Nothing Special   »   [go: up one dir, main page]

EP2415450A1 - Agent aqueux de nettoyage des cheveux - Google Patents

Agent aqueux de nettoyage des cheveux Download PDF

Info

Publication number
EP2415450A1
EP2415450A1 EP10758226A EP10758226A EP2415450A1 EP 2415450 A1 EP2415450 A1 EP 2415450A1 EP 10758226 A EP10758226 A EP 10758226A EP 10758226 A EP10758226 A EP 10758226A EP 2415450 A1 EP2415450 A1 EP 2415450A1
Authority
EP
European Patent Office
Prior art keywords
weight
acid
cleansing agent
hair cleansing
aqueous hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10758226A
Other languages
German (de)
English (en)
Other versions
EP2415450B1 (fr
EP2415450A4 (fr
Inventor
Eiji Terada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Publication of EP2415450A1 publication Critical patent/EP2415450A1/fr
Publication of EP2415450A4 publication Critical patent/EP2415450A4/fr
Application granted granted Critical
Publication of EP2415450B1 publication Critical patent/EP2415450B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to an aqueous hair cleansing agent.
  • a principal purpose of a hair cleansing agent resides in removing dirt on hair and scalp, preventing dandruff and itchiness of the scalp, and keeping the hair and scalp clean.
  • an anionic surfactant electrically charged at the equivalent level with the hair and scalp.
  • a strong-acid-based anionic surfactant having a sulfuric acid group or sulfonic acid group in the anionic portion thereof, in view of preventing re-adsorption of dirt.
  • an alkyl sulfate and alkyl ether sulfate are most generally used as the main component of a hair cleansing agent, by virtue of their rich foaming property and excellent cleansing performance.
  • alkyl sulfate and alkyl ether sulfate still have problems in terms of mildness to the scalp.
  • Horny layer cells which form 10 to 20 layers in the surficial portion of the skin have important roles of keeping moisture within the skin, and protection from an external stimulation.
  • the above-described alkyl sulfate and alkyl ether sulfate permeate into the horny layer, strongly swell the cells, and elutes natural moisturizing components, such as an amino acid or lipid inherent to the cells, out from the cells.
  • Patent Document 1 proposes an amino-acid-based surfactant such as an anionic surfactant in the form of alkyloylalkyl taurine salt
  • Patent Document 2 proposes a weakly-acidic anionic surfactant such as polyoxyethylene alkyl ether carboxylate.
  • the amino-acid-based surfactant and the polyoxyethylene alkyl ether carboxylate are less likely to swell the horny layer, and are mild to the skin. They, however, still have room for improvement as for basic performance of the cleansing agent, such as foamability and cleansing performance.
  • Patent Document 3 describes a technique of adding conditioning performance to a hair treatment composition.
  • the document describes that a composition excellent in the conditioning performance may be obtained, without degrading the basic performances of the hair conditioner such as foamability and viscosity, by using a specific polyxoyalkylene alkenyl ether acetate.
  • an aqueous hair cleansing agent which includes components (A), (B) and (C):
  • the present inventor investigated a hair cleansing agent which contains a sulfate-type anionic surfactant, more specifically alkyl sulfate or alkyl ether sulfate as a main cleansing component, aiming at improving mildness to the scalp, while keeping the basic performances of a cleansing agent. It was finally found that the technique described in Patent Document 3, previously mentioned in BACKGROUND ART, still has room for improvement in terms of a good balance between suppression of stimulation or itchiness of the scalp, and foamability.
  • a sulfate-type anionic surfactant more specifically alkyl sulfate or alkyl ether sulfate
  • an aqueous hair cleansing agent excellent in foamability which is a basic performance of a cleansing agent, suppressive to swelling of the horny layer of the skin, and less stimulus to the scalp, such as being less causative of itchiness
  • an aqueous hair cleansing agent capable of ensuring rich foam, low stimulation and less itchiness to the scalp may be provided.
  • the aqueous hair cleansing agent of the present invention contains the components (A), (B) and (C) described below, and occasionally contains water. Note that all numerical ranges expressed using “to” in this specification are defined to include the upper and lower limits of the ranges. The individual components will specifically be explained.
  • the component (A) is a sulfate-type anionic surfactant, and more specifically, an alkyl sulfate or alkyl ether sulfate represented by the general formula (1) in the above.
  • the general formula (1) From the viewpoint of stably obtaining rich foam, it is preferable for the general formula (1) to assume R 1 having 12 to 14 carbon atoms, 1 to 2 estimated based on weight average for n, and ammonium or sodium for M. Among these, in view of ensuring quick foaming and excellent cleansing performance, polyoxyethylene alkyl ether sulfate having an alkyl group of 12 to 14 carbon atoms for R 1 , 1 to 2 for n estimated based on weight average, and ammonium or sodium for M in the general formula (1), is preferable.
