Nothing Special   »   [go: up one dir, main page]

FR2430411A1 - Phenethanolamines et leur utilisation therapeutique - Google Patents

Phenethanolamines et leur utilisation therapeutique

Info

Publication number
FR2430411A1
FR2430411A1 FR7916994A FR7916994A FR2430411A1 FR 2430411 A1 FR2430411 A1 FR 2430411A1 FR 7916994 A FR7916994 A FR 7916994A FR 7916994 A FR7916994 A FR 7916994A FR 2430411 A1 FR2430411 A1 FR 2430411A1
Authority
FR
France
Prior art keywords
phenethanolamines
therapeutic use
therapeutic
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7916994A
Other languages
English (en)
Other versions
FR2430411B1 (fr
Inventor
Jack Mills
Klaus Kurt Schmiegel
Walter Norman Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2430411A1 publication Critical patent/FR2430411A1/fr
Application granted granted Critical
Publication of FR2430411B1 publication Critical patent/FR2430411B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/06—Preparation of carboxylic acid nitriles from N-formylated amino compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Dairy Products (AREA)

Abstract

L'invention concerne des composés de formule :
FR7916994A 1978-07-03 1979-06-29 Phenethanolamines et leur utilisation therapeutique Granted FR2430411A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92167078A 1978-07-03 1978-07-03

Publications (2)

Publication Number Publication Date
FR2430411A1 true FR2430411A1 (fr) 1980-02-01
FR2430411B1 FR2430411B1 (fr) 1983-08-19

Family

ID=25445792

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7916993A Expired FR2430410B1 (fr) 1978-07-03 1979-06-29 Phenethanolamines et compositions pharmaceutiques en contenant
FR7916994A Granted FR2430411A1 (fr) 1978-07-03 1979-06-29 Phenethanolamines et leur utilisation therapeutique
FR8009239A Expired FR2450806B1 (fr) 1978-07-03 1980-04-24 S-1-alkyl-3-phenylpropylamines utiles comme intermediaires de synthese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7916993A Expired FR2430410B1 (fr) 1978-07-03 1979-06-29 Phenethanolamines et compositions pharmaceutiques en contenant

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8009239A Expired FR2450806B1 (fr) 1978-07-03 1980-04-24 S-1-alkyl-3-phenylpropylamines utiles comme intermediaires de synthese

Country Status (31)

Country Link
EP (3) EP0007204B1 (fr)
JP (2) JPS559096A (fr)
KR (1) KR880002310B1 (fr)
AR (4) AR229080A1 (fr)
AT (2) AT367025B (fr)
AU (2) AU523720B2 (fr)
BE (2) BE877394A (fr)
BG (4) BG31647A3 (fr)
CA (2) CA1142954A (fr)
CH (2) CH642618A5 (fr)
CS (4) CS209815B2 (fr)
DD (2) DD144761A5 (fr)
DE (2) DE2964604D1 (fr)
DK (2) DK160936C (fr)
EG (1) EG14238A (fr)
ES (4) ES482155A1 (fr)
FI (2) FI792081A (fr)
FR (3) FR2430410B1 (fr)
GB (3) GB2101582B (fr)
GR (2) GR72940B (fr)
HU (2) HU179171B (fr)
IE (2) IE48769B1 (fr)
IL (2) IL57672A (fr)
LU (2) LU81457A1 (fr)
NZ (2) NZ190861A (fr)
PH (2) PH14522A (fr)
PL (4) PL117551B1 (fr)
PT (2) PT69843A (fr)
RO (4) RO77732A (fr)
SU (4) SU965350A3 (fr)
ZA (2) ZA793297B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006735B1 (fr) * 1978-06-28 1983-06-15 Beecham Group Plc Amines secondaires, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur utilisation
DE3061693D1 (en) * 1979-10-25 1983-02-24 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
EP0029320B1 (fr) * 1979-11-15 1985-07-10 Beecham Group Plc Ethanolamines secondaires, leur préparation et leur utilisation dans des compositions pharmaceutiques
DE3161165D1 (en) * 1980-05-08 1983-11-17 Beecham Group Plc Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
DE3264364D1 (en) * 1981-03-06 1985-08-01 Beecham Group Plc Arylethanol amine derivatives, their preparation and use in pharmaceutical compositions
EP0061907B1 (fr) * 1981-03-31 1984-08-01 Beecham Group Plc Amines secondaires, leur préparation, compositions pharmaceutiques les contenant et leur utilisation
DE3271132D1 (en) * 1981-07-11 1986-06-19 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0089154A3 (fr) * 1982-03-12 1984-08-08 Beecham Group Plc Dérivés d'éthanolamine, leur fabrication et leur utilisation en compositions pharmaceutiques
CA1219865A (fr) * 1982-05-14 1987-03-31 Leo Alig Derives de phenethanolamine d'aziridine
CA1258454A (fr) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
JPS5980640A (ja) * 1982-09-27 1984-05-10 イーライ・リリー・アンド・カンパニー ２−ヒドロキシ−２−フエニルエチルアミン類の製造方法
DE3473439D1 (en) * 1983-01-31 1988-09-22 Lilly Co Eli Improvements in or relating to phenethanolamines
CA1262729A (fr) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
US4602044A (en) * 1983-12-19 1986-07-22 Eli Lilly And Company β-phenethanolamine antiobesity agents
EP0151513A1 (fr) * 1984-01-12 1985-08-14 Eli Lilly And Company Agents inotropes
ES8800842A1 (es) * 1985-03-01 1987-12-01 Beecham Group Plc Un procedimiento para preparar una formulacion veterinariamente aceptable de ariletanolaminas promotora del crecimiento.
GB8505284D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Growth promoters
IT1204416B (it) * 1986-06-27 1989-03-01 Midy Spa Medicamenti a base di analoghi di feniletanolammine per il trattamento di disturbi gastro-intestinali ed uterini
JP2837408B2 (ja) * 1987-05-30 1998-12-16 鐘紡株式会社 アクリル系繊維の処理方法
US5135955A (en) * 1988-04-25 1992-08-04 Eli Lilly And Company Propanamine derivatives
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
CA2023954C (fr) * 1989-10-17 1999-05-04 Hiroyuki Nohira Procede de resolution optique de l'acide 2-(3-benzoyl) phenylpropionique
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
CA2115828C (fr) * 1991-08-23 2011-09-20 Edward F. Nemeth Molecules actives pour la reception du calcium
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
HU229474B1 (en) 1994-10-21 2014-01-28 Nps Pharma Inc Calcium receptor-active compounds, pharmaceutical compositions containing them and use of the compositions
ES2280460T3 (es) 1996-05-01 2007-09-16 Nps Pharmaceuticals, Inc. Compuestos activos frente a receptores de iones inorganicos.
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1557677A (fr) * 1966-09-23 1969-02-21
FR2228487A1 (fr) * 1973-05-07 1974-12-06 Allen & Hanburys Ltd

