HK1054927A1 - Tropane derivatives useful in therapy - Google Patents

Tropane derivatives useful in therapy

Info

Publication number: HK1054927A1
Authority: HK; Hong Kong
Prior art keywords: fluorine atoms; therapy; optionally substituted; derivatives useful; tropane derivatives
Prior art date: 2000-05-26

Application number

HK03107045A

Other languages

English (en)

Inventor

Manoussos Perros

David Anthony Price

Blanda Luzia Christa Stammen

Anthony Wood

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-26

Filing date

2003-09-30

Publication date

2003-12-19

2000-05-26 Priority claimed from GB0014046A external-priority patent/GB0014046D0/en

2000-06-27 Priority claimed from GB0015835A external-priority patent/GB0015835D0/en

2003-09-30 Application filed by Pfizer filed Critical Pfizer

2003-12-19 Publication of HK1054927A1 publication Critical patent/HK1054927A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)

HK03107045A 2000-05-26 2003-09-30 Tropane derivatives useful in therapy HK1054927A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0014046A GB0014046D0 (en)	2000-05-26	2000-05-26	Compounds useful in therapy
GB0015835A GB0015835D0 (en)	2000-06-27	2000-06-27	Compounds useful in therapy
PCT/IB2001/000806 WO2001090106A2 (en)	2000-05-26	2001-05-09	Tryasolyl tropane derivatives as ccr5 modulators

Publications (1)

Publication Number	Publication Date
HK1054927A1 true HK1054927A1 (en)	2003-12-19

Family

ID=26244452

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
HK03107045A HK1054927A1 (en)	2000-05-26	2003-09-30	Tropane derivatives useful in therapy
HK05110416A HK1078573A1 (en)	2000-05-26	2005-11-18	Tropane derivatives usefull in therapy
HK06111446A HK1090836A1 (en)	2000-05-26	2006-10-18	Intermediates for the preparation of tropane derivatives useful in therapy

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
HK05110416A HK1078573A1 (en)	2000-05-26	2005-11-18	Tropane derivatives usefull in therapy
HK06111446A HK1090836A1 (en)	2000-05-26	2006-10-18	Intermediates for the preparation of tropane derivatives useful in therapy

Country Status (51)