  • the component (A) may be a single species, or may be a combination of two or more species.
  • the content of component (A) may be adjusted typically to 1% by weight or more of the total aqueous hair cleansing agent, preferably 5% by weight or more, and more preferably 8% by weight or more.
  • the content of component (A) relative to the total aqueous hair cleansing agent may be adjusted typically to 25% by weight or less, preferably 23% by weight or less, and more preferably 20% by weight or less.
  • the content is preferably 1 to 25% by weight relative to the total aqueous hair cleansing agent of the present invention, more preferably 5 to 23% by weight, and even more preferably 8 to 20% by weight.
  • the ether carboxylate-type anionic surfactant composing the component (B) means a group of compounds each having a hydrophobic group and a carboxyl group bound via a polyoxyethylene chain placed in between, and therefore includes alkyl ether carboxylate and alkylamide ether carboxylate, which are represented by the general formulae (2) and (3) in the above, respectively.
  • R 2 in the formulae (2) and (3) is preferably an alkyl group having 12 to 16 carbon atoms, and more preferably an alkyl group having 12 carbon atoms.
  • an average molar number m of addition of ethylene oxide is 0.5 to 10, it is preferably 1 to 6 from the view point of foamability.
  • the counter ion X in the general formula (2) and (3) may be exemplified by alkali metal such as sodium and potassium; alkali earth metal such as calcium and magnesium; ammonium; ammonium derived from alkanolamine such as monoethanolamine, diethanolamine, and triethanolamine; and cation derived from basic amino acid such as arginine and lysine.
  • alkali metal such as sodium and potassium
  • alkali earth metal such as calcium and magnesium
  • ammonium ammonium derived from alkanolamine such as monoethanolamine, diethanolamine, and triethanolamine
  • cation derived from basic amino acid such as arginine and lysine.
  • the component represented by the general formula (2) in the above is preferable as the component (B).
  • the component (B) may be a single species, or may be a combination of two or more species.
  • content of the component (B) may typically be 0.5% by weight or more of the total aqueous hair cleansing agent, preferably 1% by weight or more, and more preferably 2% by weight or more.
  • the content of the component (B) relative to the total aqueous hair cleansing agent may be adjusted typically to 10% by weight or less, preferably 8% by weight or less, and more preferably 6% by weight or less.
  • the content of component (B) relative to the total aqueous hair cleansing agent of the present invention is preferably 0.5 to 10% by weight, more preferably 1 to 8% by weight, and even more preferably 2 to 6% by weight.
  • the components (A) and (B) preferably give the weight ratio of the component (B) relative to the total of the components (A) and (B) (i.e. (B)/((A)+(B))) of from, of 50% or less, more preferably 40% or less, and even more preferably 30% or less.
  • the weight ratio given by (B)/((A)+(B)) ⁇ 100(%) may typically be 5% or larger, and preferably 10% or larger.
  • the aqueous hair cleansing agent of the present invention further contains one or more species of organic carboxylic acid or salt thereof which composes the component (C).
  • the component (C) will be explained below.
  • the organic carboxylic acid composing the component (C) preferably has 2 to 6 carbon atoms, and is more preferably dicarboxylic acid (which may have hydroxy groups) or hydroxymonocarboxylic acid. More specifically, the dicarboxylic acid may be exemplified by malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, phthalic acid, and oxalic acid. The dicarboxylic acid having hydroxy groups may be exemplified by malic acid and tartaric acid.
  • the hydroxymonocarboxylic acid may be exemplified by glycolic acid, lactic acid, hydroxyacrylic acid, oxybutyric acid, glyceric acid, and gluconic acid.
  • organic carboxylic acids preferable examples include glycolic acid, lactic acid, malonic acid, maleic acid, and malic acid.
  • Salts of these organic carboxylic acids may be exemplified by those formed with alkali metal, alkali earth metal, ammonia, and organic amine compound.
  • the component (C) may be a single species, or may be a combination of two or more species, wherein the content of which is preferably 0.1 to 5% by weight, more preferably 0.2 to 3% by weight, and even more preferably 0.5 to 2% by weight of the aqueous hair cleansing agent, in view of ensuring a sufficient level of scalp improvement.
  • the aqueous hair cleansing agent of the present invention containing such component(C), preferably has a pH value of 2 to 4.5, and more preferably 3 to 4.5, at 25°C when diluted 20-fold by weight with water.
  • the aqueous hair cleansing agent of the present invention preferably has a pH value of 1 to 5, more preferably 2 to 4.5, and even more preferably 3 to 4.5, at 25°C when diluted 20-fold by weight with water.
  • the ether carboxylate composing the component (B) is a weak acid, it exists in a form of acid (undissociated form) under low pH, whereas it exists in a form of anion (dissociated form) under high pH. More specifically, most of the ether carboxylate exists in a form of acid at 25°C under pH 1 to 5 when diluted 20-fold with water, and is particularly effective for suppressing swelling of the horny layer.