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL56308C (fr) * 1941-03-15
GB1301134A (en) 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
BE788850A (fr) * 1972-09-15 1973-03-15 Hoffmann La Roche Derives d'acide benzoique
US4000192A (en) * 1973-05-07 1976-12-28 Allen & Hanburys Limited Pharmacologically active compounds
NZ190854A (en) * 1978-06-28 1984-10-19 Beecham Group Ltd 2-hydroxy-2-phenyl ethylamine derivatives;pharmaceutical compositions
IL57673A0 (en) * 1978-07-03 1979-10-31 Lilly Co Eli Optically active phenethanolamines and method for increasing cardiac contractility

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1557677A (fr) * 1966-09-23 1969-02-21
FR2228487A1 (fr) * 1973-05-07 1974-12-06 Allen & Hanburys Ltd

Also Published As

Publication number Publication date
ES482155A1 (es) 1980-08-16
BG31645A3 (en) 1982-02-15
HU179172B (en) 1982-08-28
ZA793296B (en) 1981-02-25
FR2430410A1 (fr) 1980-02-01
DK160936C (da) 1991-10-21
RO77728A (fr) 1981-11-24
FI792082A (fi) 1980-01-04
KR880002310B1 (ko) 1988-10-22
RO83052A (fr) 1984-02-21
PL216811A1 (fr) 1980-08-25
PL117997B1 (en) 1981-09-30
SU965350A3 (ru) 1982-10-07
ZA793297B (en) 1981-02-25
GR72940B (fr) 1984-01-16
GB2028799A (en) 1980-03-12
BG31647A3 (en) 1982-02-15
EP0048037A1 (fr) 1982-03-24
GB2028799B (en) 1982-09-08
IL57672A (en) 1983-03-31
GB2028802A (en) 1980-03-12
GB2101582A (en) 1983-01-19
KR830001187A (ko) 1983-04-29
DK268679A (da) 1980-01-04
AU523721B2 (en) 1982-08-12
ES490214A0 (es) 1981-04-16
SU1007554A3 (ru) 1983-03-23
FI792081A (fi) 1980-01-04
BG31375A3 (en) 1981-12-15
GB2101582B (en) 1983-06-08
DD144762A5 (de) 1980-11-05
AR231434A1 (es) 1984-11-30
CH642618A5 (fr) 1984-04-30
EG14238A (en) 1983-12-31
PH15275A (en) 1982-11-02
CH643529A5 (fr) 1984-06-15
JPS559096A (en) 1980-01-22
JPS559097A (en) 1980-01-22
PL216814A1 (fr) 1980-03-24
AU4848779A (en) 1980-01-10
AT367025B (de) 1982-05-25
PL117551B1 (en) 1981-08-31
JPS6254095B2 (fr) 1987-11-13
PT69843A (en) 1979-07-01
LU81457A1 (fr) 1979-10-30
LU81458A1 (fr) 1979-10-30
RO83051A (fr) 1984-02-21
BE877393A (fr) 1980-01-02
FR2450806B1 (fr) 1985-07-12
PT69839A (en) 1979-07-01
EP0006766B1 (fr) 1983-01-26
SU849997A3 (ru) 1981-07-23
DE2964604D1 (en) 1983-03-03
EP0006766A1 (fr) 1980-01-09
ATA463679A (de) 1981-10-15
RO83052B (ro) 1984-02-28
DD144761A5 (de) 1980-11-05
HU179171B (en) 1982-08-28
FR2430410B1 (fr) 1986-03-21
ES490215A0 (es) 1981-04-16
AU4848979A (en) 1980-01-10
IL57671A (en) 1982-11-30
ES8104190A1 (es) 1981-04-16
BG31646A3 (en) 1982-02-15
CS209815B2 (en) 1981-12-31
PL117996B1 (en) 1981-09-30
DE2964091D1 (en) 1982-12-30
ES482156A1 (es) 1980-08-16
IE48586B1 (en) 1985-03-20
IL57671A0 (en) 1979-10-31
IL57672A0 (en) 1979-10-31
DK268779A (da) 1980-01-04
AR227165A1 (es) 1982-09-30
ES8104189A1 (es) 1981-04-16
AR229080A1 (es) 1983-06-15
CS208663B2 (en) 1981-09-15
GR74524B (fr) 1984-06-29
NZ190863A (en) 1982-05-25
BE877394A (fr) 1980-01-02
CA1145767A (fr) 1983-05-03
FR2450806A1 (fr) 1980-10-03
PH14522A (en) 1981-08-26
DK160936B (da) 1991-05-06
