DK3746446T3 - PRC2-inhibitorer - Google Patents
PRC2-inhibitorer Download PDFInfo
- Publication number
- DK3746446T3 DK3746446T3 DK19710816.0T DK19710816T DK3746446T3 DK 3746446 T3 DK3746446 T3 DK 3746446T3 DK 19710816 T DK19710816 T DK 19710816T DK 3746446 T3 DK3746446 T3 DK 3746446T3
- Authority
- DK
- Denmark
- Prior art keywords
- prc2
- inhibitors
- prc2 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862624176P | 2018-01-31 | 2018-01-31 | |
| US201862672701P | 2018-05-17 | 2018-05-17 | |
| US201862747736P | 2018-10-19 | 2018-10-19 | |
| PCT/US2019/015677 WO2019152419A1 (en) | 2018-01-31 | 2019-01-29 | Prc2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3746446T3 true DK3746446T3 (da) | 2022-06-27 |
Family
ID=65763738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19710816.0T DK3746446T3 (da) | 2018-01-31 | 2019-01-29 | PRC2-inhibitorer |
| DK22165237.3T DK4043466T3 (da) | 2018-01-31 | 2019-01-29 | PRC2-inhibitorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK22165237.3T DK4043466T3 (da) | 2018-01-31 | 2019-01-29 | PRC2-inhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US11485738B2 (da) |
| EP (2) | EP3746446B1 (da) |
| JP (3) | JP7025556B2 (da) |
| KR (2) | KR20220139439A (da) |
| CN (1) | CN112004816B (da) |
| AU (2) | AU2019214861B2 (da) |
| BR (1) | BR112020015583B1 (da) |
| CA (1) | CA3089639C (da) |
| DK (2) | DK3746446T3 (da) |
| ES (1) | ES2923290T3 (da) |
| FI (1) | FI4043466T3 (da) |
| HU (1) | HUE059536T2 (da) |
| IL (2) | IL276156B (da) |
| MX (2) | MX2020007974A (da) |
| NZ (1) | NZ766447A (da) |
| PL (1) | PL3746446T3 (da) |
| PT (2) | PT3746446T (da) |
| WO (1) | WO2019152419A1 (da) |
| ZA (2) | ZA202004453B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3746446T3 (da) * | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| MX2021006026A (es) * | 2018-11-30 | 2021-07-06 | Tuojie Biotech Shanghai Co Ltd | Pirimidina y derivado heterociclico de nitrogeno de cinco miembros, metodo de preparacion y usos medicos de los mismos. |
| EP3980422A1 (en) * | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
| CN112409385B (zh) * | 2019-08-22 | 2024-08-13 | 上海青煜医药科技有限公司 | 氮杂芳基化合物及其应用 |
| CN113004233B (zh) * | 2019-12-18 | 2022-12-20 | 南京优氟医药科技有限公司 | 一种用于制备prc2抑制剂的化合物、其制备方法和用途 |
| CN114907385A (zh) | 2021-02-10 | 2022-08-16 | 上海青煜医药科技有限公司 | 氮杂芳基化合物、其制备方法及应用 |
| WO2023049724A1 (en) * | 2021-09-24 | 2023-03-30 | Oric Pharmaceuticals, Inc. | Prc2 inhibitors for use in treating blood disorders |
| WO2024059607A1 (en) * | 2022-09-14 | 2024-03-21 | Oric Pharmaceuticals, Inc. | Physical forms of an inhibitor of prc2 |
| GB202216323D0 (en) | 2022-11-02 | 2022-12-14 | Cerevance Ltd | Novel compounds |
| WO2024123669A1 (en) * | 2022-12-05 | 2024-06-13 | Oric Pharmaceuticals, Inc. | Treatment of prostate cancer having androgen receptor variants |
| WO2024148008A1 (en) * | 2023-01-03 | 2024-07-11 | Oric Pharmaceuticals, Inc. | Treatment of neuroendocrine prostate cancer |
| WO2024215699A1 (en) * | 2023-04-11 | 2024-10-17 | Oric Pharmaceuticals, Inc. | Treatment of t-cell lymphoma |
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| US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| WO2010021381A1 (ja) | 2008-08-22 | 2010-02-25 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| UA110112C2 (uk) | 2010-05-07 | 2015-11-25 | Глаксосмітклайн Ллс | Індоли |
