ES2722048T3 - Compuestos de triazolopirimidina y usos de los mismos - Google Patents
Compuestos de triazolopirimidina y usos de los mismos Download PDFInfo
- Publication number
- ES2722048T3 ES2722048T3 ES15820637T ES15820637T ES2722048T3 ES 2722048 T3 ES2722048 T3 ES 2722048T3 ES 15820637 T ES15820637 T ES 15820637T ES 15820637 T ES15820637 T ES 15820637T ES 2722048 T3 ES2722048 T3 ES 2722048T3
- Authority
- ES
- Spain
- Prior art keywords
- independently selected
- alkyl
- halogen
- substituted
- nrerf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de Fórmula (I): **(Ver fórmulas)** o una sal farmacéuticamente aceptable del mismo, en donde: es un enlace sencillo o un enlace doble; R1 y R2 son independientemente H o halógeno; R3 se selecciona independientemente de: halógeno, fenilo, y un heteroarilo de 5 a 6 miembros que comprende átomos de carbono y 1-4 heteroátomos seleccionados entre N, NRa, O, y S(O)p; en el que dichos fenilo y heteroarilo son sustituidos por 0 -3 R3A; cada R3A se selecciona independientemente de: halógeno, CN, -(O)m-(alquilo C1 -C6 sustituido por 0-1 R3B), haloalquilo C1 -C6, haloalcoxilo C1 -C6, R3C, -OR3C, -C (= O)R3D, NR3ER3F, -C(=O)NR3ER3F, -NHC(=O)R3D, -S(=O)2 R3D, - S(=O)2NR3ER3F, -NHS(=O)2(alquilo C1 -C4), y -CR3CR3ER3G; R3B se selecciona independientemente de: OH, NReRf, alcoxilo C1-C4, -C(=O)NReRf, -S(=O)2(alquilo C1-C4), -NHC(=O)(alquilo C1-C4), y un heterocicloalquilo de 5 a 6 miembros que comprende átomos de carbono y 1-2 heteroátomos seleccionados entre N, NRa, O, y S(O)p; en el que dicho heterocicloalquilo es sustituido por 0-2 Rc; cada R3C se selecciona independientemente de: cicloalquilo C3-C6, fenilo, y un heterociclo de 4 a 7 miembros que comprende átomos de carbono y 1-4 heteroátomos seleccionados de N, NRa, O, y S(O)p; en donde cada fracción es sustituida por 0-2 Rc; cada R3D se selecciona independientemente de: alquilo C1-C4 y R3C; R3E y R3G son, en cada caso, independientemente seleccionados de: H y alquilo C1 -C4; cada R3F se selecciona independientemente de: H y alquilo C1-C4 sustituido por 0-1 Rd; R4 se selecciona independientemente de: H, halógeno y alquilo C1-C4; R5 se selecciona independientemente de OH y alquilo C1-C4; cada Ra se selecciona independientemente de: H, ®O, alquilo C1-C4 sustituido por 0-1 Rb, -C(=O)H, -C(=O)(alquilo C1-C4), -CO2(alquilo C1-C4), cicloalquilo C3-C6, y bencilo; Rb se selecciona independientemente de: halógeno, OH y alcoxilo C1-C4; cada Rc se selecciona independientemente de: =O, halógeno, OH, alquilo C1-C4, haloalquilo C1-C4, alcoxilo C1-C4, y haloalcoxilo C1-C4; Rd se selecciona independientemente de: OH y NReRf; Re y Rf son, en cada caso, independientemente seleccionados de: H y alquilo C1 -C4; cada p es independientemente seleccionada de 0, 1 y 2; y m y n son, en cada caso, independientemente seleccionados de 0 y 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014094644 | 2014-12-23 | ||
| CN2015095320 | 2015-11-23 | ||
| PCT/IB2015/059843 WO2016103155A1 (en) | 2014-12-23 | 2015-12-21 | Triazolopyrimidine compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2722048T3 true ES2722048T3 (es) | 2019-08-07 |
Family
