ATE260914T1 - Triazolyltropanderivate als ccr5-modulatoren - Google Patents

Triazolyltropanderivate als ccr5-modulatoren

Info

Publication number: ATE260914T1
Authority: AT; Austria
Prior art keywords: triazolyltropand; derivatives; ccr5 modulators; ccr5; modulators
Prior art date: 2000-05-26

Application number

AT01925808T

Other languages

English (en)

Inventor

Manoussos Perros

David Anthony Price

Blanda L Stammen

Anthony Wood

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-26

Filing date

2001-05-09

Publication date

2004-03-15

2000-05-26 Priority claimed from GB0014046A external-priority patent/GB0014046D0/en

2000-06-27 Priority claimed from GB0015835A external-priority patent/GB0015835D0/en

2001-05-09 Application filed by Pfizer filed Critical Pfizer

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260914T1 publication Critical patent/ATE260914T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)

AT01925808T 2000-05-26 2001-05-09 Triazolyltropanderivate als ccr5-modulatoren ATE260914T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0014046A GB0014046D0 (en)	2000-05-26	2000-05-26	Compounds useful in therapy
GB0015835A GB0015835D0 (en)	2000-06-27	2000-06-27	Compounds useful in therapy
PCT/IB2001/000806 WO2001090106A2 (en)	2000-05-26	2001-05-09	Tryasolyl tropane derivatives as ccr5 modulators

Publications (1)

Publication Number	Publication Date
ATE260914T1 true ATE260914T1 (de)	2004-03-15

Family

ID=26244452

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04004193T ATE407134T1 (de)	2000-05-26	2001-05-09	Triazolyltropanderivate als ccr5-modulatoren
AT01925808T ATE260914T1 (de)	2000-05-26	2001-05-09	Triazolyltropanderivate als ccr5-modulatoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04004193T ATE407134T1 (de)	2000-05-26	2001-05-09	Triazolyltropanderivate als ccr5-modulatoren

Country Status (51)

