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FR2375253A1 - Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques - Google Patents

Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques

Info

Publication number
FR2375253A1
FR2375253A1 FR7739218A FR7739218A FR2375253A1 FR 2375253 A1 FR2375253 A1 FR 2375253A1 FR 7739218 A FR7739218 A FR 7739218A FR 7739218 A FR7739218 A FR 7739218A FR 2375253 A1 FR2375253 A1 FR 2375253A1
Authority
FR
France
Prior art keywords
carboxylic
acids
alcoxycarbonyl
halog
pregn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7739218A
Other languages
English (en)
Other versions
FR2375253B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2375253A1 publication Critical patent/FR2375253A1/fr
Application granted granted Critical
Publication of FR2375253B1 publication Critical patent/FR2375253B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de formule :
FR7739218A 1976-12-27 1977-12-26 Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques Granted FR2375253A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (2)

Publication Number Publication Date
FR2375253A1 true FR2375253A1 (fr) 1978-07-21
FR2375253B1 FR2375253B1 (fr) 1981-04-30

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7739218A Granted FR2375253A1 (fr) 1976-12-27 1977-12-26 Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques

Country Status (19)

Country Link
US (1) US4069219A (fr)
JP (1) JPS5382767A (fr)
AU (1) AU518862B2 (fr)
BE (1) BE862365A (fr)
CA (1) CA1099702A (fr)
CH (6) CH637403A5 (fr)
DE (1) DE2758279A1 (fr)
DK (1) DK577377A (fr)
FI (1) FI773936A (fr)
FR (1) FR2375253A1 (fr)
GB (1) GB1575986A (fr)
IE (1) IE46128B1 (fr)
IL (1) IL53692A (fr)
NL (1) NL7714428A (fr)
NO (2) NO774464L (fr)
NZ (1) NZ186119A (fr)
PT (1) PT67455B (fr)
SE (1) SE7714764L (fr)
ZA (1) ZA777684B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK0973791T3 (da) 1995-12-11 2007-09-17 Searle Llc Fremgangsmåde til fremstilling af en epoxyforbindelse
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
CA2480151A1 (fr) * 2002-03-22 2003-10-09 Pharmacia Corporation Spirolactonisation c-17 et oxydation 6,7 de steroides
MXPA05004913A (es) * 2002-11-06 2005-07-22 Pharmacia & Upjohn Co Llc Procedimientos para preparar esteroides sustituidos por carboxi en posicion 7.
KR100667123B1 (ko) * 2002-11-07 2007-01-12 파마시아 앤드 업존 캄파니 엘엘씨 Ｃ-7 치환된 5-안드로스텐의 제조 방법
PL2527356T3 (pl) 2005-07-21 2018-06-29 Bayer Intellectual Property Gmbh Sposób wytwarzania 3-okso-pregn-4-eno-21,17-karbolaktonów za pomocą wolnego od metali utleniania 17-(3-hydroksypropylo)-3,17- dihydroksyandrostanów
DE502005004948D1 (de) 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 (fr) * 1971-08-25 1973-04-13 Searle & Co
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 (fr) * 1971-08-25 1973-04-13 Searle & Co
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
CH638536A5 (de) 1983-09-30
NZ186119A (en) 1979-08-31
CH637404A5 (de) 1983-07-29
JPS5382767A (en) 1978-07-21
FR2375253B1 (fr) 1981-04-30
CA1099702A (fr) 1981-04-21
BE862365A (fr) 1978-06-27
DK577377A (da) 1978-06-28
CH637408A5 (de) 1983-07-29
AU518862B2 (en) 1981-10-22
IL53692A0 (en) 1978-03-10
NO774464L (no) 1978-06-28
GB1575986A (en) 1980-10-01
SE7714764L (sv) 1978-06-28
NO820059L (no) 1978-06-28
PT67455A (en) 1978-01-01
IL53692A (en) 1982-07-30
IE46128B1 (en) 1983-02-23
IE46128L (en) 1978-06-27
AU3201277A (en) 1979-06-28
NL7714428A (nl) 1978-06-29
CH637403A5 (de) 1983-07-29
FI773936A (fi) 1978-06-28
ZA777684B (en) 1979-08-29
DE2758279A1 (de) 1978-06-29
US4069219A (en) 1978-01-17
CH637405A5 (de) 1983-07-29
CH635595A5 (de) 1983-04-15
PT67455B (en) 1979-05-25

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