AU523720B2 (en) 1982-08-12
IE48769B1 (en) 1985-05-15
CA1142954A (fr) 1983-03-15
SU957761A3 (ru) 1982-09-07
RO77732A (fr) 1981-11-24
FR2430411B1 (fr) 1983-08-19
GB2028802B (en) 1983-03-30
RO83051B (ro) 1984-02-28
EP0007204B1 (fr) 1982-11-24
CS208662B2 (en) 1981-09-15
PL121297B1 (en) 1982-04-30
EP0007204A1 (fr) 1980-01-23
NZ190861A (en) 1981-12-15
AT372937B (de) 1983-11-25
IE791227L (en) 1980-01-03
CS208664B2 (en) 1981-09-15
IE791228L (en) 1980-01-03
AR225744A1 (es) 1982-04-30
ATA463579A (de) 1983-04-15

Similar Documents

Publication Publication Date Title
FR2430411A1 (fr) Phenethanolamines et leur utilisation therapeutique
FR2417510A1 (fr) 9-amino- et imino-dibenzopyrannes et leur utilisation therapeutique
FR2416891A1 (fr) 6-n-propyl-8-methoxymethyl ou methylmercaptomethylergolines et composes apparentes, et leur utilisation therapeutique
FR2446832A1 (fr) Octahydro-pyrazolo(3,4-g)quinoleines et leur utilisation therapeutique
FR2417500A1 (fr) Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
FR2400517A1 (fr) Triazolo-2,4-benzodiazepines et leur utilisation therapeutique
FR2430408A1 (fr) Phenethanolamines optiquement actives et leur utilisation therapeutique
FR2446283A1 (fr) Phenoxyphenylpiperidines, leur preparation et leurs applications therapeutiques
FR2430409A1 (fr) Phenethanolamines et leur utilisation comme potentialisateurs des medicaments destructeurs des cellules cancereuses
FR2442836A1 (fr) 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique
FR2356651A1 (fr) Nouveaux derives d'acide penicillanique et leur utilisation therapeutique
FR2445834A1 (fr) Derives heterobicycliques de l'acide 7-acylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci et utilisation en therapeutique
FR2385682A1 (fr) Nouveaux 1-amino-indanes et leur utilisation comme medicaments
FR2404629A1 (fr) Nouveaux tetrapeptides et leur utilisation therapeutique
FR2375253A1 (fr) Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques
FR2417499A1 (fr) Mercaptoacylamino-acides halogenes et leur utilisation therapeutique
FR2378016A1 (fr) 1-alkylthiophenyl-2,3,4,5-tetrahydro-1h-3-benzazepine substituees et leur application en therapeutique
FR2361345A1 (fr) Homologues de somatostatine, sa preparation et son utilisation therapeutique
FR2383944A1 (fr) Derives de bis-benzimidazolyle substitues, leur procede de preparation et leur application en therapeutique
FR2430407A1 (fr) R-n-(2-phenyl-2-hydroxyethyl)-3-phenylpropylamines et leur utilisation therapeutique
FR2434805A1 (fr) 1-benzoyl-3-pyridinylurees, leur preparation et leur utilisation comme insecticides
FR2446833A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines et leur utilisation therapeutiques
FR2419291A1 (fr) 2,3-dihydroimidazo(1,2-c)pyrimidines substituees et leur utilisation therapeutique
FR2399406A1 (fr) Derives de perhydronaphtalenepentol et leur utilisation therapeutique
FR2368486A1 (fr) Phtalides et leur utilisation comme precurseurs de couleurs

Legal Events

Date Code Title Description
ST Notification of lapse