Country	Link
EP (3)	EP1526134B1 (de)
JP (2)	JP3693957B2 (de)
KR (2)	KR100548854B1 (de)
CN (2)	CN1279040C (de)
AP (1)	AP1965A (de)
AR (2)	AR028622A1 (de)
AT (2)	ATE407134T1 (de)
AU (2)	AU5248201A (de)
BG (1)	BG65966B1 (de)
BR (1)	BRPI0110955B8 (de)
CA (1)	CA2408909C (de)
CR (1)	CR10145A (de)
CU (1)	CU23288B7 (de)
CY (3)	CY2008006I1 (de)
CZ (1)	CZ299102B6 (de)
DE (3)	DE60135685D1 (de)
DK (2)	DK1526134T3 (de)
DZ (1)	DZ3464A1 (de)
EA (2)	EA005382B1 (de)
EE (1)	EE05110B1 (de)
EG (1)	EG24137A (de)
ES (3)	ES2401812T3 (de)
FR (1)	FR08C0007I2 (de)
GE (1)	GEP20063799B (de)
HK (3)	HK1054927A1 (de)
HR (1)	HRP20020938B1 (de)
HU (1)	HU225810B1 (de)
IL (2)	IL152531A0 (de)
IS (1)	IS2511B (de)
LT (1)	LTC1284974I2 (de)
LU (1)	LU91417I2 (de)
MA (1)	MA26902A1 (de)
ME (1)	ME00555B (de)
MX (1)	MXPA02011631A (de)
MY (3)	MY131019A (de)
NL (1)	NL300338I2 (de)
NO (3)	NO327892B1 (de)
NZ (1)	NZ521477A (de)
OA (1)	OA12264A (de)
PA (1)	PA8517101A1 (de)
PE (1)	PE20011371A1 (de)
PL (1)	PL200551B1 (de)
PT (2)	PT1284974E (de)
RS (2)	RS51436B (de)
SI (2)	SI1284974T1 (de)
SK (1)	SK286129B6 (de)
TN (1)	TNSN01077A1 (de)
TR (1)	TR200400541T4 (de)
TW (1)	TWI230160B (de)
UY (1)	UY26727A1 (de)
WO (1)	WO2001090106A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02011631A (es) *	2000-05-26	2003-03-27	Pfizer	Derivados de tropano utiles en terapia.
EP1401821A4 (de) *	2001-06-12	2006-05-31	Sk Corp	Neue phenylalkyldiamin- und -amidanaloga
SE0200919D0 (sv) *	2002-03-25	2002-03-25	Astrazeneca Ab	Chemical compounds
GB0208071D0 (en) *	2002-04-08	2002-05-22	Pfizer Ltd	Tropane derivatives useful in therapy
AP1789A (en) *	2002-04-08	2007-10-05	Pfizer	Tropane derivatives useful in therapy.
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
AU2003230129A1 (en) *	2002-05-23	2003-12-12	Pfizer Inc.	Method for identification of a ligand whereby receptor residence time is measured
JP2006514646A (ja)	2002-12-13	2006-05-11	スミスクラインビーチャムコーポレーション	Ｃｃｒ５アンタゴニストとしてのシクロヘキシル化合物類
DE10336274A1 (de) *	2003-08-07	2005-03-10	Honeywell Specialty Chemicals	Verfahren zur Herstellung von geminalen Difluoralkanen
AR045536A1 (es)	2003-08-29	2005-11-02	Ranbaxy Lab Ltd	Inhibidores de la fosfodiesterasa tipo -iv
WO2005023810A1 (en)	2003-09-10	2005-03-17	Virochem Pharma Inc.	Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
EP1682545B1 (de) *	2003-10-03	2007-12-12	Pfizer Limited	Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen
TW200610761A (en)	2004-04-23	2006-04-01	Astrazeneca Ab	Chemical compounds
DK1761542T3 (da)	2004-06-09	2008-04-28	Hoffmann La Roche	Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler
CA2586231A1 (en) *	2004-11-19	2006-05-26	Boehringer Ingelheim International Gmbh	Method for treating hiv infection through co-administration of tipranavir and uk-427, 857
WO2006064340A2 (en) *	2004-12-13	2006-06-22	Pfizer Limited	Process for the preparation of n-acyl beta-aminoaldehydes
US7665658B2 (en)	2005-06-07	2010-02-23	First Data Corporation	Dynamic aggregation of payment transactions
JP2009514790A (ja)	2005-07-22	2009-04-09	プロジェニクス・ファーマスーティカルズ・インコーポレイテッド	Ｈｉｖ−１−感染患者におけるウイルス負荷を減少させる方法
AU2006303368B2 (en)	2005-10-19	2011-05-26	F. Hoffmann-La Roche Ag	Non-Nucleoside Reverse Transcriptase Inhibitors
WO2008019968A1 (en)	2006-08-16	2008-02-21	F. Hoffmann-La Roche Ag	Non-nucleoside reverse transcriptase inhibitors
US7932235B2 (en)	2006-11-17	2011-04-26	Concert Pharmaceuticals, Inc.	Triazolyl tropane derivatives
CN101553483B (zh)	2006-12-13	2013-04-17	弗·哈夫曼-拉罗切有限公司	作为非核苷逆转录酶抑制剂的2-(哌啶-4-基)-4-苯氧基-或苯基氨基-嘧啶衍生物