  • the aqueous hair cleansing agent of the present invention typically has excellent foamability and anti-dandruff performance, and is also capable of suppressing itchiness of the scalp as a result of suppression of swelling of the horny layer.
  • inorganic or organic acid, or alkali agent may be used while being appropriately combined and quantified.
  • the inorganic acid may be exemplified by hydrochloric acid, sulfuric acid, and phosphoric acid.
  • the organic acid may be exemplified by citric acid and glutamic acid, besides the above-described organic carboxylic acid.
  • an additional effect of preventing dandruff and itchiness may be obtained, particularly by using one or more species of organic carboxylic acid or salt thereof, which composes the component (C).
  • An aqueous hair cleansing agent which is further well balanced among foamability, anti-dandruff performance, and low stimulation, and also excellent in stability in manufacturing, may be obtained by using the alkyl sulfate or alkyl ether sulfate represented by the general formula (1), that is the component (A), as the base, together with the alkylether carboxylate composing the component (B), and the organic acid salt composing the component (C), and by adjusting pH at 25°C to 1 to 5 when diluted 20-fold with water.
  • the aqueous hair cleansing agent of the present invention may also reduce volume of water for rinsing, since the surfactant contained therein is less likely to remain on the hair or scalp.
  • the aqueous hair cleansing agent of the present invention may further be configured to contain at least one species of an anti-inflammatory agent.
  • the anti-inflammatory agent includes glycyrrhetinic acid, glycyrrhizic acid and derivatives thereof; and also include components having an anti-inflammatory function, such as ⁇ -aminocaproic acid, allantoin, sodium guaiazulene sulfonate, d-camphor, 1- menthol, urea, pyridoxine dipalmitate, glycyrrhetinyl stearate, tranexamic acid, vitamin A oil, hydrocortisone, prednisolone, pyridoxine hydrochloride, Kankohso (photosensitizer) 301, zinc oxide, and hydrocortisone acetate.
  • the derivatives of glycyrrhetinic acid or glycyrrhizic acid include salts which include alkali metal salts represented by sodium salt and potassium salt, and ammonium salt; and esters such as glycerin ester and stearyl ester. More specifically, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, glycerin glycyrrhetinate, and stearyl glycyrrhetinate may be exemplified.
  • the anti-inflammatory agent may be a single species, or may be a combination of two or more species, wherein the content of which is preferably 0.001 to 10% by weight, more preferably 0.005 to 5% by weight, and even more preferably 0.01 to 1% by weight.
  • the aqueous hair cleansing agent of the present invention may contain a nonionic surfactant or amphoteric surfactant.
  • the nonionic surfactant adoptable herein may be exemplified by polyoxyalkylene solbitan fatty acid ester, polyoxyalkylene solbit fatty acid ester, polyoxyalkylene glycerin fatty acid ester, polyoxyalkylene fatty acid ester, polyoxyalkylene alkyl ether, polyoxyalkylene alkylphenyl ether, polyoxyalkylene (hydrogenated)castor oil, sucrose fatty acid ester, polyglycerin alkyl ether, polyglycerin fatty acid ester, fatty acid alkanolamide, alkylglycoside, mono alkyl and monoalkenyl glyceryl ether.
  • polyoxyalkylene solbitan fatty acid ester such as polyoxyethylene solbitan fatty acid ester, polyoxyalkylene fatty acid ester such as polyoxyalkylene (C 8 to C 20 ) fatty acid ester, and polyoxyalkylene (hydrogenated) castor oil such as polyoxyethylene hydrogenated castor oil, and alkylglycoside are preferable.
  • fatty acid alkanolamide is a preferable nonionic surfactant, allowing either monoalkanolamide or dialkanolamide.
  • Those having an acyl group of 8 to 18 carbon atoms, in particular 10 to 16 carbon atoms are preferable.
  • those having a hydroxyalkyl group of 2 to 3 carbon atoms are preferable, which are exemplified by oleic acid diethanolamide, palm kernel oil fatty acid diethanolamide, coconut oil fatty acid diethanolamide, lauric acid diethanolamide, polyoxyethylene coconut oil fatty acid monoethanolamide, coconut oil fatty acid monoethanolamide, lauric acid isopropanolamide, and lauric acid monoethanolamide.
  • glyceryl monoalkyl ether or glyceryl monoalkenyl ether is a preferable nonionic surfactant, where the alkyl group or alkenyl group is preferably a straight-chain or branched alkyl group having 4 to 10 carbon atoms, in particular 8 to 10 carbon atoms.
  • the specific examples include n-butyl group, isobutyl group, n -pentyl group, 2-methylbutyl group, isopentyl group, n-hexyl group, isohexyl group, n-heptyl group, n -octyl group, 2-ethylhexyl group, n-decyl group, and isodecyl group.
  • 2-ethylhexyl group and isodecyl group are preferable.
  • the amphoteric surfactant may be exemplified by betaine-based surfactants.
  • betaine-based surfactants alkyl dimethyl aminoacetic acid betaine, fatty acid amidopropyl betaine, and alkyl hydroxy sulfobetaine are more preferable, wherein fatty acid amidopropyl betaine is more preferable.