ID=55071101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15820637T Active ES2722048T3 (es) | 2014-12-23 | 2015-12-21 | Compuestos de triazolopirimidina y usos de los mismos |
Country Status (40)
| Country | Link |
|---|---|
| US (5) | US10220036B2 (es) |
| EP (1) | EP3237418B1 (es) |
| JP (1) | JP6736559B2 (es) |
| KR (1) | KR102534028B1 (es) |
| CN (1) | CN107108637B (es) |
| AU (1) | AU2015370524B2 (es) |
| BR (1) | BR112017010354B8 (es) |
| CA (1) | CA2969090C (es) |
| CL (1) | CL2017001572A1 (es) |
| CO (1) | CO2017005992A2 (es) |
| CR (1) | CR20170285A (es) |
| CY (1) | CY1121901T1 (es) |
| DK (1) | DK3237418T3 (es) |
| DO (1) | DOP2017000149A (es) |
| EA (1) | EA032416B1 (es) |
| EC (1) | ECSP17047153A (es) |
| ES (1) | ES2722048T3 (es) |
| GT (1) | GT201700146A (es) |
| HR (1) | HRP20190805T1 (es) |
| HU (1) | HUE043060T2 (es) |
| IL (1) | IL252135B (es) |
| JO (1) | JO3489B1 (es) |
| LT (1) | LT3237418T (es) |
| ME (1) | ME03385B (es) |
| MX (1) | MX2017008529A (es) |
| MY (1) | MY186837A (es) |
| NZ (1) | NZ731664A (es) |
| PE (1) | PE20171307A1 (es) |
| PH (1) | PH12017501016A1 (es) |
| PL (1) | PL3237418T3 (es) |
| PT (1) | PT3237418T (es) |
| RS (1) | RS58679B1 (es) |
| SG (1) | SG11201703880VA (es) |
| SI (1) | SI3237418T1 (es) |
| SV (1) | SV2017005472A (es) |
| TN (1) | TN2017000204A1 (es) |
| TW (1) | TWI694076B (es) |
| UA (1) | UA120945C2 (es) |
| UY (1) | UY36462A (es) |
| WO (1) | WO2016103155A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2722048T3 (es) * | 2014-12-23 | 2019-08-07 | Novartis Ag | Compuestos de triazolopirimidina y usos de los mismos |
| EP3464643A4 (en) * | 2016-06-01 | 2020-04-01 | Epizyme Inc | USE OF EZH2 INHIBITORS FOR THE TREATMENT OF CANCER |
| IL263429B (en) * | 2016-06-20 | 2022-08-01 | Novartis Ag | Crystalline forms of a triazolopyrimidine compound |
| EP3472161B1 (en) * | 2016-06-20 | 2020-03-25 | Novartis AG | Triazolopyridine compounds and uses thereof |
| CN109790166A (zh) * | 2016-06-20 | 2019-05-21 | 诺华股份有限公司 | 咪唑并吡啶化合物用于治疗癌症 |
| TWI806832B (zh) | 2016-07-12 | 2023-07-01 | 美商銳新醫藥公司 | 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪 |
| CN106831601A (zh) * | 2017-01-13 | 2017-06-13 | 河北博伦特药业有限公司 | 一种2‑氨基甲基嘧啶盐酸盐及其衍生物的合成方法 |
| BR112019014527A2 (pt) | 2017-01-23 | 2020-02-27 | Revolution Medicines, Inc. | Compostos de piridina como inibidores de shp2 alostéricos |
| EP3571199A1 (en) | 2017-01-23 | 2019-11-27 | Revolution Medicines, Inc. | Bicyclic compounds as allosteric shp2 inhibitors |
| WO2018170290A1 (en) * | 2017-03-15 | 2018-09-20 | Fulcrum Therapeutics, Inc. | Compositions and methods for increasing fmr1 expression |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| BR112019017108A2 (pt) * | 2017-03-16 | 2020-04-07 | Jiangsu Hengrui Medicine Co | derivados de heteroaril[4,3-c]pirimidina-5-amina, método de preparação dos mesmos, e usos médicos dos mesmos |
| CN110944628A (zh) | 2017-06-02 | 2020-03-31 | Epizyme股份有限公司 | 使用ezh2抑制剂治疗癌症 |
| CN109575013A (zh) | 2017-09-28 | 2019-04-05 | 中国科学院上海药物研究所 | 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗prc2介导的疾病 |
| WO2019062435A1 (zh) * | 2017-09-28 | 2019-04-04 | 中国科学院上海药物研究所 | 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗prc2介导的疾病 |
