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EA201791744A2 - Улучшенная липидная композиция - Google Patents

Улучшенная липидная композиция

Info

Publication number
EA201791744A2
EA201791744A2 EA201791744A EA201791744A EA201791744A2 EA 201791744 A2 EA201791744 A2 EA 201791744A2 EA 201791744 A EA201791744 A EA 201791744A EA 201791744 A EA201791744 A EA 201791744A EA 201791744 A2 EA201791744 A2 EA 201791744A2
Authority
EA
Eurasian Patent Office
Prior art keywords
lipid composition
improved lipid
lipid
formula
improved
Prior art date
Application number
EA201791744A
Other languages
English (en)
Other versions
EA201791744A3 (ru
Inventor
Акин Акинг
Джозеф Р. Доркин
Сяоцзюнь Цинь
Вильям Кентли
Мутиах Манохаран
Каллантоттатил Г. Раджив
Джаяпракаш К. Нараянаннаир
Мутусами Джаяраман
Цзяньсинь Чэнь
Стивен Энселл
Original Assignee
Арбутус Биофарма Корпорэйшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арбутус Биофарма Корпорэйшн filed Critical Арбутус Биофарма Корпорэйшн
Publication of EA201791744A2 publication Critical patent/EA201791744A2/ru
Publication of EA201791744A3 publication Critical patent/EA201791744A3/ru

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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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Abstract

Изобретение относится к катионному липиду формулы (I), улучшенной липидной композиции, содержащей катионный липид формулы (I), и соответствующим способам применения. Также описаны нацеливающие липиды и специфичные липидные композиции, содержащие указанные нацеливающие липиды.
EA201791744A 2009-06-10 2010-06-10 Улучшенная липидная композиция EA201791744A3 (ru)

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