  • the fatty acid amidopropyl betaine preferably has an acyl group of 8 to 18 carbon atoms, in particular 10 to 16 carbon atoms, wherein more preferable examples include lauric acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine, and coconut oil fatty acid amidopropyl betaine.
  • Each of these surfactants may be a single species, or may be a combination of two or more species contained in the aqueous hair cleansing agent.
  • fatty acid amidopropyl betaine, fatty acid alkanolamide, or mono alkylglyceryl ether it is preferable to use fatty acid amidopropyl betaine, fatty acid alkanolamide, or mono alkylglyceryl ether, together with the components (A), (B), not only because the foamability is improved, but also because the appropriate level of pH may be obtained.
  • the content of these surfactant is preferably 0.1 to 15% by weight in the hair cleansing agent of the present invention, in view of obtaining a good effect of enhancing the foamability. From this point of view, the content is more preferably 0.5 to 8% by weight, and even more preferably 1 to 6% by weight.
  • the aqueous hair cleansing agent of the present invention may further contain a cationic surfactant, cationized polymer or silicones, for the purpose of improving the finger combability during rinsing, and of improving styling of hair after being dried.
  • the cationic surfactant may be exemplified by alkyltrimethyl ammonium salt, alkoxy trimethyl ammonium salt, dialkyldimethyl ammonium salt, alkyldimethylamine salt, alkoxy dimethylamine salt, and alkylamide dimethylamine salt.
  • R 4 -N + (CH 3 ) 3 Q - (in the general formula, R 4 represents an alkyl group having 12 to 22 carbon atoms, and Q - represents a halogen (chlorine or bromine) ion.) More specifically, cetyl trimethylammonium chloride, stearyl trimethylammonium chloride, and behenyl trimethylammonium chloride may be exemplified.
  • R 5 -O-R 6 -N (CH 3 ) 3 Q - (in the formula, R 5 represents an alkyl group having 12 to 22 carbon atoms, R 6 represents an ethylene group or propylene group, and Q - is same as described in the above.) More specifically, stearoxypropyl trimethylammonium chloride, stearoxyethyl trimethylammonium chloride, and stearoxyhydroxypropyl trimethylammonium chloride may be exemplified.
  • R 7 2 -N + (CH 3 ) 2 Q - (in the general formula, R 7 represents an alkyl group having 12 to 22 carbon atoms or benzyl group, and Q - is same as described in the above.) More specifically, distearyl dimethyl ammonium chloride may be exemplified.
  • R 8 -N(CH 3 ) 2 in the general formula, R 8 represents an alkyl group having 12 to 22 carbon atoms.
  • organic acid salts of behenyl dimethylamine and stearyl dimethylamine may be exemplified.
  • R 9 -O-R 10 - N(CH 3 ) 2 represents an alkyl group having 12 to 22 carbon atoms, and R 10 represents an ethylene group or propylene group.
  • Cationic surfactants other than the above-described (i) to (vi) may be exemplified by lanolin fatty acid aminopropylethyldimethyl ammonium ethyl sulfate, lanolin fatty acid aminoethyltriethylammonium ethyl sulfate, lanolin fatty acid aminopropyltriethylammonium ethyl sulfate, lanolin fatty acid aminoethyltrimethylammonium methyl sulfate, lanolin fatty acid aminopropylethyldimethylammonium methyl sulfate, isoalkanoic acid (C 14 to C 20 ) aminopropylethyldimethylammonium ethyl sulfate, isoalkanoic acid (C 18 to C 22 ) aminopropylethyldimethylammonium ethyl sulfate, isostearic acid aminoprop
  • Two or more species of the cationic surfactant may be combined, wherein the content of which is preferably 0.01 to 10% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.05 to 5% by weight, and even more preferably 0.1 to 2% by weight, in view of smoothness over a period from washing to rinsing.
  • the cationized polymer may be exemplified by cationized cellulose, cationized starch, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, cationized xanthan gum, diallyldialkylammonium salt/acrylamide copolymer, vinylimidazolium trichloride/vinylpyrrolidone copolymer, hydroxyethylcellulose/dimethyldiallyl ammonium chloride copolymer, vinylpyrrolidone/quaternized dimethylaminoethyl methacrylate copolymer, polyvinylpyrrolidone/alkylamino acrylate copolymer, polyvinylpyrrolidone/alkylamino acrylate/vinylcaprolactam copolymer, vinylpyrrolidone/methacrylamidopropyl trimethylammonium chloride copolymer
  • JP-A-S53-139734 and JP-A-S60-36407 are preferable.
  • cationized cellulose, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, and diallyldialkylammonium salt/acrylamide copolymer are preferable.
  • Two or more species of these cationized polymers may be combined, wherein the content of which is preferably 0.01 to 3% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.05 to 2% by weight, and even more preferably 0.1 to 1% by weight, in view of smoothness over a period from washing to rinsing.
  • the silicones may be exemplified by (I) to (III) listed below.
  • the dimethylpolysiloxane exist as dispersed particles in the aqueous hair cleansing agent, wherein average particle size of the dispersed particles is preferably 0.1 to 100 ⁇ m, more preferably 0.1 to 50 ⁇ m, even more preferably 0.1 to 4 ⁇ m, and even more preferably 0.1 to 2 ⁇ m, in view of excellence of finishing after drying, and storage stability of the hair cleansing agent.
