HRP20240422T1 - Novi azoli za moduliranje vezanja i djelovanja fxr (nr1h4) - Google Patents
Novi azoli za moduliranje vezanja i djelovanja fxr (nr1h4) Download PDFInfo
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- HRP20240422T1 HRP20240422T1 HRP20240422TT HRP20240422T HRP20240422T1 HR P20240422 T1 HRP20240422 T1 HR P20240422T1 HR P20240422T T HRP20240422T T HR P20240422TT HR P20240422 T HRP20240422 T HR P20240422T HR P20240422 T1 HRP20240422 T1 HR P20240422T1
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- 150000003851 azoles Chemical class 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- -1 SO2NR7R8 Chemical group 0.000 claims 1
- 229910006069 SO3H Inorganic materials 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (12)
1. Farmaceutski pripravak, naznačen time, da sadrži 7 mg do 350 mg spoja u skladu sa sljedećom Formulom (1), njegovog enantiomera, dijastereomera, tautomera ili njegove farmaceutski prihvatljive soli
[image]
gdje
R se bira iz skupine koju čine COOR6, CONR7R8, tetrazolil, SO2NR7R8, C1-6alkil, SO2-C1-6alkil i H, s R6 koji se neovisno bira iz skupine koju čine H ili C1-6 alkil, i R7 i R8 koji se međusobno neovisno biraju iz skupine koju čine H, C1-6 alkil, halo-C1-6 alkil, C1-6 alkilen-R9, SO2-C1-6 alkil, gdje se R9 neovisno bira iz skupine koju čine COOH, OH i SO3H;
A se bira iz skupine koju čine fenil, piridil, pirimidil, pirazolil, indolil, tienil, benzotienil, indazolil, benzizoksazolil, benzofuranil, benzotriazolil, furanil, benzotiazolil, tiazolil, oksadiazolil, od kojih je svaki opcionalno supstituiran s jednom ili dvije skupine neovisno odabrane iz skupine koju čine OH, O-C1-6 alkil, O-halo-C1-6 alkil, C1-6 alkil, halo-C1-6 alkil, C3-6 cikloalkil, i halogen;
Q se bira iz skupine koju čine fenil, piridil, tiazolil, tiofenil, pirimidil, od kojih je svaki supstituiran s jednom ili dvije skupine neovisno odabrane iz skupine koju čine C1-6 alkil, halo-C1-6 alkil, halogen, i CF3;
Y se bira od N ili CH;
Z se bira od
[image]
pri čemu
X = CH, N, NO;
R1 se bira iz skupine koju čine vodik, C1-3 alkil, C3-6 cikloalkil, C4-5 alkilcikloalkil, gdje je C1-3 alkil opcionalno supstituiran s 1 do 3 supstituenta neovisno odabrana od halogena, hidroksi ili C1-6 alkoksi;
R2 i R3 se neovisno biraju iz skupine koju čine vodik, C1-3 alkil, C1-3 haloalkil, C1-3 alkoksi, C1-3 haloalkoksi, i halogen;
i farmaceutski prihvatljiv nosač, za uporabu u ukupnoj dnevnoj dozi za odraslog čovjeka od 70 kg težine.
2. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj je spoj Formule (1) kako je definirano u patentnom zahtjevu 1, ili njegova farmaceutski prihvatljiva sol.
3. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačen time, da se R-A bira od
[image]
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4. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da Q je
[image]
5. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da Z je
[image]
6. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 5, naznačen time, da se spoj Formule (1) bira od sljedećih
[image]
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[image]
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i
[image]
7. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 6, naznačen time, da spoj ima sljedeću strukturu
[image]
ili njegova farmaceutski prihvatljiva sol.
8. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 7, naznačen time, da se formulira za oralnu, rektalnu, topikalnu, parenteralnu, okularnu, pulmonarnu ili nazalnu primjenu.
9. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time, da se farmaceutski pripravak formulira kao tableta, pastila, disperzija, suspenzija, otopina, kapsula, krema, pomada ili aerosol.
10. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time, da se formulira za oralnu primjenu.
11. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 10, naznačen time, da se farmaceutski pripravak formulira kao tableta ili kapsula.
12. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 10 ili patentnom zahtjevu 11, naznačen time, da se farmaceutski pripravak formulira kao tableta.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161507153P | 2011-07-13 | 2011-07-13 | |
| EP11005722A EP2545964A1 (en) | 2011-07-13 | 2011-07-13 | Novel FXR (NR1H4) binding and activity modulating compounds |
| EP17000383.4A EP3246070B1 (en) | 2011-07-13 | 2012-07-12 | Novel fxr (nr1h4) binding and activity modulating azoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240422T1 true HRP20240422T1 (hr) | 2024-06-21 |
Family
ID=44513243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240422TT HRP20240422T1 (hr) | 2011-07-13 | 2012-07-12 | Novi azoli za moduliranje vezanja i djelovanja fxr (nr1h4) |
| HRP20160442TT HRP20160442T1 (hr) | 2011-07-13 | 2016-04-25 | Novi spojevi koji moduliraju fxr (nr1h4) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160442TT HRP20160442T1 (hr) | 2011-07-13 | 2016-04-25 | Novi spojevi koji moduliraju fxr (nr1h4) |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US9139539B2 (hr) |
| EP (5) | EP2545964A1 (hr) |
| JP (2) | JP5986633B2 (hr) |
| KR (4) | KR101934335B1 (hr) |
| CN (2) | CN107252424B (hr) |
| AR (1) | AR087127A1 (hr) |
| AU (4) | AU2012283387C1 (hr) |
| BR (3) | BR122019026062B1 (hr) |
| CA (1) | CA2839357C (hr) |
| CY (1) | CY1117453T1 (hr) |
| DK (2) | DK3246070T3 (hr) |
| EA (1) | EA024843B1 (hr) |
| ES (3) | ES2632492T3 (hr) |
| FI (1) | FI3246070T3 (hr) |
| HK (2) | HK1192181A1 (hr) |
| HR (2) | HRP20240422T1 (hr) |
| HU (2) | HUE027931T2 (hr) |
| IL (1) | IL229944A (hr) |
| LT (1) | LT3246070T (hr) |
| ME (1) | ME02434B (hr) |
| MX (2) | MX368371B (hr) |
| MY (1) | MY161158A (hr) |
| PL (3) | PL2987532T3 (hr) |
| PT (2) | PT2987532T (hr) |
| RS (1) | RS54786B1 (hr) |
| SI (3) | SI2731676T1 (hr) |
| SM (1) | SMT201600169B (hr) |
| TW (1) | TWI439455B (hr) |
| UY (1) | UY34196A (hr) |
| WO (1) | WO2013007387A1 (hr) |
| ZA (1) | ZA201309521B (hr) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| IL253437A0 (en) * | 2011-07-13 | 2017-09-28 | Gilead Sciences Inc | New compounds modulate fxr (nr1h4) activity and bind |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| AU2014320463B2 (en) | 2013-09-11 | 2018-08-02 | Centre National De La Recherche Scientifique (Cnrs) | Methods and pharmaceutical compositions for the treatment of hepatitis B virus infection |
| EP3524243A1 (en) | 2014-09-24 | 2019-08-14 | Gilead Sciences, Inc. | Methods of treating liver disease |
| EP3006939A1 (en) | 2014-10-06 | 2016-04-13 | Gilead Sciences, Inc. | Histidine-rich Glycoprotein as a marker for hepatic Farnesoid X receptor activation |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| EP3034499A1 (en) * | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
| EP3034501A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
| SG11201704340VA (en) * | 2014-12-18 | 2017-07-28 | Novartis Ag | Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
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- 2013-12-17 IL IL229944A patent/IL229944A/en active IP Right Grant
- 2013-12-17 ZA ZA2013/09521A patent/ZA201309521B/en unknown
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2014
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- 2014-06-11 HK HK14105521.1A patent/HK1192181A1/zh unknown
- 2014-06-11 HK HK16109776.3A patent/HK1221680A1/zh unknown
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2015
- 2015-08-12 US US14/824,971 patent/US9539244B2/en active Active
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2016
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- 2016-04-28 CY CY20161100369T patent/CY1117453T1/el unknown
- 2016-06-10 SM SM201600169T patent/SMT201600169B/it unknown
- 2016-08-05 JP JP2016154511A patent/JP6321097B2/ja active Active
- 2016-11-29 AU AU2016265993A patent/AU2016265993B2/en active Active
- 2016-12-05 US US15/369,521 patent/US9820979B2/en active Active
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2017
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2018
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