IN2012DN00721A - - Google Patents
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- Publication number
- IN2012DN00721A IN2012DN00721A IN721DEN2012A IN2012DN00721A IN 2012DN00721 A IN2012DN00721 A IN 2012DN00721A IN 721DEN2012 A IN721DEN2012 A IN 721DEN2012A IN 2012DN00721 A IN2012DN00721 A IN 2012DN00721A
- Authority
- IN
- India
- Prior art keywords
- enzyme
- dipeptidyl peptidase
- diabetes
- diseases
- involved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23924209P | 2009-09-02 | 2009-09-02 | |
| US26227809P | 2009-11-18 | 2009-11-18 | |
| PCT/US2010/046270 WO2011028455A1 (en) | 2009-09-02 | 2010-08-23 | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00721A true IN2012DN00721A (ru) | 2015-06-19 |
Family
ID=43649576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN721DEN2012 IN2012DN00721A (ru) | 2009-09-02 | 2010-08-23 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455533B2 (ru) |
| EP (1) | EP2473047B1 (ru) |
| JP (1) | JP5734981B2 (ru) |
| KR (1) | KR20120092096A (ru) |
| CN (1) | CN102595897A (ru) |
| AU (1) | AU2010289871B2 (ru) |
| BR (1) | BR112012004335A8 (ru) |
| CA (1) | CA2771352A1 (ru) |
| IN (1) | IN2012DN00721A (ru) |
| MX (1) | MX2012002633A (ru) |
| RU (1) | RU2550508C2 (ru) |
| WO (1) | WO2011028455A1 (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011103256A1 (en) | 2010-02-22 | 2011-08-25 | Merck Sharp & Dohme Corp. | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2011146358A1 (en) | 2010-05-21 | 2011-11-24 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| EP2648517B1 (en) | 2010-12-06 | 2015-08-05 | Merck Sharp & Dohme Corp. | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| EA201690035A1 (ru) | 2011-02-25 | 2016-05-31 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US9181214B2 (en) | 2011-06-09 | 2015-11-10 | Rhizen Pharmaceuticals Sa | Bicyclic compounds as modulators of GPR-119 |
| JP5873554B2 (ja) * | 2011-06-29 | 2016-03-01 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の調製プロセス |
| US9051329B2 (en) | 2011-07-05 | 2015-06-09 | Merck Sharp & Dohme Corp. | Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors |
| EP2814485A4 (en) | 2012-02-17 | 2015-08-26 | Merck Sharp & Dohme | DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES |
| US9315508B2 (en) | 2012-07-23 | 2016-04-19 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-IV inhibitors |
| WO2014018355A1 (en) * | 2012-07-23 | 2014-01-30 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-iv inhibitors |
| TWI500613B (zh) * | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
| CN105085528A (zh) * | 2014-05-15 | 2015-11-25 | 成都贝斯凯瑞生物科技有限公司 | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 |
| WO2015192701A1 (zh) | 2014-06-17 | 2015-12-23 | 四川海思科制药有限公司 | 氨基吡喃环衍生物及其组合物和应用 |
| WO2016014324A1 (en) | 2014-07-21 | 2016-01-28 | Merck Sharp & Dohme Corp. | Process for preparing chiral dipeptidyl peptidase-iv inhibitors |
| CN105985357A (zh) * | 2015-02-12 | 2016-10-05 | 北京赛林泰医药技术有限公司 | 取代的氨基六元饱和杂脂环类长效dpp-iv抑制剂 |
| TWI681962B (zh) * | 2015-08-26 | 2020-01-11 | 大陸商四川海思科製藥有限公司 | 胺基六員環類衍生物及其在醫藥上的應用 |
| BR112019025049A2 (pt) | 2017-05-31 | 2020-06-16 | Chemocentryx, Inc. | Anéis 6- 5 fundidos como inibidores de c5a |
| CN107459501B (zh) * | 2017-08-22 | 2020-06-09 | 钟桂发 | 一种奥格列汀的手性中间体的制备方法 |
| WO2019154218A1 (zh) * | 2018-02-06 | 2019-08-15 | 四川海思科制药有限公司 | 一种氨基吡喃衍生物的组合物 |
| CA3095184A1 (en) | 2018-04-02 | 2019-10-10 | Chemocentryx, Inc. | Prodrugs of fused-bicyclic c5ar antagonists |
| KR102131359B1 (ko) * | 2018-09-07 | 2020-07-07 | 오토텔릭바이오 주식회사 | 안정성이 향상된 의약 조성물 |
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| WO2009025784A1 (en) | 2007-08-21 | 2009-02-26 | Merck & Co., Inc. | Heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
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| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
| WO2011037793A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
-
2010
- 2010-08-23 IN IN721DEN2012 patent/IN2012DN00721A/en unknown
- 2010-08-23 CA CA2771352A patent/CA2771352A1/en not_active Abandoned
- 2010-08-23 AU AU2010289871A patent/AU2010289871B2/en not_active Ceased
- 2010-08-23 BR BR112012004335A patent/BR112012004335A8/pt not_active IP Right Cessation
- 2010-08-23 US US13/390,538 patent/US8455533B2/en active Active
- 2010-08-23 EP EP10814188.8A patent/EP2473047B1/en not_active Not-in-force
- 2010-08-23 CN CN2010800391645A patent/CN102595897A/zh active Pending
- 2010-08-23 JP JP2012527901A patent/JP5734981B2/ja not_active Expired - Fee Related
- 2010-08-23 KR KR1020127005395A patent/KR20120092096A/ko not_active Application Discontinuation
- 2010-08-23 WO PCT/US2010/046270 patent/WO2011028455A1/en active Application Filing
- 2010-08-23 RU RU2012112471/04A patent/RU2550508C2/ru not_active IP Right Cessation
- 2010-08-23 MX MX2012002633A patent/MX2012002633A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2473047A4 (en) | 2013-02-13 |
| US8455533B2 (en) | 2013-06-04 |
| WO2011028455A1 (en) | 2011-03-10 |
| US20120149734A1 (en) | 2012-06-14 |
| AU2010289871A1 (en) | 2012-04-26 |
| RU2012112471A (ru) | 2013-10-10 |
| EP2473047B1 (en) | 2014-08-13 |
| MX2012002633A (es) | 2012-04-20 |
| BR112012004335A8 (pt) | 2016-06-21 |
| CN102595897A (zh) | 2012-07-18 |
| BR112012004335A2 (pt) | 2015-09-08 |
| RU2550508C2 (ru) | 2015-05-10 |
| CA2771352A1 (en) | 2011-03-10 |
| JP5734981B2 (ja) | 2015-06-17 |
| AU2010289871B2 (en) | 2014-07-10 |
| KR20120092096A (ko) | 2012-08-20 |
| EP2473047A1 (en) | 2012-07-11 |
| JP2013503864A (ja) | 2013-02-04 |
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