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HK1222566A1 - 氯甲基 -二氫- -苯並 吲哚二聚體抗體-藥物綴合物化合物，及使用和治療方法 - Google Patents

氯甲基 -二氫- -苯並 吲哚二聚體抗體-藥物綴合物化合物，及使用和治療方法

Info

Publication number
HK1222566A1
HK1222566A1 HK16110804.7A HK16110804A HK1222566A1 HK 1222566 A1 HK1222566 A1 HK 1222566A1 HK 16110804 A HK16110804 A HK 16110804A HK 1222566 A1 HK1222566 A1 HK 1222566A1
Authority
HK
Hong Kong
Prior art keywords
chloromethyl
benzo
dihydro
treatment
methods
Prior art date
Application number
HK16110804.7A
Other languages
English (en)
Inventor
John A Flygare
Thomas H Pillow
Brian Safina
Visha Verma
Binqing Wei
William Denny
Anna Giddens
Ho Lee
Guo-Liang Lu
Christian Miller
Gordon REWCASTLE
Moana Tercel
Muriel Bonnet
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HK1222566A1 publication Critical patent/HK1222566A1/zh

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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16110804.7A 2013-08-12 2016-09-13 氯甲基 -二氫- -苯並 吲哚二聚體抗體-藥物綴合物化合物，及使用和治療方法 HK1222566A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361864889P 2013-08-12 2013-08-12
US201361916388P 2013-12-16 2013-12-16
US201461969499P 2014-03-24 2014-03-24
PCT/US2014/042560 WO2015023355A1 (en) 2013-08-12 2014-06-16 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

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HK1222566A1 true HK1222566A1 (zh) 2017-07-07

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HK16110804.7A HK1222566A1 (zh) 2013-08-12 2016-09-13 氯甲基 -二氫- -苯並 吲哚二聚體抗體-藥物綴合物化合物，及使用和治療方法

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US (1) US10442836B2 (zh)
EP (1) EP3033111B1 (zh)
JP (2) JP6993084B2 (zh)
KR (1) KR20160042080A (zh)
CN (1) CN105636612B (zh)
AU (1) AU2014307080B2 (zh)
BR (1) BR112016002829A2 (zh)
CA (1) CA2918139A1 (zh)
CL (1) CL2016000318A1 (zh)
CR (1) CR20160125A (zh)
EA (1) EA201690195A1 (zh)
HK (2) HK1222544A1 (zh)
IL (1) IL243586A0 (zh)
MX (1) MX2016001862A (zh)
PH (1) PH12016500246A1 (zh)
SG (1) SG11201601005XA (zh)
TW (1) TWI636792B (zh)
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CA3220104A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
WO2013093809A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
MA39095A1 (fr) * 2013-12-13 2018-08-31 Genentech Inc Anticorps et immunoconjugués anti-cd33
PE20161394A1 (es) 2013-12-16 2017-01-06 Genentech Inc Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco
CA2929565A1 (en) * 2013-12-16 2015-06-25 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
CN105848685B (zh) 2013-12-16 2020-09-22 健泰科生物技术公司 拟肽化合物及其抗体药物偶联物
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