BR0314759A - Derivados de pirazol - Google Patents
Derivados de pirazolInfo
- Publication number
- BR0314759A BR0314759A BR0314759-2A BR0314759A BR0314759A BR 0314759 A BR0314759 A BR 0314759A BR 0314759 A BR0314759 A BR 0314759A BR 0314759 A BR0314759 A BR 0314759A
- Authority
- BR
- Brazil
- Prior art keywords
- sup
- compounds
- preparation
- reverse transcriptase
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE PIRAZOL". A presente invenção refere-se a derivados de pirazol de fórmula ou seus sais, solvatos ou derivados farmaceuticamente aceitáveis, em que R^ 1^ a R^ 4^, n, W, X e Y são definidos na descrição, e a processos para a sua preparação, intermediários usados na sua preparação, composições que os contêm e aos usos de tais derivados. Os compostos da presente invenção ligam-se à enzima transcriptase reversa e são seus moduladores, especialmente inibidores. Como tal, os compostos da presente invenção são úteis no tratamento de uma variedade de desordens incluindo aquelas nas quais a inibição de transcriptase reversa está implicada. As desordens de interesse incluem as causadas por Vírus da Imunodeficiência Humana (HIV) e retrovírus geneticamente relacionados, tais como Síndrome da lmunodeficiência Adquirida (AIDS).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0222375 | 2002-09-26 | ||
| GB0223357A GB0223357D0 (en) | 2002-10-08 | 2002-10-08 | Chemical compounds |
| PCT/IB2003/004071 WO2004029051A1 (en) | 2002-09-26 | 2003-09-15 | Pyrazole amides for treating hiv infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314759A true BR0314759A (pt) | 2005-07-26 |
Family
ID=32044463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314759-2A BR0314759A (pt) | 2002-09-26 | 2003-09-15 | Derivados de pirazol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7157468B2 (pt) |
| EP (1) | EP1556381B1 (pt) |
| JP (1) | JP2006505625A (pt) |
| AT (1) | ATE386741T1 (pt) |
| AU (1) | AU2003263455A1 (pt) |
| BR (1) | BR0314759A (pt) |
| CA (1) | CA2495338A1 (pt) |
| DE (1) | DE60319254T2 (pt) |
| ES (1) | ES2298615T3 (pt) |
| MX (1) | MXPA05002004A (pt) |
| WO (1) | WO2004029051A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019968A1 (en) | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| CN101784529A (zh) | 2007-06-22 | 2010-07-21 | 弗·哈夫曼-拉罗切有限公司 | 作为非核苷逆转录酶抑制剂的脲和氨基甲酸酯衍生物 |
| DK3640241T3 (da) | 2013-10-18 | 2022-11-28 | Celgene Quanticel Res Inc | Bromdomænehæmmere |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303200A (en) * | 1963-11-05 | 1967-02-07 | American Home Prod | Pyrazole-1-ethanol derivatives |
| WO1989005643A1 (en) * | 1987-12-18 | 1989-06-29 | Pfizer Inc. | Heterocyclic-substituted quinoline-carboxylic acids |
| GB2233578A (en) | 1989-07-01 | 1991-01-16 | Edwards & Jones | Filtering yeast slurry |
| US5028322A (en) | 1989-07-11 | 1991-07-02 | The Graver Company | Low profile underdrain strainer assembly with improved distribution/fastening means |
| NZ325248A (en) | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
| GB9700504D0 (en) | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
| US6933312B2 (en) * | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
-
2003
- 2003-09-15 JP JP2005501939A patent/JP2006505625A/ja not_active Withdrawn
- 2003-09-15 CA CA002495338A patent/CA2495338A1/en not_active Abandoned
- 2003-09-15 BR BR0314759-2A patent/BR0314759A/pt not_active IP Right Cessation
- 2003-09-15 AU AU2003263455A patent/AU2003263455A1/en not_active Abandoned
- 2003-09-15 MX MXPA05002004A patent/MXPA05002004A/es unknown
- 2003-09-15 DE DE60319254T patent/DE60319254T2/de not_active Expired - Fee Related
- 2003-09-15 AT AT03798295T patent/ATE386741T1/de not_active IP Right Cessation
- 2003-09-15 EP EP03798295A patent/EP1556381B1/en not_active Expired - Lifetime
- 2003-09-15 WO PCT/IB2003/004071 patent/WO2004029051A1/en active IP Right Grant
- 2003-09-15 ES ES03798295T patent/ES2298615T3/es not_active Expired - Lifetime
- 2003-09-23 US US10/669,794 patent/US7157468B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7157468B2 (en) | 2007-01-02 |
| EP1556381B1 (en) | 2008-02-20 |
| WO2004029051A1 (en) | 2004-04-08 |
| DE60319254T2 (de) | 2009-02-12 |
| US20050004129A1 (en) | 2005-01-06 |
| ES2298615T3 (es) | 2008-05-16 |
| AU2003263455A1 (en) | 2004-04-19 |
| ATE386741T1 (de) | 2008-03-15 |
| MXPA05002004A (es) | 2005-04-28 |
| CA2495338A1 (en) | 2004-04-08 |
| DE60319254D1 (de) | 2008-04-03 |
| EP1556381A1 (en) | 2005-07-27 |
| JP2006505625A (ja) | 2006-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |