2443449A1 (en)	2002-10-31
BG66349B1 (bg)	2013-08-30
US7109228B2 (en)	2006-09-19
EP1762567B1 (en)	2012-05-02
EE200300497A (et)	2004-02-16
CZ20032676A3 (cs)	2004-11-10
US20090215712A1 (en)	2009-08-27
IL157875A0 (en)	2004-03-28
AR076259A2 (es)	2011-06-01
BG108244A (bg)	2005-04-30
EP1377556A1 (en)	2004-01-07
ATE358669T1 (de)	2007-04-15
MA27009A1 (fr)	2004-12-20
OA12501A (en)	2006-05-26
CN100408564C (zh)	2008-08-06
AR037319A1 (es)	2004-11-03
HUP0303735A3 (en)	2004-07-28
JP3806090B2 (ja)	2006-08-09
DE60219292T2 (de)	2008-04-10
JP2004531535A (ja)	2004-10-14
KR100569324B1 (ko)	2006-04-07
PL365026A1 (en)	2004-12-27
RS51166B (sr)	2010-10-31
IL157875A (en)	2010-05-17
AU2002242926B2 (en)	2007-10-11
CY1113515T1 (el)	2016-06-22
HRP20030783A2 (en)	2005-08-31
PL217224B1 (pl)	2014-06-30
DK1762567T3 (da)	2012-06-25
GEP20053619B (en)	2005-09-26
HK1063781A1 (en)	2005-01-14
DOP2002000378A (es)	2002-10-15
CZ305099B6 (cs)	2015-05-06

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