  • the average particle size of the polydimethylsiloxane emulsion herein means the median diameter measured by laser light scattering method, and may be measured using a general particle analyzer based on laser light scattering, such as LS-130 from Coulter Corporation.
  • the dimethylpolysiloxane is preferably contained in an amount of from 0.01 to 10% by weight of the aqueous hair cleansing agent of the present invention, preferably 0.05 to 6% by weight, more preferably 0.3 to 3% by weight, and even more preferably 0.5 to 2% by weight, in view of improving foam texture, and touch or gloss of hair after being dried.
  • While various amino-modified silicones may be adoptable, a product listed under the name of Amodimethicone in CTFA Dictionary (Cosmetic Ingredient Dictionary, USA), 9th Edition, 2002, Volume 1, p.107 , having an average molecular weight of approximately 3000 to 100,000, is preferable.
  • the commercially available products may be exemplified by SM 8704C (from Dow Corning Toray Co., Ltd.), DC 929 (from Dow Corning Corporation), KT 1989 (from Momentive Performance Materials Inc.), 8500 Conditioning Agent, DOW CORNING TORAY SS-3588, and DOW CORNING TORAY SILSTYLE 104 (from Dow Corning Toray Co., Ltd.).
  • silicones besides those described above may be exemplified by polyether-modified silicone, methylphenyl polysiloxane, aliphatic acid-modified silicone, alcohol-modified silicone, alkoxy-modified silicone, epoxy-modified silicone, fluorine-modified silicone, cyclic silicone, and alkyl-modified silicone.
  • Two or more species of these amino-modified silicone and other silicones may be combined, wherein the content of which is preferably 0.01 to 5% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.05 to 2% by weight, and even more preferably 0.1 to 1% by weight, in view of smoothness over a period from washing to rinsing.
  • the aqueous hair cleansing agent of the present invention may further contain a pearlescent agent containing ethylene glycol monofatty acid ester, ethylene glycol difatty acid ester, ethylene glycol mono alkyl ether or ethylene glycol dialkyl ether.
  • the ethylene glycol monofatty acid ester may be exemplified by ethylene glycol monostearate and ethylene glycol monobehenate
  • the ethylene glycol difatty acid ester may be exemplified by ethylene glycol distearate and ethylene glycol dibehenate.
  • the ethylene glycol mono alkyl ether may be exemplified by ethylene glycol monostearyl ether, and the ethylene glycol dialkyl ether may be exemplified by ethylene glycol distearyl ether.
  • Each of them may be a combination of two or more species, wherein the content of which is preferably 0.1 to 10% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.5 to 5% by weight, and even more preferably 1 to 4% by weight, in view of improving storage stability, smoothness during foaming and rinsing, and stability of the hair cleansing agent.
  • the aqueous hair cleansing agent of the present invention may contain an oil component as another conditioning agent.
  • the oil component may be exemplified by hydrocarbon oils such as squalene, squalane, liquid paraffin, liquid isoparaffin, and cycloparaffin; glycerides such as castor oil, cacao oil, mink oil, avocado oil, olive oil, sunflower oil, and camellia oil; waxes such as beeswax, spermaceti, lanolin, and carnauba wax; higher alcohols such as cetyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyl dodecanol, myristyl alcohol, behenyl alcohol, and cetostearyl alcohol; ester oils such as isopropyl palmitate, isopropyl myristate, octyldodecyl myristate, hexyl laurate, cetyl lactate, propylene glycol mono
  • higher fatty acids, higher alcohol, and glyceride are preferable, and lauric acid, myristyl alcohol, cetyl alcohol, stearyl alcohol, sunflower oil, and camellia oil are more preferable.
  • These oil components may be a single species, or may be a combination of two or more species, wherein the content of which is preferably 0.1 to 2% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.2 to 1.5% by weight, and even more preferably 0.3 to 1% by weight.
  • the aqueous hair cleansing agent of the present invention may contain a viscosity adjusting agent.
  • the viscosity adjusting agent may be exemplified by hydroxyethylcellulose, methylcellulose, polyethylene glycol, polypropylene glycol, ethylene glycol, propylene glycol, isoprene glycol, ethanol, glycerin, benzyl alcohol, benzyloxy ethanol, phenoxy ethanol, and clay minerals, salts (sodium chloride, ammonium chloride, sodium citrate, and so forth), among which benzyl alcohol, ethanol, polypropylene glycol, sodium chloride, and sodium citrate are preferable.
  • the viscosity adjusting agent may be a single species, or may be a combination of two or more species, wherein the content of which is preferably 0.01 to 5% by weight of the aqueous hair cleansing agent of the present invention, more preferably 0.05 to 4% by weight, and even more preferably 0.1 to 3% by weight, in view of richness and quality of foam.
  • any components adopted to a general hair cleansing agent may appropriately be added to the aqueous hair cleansing agent of the present invention, depending on the need.