| RU2020115095A (ru) | 2017-10-12 | 2021-11-12 | Революшн Медсинз, Инк. | Пиридиновые, пиразиновые и триазиновые соединения в качестве аллостерических ингибиторов shp2 |
| CN109867645B (zh) * | 2017-12-05 | 2021-09-14 | 中国医学科学院药物研究所 | 一种2,2-二氟-2,3-二氢取代苯并呋喃类化合物的合成方法 |
| KR20200099530A (ko) * | 2017-12-15 | 2020-08-24 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 다환식 화합물 |
| CN109942556A (zh) * | 2017-12-21 | 2019-06-28 | 上海青煜医药科技有限公司 | 嘧啶酮化合物及其应用 |
| EP3743416B1 (en) | 2018-01-23 | 2023-03-15 | Basf Se | Halogenation of pyridine derivatives |
| DK3746446T3 (da) * | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CN110156787B (zh) * | 2018-02-13 | 2021-11-02 | 中国科学院上海药物研究所 | 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途 |
| CN110563722A (zh) * | 2018-06-06 | 2019-12-13 | 上海青煜医药科技有限公司 | 吡啶或哒嗪并环化合物及其应用 |
| CN110734436A (zh) * | 2018-07-19 | 2020-01-31 | 上海青煜医药科技有限公司 | 嘧啶或吡嗪并环化合物及其应用 |
| MX2021006026A (es) * | 2018-11-30 | 2021-07-06 | Tuojie Biotech Shanghai Co Ltd | Pirimidina y derivado heterociclico de nitrogeno de cinco miembros, metodo de preparacion y usos medicos de los mismos. |
| CN111518100A (zh) * | 2019-02-02 | 2020-08-11 | 上海青煜医药科技有限公司 | 环丙烯并苯并呋喃取代的氮杂芳基化合物及其应用 |
| MX2021011118A (es) * | 2019-03-15 | 2022-01-18 | Fulcrum Therapeutics Inc | Derivados de azolopiridina macrocíclicos como moduladores de eed y prc2. |
| JP7299307B2 (ja) * | 2019-04-03 | 2023-06-27 | テラ・ストーン株式会社 | チミン核酸塩基をベースとするトリアゾロピリミジン類及びその製造方法 |
| US20220213097A1 (en) * | 2019-04-22 | 2022-07-07 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as prc2 inhibitors |
| CN113874377A (zh) | 2019-05-13 | 2021-12-31 | 埃科莱布美国股份有限公司 | 作为铜腐蚀抑制剂的1,2,4-三唑并[1,5-a]嘧啶衍生物 |
| CA3142477A1 (en) * | 2019-06-05 | 2020-12-10 | Athenex, Inc. | Methods of treating and/or preventing psoriasis |
| EP3980422A1 (en) * | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
| CN112409385B (zh) * | 2019-08-22 | 2024-08-13 | 上海青煜医药科技有限公司 | 氮杂芳基化合物及其应用 |
| CA3150284A1 (en) * | 2019-09-26 | 2021-04-01 | Novartis Ag | Aza-quinoline compounds and uses thereof |
| EP4056570A4 (en) * | 2019-11-01 | 2023-12-20 | ShanghaiTech University | EED INHIBITOR AND PRODUCTION METHOD AND USE THEREOF |
| CN113004233B (zh) * | 2019-12-18 | 2022-12-20 | 南京优氟医药科技有限公司 | 一种用于制备prc2抑制剂的化合物、其制备方法和用途 |
| CN111333655B (zh) * | 2020-04-13 | 2021-07-13 | 武汉工程大学 | 一种三唑并嘧啶类化合物及其制备方法和应用 |
| EP4149932A4 (en) * | 2020-05-11 | 2024-06-26 | Ascentage Pharma (Suzhou) Co., Ltd. | PROCESS FOR PREPARING (5-FLUOR-2, 3-DIHYDROBENZOFURAN-4-YL) METHANAMINE OR ITS SALT AND INTERMEDIATE PRODUCTS THEREOF |
| CA3185154A1 (en) | 2020-05-28 | 2021-12-02 | Novartis Ag | Dosing regimens for n-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, or a pharmaceutically acceptable salt thereof, for use in treating prc2-mediated diseases or disorders |
| CN114907385A (zh) | 2021-02-10 | 2022-08-16 | 上海青煜医药科技有限公司 | 氮杂芳基化合物、其制备方法及应用 |
| TW202312995A (zh) * | 2021-08-11 | 2023-04-01 | 大陸商上海青煜醫藥科技有限公司 | 氮雜芳基化合物、其製備方法及應用 |
| CN117384153A (zh) * | 2022-07-12 | 2024-01-12 | 上海赛岚生物科技有限公司 | 一类甲基转移酶抑制剂及其用途 |