| ES2534804T3 (es) | 2010-05-07 | 2015-04-28 | Glaxosmithkline Llc | Indazoles |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| WO2012068589A2 (en) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2012082436A2 (en) | 2010-12-03 | 2012-06-21 | Epizyme, Inc. | Modulators of histone methyltransferase, and methods of use thereof |
| WO2012118812A2 (en) | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| MX361350B (es) | 2011-05-10 | 2018-12-04 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal de sodio. |
| KR20140082742A (ko) | 2011-09-30 | 2014-07-02 | 글락소스미스클라인 엘엘씨 | 암을 치료하는 방법 |
| EP2771343B1 (en) | 2011-10-27 | 2016-07-13 | Memorial Sloan-Kettering Cancer Center | Methyltransferase inhibitors for treating cancer |
| WO2013075084A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9206128B2 (en) | 2011-11-18 | 2015-12-08 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2812001B1 (en) | 2012-02-10 | 2017-06-14 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| IL308807A (en) | 2012-04-13 | 2024-01-01 | Epizyme Inc | Combined treatment for cancer |
| US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| US9105490B2 (en) | 2012-09-27 | 2015-08-11 | Taiwan Semiconductor Manufacturing Company, Ltd. | Contact structure of semiconductor device |
| US20150239842A1 (en) | 2012-09-28 | 2015-08-27 | Pfizer Inc. | Benzamide and heterobenzamide compounds |
| EP3725314A1 (en) | 2012-10-15 | 2020-10-21 | Epizyme, Inc. | Substituted benzene compounds |
| MX2015004771A (es) | 2012-10-15 | 2016-01-08 | Epizyme Inc | Metodos para tratar cancer. |
| EP2931707A4 (en) | 2012-12-13 | 2016-07-20 | Glaxosmithkline Llc | AMPLIFIER OF ZEST HOMOLOG 2 INHIBITORS |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
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| TWI629273B (zh) | 2013-02-11 | 2018-07-11 | 美商星宿藥物公司 | 甲基修飾酵素之調節劑、其組成物及用途 |
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| EP2970306A4 (en) | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS CONDENSED IN 6.5 |
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| EP2970281A4 (en) | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BENZENE COMPOUNDS |
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| AU2014276417B2 (en) | 2013-06-06 | 2016-11-24 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of Zeste Homolog 2 inhibitors |
| RU2016104044A (ru) | 2013-07-10 | 2017-08-15 | Глэксосмитклайн Интеллекчуал Проперти (Nо.2) Лимитед | Ингибиторы усилителя zeste гомолога 2 |
| WO2015010078A2 (en) | 2013-07-19 | 2015-01-22 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
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| US9738630B2 (en) | 2013-11-19 | 2017-08-22 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
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| EP3111222A1 (en) | 2014-02-26 | 2017-01-04 | Glaxosmithkline Intellectual Property (No. 2) Limited | Methods of treating cancer patients responding to ezh2 inhibitor gsk126 |
| KR20160122266A (ko) | 2014-03-07 | 2016-10-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 제스트 인핸서 상동체 2 억제제 |
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| IL236420A (en) * | 2014-12-23 | 2016-06-30 | Ron Schneider | Methods and systems for producing an enlarged 3D image |