Country	Link
EP (3)	EP1990341B1 (no)
JP (2)	JP3693957B2 (no)
KR (2)	KR100523501B1 (no)
CN (2)	CN1279040C (no)
AP (1)	AP1965A (no)
AR (2)	AR028622A1 (no)
AT (2)	ATE407134T1 (no)
AU (2)	AU2001252482B2 (no)
BG (1)	BG65966B1 (no)
BR (1)	BRPI0110955B8 (no)
CA (1)	CA2408909C (no)
CR (1)	CR10145A (no)
CU (1)	CU23288B7 (no)
CY (3)	CY2008006I1 (no)
CZ (1)	CZ299102B6 (no)
DE (3)	DE122008000011I1 (no)
DK (2)	DK1526134T3 (no)
DZ (1)	DZ3464A1 (no)
EA (2)	EA005382B1 (no)
EE (1)	EE05110B1 (no)
EG (1)	EG24137A (no)
ES (3)	ES2401812T3 (no)
FR (1)	FR08C0007I2 (no)
GE (1)	GEP20063799B (no)
HK (3)	HK1054927A1 (no)
HR (1)	HRP20020938B1 (no)
HU (1)	HU225810B1 (no)
IL (2)	IL152531A0 (no)
IS (1)	IS2511B (no)
LT (1)	LTC1284974I2 (no)
LU (1)	LU91417I2 (no)
MA (1)	MA26902A1 (no)
ME (1)	ME00555A (no)
MX (1)	MXPA02011631A (no)
MY (3)	MY153023A (no)
NL (1)	NL300338I2 (no)
NO (3)	NO327892B1 (no)
NZ (1)	NZ521477A (no)
OA (1)	OA12264A (no)
PA (1)	PA8517101A1 (no)
PE (1)	PE20011371A1 (no)
PL (1)	PL200551B1 (no)
PT (2)	PT1526134E (no)
RS (2)	RS51436B (no)
SI (2)	SI1526134T1 (no)
SK (1)	SK286129B6 (no)
TN (1)	TNSN01077A1 (no)
TR (1)	TR200400541T4 (no)
TW (1)	TWI230160B (no)
UY (1)	UY26727A1 (no)
WO (1)	WO2001090106A2 (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2401812T3 (es) *	2000-05-26	2013-04-24	Pfizer Inc.	Derivados de triazolil tropano como moduladores de CCR5
CN1547575A (zh) *	2001-06-12	2004-11-17	Sk��ʽ��	新颖苯基烷基二胺和酰胺类似物
SE0200919D0 (sv) *	2002-03-25	2002-03-25	Astrazeneca Ab	Chemical compounds
AU2003214503B2 (en) *	2002-04-08	2008-08-07	Pfizer Inc.	Tropane derivatives as CCR5 modulators
GB0208071D0 (en) *	2002-04-08	2002-05-22	Pfizer Ltd	Tropane derivatives useful in therapy
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
EP1506405A1 (en) *	2002-05-23	2005-02-16	Pfizer Limited	Method for identification of a ligand whereby receptor residence time is measured
ATE405269T1 (de)	2002-12-13	2008-09-15	Smithkline Beecham Corp	Cyclohexylverbindungen als ccr5-antagonisten
DE10336274A1 (de) *	2003-08-07	2005-03-10	Honeywell Specialty Chemicals	Verfahren zur Herstellung von geminalen Difluoralkanen
JP2007504123A (ja)	2003-08-29	2007-03-01	ランバクシーラボラトリーズリミテッド	Ｉｖ型ホスホジエステラーゼの阻害剤
WO2005023810A1 (en)	2003-09-10	2005-03-17	Virochem Pharma Inc.	Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
ES2295924T3 (es) *	2003-10-03	2008-04-16	Pfizer, Inc.	Derivados de tropano imidazopirina sustituidos con actividad antagonista de los receptores ccr5 para el tratamiento de vih y de la inflamacion.
TW200610761A (en)	2004-04-23	2006-04-01	Astrazeneca Ab	Chemical compounds
CN101001860A (zh)	2004-06-09	2007-07-18	霍夫曼-拉罗奇有限公司	杂环抗病毒化合物
WO2006055660A2 (en) *	2004-11-19	2006-05-26	Boehringer Ingelheim International Gmbh	Method for treating hiv infection through co-administration of tipranavir and uk-427, 857
WO2006064340A2 (en) *	2004-12-13	2006-06-22	Pfizer Limited	Process for the preparation of n-acyl beta-aminoaldehydes
US7665658B2 (en)	2005-06-07	2010-02-23	First Data Corporation	Dynamic aggregation of payment transactions
JP2009514790A (ja)	2005-07-22	2009-04-09	プロジェニクス・ファーマスーティカルズ・インコーポレイテッド	Ｈｉｖ−１−感染患者におけるウイルス負荷を減少させる方法
CN101291905A (zh)	2005-10-19	2008-10-22	弗·哈夫曼-拉罗切有限公司	苯乙酰胺nnrt抑制剂
RU2451676C2 (ru)	2006-08-16	2012-05-27	Ф.Хоффманн-Ля Рош Аг	Ненуклеозидные ингибиторы обратной транскриптазы
WO2008063600A2 (en) *	2006-11-17	2008-05-29	Concert Pharmaceuticals Inc.	Triazolyl tropane derivatives
JP5415957B2 (ja)	2006-12-13	2014-02-12	エフ．ホフマン−ラロシュアーゲー	非ヌクレオシド逆転写酵素阻害剤としての２−（ピペリジン−４−イル）−４−フェノキシ−又はフェニルアミノ−ピリミジン誘導体