US20080146605A1 (en) *	2006-12-19	2008-06-19	Auspex Pharmaceuticals, Inc.	Preparation and utility of ccr5 inhibitors
EP1958947A1 (de)	2007-02-15	2008-08-20	Ranbaxy Laboratories Limited	Inhibitoren für Phosphodiesterase Typ 4
WO2008132128A2 (en) *	2007-04-27	2008-11-06	Solvay (Société Anonyme)	Synthesis of a pharmaceutically active compound
WO2009111218A2 (en) *	2008-02-29	2009-09-11	Schering Corporation	Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same
CN101712679B (zh)	2008-10-08	2013-04-10	中国科学院上海药物研究所	一种酰胺类化合物、其药物组合物及其制备方法和用途
EP2456309B1 (de) *	2009-07-24	2015-12-23	GlaxoSmithKline LLC	Azabicyclo[3.2.1]octyl Derivate zur Verwendung bei der Behandlung von HIV
CN102140104B (zh) *	2010-02-03	2014-11-12	中国科学院上海药物研究所	1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途
KR20130025899A (ko)	2010-04-02	2013-03-12	피비코-1 엘엘씨	Ｃｃｒ５ 길항제，ｈｉｖ―1 프로테아제 억제제 및 약동학적 인핸서를 포함하는 병용 요법
CN106977511B (zh) *	2011-12-19	2019-04-12	中国科学院上海药物研究所	一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
EP2912047B1 (de)	2012-10-29	2016-08-24	Cipla Limited	Antivirale phosphonatanaloga und verfahren zur herstellung davon
CZ306455B6 (cs)	2013-04-26	2017-02-01	Zentiva, K.S.	Nový způsob syntézy Maravirocu
CN103497164B (zh) *	2013-09-23	2015-12-23	西安近代化学研究所	一种蒽衍生物及其制备方法
CN104304248B (zh) *	2014-10-23	2016-08-10	西北农林科技大学	3-芳基丙酸酯类化合物作为制备杀螨药物的应用
CN104402883B (zh) *	2014-10-24	2016-04-27	艾琪康医药科技（上海）有限公司	4，4-二氟金刚烷甲酰胺衍生物、药物组合物及其制备方法和用途
CN104387379B (zh) *	2014-11-26	2017-01-11	扬州氟药科技有限公司	一种二氟亚甲基哌啶甲酰胺衍生物及其制备方法和用途
CN104860946A (zh) *	2015-05-14	2015-08-26	湖北生物医药产业技术研究院有限公司	Ccr5拮抗剂的制备方法
CN107879963A (zh) *	2016-09-29	2018-04-06	中国科学院上海药物研究所	新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en)	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5648511A (en) *	1990-11-19	1997-07-15	G.D. Searle & Co.	Method for making intermediates useful in the synthesis of retroviral protease inhibitors
FR2676444B1 (fr) *	1991-05-16	1995-03-10	Sanofi Elf	Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
DK0756596T3 (da) *	1994-04-19	2002-12-23	Neurosearch As	Tropan-2-aldoximderivater som neurotransmitter-genoptagelsesinhibitorer
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
DE19546462A1 (de) *	1995-12-13	1997-06-19	Bayer Ag	Diarylacetylenketone
WO1997024325A1 (en) *	1995-12-28	1997-07-10	Takeda Chemical Industries, Ltd.	DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
US6323206B1 (en) *	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
JP2000516210A (ja) *	1996-07-12	2000-12-05	ロイコサイト，インコーポレーテッド	ケモカインレセプターアンタゴニストとその使用方法
AU5522498A (en) *	1996-12-13	1998-07-03	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
WO1998025604A1 (en) *	1996-12-13	1998-06-18	Merck & Co., Inc.	Spiro-substituted azacycles as modulators of chemokine receptor activity
GB9711643D0 (en)	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
WO1999004794A1 (en) *	1997-07-25	1999-02-04	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
IL125658A0 (en) *	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
CA2318088A1 (en) *	1998-01-21	1999-07-29	Yoshisuke Nakasato	Chemokine receptor antagonists and methods of use therefor
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
EP1013276A1 (de)	1998-12-23	2000-06-28	Pfizer Inc.	Aminoazacycloalkane als CCR5-Modulatoren
US7217714B1 (en) *	1998-12-23	2007-05-15	Agouron Pharmaceuticals, Inc.	CCR5 modulators
MXPA02011631A (es) *	2000-05-26	2003-03-27	Pfizer	Derivados de tropano utiles en terapia.