  • the components may be exemplified by antiseptic agent; chelating agent; moisturizers such as sorbitol and panthenol; colorants such as dye and pigment; extracts such as polar solvent extract of eucalyptus, protein obtained from shell having a nacreous layer or from pearl, or hydrolysate thereof, honey, royal jelly, silk-derived protein or hydrolysate thereof, protein-containing extract obtained from leguminous plant seed, Panax ginseng extract, rice germ extract, bladderwrack extract, aloe extract, Alpinia leaf extract, and chlorella extract; pearl pigment such as mica-titanium; perfume; UV absorber; antioxidant; and other components listed in Encyclopedia of Shampoo Ingredients (written by Anthony L.L. Hunting, 1983, published by Micelle Press )).
  • aqueous hair cleansing agent of the present invention may appropriately be selectable from liquid, gel and so forth, it is preferable to use water or lower alcohol, and particularly water, as a medium.
  • Aqueous hair cleansing agents listed in Table 1 were prepared, and evaluated by the methods described below. Results are shown in Table 1. Note that the pH values herein were measured at 25°C after 20-fold dilution with water.
  • FIG. 1 illustrates an apparatus for evaluating foamability, having a container 10 for housing an article to be applied with the cleansing agent (hair 1), projections 21, 22 which are brought into contact with the hair 1, a gauge 50 for measuring foam produced in the container 10, a lid 20 which covers the container 10, and guides the foam produced in the container 10 towards the gauge 50, and a motor 30 for moving the container 10 so as to bring the hair 1 housed in the container 10 and the projections 21, 22 into sliding contact.
  • the cleansing agent hair 1
  • FIG. 1 illustrates an apparatus for evaluating foamability, having a container 10 for housing an article to be applied with the cleansing agent (hair 1), projections 21, 22 which are brought into contact with the hair 1, a gauge 50 for measuring foam produced in the container 10, a lid 20 which covers the container 10, and guides the foam produced in the container 10 towards the gauge 50, and a motor 30 for moving the container 10 so as to bring the hair 1 housed in the container 10 and the projections 21, 22 into sliding contact.
  • the hair 1 was wet with an equal volume of water, 1.5 mL of each sample to be evaluated and 0.3 mL of model sebum composed of lanolin were injected through an injection port 25, and the amount of foam was measured. Quickness of foaming was evaluated by time required for the amount of foam to reach 250 mL.
  • the hair 1 used herein was 90 mm long, 30 g in weight in total, and attached onto a disk of approximately 160 mm in diameter.
  • the container 10 was a cylinder of 160 mm in diameter and 20 mm high.
  • the lid 20 had three first cylindrical projections 21 each having a diameter of 15 mm and a height of 12 mm, and nine second projections 22 each of which being 10 mm long, 2 mm wide, and 12 mm high. Number of rotations of the container 10 driven by the motor was set to 70 revolutions per minute.
  • compositions of Examples 1 to 7 were excellent in foamability and anti-dandruff performance, highly effective in suppressing swelling of the horny layer, and effective in suppressing itchiness of the scalp.
  • the hair cleansing agents of Examples 8 to 10 were found to be excellent in foamability and anti-dandruff performance, and to have effects of suppressing swelling of the horny layer and itchiness of the scalp.
  • Samples were measured according to (3) Swellability of the horny layer for Examples 1 to 7 and Comparative Examples 1 to 8, described in the above. More specifically, the components (A) and (B) or (B') were added to deionized water, so as to adjust the surfactant concentration, or the total concentration of the components (A) and (B) or (B'), to 30 mM, to thereby prepare surfactant samples having various concentrations as listed in Table 2.
  • the surfactant concentration herein corresponds to a concentration of the shampoo when foamed on hair during washing.
  • 20 mg of the horny layer powder was placed into the NMR measurement tube, and 0.8 mL of each of the above-described surfactant samples was added and mixed.
  • Example 11 was capable of further effectively suppressing swelling of the horny layer, only with a small amount of addition, by using the component (A) together with the component (B), still also with the component (C), and by lowering the pH. Also Comparative Example 9, with its pH adjusted to 6.0, was found to be more effective in suppressing swelling of the horny layer, as compared with Comparative Example 10 having no component (B) contained therein. Example 11 showed a more distinctive effect of suppressing swelling of the horny layer. Example 11 was found to be excellent, also in terms of more stably obtaining a sample well balanced between the swellability and foamability.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cosmetics (AREA)
EP10758226.4A 2009-03-31 2010-03-26 Agent aqueux de nettoyage des cheveux Not-in-force EP2415450B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009085836A JP2010235523A (ja) 2009-03-31 2009-03-31 水性毛髪洗浄剤
PCT/JP2010/002177 WO2010113446A1 (fr) 2009-03-31 2010-03-26 Agent aqueux de nettoyage des cheveux