WO2008077103A1 (en) *	2006-12-19	2008-06-26	Auspex Pharmaceuticals, Inc.	Preperation and utility of ccr5 inhibitors
EP1958947A1 (en)	2007-02-15	2008-08-20	Ranbaxy Laboratories Limited	Inhibitors of phosphodiesterase type 4
WO2008132128A2 (en) *	2007-04-27	2008-11-06	Solvay (Société Anonyme)	Synthesis of a pharmaceutically active compound
AU2009220462A1 (en) *	2008-02-29	2009-09-11	Merck Sharp & Dohme Corp.	CCR5 antagonists as prophylactics for preventing HIV infection and methods of inhibiting transmission of same
CN101712679B (zh) *	2008-10-08	2013-04-10	中国科学院上海药物研究所	一种酰胺类化合物、其药物组合物及其制备方法和用途
JP5730871B2 (ja) *	2009-07-24	2015-06-10	グラクソスミスクラインエルエルシー	治療化合物
CN102140104B (zh) *	2010-02-03	2014-11-12	中国科学院上海药物研究所	1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途
PH12012501930A1 (en)	2010-04-02	2013-02-04	Phivco 1 Llc	Combination therapy comprising a ccr5 antagonist, a hiv-1 protease inhibitor and a pharmacokinetic enhancer
CN106977511B (zh) *	2011-12-19	2019-04-12	中国科学院上海药物研究所	一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
AU2013340559B2 (en)	2012-10-29	2018-03-15	Cipla Limited	Antiviral phosphonate analogues and process for preparation thereof
CZ306455B6 (cs)	2013-04-26	2017-02-01	Zentiva, K.S.	Nový způsob syntézy Maravirocu
CN103497164B (zh) *	2013-09-23	2015-12-23	西安近代化学研究所	一种蒽衍生物及其制备方法
CN104304248B (zh) *	2014-10-23	2016-08-10	西北农林科技大学	3-芳基丙酸酯类化合物作为制备杀螨药物的应用
CN104402883B (zh) *	2014-10-24	2016-04-27	艾琪康医药科技（上海）有限公司	4，4-二氟金刚烷甲酰胺衍生物、药物组合物及其制备方法和用途
CN104387379B (zh) *	2014-11-26	2017-01-11	扬州氟药科技有限公司	一种二氟亚甲基哌啶甲酰胺衍生物及其制备方法和用途
CN104860946A (zh) *	2015-05-14	2015-08-26	湖北生物医药产业技术研究院有限公司	Ccr5拮抗剂的制备方法
CN107879963A (zh) *	2016-09-29	2018-04-06	中国科学院上海药物研究所	新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5376645A (en)	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5648511A (en) *	1990-11-19	1997-07-15	G.D. Searle & Co.	Method for making intermediates useful in the synthesis of retroviral protease inhibitors
FR2676444B1 (fr) *	1991-05-16	1995-03-10	Sanofi Elf	Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
JP2899418B2 (ja) *	1994-04-19	1999-06-02	ノイロサーチアクティーゼルスカブ	トロパン誘導体、それらの製造及び用途
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
DE19546462A1 (de) *	1995-12-13	1997-06-19	Bayer Ag	Diarylacetylenketone
AU1208397A (en) *	1995-12-28	1997-07-28	Takeda Chemical Industries Ltd.	Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
CA2259927A1 (en) *	1996-07-12	1998-01-22	Leukosite, Inc.	Chemokine receptor antagonists and methods of use therefor
US6323206B1 (en) *	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
WO1998025617A1 (en) *	1996-12-13	1998-06-18	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
WO1998025604A1 (en) *	1996-12-13	1998-06-18	Merck & Co., Inc.	Spiro-substituted azacycles as modulators of chemokine receptor activity
GB9711643D0 (en)	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
CA2296314A1 (en) *	1997-07-25	1999-02-04	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
IL125658A0 (en) *	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
US6433165B1 (en) *	1998-01-21	2002-08-13	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
EP1013276A1 (en)	1998-12-23	2000-06-28	Pfizer Inc.	Aminoazacycloalkanes as CCR5 modulators
US7217714B1 (en) *	1998-12-23	2007-05-15	Agouron Pharmaceuticals, Inc.	CCR5 modulators
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
ES2401812T3 (es) *	2000-05-26	2013-04-24	Pfizer Inc.	Derivados de triazolil tropano como moduladores de CCR5