2001
- 2001-05-09 MX MXPA02011631A patent/MXPA02011631A/es active IP Right Grant
- 2001-05-09 AT AT04004193T patent/ATE407134T1/de active
- 2001-05-09 RS RSP-2009/0438A patent/RS51436B/en unknown
- 2001-05-09 WO PCT/IB2001/000806 patent/WO2001090106A2/en active IP Right Grant
- 2001-05-09 ES ES08163025T patent/ES2401812T3/es not_active Expired - Lifetime
- 2001-05-09 AT AT01925808T patent/ATE260914T1/de active
- 2001-05-09 JP JP2001586293A patent/JP3693957B2/ja not_active Expired - Lifetime
- 2001-05-09 DE DE60135685T patent/DE60135685D1/de not_active Expired - Lifetime
- 2001-05-09 DK DK04004193T patent/DK1526134T3/da active
- 2001-05-09 EA EA200201141A patent/EA005382B1/ru not_active IP Right Cessation
- 2001-05-09 EP EP20040004193 patent/EP1526134B1/de not_active Expired - Lifetime
- 2001-05-09 CN CNB018088287A patent/CN1279040C/zh not_active Expired - Lifetime
- 2001-05-09 KR KR1020057003492A patent/KR100548854B1/ko active IP Right Grant
- 2001-05-09 EP EP20080163025 patent/EP1990341B1/de not_active Expired - Lifetime
- 2001-05-09 AU AU5248201A patent/AU5248201A/xx active Pending
- 2001-05-09 ES ES04004193T patent/ES2311126T3/es not_active Expired - Lifetime
- 2001-05-09 EE EEP200200656A patent/EE05110B1/xx active Protection Beyond IP Right Term
- 2001-05-09 AU AU2001252482A patent/AU2001252482B2/en not_active Expired
- 2001-05-09 ES ES01925808T patent/ES2215129T3/es not_active Expired - Lifetime
- 2001-05-09 DK DK01925808T patent/DK1284974T3/da active
- 2001-05-09 BR BRPI0110955A patent/BRPI0110955B8/pt not_active IP Right Cessation
- 2001-05-09 NZ NZ521477A patent/NZ521477A/en not_active IP Right Cessation
- 2001-05-09 CN CNB2005100068151A patent/CN100355753C/zh not_active Expired - Lifetime
- 2001-05-09 IL IL15253101A patent/IL152531A0/xx unknown
- 2001-05-09 PT PT01925808T patent/PT1284974E/pt unknown
- 2001-05-09 PL PL359267A patent/PL200551B1/pl unknown
- 2001-05-09 CA CA 2408909 patent/CA2408909C/en not_active Expired - Lifetime
- 2001-05-09 GE GEAP2001004960 patent/GEP20063799B/en unknown
- 2001-05-09 ME MEP-2008-693A patent/ME00555B/me unknown
- 2001-05-09 SI SI200130090T patent/SI1284974T1/xx unknown
- 2001-05-09 SK SK1643-2002A patent/SK286129B6/sk active Protection Beyond IP Right Term
- 2001-05-09 HU HU0302474A patent/HU225810B1/hu active Protection Beyond IP Right Term
- 2001-05-09 OA OA1200200343A patent/OA12264A/en unknown
- 2001-05-09 PT PT04004193T patent/PT1526134E/pt unknown
- 2001-05-09 AP APAP/P/2002/002663A patent/AP1965A/en active
- 2001-05-09 TR TR200400541T patent/TR200400541T4/xx unknown
- 2001-05-09 KR KR10-2002-7015934A patent/KR100523501B1/ko active IP Right Grant