Publications (3)

Publication Number Publication Date
EP2415450A1 true EP2415450A1 (fr) 2012-02-08
EP2415450A4 EP2415450A4 (fr) 2015-07-29
EP2415450B1 EP2415450B1 (fr) 2018-07-04

Family

ID=42827757

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10758226.4A Not-in-force EP2415450B1 (fr) 2009-03-31 2010-03-26 Agent aqueux de nettoyage des cheveux

Country Status (6)

Country Link
US (2) US8632758B2 (fr)
EP (1) EP2415450B1 (fr)
JP (1) JP2010235523A (fr)
CN (1) CN102361627B (fr)
TW (1) TWI442939B (fr)
WO (1) WO2010113446A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112218615A (zh) * 2018-06-12 2021-01-12 花王株式会社 清洁剂
EP3808333A4 (fr) * 2018-06-12 2022-03-16 Kao Corporation Agent nettoyant
EP3808332A4 (fr) * 2018-06-12 2022-03-16 Kao Corporation Agent nettoyant

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010235523A (ja) * 2009-03-31 2010-10-21 Kao Corp 水性毛髪洗浄剤
JP5341029B2 (ja) 2010-06-18 2013-11-13 花王株式会社 水性毛髪洗浄剤
JP5703116B2 (ja) 2010-12-28 2015-04-15 花王株式会社 皮膚洗浄剤組成物
CN103347488B (zh) 2010-12-28 2016-01-13 花王株式会社 毛发化妆品
JP5665581B2 (ja) * 2011-02-08 2015-02-04 花王株式会社 洗浄剤組成物
EP2705834B1 (fr) * 2011-05-02 2019-07-03 Kao Corporation Composition d'agent lavant
JP5833336B2 (ja) * 2011-05-02 2015-12-16 花王株式会社 水性毛髪洗浄剤
JP5406959B2 (ja) * 2011-05-02 2014-02-05 花王株式会社 水性毛髪洗浄剤
JP5856754B2 (ja) * 2011-05-02 2016-02-10 花王株式会社 洗浄剤組成物
WO2013174615A2 (fr) * 2012-05-22 2013-11-28 Unilever N.V. Composition d'hygiène corporelle
JP6207068B2 (ja) * 2013-10-18 2017-10-04 花王株式会社 介護用皮膚洗浄剤組成物
JP6426914B2 (ja) * 2014-05-26 2018-11-21 花王株式会社 毛髪洗浄剤組成物
JP2015224196A (ja) * 2014-05-26 2015-12-14 花王株式会社 毛髪洗浄剤組成物
JP6423618B2 (ja) * 2014-05-26 2018-11-14 花王株式会社 毛髪洗浄剤組成物
JP6364247B2 (ja) * 2014-06-04 2018-07-25 花王株式会社 毛髪洗浄剤
MX2017013983A (es) 2015-05-01 2018-03-15 Oreal Uso de agentes activos durante tratamientos quimicos.
SG10201603461TA (en) * 2015-05-08 2016-12-29 Kao Corp Hair cleansing agent
BR112018010381B1 (pt) 2015-11-24 2021-08-17 L'oreal Composição para tratamento de cabelo, sistema para tratamento de cabelo, métodos para tratamento de cabelo e para alteração da cor do cabelo, e, kit de multicompartimentos para alteração da cor ou do formato do cabelo
US10441518B2 (en) 2015-11-24 2019-10-15 L'oreal Compositions for treating the hair
RU2771234C2 (ru) 2015-11-24 2022-04-28 Л'Ореаль Композиции для обработки волос
MX2018010550A (es) 2016-03-03 2018-11-09 Procter & Gamble Metodo para limpiar el cabello con el uso de una composicion para el cuidado del cabello de bajo ph.
US11135150B2 (en) 2016-11-21 2021-10-05 L'oreal Compositions and methods for improving the quality of chemically treated hair
US9974725B1 (en) 2017-05-24 2018-05-22 L'oreal Methods for treating chemically relaxed hair
EP3731801B1 (fr) 2017-12-29 2022-03-09 L'oreal Compositions pour modifier la couleur des cheveux
US11090249B2 (en) 2018-10-31 2021-08-17 L'oreal Hair treatment compositions, methods, and kits for treating hair
US11419809B2 (en) 2019-06-27 2022-08-23 L'oreal Hair treatment compositions and methods for treating hair
JP7336426B2 (ja) * 2020-10-30 2023-08-31 花王株式会社 皮膚又は毛髪洗浄剤組成物
JP7419438B2 (ja) * 2021-08-23 2024-01-22 三洋化成工業株式会社 界面活性剤組成物及び洗浄剤組成物
CN113925796B (zh) * 2021-09-18 2023-12-12 上海百雀羚生物科技有限公司 一种具有抵御式舒缓效果的植物成分的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU76955A1 (fr) 1977-03-15 1978-10-18
JPS6191137A (ja) * 1984-10-11 1986-05-09 Kao Corp 外用薬剤組成物
JPH0684510B2 (ja) 1985-05-29 1994-10-26 株式会社資生堂 洗浄剤組成物
US4759875A (en) * 1986-01-14 1988-07-26 S. C. Johnson & Son, Inc. Oxo-derived mild surfactant blends
JPS6473584A (en) 1987-09-14 1989-03-17 Sony Corp Tape cassette
JPH0794674B2 (ja) 1988-04-30 1995-10-11 三洋化成工業株式会社 洗浄剤組成物
JP2878528B2 (ja) 1992-07-21 1999-04-05 株式会社日立製作所 磁気記録再生装置
JPH08119828A (ja) * 1994-10-18 1996-05-14 Kanebo Ltd 化粧料
DE19530550A1 (de) 1995-08-19 1997-02-20 Kao Corp Gmbh Haarwaschmittel
JP2000319136A (ja) * 1999-05-14 2000-11-21 Milbon Co Ltd 毛髪の処理方法
JP2001010934A (ja) * 1999-06-30 2001-01-16 Lion Corp 毛髪用洗浄剤組成物
JP4127777B2 (ja) * 2002-08-09 2008-07-30 花王株式会社 毛髪洗浄剤組成物
JP2004123575A (ja) * 2002-09-30 2004-04-22 Rohto Pharmaceut Co Ltd 外用ゲル状組成物
JP2006001846A (ja) 2004-06-15 2006-01-05 New Japan Chem Co Ltd 毛髪処理剤組成物
JP2007001889A (ja) * 2005-06-22 2007-01-11 Mandom Corp シャンプー組成物
JP2007131583A (ja) * 2005-11-11 2007-05-31 Kao Corp スカルプケア剤
JP2007254356A (ja) * 2006-03-23 2007-10-04 Kao Corp 毛髪化粧料
JP5075345B2 (ja) * 2006-03-23 2012-11-21 花王株式会社 毛髪洗浄剤組成物
CN101077331A (zh) 2006-05-22 2007-11-28 花王株式会社 水性毛发洗净剂
CN101077332B (zh) 2006-05-22 2012-05-23 花王株式会社 水性毛发洗净剂
JP4678536B2 (ja) 2007-10-01 2011-04-27 株式会社デンソー 照度センサ
JP2010235523A (ja) * 2009-03-31 2010-10-21 Kao Corp 水性毛髪洗浄剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2010113446A1 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112218615A (zh) * 2018-06-12 2021-01-12 花王株式会社 清洁剂
EP3808331A4 (fr) * 2018-06-12 2022-03-16 Kao Corporation Agent nettoyant
EP3808333A4 (fr) * 2018-06-12 2022-03-16 Kao Corporation Agent nettoyant
EP3808332A4 (fr) * 2018-06-12 2022-03-16 Kao Corporation Agent nettoyant