2001
- 2001-05-09 ES ES08163025T patent/ES2401812T3/es not_active Expired - Lifetime
- 2001-05-09 SI SI200130862T patent/SI1526134T1/sl unknown
- 2001-05-09 RS RSP-2009/0438A patent/RS51436B/en unknown
- 2001-05-09 SK SK1643-2002A patent/SK286129B6/sk active Protection Beyond IP Right Term
- 2001-05-09 BR BRPI0110955A patent/BRPI0110955B8/pt not_active IP Right Cessation
- 2001-05-09 DE DE200812000011 patent/DE122008000011I1/de active Pending
- 2001-05-09 SI SI200130090T patent/SI1284974T1/xx unknown
- 2001-05-09 GE GEAP2001004960 patent/GEP20063799B/en unknown
- 2001-05-09 KR KR10-2002-7015934A patent/KR100523501B1/ko active IP Right Grant
- 2001-05-09 AU AU2001252482A patent/AU2001252482B2/en not_active Expired
- 2001-05-09 DK DK04004193T patent/DK1526134T3/da active
- 2001-05-09 ES ES01925808T patent/ES2215129T3/es not_active Expired - Lifetime
- 2001-05-09 CN CNB018088287A patent/CN1279040C/zh not_active Expired - Lifetime
- 2001-05-09 EE EEP200200656A patent/EE05110B1/xx active Protection Beyond IP Right Term
- 2001-05-09 TR TR200400541T patent/TR200400541T4/xx unknown
- 2001-05-09 EP EP20080163025 patent/EP1990341B1/en not_active Expired - Lifetime
- 2001-05-09 DE DE2001602233 patent/DE60102233T2/de not_active Expired - Lifetime
- 2001-05-09 OA OA1200200343A patent/OA12264A/en unknown
- 2001-05-09 DE DE60135685T patent/DE60135685D1/de not_active Expired - Lifetime
- 2001-05-09 EA EA200201141A patent/EA005382B1/ru not_active IP Right Cessation
- 2001-05-09 DK DK01925808T patent/DK1284974T3/da active
- 2001-05-09 RS YUP82202 patent/RS50904B/sr unknown
- 2001-05-09 CZ CZ20023806A patent/CZ299102B6/cs not_active IP Right Cessation
- 2001-05-09 CA CA 2408909 patent/CA2408909C/en not_active Expired - Lifetime
- 2001-05-09 PL PL359267A patent/PL200551B1/pl unknown
- 2001-05-09 ME MEP-693/08A patent/ME00555A/xx unknown
- 2001-05-09 AU AU5248201A patent/AU5248201A/xx active Pending
- 2001-05-09 ES ES04004193T patent/ES2311126T3/es not_active Expired - Lifetime
- 2001-05-09 NZ NZ521477A patent/NZ521477A/en not_active IP Right Cessation
- 2001-05-09 WO PCT/IB2001/000806 patent/WO2001090106A2/en active IP Right Grant
- 2001-05-09 DZ DZ013464A patent/DZ3464A1/fr active
- 2001-05-09 IL IL15253101A patent/IL152531A0/xx unknown
- 2001-05-09 HU HU0302474A patent/HU225810B1/hu active Protection Beyond IP Right Term
- 2001-05-09 EP EP20010925808 patent/EP1284974B1/en not_active Expired - Lifetime
- 2001-05-09 AT AT04004193T patent/ATE407134T1/de active
- 2001-05-09 KR KR1020057003492A patent/KR100548854B1/ko active IP Right Grant
- 2001-05-09 EA EA200401056A patent/EA007580B1/ru not_active IP Right Cessation
