HRP20200070T1 - Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene - Google Patents
Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene Download PDFInfo
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- HRP20200070T1 HRP20200070T1 HRP20200070TT HRP20200070T HRP20200070T1 HR P20200070 T1 HRP20200070 T1 HR P20200070T1 HR P20200070T T HRP20200070T T HR P20200070TT HR P20200070 T HRP20200070 T HR P20200070T HR P20200070 T1 HRP20200070 T1 HR P20200070T1
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- Prior art keywords
- antibody
- antigen
- binding portion
- lag
- antibodies
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- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 9
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 5
- 230000003308 immunostimulating effect Effects 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 101150000931 L6 gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (17)
1. Izolirano humano monoklonsko antitijelo, ili njegov antigen-vezujući dio, koje vezuje humani limfocitni aktivacijski gen 3 (LAG-3) i vezuje epitop humanog LAG-3 koji sadrži aminokiselinsku sekvencu sa SEQ ID NO (SEK ID BR): 77.
2. Izolirano humano monoklonsko antitijelo, ili njegov antigen-vezujući dio, koje vezuje humani limfocitni aktivacijski gen 3 (LAG-3) i vezuje se za isti epitop na humanom LAG-3 kao referentno antitijelo, navedeno referentno antitijelo koje sadrži varijabilni region teškog lanca koji sadrži aminokiselinsku sekvencu sa SEQ ID NO:37 i varijabilni region lakog lanca koji sadrži aminokiselinsku sekvencu sa SEQ ID NO:43.
3. Antitijelo ili antigen vezujući dio iz patentnog zahtjeva 1 ili patentnog zahtjeva 2, koje sadrži varijabilni region teškog lanca koji je proizvod ili je izveden iz humanog VH 4-34 gena, i varijabilni region lakog lanca koji je proizvod ili je izveden iz humanog VK L6 gena.
4. Antitijelo ili antigen vezujući dio iz bilo kojeg od prethodnih patentnih zahtjeva, koje inhibira vezivanje LAG-3 za glavne histokompatibilne (MHC) molekule klase II.
5. Antitijelo ili antigen vezujući dio iz bilo kojeg od prethodnih patentnih zahtjeva, koje stimulira antigen-specifični T-stanični odgovor.
6. Antitijelo ili antigen vezujući dio iz patentnog zahtjeva 5, koje stimulira proizvodnju interleukina-2 od strane antigen-specifične T-stanice.
7. Antitijelo ili antigen vezujući dio iz bilo kojeg od prethodnih patentnih zahtjeva, koje se vezuje za humani LAG-3 protein sa KD od 1 x 10-9 M ili manje.
8. Antitijelo ili antigen vezujući dio iz bilo kojeg od prethodnih patentnih zahtjeva, koje se vezuje za humani LAG-3 protein sa KD od 5 x 10-10 M ili manje.
9. Kompozicija koja sadrži antitijelo ili antigen vezujući dio iz bilo kojeg od prethodnih patentnih zahtjeva, i farmaceutski prihvatljiv nosač.
10. Kompozicija iz patentnog zahtjeva 9, koja dalje sadrži jedno ili više dodatnih imunostimulatornih antitijela odabranih od anti-PD-1 antitijela, anti-PD-L1 antitijela i anti- CTLA-4 antitijela.
11. Kompozicija iz patentnog zahtjeva 10, gdje dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo.
12. Imunokonjugat koji sadrži antitijelo ili antigen-vezujući dio iz bilo kojeg od patentnih zahtjeva 1-8 vezan za terapijski agens.
13. Izolirana molekula nukleinske kiseline koji kodira antitijelo ili antigen-vezujući dio iz bilo kojeg od patentnih zahtjeva 1-8.
14. Antitijelo ili antigen vezujući dio iz bilo kojeg od patentnih zahtjeva 1-8 za primjenu u terapiji.
15. Antitijelo ili antigen vezujući dio za primjenu u skladu sa patentnim zahtjevom 14, gdje antitijelo ili antigen vezujući dio je za administraciju istovremeno, odvojeno, ili sekvencijalno sa najmanje jednim dodatnim imunostimulatornim antitijelom odabranim od anti-PD-1 antitijela, anti-PD-L1 antitijela i anti-CTLA-4 antitijela.
16. Antitijelo ili antigen vezujući dio za primjenu u skladu sa patentnim zahtjevom 15, gdje dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo.