Also Published As

Publication number Publication date
JP2010235523A (ja) 2010-10-21
US20120015894A1 (en) 2012-01-19
CN102361627A (zh) 2012-02-22
US8632758B2 (en) 2014-01-21
WO2010113446A1 (fr) 2010-10-07
EP2415450B1 (fr) 2018-07-04
US20140094423A1 (en) 2014-04-03
TW201041601A (en) 2010-12-01
EP2415450A4 (fr) 2015-07-29
TWI442939B (zh) 2014-07-01
CN102361627B (zh) 2013-11-13

Similar Documents

Publication Publication Date Title
EP2415450B1 (fr) Agent aqueux de nettoyage des cheveux
EP2415452B1 (fr) Agent aqueux de nettoyage des cheveux
EP0651632B1 (fr) Composition de produit capillaire
EP2583666B1 (fr) Agent aqueux de lavage pour cheveux
EP1707239B1 (fr) Composition de lavage capillaire
EP2110121B1 (fr) Compositions cosmétiques et dermatologiques, en particulier pour le traitement de substrats contenant de la kératine
JP2018538338A (ja) シリコーン及び界面活性剤を含むヘア・コスメティック組成物、並びにコスメティックトリートメント方法
KR20050050142A (ko) 두피 트리트먼트제
ZA200802845B (en) Cosmetic compositions comprising at least one carboxylic anionic surfactant and at least one vinylamide/vinylamine copolymer
US7604796B2 (en) Hair cleansing compositions
JP5607311B2 (ja) 水性毛髪洗浄剤
JP5426212B2 (ja) 水性毛髪洗浄剤
US6620409B2 (en) Hair and skin care agents
EP3435967B1 (fr) Composition d'après-shampoing contenant un/des esters de pentaérythritol et un/des éthers alkyliques de ppg
JP5426213B2 (ja) 水性毛髪洗浄剤
DE102015223831A1 (de) Leistungsstarke Haarbehandlungsmittel mit Anti-Auswasch-Effekt
EP3714871B1 (fr) Cosmétique capillaire
JPH0798736B2 (ja) 毛髪化粧料
KR100740733B1 (ko) 두피케어용 샴푸 조성물
WO2020104129A1 (fr) Composition de nettoyage cosmétique
DE102017218962A1 (de) Strukturkräftigende Haarbehandlungsmittel mit gesteigerter Pflegewirkung
DE102015223819A1 (de) "Leistungsstarke Haarbehandlungsmittel mit Anti-Auswasch-Effekt "

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20111012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150625

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 8/365 20060101ALI20150619BHEP

Ipc: A61Q 5/02 20060101ALI20150619BHEP

Ipc: A61K 8/39 20060101AFI20150619BHEP

Ipc: A61K 8/63 20060101ALI20150619BHEP

Ipc: A61K 8/46 20060101ALI20150619BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20170323

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20180309

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1013734

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180715

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602010051655

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20180704

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1013734

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180704

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181005

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181104

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181004

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181004

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602010051655

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

26N No opposition filed

Effective date: 20190405

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190326

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20190331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190326

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181105

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190326

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20100326

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180704

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230208

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230202

Year of fee payment: 14

Ref country code: DE

Payment date: 20230131

Year of fee payment: 14

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230522

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602010051655

Country of ref document: DE

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20240326

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20241001

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240326

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240326

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240331

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20241001