- 2001-05-09 EA EA200401056A patent/EA007580B1/ru not_active IP Right Cessation
- 2001-05-09 DE DE2001602233 patent/DE60102233T2/de not_active Expired - Lifetime
- 2001-05-09 CZ CZ20023806A patent/CZ299102B6/cs not_active IP Right Cessation
- 2001-05-09 DE DE200812000011 patent/DE122008000011I1/de active Pending
- 2001-05-09 SI SI200130862T patent/SI1526134T1/sl unknown
- 2001-05-09 EP EP20010925808 patent/EP1284974B1/de not_active Expired - Lifetime
- 2001-05-09 DZ DZ013464A patent/DZ3464A1/fr active
- 2001-05-09 RS YUP82202 patent/RS50904B/sr unknown
- 2001-05-21 TW TW90112055A patent/TWI230160B/zh active
- 2001-05-22 PA PA8517101A patent/PA8517101A1/es unknown
- 2001-05-22 EG EG20010535A patent/EG24137A/xx active
- 2001-05-23 MY MYPI20012461 patent/MY131019A/en unknown
- 2001-05-23 MY MYPI20041980 patent/MY153023A/en unknown
- 2001-05-23 MY MYPI20094132A patent/MY156920A/en unknown
- 2001-05-24 UY UY26727A patent/UY26727A1/es not_active IP Right Cessation
- 2001-05-24 PE PE2001000476A patent/PE20011371A1/es active IP Right Grant
- 2001-05-24 AR ARP010102486 patent/AR028622A1/es active IP Right Grant
- 2001-05-25 TN TNSN01077 patent/TNSN01077A1/fr unknown
2002
- 2002-09-23 BG BG107140A patent/BG65966B1/bg unknown
- 2002-09-24 IS IS6565A patent/IS2511B/is unknown
- 2002-10-28 IL IL152531A patent/IL152531A/en active Protection Beyond IP Right Term
- 2002-10-28 CU CU20020243A patent/CU23288B7/es unknown
- 2002-10-31 NO NO20025227A patent/NO327892B1/no not_active IP Right Cessation
- 2002-11-14 MA MA26910A patent/MA26902A1/fr unknown
- 2002-11-26 HR HR20020938A patent/HRP20020938B1/xx not_active IP Right Cessation
2003
- 2003-09-30 HK HK03107045A patent/HK1054927A1/xx not_active IP Right Cessation
2005
- 2005-02-15 JP JP2005038062A patent/JP4854970B2/ja not_active Expired - Lifetime
- 2005-11-18 HK HK05110416A patent/HK1078573A1/xx not_active IP Right Cessation
2006
- 2006-10-18 HK HK06111446A patent/HK1090836A1/xx not_active IP Right Cessation
2007
- 2007-03-27 AR ARP070101273 patent/AR060159A2/es unknown
2008
- 2008-02-22 LU LU91417C patent/LU91417I2/fr unknown
- 2008-02-22 NL NL300338C patent/NL300338I2/nl unknown
- 2008-02-25 LT LTPA2008004C patent/LTC1284974I2/lt unknown
- 2008-03-04 FR FR08C0007C patent/FR08C0007I2/fr active Active
- 2008-03-17 CY CY200800006C patent/CY2008006I1/el unknown
- 2008-07-16 CR CR10145A patent/CR10145A/es unknown
- 2008-10-24 CY CY081101203T patent/CY1108451T1/el unknown
2010
- 2010-04-08 NO NO2010007C patent/NO2010007I2/no unknown
2020
- 2020-06-30 NO NO2020019C patent/NO2020019I1/no not_active IP Right Cessation
2022
- 2022-04-19 CY CY2022009C patent/CY2022009I2/el unknown