| WO2024215699A1 (en) * | 2023-04-11 | 2024-10-17 | Oric Pharmaceuticals, Inc. | Treatment of t-cell lymphoma |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2779780A (en) | 1955-03-01 | 1957-01-29 | Du Pont | 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation |
| EP0647450A1 (en) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| WO2000035436A2 (en) | 1998-12-16 | 2000-06-22 | Warner-Lambert Company | Treatment of arthritis with mek inhibitors |
| NL1014106C2 (nl) | 2000-01-18 | 2001-07-20 | Univ Amsterdam | Werkwijze voor het detecteren van een pathologische afwijking bij een cel, een antistof en een assay kit. |
| AU2001273498B2 (en) | 2000-07-19 | 2006-08-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| SE519662C2 (sv) | 2001-07-04 | 2003-03-25 | Asept Int Ab | Ventilanordning vid utportioneringsanordningar |
| AU2002357667A1 (en) * | 2001-10-24 | 2003-05-06 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| AU2003224672B2 (en) | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| ES2335276T3 (es) | 2002-03-13 | 2010-03-24 | Array Biopharma, Inc. | Derivados de bencimidazol alquilado n3 como inhibidores de mek. |
| GB0228900D0 (en) | 2002-12-11 | 2003-01-15 | Ml Lab Plc | Cancer Immunotherapy |
| JP2004238296A (ja) * | 2003-02-04 | 2004-08-26 | Kissei Pharmaceut Co Ltd | 新規なトリアゾロピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| JP2007516693A (ja) | 2003-06-09 | 2007-06-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | 癌の治療および診断のための組成物および方法 |
| US20060246505A1 (en) | 2003-09-02 | 2006-11-02 | Reinhard Walther | Modulation of the synthesis of insulin |
| WO2005118796A2 (en) | 2004-06-01 | 2005-12-15 | The University Of North Carolina At Chapel Hill | Reconstituted histone methyltransferase complex and methods of identifying modulators thereof |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7452892B2 (en) | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
| CA2618218C (en) | 2005-07-21 | 2015-06-30 | Ardea Biosciences, Inc. | N-(arylamino)-sulfonamide inhibitors of mek |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| US7890267B2 (en) | 2006-03-31 | 2011-02-15 | Ordway Research Institute | Prognostic and diagnostic method for cancer therapy |
| WO2008083251A2 (en) | 2006-12-27 | 2008-07-10 | Usc Stevens - University Of Southern California | Dna methylation markers based on epigenetic stem cell signatures in cancer |
| WO2009017670A2 (en) | 2007-07-26 | 2009-02-05 | University Of Massachusetts | Ras-mediated epigenetic silencing effectors and uses thereof |
| EP2183255A4 (en) | 2007-08-29 | 2011-06-15 | Methylgene Inc | METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF CONDENSED HETEROCYCLIC KINASE INHIBITORS |
| CN101939006B (zh) | 2007-09-12 | 2015-09-16 | 吉宁特有限公司 | 磷酸肌醇3-激酶抑制剂化合物与化疗剂的联合以及使用方法 |
| JP5348725B2 (ja) | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| GB0822248D0 (en) | 2008-12-05 | 2009-01-14 | Medical Res Council | Crystal meths |
| US8895526B2 (en) | 2009-03-27 | 2014-11-25 | Cold Spring Harbor Laboratory | Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers |
| CN102020643A (zh) * | 2009-09-22 | 2011-04-20 | 上海恒瑞医药有限公司 | 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用 |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| UA110112C2 (uk) * | 2010-05-07 | 2015-11-25 | Глаксосмітклайн Ллс | Індоли |