| JP6636031B2 (ja) | 2015-01-30 | 2020-01-29 | ジェネンテック， インコーポレイテッド | 治療用化合物およびその使用 |
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| CN109790166A (zh) * | 2016-06-20 | 2019-05-21 | 诺华股份有限公司 | 咪唑并吡啶化合物用于治疗癌症 |
| IL263429B (en) * | 2016-06-20 | 2022-08-01 | Novartis Ag | Crystalline forms of a triazolopyrimidine compound |
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| WO2019062435A1 (zh) | 2017-09-28 | 2019-04-04 | 中国科学院上海药物研究所 | 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗prc2介导的疾病 |
| CN109942556A (zh) | 2017-12-21 | 2019-06-28 | 上海青煜医药科技有限公司 | 嘧啶酮化合物及其应用 |
| DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CN110156787B (zh) | 2018-02-13 | 2021-11-02 | 中国科学院上海药物研究所 | 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途 |
| CN110563722A (zh) | 2018-06-06 | 2019-12-13 | 上海青煜医药科技有限公司 | 吡啶或哒嗪并环化合物及其应用 |
| US20220213097A1 (en) | 2019-04-22 | 2022-07-07 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as prc2 inhibitors |
| EP3980422A1 (en) | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
-
2019
- 2019-01-29 DK DK19710816.0T patent/DK3746446T3/da active
- 2019-01-29 DK DK22165237.3T patent/DK4043466T3/da active
- 2019-01-29 PL PL19710816.0T patent/PL3746446T3/pl unknown
- 2019-01-29 ES ES19710816T patent/ES2923290T3/es active Active
- 2019-01-29 JP JP2020541557A patent/JP7025556B2/ja active Active
- 2019-01-29 CA CA3089639A patent/CA3089639C/en active Active
- 2019-01-29 KR KR1020227034197A patent/KR20220139439A/ko not_active Application Discontinuation
- 2019-01-29 KR KR1020207024436A patent/KR102451529B1/ko active IP Right Grant
- 2019-01-29 US US16/966,708 patent/US11485738B2/en active Active
- 2019-01-29 HU HUE19710816A patent/HUE059536T2/hu unknown
- 2019-01-29 NZ NZ766447A patent/NZ766447A/en unknown
- 2019-01-29 AU AU2019214861A patent/AU2019214861B2/en active Active
- 2019-01-29 EP EP19710816.0A patent/EP3746446B1/en active Active
- 2019-01-29 CN CN201980011176.8A patent/CN112004816B/zh active Active
- 2019-01-29 WO PCT/US2019/015677 patent/WO2019152419A1/en active Application Filing
- 2019-01-29 EP EP22165237.3A patent/EP4043466B1/en active Active
- 2019-01-29 PT PT197108160T patent/PT3746446T/pt unknown
- 2019-01-29 FI FIEP22165237.3T patent/FI4043466T3/fi active
- 2019-01-29 BR BR112020015583-7A patent/BR112020015583B1/pt active IP Right Grant
- 2019-01-29 MX MX2020007974A patent/MX2020007974A/es unknown
- 2019-01-29 PT PT221652373T patent/PT4043466T/pt unknown
-
2020
- 2020-07-20 IL IL276156A patent/IL276156B/en unknown
- 2020-07-20 ZA ZA2020/04453A patent/ZA202004453B/en unknown
- 2020-07-29 MX MX2021012501A patent/MX2021012501A/es unknown
- 2020-12-09 US US17/116,270 patent/US11091495B2/en active Active
-
2021
- 2021-03-31 US US17/219,379 patent/US11220509B2/en active Active
- 2021-08-04 IL IL285354A patent/IL285354B/en unknown
- 2021-10-13 ZA ZA2021/07835A patent/ZA202107835B/en unknown
- 2021-11-12 AU AU2021266351A patent/AU2021266351B2/en active Active
-
2022
- 2022-02-10 JP JP2022019319A patent/JP7288527B2/ja active Active
- 2022-08-26 US US17/822,667 patent/US20230137025A1/en active Pending
-
2023
- 2023-05-26 JP JP2023086866A patent/JP7495555B2/ja active Active
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