Also Published As

Publication number	Publication date
WO2001090106A2 (en)	2001-11-29
EP1284974B1 (de)	2004-03-03
DK1526134T3 (da)	2008-11-17
SK16432002A3 (sk)	2004-01-08
LTPA2008004I1 (lt)	2020-07-27
DZ3464A1 (de)	2001-11-29
CN1279040C (zh)	2006-10-11
PT1284974E (pt)	2004-06-30
UY26727A1 (es)	2001-12-28
ME00555A (en)	2011-12-20
HRP20020938B1 (en)	2011-05-31
EG24137A (en)	2008-08-06
EP1526134B1 (de)	2008-09-03
CY1108451T1 (el)	2014-04-09
CR10145A (es)	2008-08-19
HK1090836A1 (en)	2007-01-05
CY2022009I1 (el)	2022-05-27
EE05110B1 (et)	2008-12-15
PT1526134E (pt)	2008-10-28
BR0110955A (pt)	2003-06-03
TNSN01077A1 (fr)	2005-11-10
JP2005194283A (ja)	2005-07-21
NO20025227D0 (no)	2002-10-31
KR20030004417A (ko)	2003-01-14
EA005382B1 (ru)	2005-02-24
ME00555B (me)	2011-12-20
NL300338I1 (nl)	2008-05-01
AR028622A1 (es)	2003-05-14
BRPI0110955B1 (pt)	2016-06-28
CA2408909C (en)	2006-06-27
WO2001090106A3 (en)	2002-03-28
CA2408909A1 (en)	2001-11-29
SI1284974T1 (en)	2004-08-31
BG65966B1 (bg)	2010-07-30
AU2001252482C1 (en)	2001-12-03
LU91417I9 (de)	2019-01-02
EA200201141A1 (ru)	2003-04-24
HU225810B1 (en)	2007-10-29
HK1078573A1 (en)	2006-03-17
NO2020019I1 (no)	2020-06-30
IL152531A (en)	2010-05-17
YU82202A (sh)	2005-11-28
PL200551B1 (pl)	2009-01-30
DE60102233T2 (de)	2005-01-27
CN100355753C (zh)	2007-12-19
JP4854970B2 (ja)	2012-01-18
OA12264A (en)	2003-11-10
NO327892B1 (no)	2009-10-12
HUP0302474A2 (hu)	2003-11-28
BRPI0110955B8 (pt)	2021-05-25
EP1526134A2 (de)	2005-04-27
MY153023A (en)	2014-12-31
AU2001252482B2 (en)	2006-01-19
EA200401056A1 (ru)	2005-04-28
EA007580B1 (ru)	2006-12-29
MXPA02011631A (es)	2003-03-27
CZ20023806A3 (cs)	2004-01-14
DE60102233D1 (de)	2004-04-08
NL300338I2 (nl)	2008-06-02
KR20050046743A (ko)	2005-05-18
NO20025227L (no)	2002-10-31
FR08C0007I1 (de)	2008-04-25
ATE407134T1 (de)	2008-09-15
RS50904B (sr)	2010-08-31
MY156920A (en)	2016-04-15
EP1990341B1 (de)	2013-01-23
IL152531A0 (en)	2003-05-29
MA26902A1 (fr)	2004-12-20
SI1526134T1 (sl)	2008-12-31
DE122008000011I1 (de)	2008-06-05
FR08C0007I2 (fr)	2009-01-15
HUP0302474A3 (en)	2007-05-29
EP1526134A3 (de)	2006-11-29
DE60135685D1 (de)	2008-10-16
TR200400541T4 (tr)	2004-04-21
RS20090438A (en)	2010-05-07
JP3693957B2 (ja)	2005-09-14
NO2010007I1 (no)	2010-04-08
KR100548854B1 (ko)	2006-02-02
PA8517101A1 (es)	2002-10-24
HK1054927A1 (en)	2003-12-19
HRP20020938A2 (en)	2005-02-28
CY2022009I2 (el)	2022-05-27
LTC1284974I2 (lt)	2020-11-10
IS2511B (is)	2009-05-15
AR060159A2 (es)	2008-05-28
LU91417I2 (fr)	2008-04-22
SK286129B6 (sk)	2008-04-07
AP2002002663A0 (en)	2002-12-31
IS6565A (is)	2002-09-24
CU23288B7 (es)	2008-06-30
AP1965A (en)	2009-03-04
EE200200656A (et)	2004-06-15
ES2401812T3 (es)	2013-04-24
EP1990341A1 (de)	2008-11-12
ES2311126T3 (es)	2009-02-01
CY2008006I2 (el)	2009-11-04
CZ299102B6 (cs)	2008-04-23
BG107140A (bg)	2003-05-30
GEP20063799B (en)	2006-04-25
ES2215129T3 (es)	2004-10-01
RS51436B (en)	2011-04-30
MY131019A (en)	2007-07-31
NO2010007I2 (no)	2013-09-09
PE20011371A1 (es)	2002-01-18
KR100523501B1 (ko)	2005-10-25
CY2008006I1 (el)	2009-11-04
NZ521477A (en)	2004-07-30
PL359267A1 (en)	2004-08-23
EP1284974A2 (de)	2003-02-26
AU5248201A (en)	2001-12-03
JP2003534343A (ja)	2003-11-18
CN1680371A (zh)	2005-10-12
CN1437599A (zh)	2003-08-20
TWI230160B (en)	2005-04-01
DK1284974T3 (da)	2004-06-07