- 2001-05-09 CN CNB2005100068151A patent/CN100355753C/zh not_active Expired - Lifetime
- 2001-05-09 MX MXPA02011631A patent/MXPA02011631A/es active IP Right Grant
- 2001-05-09 JP JP2001586293A patent/JP3693957B2/ja not_active Expired - Lifetime
- 2001-05-09 AT AT01925808T patent/ATE260914T1/de active
- 2001-05-09 AP APAP/P/2002/002663A patent/AP1965A/en active
- 2001-05-09 PT PT04004193T patent/PT1526134E/pt unknown
- 2001-05-09 EP EP20040004193 patent/EP1526134B1/en not_active Expired - Lifetime
- 2001-05-09 PT PT01925808T patent/PT1284974E/pt unknown
- 2001-05-21 TW TW90112055A patent/TWI230160B/zh not_active IP Right Cessation
- 2001-05-22 PA PA8517101A patent/PA8517101A1/es unknown
- 2001-05-22 EG EG20010535A patent/EG24137A/xx active
- 2001-05-23 MY MYPI20041980 patent/MY153023A/en unknown
- 2001-05-23 MY MYPI20012461 patent/MY131019A/en unknown
- 2001-05-23 MY MYPI20094132A patent/MY156920A/en unknown
- 2001-05-24 AR ARP010102486 patent/AR028622A1/es active IP Right Grant
- 2001-05-24 PE PE2001000476A patent/PE20011371A1/es active IP Right Grant
- 2001-05-24 UY UY26727A patent/UY26727A1/es not_active IP Right Cessation
- 2001-05-25 TN TNSN01077 patent/TNSN01077A1/fr unknown
2002
- 2002-09-23 BG BG107140A patent/BG65966B1/bg unknown
- 2002-09-24 IS IS6565A patent/IS2511B/is unknown
- 2002-10-28 IL IL152531A patent/IL152531A/en active Protection Beyond IP Right Term
- 2002-10-28 CU CU20020243A patent/CU23288B7/es unknown
- 2002-10-31 NO NO20025227A patent/NO327892B1/no not_active IP Right Cessation
- 2002-11-14 MA MA26910A patent/MA26902A1/fr unknown
- 2002-11-26 HR HR20020938A patent/HRP20020938B1/xx not_active IP Right Cessation
2003
- 2003-09-30 HK HK03107045A patent/HK1054927A1/xx not_active IP Right Cessation
2005
- 2005-02-15 JP JP2005038062A patent/JP4854970B2/ja not_active Expired - Lifetime
- 2005-11-18 HK HK05110416A patent/HK1078573A1/xx not_active IP Right Cessation
2006
- 2006-10-18 HK HK06111446A patent/HK1090836A1/xx not_active IP Right Cessation
2007
- 2007-03-27 AR ARP070101273 patent/AR060159A2/es unknown
2008
- 2008-02-22 LU LU91417C patent/LU91417I2/fr unknown
- 2008-02-22 NL NL300338C patent/NL300338I2/nl unknown
- 2008-02-25 LT LTPA2008004C patent/LTC1284974I2/lt unknown
- 2008-03-04 FR FR08C0007C patent/FR08C0007I2/fr active Active
- 2008-03-17 CY CY200800006C patent/CY2008006I1/el unknown
- 2008-07-16 CR CR10145A patent/CR10145A/es unknown
- 2008-10-24 CY CY081101203T patent/CY1108451T1/el unknown
2010
- 2010-04-08 NO NO2010007C patent/NO2010007I2/no unknown
2020
- 2020-06-30 NO NO2020019C patent/NO2020019I1/no not_active IP Right Cessation
2022
- 2022-04-19 CY CY2022009C patent/CY2022009I1/el unknown