17. Antitijelo ili antigen vezujući dio za primjenu prema bilo kojem od patentnih zahtjeva 14-16, gdje primjena u terapiji je odabrana od primjene u liječenju raka i primjene u liječenju virusne infekcije.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18854808P | 2008-08-11 | 2008-08-11 | |
| EP15156647.8A EP2905030B1 (en) | 2008-08-11 | 2009-08-11 | Human antibodies that bind lymphocyte activation gene-3 (LAG-3) and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20200070T1 true HRP20200070T1 (hr) | 2020-04-03 |
| HRP20200070T8 HRP20200070T8 (hr) | 2021-03-05 |
Family
ID=41669613
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20221191TT HRP20221191T1 (hr) | 2008-08-11 | 2009-08-11 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
| HRP20150453TT HRP20150453T1 (hr) | 2008-08-11 | 2015-04-27 | Humana antitijela koja vežu gen aktivacije limfocita 3 (lag-3) i njihova primjena |
| HRP20200070TT HRP20200070T8 (hr) | 2008-08-11 | 2020-01-17 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20221191TT HRP20221191T1 (hr) | 2008-08-11 | 2009-08-11 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
| HRP20150453TT HRP20150453T1 (hr) | 2008-08-11 | 2015-04-27 | Humana antitijela koja vežu gen aktivacije limfocita 3 (lag-3) i njihova primjena |
Country Status (32)
| Country | Link |
|---|---|
| US (13) | US20110150892A1 (hr) |
| EP (4) | EP4147714A1 (hr) |
| JP (6) | JP5647981B2 (hr) |
| KR (6) | KR101700459B1 (hr) |
| CN (4) | CN102176921B (hr) |
| AR (3) | AR072999A1 (hr) |
| AU (2) | AU2009282134B2 (hr) |
| BR (1) | BRPI0917470B8 (hr) |
| CA (1) | CA2734335C (hr) |
| CL (4) | CL2011000308A1 (hr) |
| CO (1) | CO6351751A2 (hr) |
| CY (2) | CY1116582T1 (hr) |
| DK (3) | DK2905030T3 (hr) |
| EA (2) | EA201590777A1 (hr) |
| ES (3) | ES2537203T3 (hr) |
| HK (2) | HK1151985A1 (hr) |
| HR (3) | HRP20221191T1 (hr) |
| HU (2) | HUE025250T2 (hr) |
| IL (4) | IL210731A (hr) |
| LT (2) | LT3597216T (hr) |
| MX (2) | MX2011001250A (hr) |
| NZ (3) | NZ590991A (hr) |
| PE (3) | PE20110306A1 (hr) |
| PL (3) | PL3597216T3 (hr) |
| PT (3) | PT3597216T (hr) |
| SG (1) | SG10201706497QA (hr) |
| SI (2) | SI2905030T1 (hr) |
| SM (1) | SMT201500125B (hr) |
| TN (1) | TN2011000025A1 (hr) |
| TW (1) | TWI491408B (hr) |
| WO (1) | WO2010019570A2 (hr) |
| ZA (1) | ZA201101009B (hr) |
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| NZ569236A (en) | 2005-12-08 | 2012-06-29 | Medarex Inc | Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and their use |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| SG190726A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Cytotoxicity-inducing therapeutic agent |
| US8440797B2 (en) | 2010-12-06 | 2013-05-14 | Dainippon Sumitomo Pharma Co., Ltd. | Human monoclonal antibody |
| CA2820134A1 (en) * | 2010-12-06 | 2012-06-14 | Dainippon Sumitomo Pharma Co., Ltd. | Human monoclonal antibody |
| EP2655409A4 (en) | 2010-12-22 | 2015-07-01 | Univ Leland Stanford Junior | SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 |
| EP2726101B1 (en) | 2011-06-30 | 2018-08-08 | Genzyme Corporation | Inhibitors of t-cell activation |
| EP3409278B8 (en) | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP3404116B1 (en) | 2013-03-15 | 2022-10-19 | The University of Chicago | Methods and compositions related to t-cell activity |
| LT2970464T (lt) * | 2013-03-15 | 2020-08-25 | Glaxosmithkline Intellectual Property Development Limited | Anti-lag-3 surišantys baltymai |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| PT2992017T (pt) | 2013-05-02 | 2021-01-29 | Anaptysbio Inc | Anticorpos dirigidos contra a morte programada 1 (pd-1) |
| SG10201902380SA (en) | 2013-06-25 | 2019-04-29 | Vaccinex Inc | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases |
| AU2014296887A1 (en) | 2013-08-02 | 2016-01-28 | Aduro Biotech Holdings, Europe B.V. | Combining CD27 agonists and immune checkpoint inhibition for immune stimulation |
| US20160184399A1 (en) | 2013-08-08 | 2016-06-30 | Cytune Pharma | Combined pharmaceutical composition |
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| KR20230008255A (ko) | 2013-09-20 | 2023-01-13 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하기 위한 항-lag-3 항체 및 항-pd-1 항체의 조합물 |
| JP2016533167A (ja) | 2013-09-24 | 2016-10-27 | メディシナ セラピューティクス ピーティーイー リミテッド | インターロイキン−２融合タンパク質及びその使用 |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| WO2015066413A1 (en) | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| BR112016013741A2 (pt) * | 2013-12-17 | 2017-10-03 | Genentech Inc | Usos de antagonistas de ligação de eixo de pd-1 e um anticorpo de anti-cd20, e kit compreendendo os mesmos |
| KR102447878B1 (ko) * | 2013-12-17 | 2022-09-26 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 탁산을 이용한 암 치료 방법 |
| GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
| CA3225456A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| US20160318928A1 (en) | 2013-12-24 | 2016-11-03 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
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| SI3556775T1 (sl) * | 2014-01-28 | 2022-02-28 | Bristol-Myers Squibb Company | Protitelesa proti-LAG-3 za zdravljenje hematoloških malignosti |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
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