Publication	Publication Date	Title
ATE260914T1 (de)	2004-03-15	Triazolyltropanderivate als ccr5-modulatoren
DE60134094D1 (de)	2008-07-03	C7-taxanester als antitumormittel
DE60305903D1 (de)	2006-07-20	Tropanderivative als ccr5-modulatoren
ATE437862T1 (de)	2009-08-15	Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
DE69943352D1 (de)	2011-05-26	Azabicycloalkane als ccr5-modulatoren
DE60030764D1 (de)	2006-10-26	Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten
ID29031A (id)	2001-07-26	Piperidin sebagai modulator ccr5
ATE297921T1 (de)	2005-07-15	Tetrazolylphenyl-acetamide als glukokinaseaktivatoren
DE60021371D1 (de)	2005-08-25	Piperidinderivate verwendbar als ccr5 antagonisten
ATE516030T1 (de)	2011-07-15	Benzimidazolidinon-derivate als muscarinische mittel
DK1181017T3 (da)	2003-07-14	Metalloproteaseinhibitorer
NO20025590L (no)	2002-11-21	Fenylglycin-derivater
PT1303521E (pt)	2005-05-31	Derivados de tetra-hidro-heterocicloazepinil-pirimidina
DE60118569D1 (de)	2006-05-18	4-phenylpyridin-derivate als neurokinin-1-rezeptor-antagonisten
DE60137061D1 (de)	2009-01-29	Platin-verbindungen als antitumorwirkstoffe
DE60028085D1 (de)	2006-06-22	Piperidinyloxy- und pyrrolidinyloxyphenyloxazolidinone als antibakterielle mittel
ATE428420T1 (de)	2009-05-15	Substituierte 8-arylchinoline als phosphodiesterase-4-hemmer
DE50011908D1 (de)	2006-01-26	16-hydroxyestratriene als selektiv wirksame estrogene
AR028602A1 (es)	2003-05-14	Derivados de pirrol
AR028282A1 (es)	2003-04-30	Derivados de aminofenil pirimidona
DE60003072D1 (de)	2003-07-03	Thiazolidindion-derivate als antidiabetika
DE60201463D1 (de)	2004-11-11	Indanon-Derivate als Duftstoffe
ATE280752T1 (de)	2004-11-15	Aminomethyl-phenyl-cyclohexanonderivate
ATE367379T1 (de)	2007-08-15	Quinolin-derivate als antientzündungsmittel
ATE287708T1 (de)	2005-02-15	1-amino-alkylcyclohexanederivate als trypanocide mittel