Also Published As

Publication number	Publication date
DK1284974T3 (da)	2004-06-07
ES2215129T3 (es)	2004-10-01
CZ299102B6 (cs)	2008-04-23
CY2008006I2 (el)	2009-11-04
MA26902A1 (fr)	2004-12-20
NL300338I1 (nl)	2008-05-01
CN1437599A (zh)	2003-08-20
AP2002002663A0 (en)	2002-12-31
SI1526134T1 (sl)	2008-12-31
EP1284974B1 (en)	2004-03-03
IS2511B (is)	2009-05-15
NO2020019I1 (no)	2020-06-30
EP1526134A3 (en)	2006-11-29
EP1526134B1 (en)	2008-09-03
FR08C0007I1 (no)	2008-04-25
AU2001252482C1 (en)	2001-12-03
RS50904B (sr)	2010-08-31
BR0110955A (pt)	2003-06-03
TNSN01077A1 (fr)	2005-11-10
BG65966B1 (bg)	2010-07-30
CY2008006I1 (el)	2009-11-04
HUP0302474A2 (hu)	2003-11-28
NO20025227D0 (no)	2002-10-31
ME00555B (me)	2011-12-20
LU91417I9 (no)	2019-01-02
CN100355753C (zh)	2007-12-19
ATE260914T1 (de)	2004-03-15
MY153023A (en)	2014-12-31
NO327892B1 (no)	2009-10-12
JP4854970B2 (ja)	2012-01-18
DZ3464A1 (no)	2001-11-29
NL300338I2 (nl)	2008-06-02
SI1284974T1 (en)	2004-08-31
EP1990341B1 (en)	2013-01-23
KR100548854B1 (ko)	2006-02-02
PA8517101A1 (es)	2002-10-24
NO20025227L (no)	2002-10-31
ATE407134T1 (de)	2008-09-15
YU82202A (sh)	2005-11-28
MY156920A (en)	2016-04-15
FR08C0007I2 (fr)	2009-01-15
TWI230160B (en)	2005-04-01
EE200200656A (et)	2004-06-15
EE05110B1 (et)	2008-12-15
EA005382B1 (ru)	2005-02-24
HRP20020938A2 (en)	2005-02-28
CA2408909A1 (en)	2001-11-29
CY1108451T1 (el)	2014-04-09
ES2401812T3 (es)	2013-04-24
NZ521477A (en)	2004-07-30
LU91417I2 (fr)	2008-04-22
CY2022009I2 (el)	2022-05-27
HK1078573A1 (en)	2006-03-17
GEP20063799B (en)	2006-04-25
SK16432002A3 (sk)	2004-01-08
EG24137A (en)	2008-08-06
RS51436B (en)	2011-04-30
DE60102233T2 (de)	2005-01-27
EP1284974A2 (en)	2003-02-26
HUP0302474A3 (en)	2007-05-29
CN1279040C (zh)	2006-10-11
CY2022009I1 (el)	2022-05-27
AR028622A1 (es)	2003-05-14
ME00555A (en)	2011-12-20
LTC1284974I2 (lt)	2020-11-10
BRPI0110955B1 (pt)	2016-06-28
HU225810B1 (en)	2007-10-29
WO2001090106A2 (en)	2001-11-29
OA12264A (en)	2003-11-10
JP2003534343A (ja)	2003-11-18
CZ20023806A3 (cs)	2004-01-14
DE60135685D1 (de)	2008-10-16
KR20030004417A (ko)	2003-01-14
PL200551B1 (pl)	2009-01-30
MXPA02011631A (es)	2003-03-27
WO2001090106A3 (en)	2002-03-28
PT1284974E (pt)	2004-06-30
CR10145A (es)	2008-08-19
BRPI0110955B8 (pt)	2021-05-25
ES2311126T3 (es)	2009-02-01
DE60102233D1 (de)	2004-04-08
HRP20020938B1 (en)	2011-05-31
AP1965A (en)	2009-03-04
UY26727A1 (es)	2001-12-28
AR060159A2 (es)	2008-05-28
DK1526134T3 (da)	2008-11-17
RS20090438A (en)	2010-05-07
EP1526134A2 (en)	2005-04-27
EA200201141A1 (ru)	2003-04-24
BG107140A (bg)	2003-05-30
IL152531A0 (en)	2003-05-29
KR20050046743A (ko)	2005-05-18
JP2005194283A (ja)	2005-07-21
PE20011371A1 (es)	2002-01-18
NO2010007I1 (no)	2010-04-08
CN1680371A (zh)	2005-10-12
MY131019A (en)	2007-07-31
AU5248201A (en)	2001-12-03
EA007580B1 (ru)	2006-12-29
TR200400541T4 (tr)	2004-04-21
DE122008000011I1 (de)	2008-06-05
SK286129B6 (sk)	2008-04-07
LTPA2008004I1 (lt)	2020-07-27
EA200401056A1 (ru)	2005-04-28
KR100523501B1 (ko)	2005-10-25
HK1090836A1 (en)	2007-01-05
PL359267A1 (en)	2004-08-23
NO2010007I2 (no)	2013-09-09
IS6565A (is)	2002-09-24
CU23288B7 (es)	2008-06-30
EP1990341A1 (en)	2008-11-12
CA2408909C (en)	2006-06-27
JP3693957B2 (ja)	2005-09-14
IL152531A (en)	2010-05-17
AU2001252482B2 (en)	2006-01-19
PT1526134E (pt)	2008-10-28

Publication	Publication Date	Title
HK1054927A1 (en)	2003-12-19	Tropane derivatives useful in therapy
DE60112974D1 (en)	2005-09-29	Carbolinderivate
BG108269A (en)	2004-12-30	Pyrazolopyrimidines as therapeutic agents
DE60216233D1 (en)	2007-01-04	Carbolinderivate
AU2002213421A1 (en)	2002-04-15	Condensed pyridoindole derivatives
HK1012341A1 (en)	1999-07-30	Pyrrolocarbazole
MXPA03002909A (es)	2003-09-10	Compuestos quimicos.
MXPA03003971A (es)	2004-02-12	Derivados de indol como inhibidores de pde5.
EP1034783A4 (en)	2001-03-28	AMIDE DERIVATIVES
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
MXPA03004023A (es)	2004-02-12	Compuestos quimicos.
CA2445620A1 (en)	2002-12-12	Tetracyclic compounds as pde5-inhibitors
EP1023062A4 (en)	2001-11-21	ANTIBACTERIAL CARBAPENEMAS, COMPOSITIONS AND METHODS OF TREATMENT

Legal Events

Date	Code	Title	Description
2021-05-21	PE	Patent expired	Effective date: 20210508