| CA3176977A1 (en) | 2010-09-10 | 2012-03-15 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
| WO2012151277A1 (en) | 2011-05-02 | 2012-11-08 | Applied Informatic Solutions, Inc. | Kits and methods for selecting a treatment for ovarian cancer |
| US20140213475A1 (en) | 2011-07-14 | 2014-07-31 | University Of Massachusetts | Methods of diagnosing cancer using epigenetic biomarkers |
| KR20140082742A (ko) | 2011-09-30 | 2014-07-02 | 글락소스미스클라인 엘엘씨 | 암을 치료하는 방법 |
| CA2867282C (en) | 2012-03-12 | 2024-04-02 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
| US20150291598A1 (en) | 2012-11-19 | 2015-10-15 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014100080A1 (en) | 2012-12-19 | 2014-06-26 | Glaxosmithkline Llc | Combination |
| WO2014124326A1 (en) | 2013-02-08 | 2014-08-14 | Stem Centrx, Inc. | Novel multispecific constructs |
| TWI629273B (zh) | 2013-02-11 | 2018-07-11 | 美商星宿藥物公司 | 甲基修飾酵素之調節劑、其組成物及用途 |
| JP2016516046A (ja) | 2013-03-14 | 2016-06-02 | ジェネンテック， インコーポレイテッド | がんの治療方法及びがん薬物耐性を阻止する方法 |
| WO2014151142A1 (en) | 2013-03-15 | 2014-09-25 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2970306A4 (en) | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS CONDENSED IN 6.5 |
| EP3104706B1 (en) | 2014-02-11 | 2022-03-23 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| PL3218329T3 (pl) | 2014-11-14 | 2019-09-30 | Basf Se | Etery benzylowo-propargilowe jako inhibitory nitrifikacji |
| ES2668688T3 (es) | 2014-12-16 | 2018-05-21 | Omya International Ag | Carbonato de calcio para protección vegetal |
| MA41272A (fr) | 2014-12-23 | 2017-10-31 | Adama Makhteshim Ltd | 5-fluoro-4-imino-3-(alkyle/alkyle substitué)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one en tant que traitement des semences |
| ES2722048T3 (es) * | 2014-12-23 | 2019-08-07 | Novartis Ag | Compuestos de triazolopirimidina y usos de los mismos |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
-
2015
- 2015-12-21 ES ES15820637T patent/ES2722048T3/es active Active
- 2015-12-21 NZ NZ731664A patent/NZ731664A/en unknown
- 2015-12-21 PL PL15820637T patent/PL3237418T3/pl unknown
- 2015-12-21 CA CA2969090A patent/CA2969090C/en active Active
- 2015-12-21 UA UAA201704770A patent/UA120945C2/uk unknown
- 2015-12-21 KR KR1020177016880A patent/KR102534028B1/ko active IP Right Grant
- 2015-12-21 US US15/538,348 patent/US10220036B2/en active Active
- 2015-12-21 UY UY0001036462A patent/UY36462A/es not_active Application Discontinuation
- 2015-12-21 LT LTEP15820637.5T patent/LT3237418T/lt unknown
- 2015-12-21 ME MEP-2019-127A patent/ME03385B/me unknown
- 2015-12-21 SG SG11201703880VA patent/SG11201703880VA/en unknown
- 2015-12-21 EA EA201791420A patent/EA032416B1/ru not_active IP Right Cessation
- 2015-12-21 CN CN201580070691.5A patent/CN107108637B/zh active Active
- 2015-12-21 MY MYPI2017701623A patent/MY186837A/en unknown
- 2015-12-21 DK DK15820637.5T patent/DK3237418T3/da active
- 2015-12-21 AU AU2015370524A patent/AU2015370524B2/en active Active
- 2015-12-21 CR CR20170285A patent/CR20170285A/es unknown
- 2015-12-21 PE PE2017001154A patent/PE20171307A1/es unknown
- 2015-12-21 PT PT15820637T patent/PT3237418T/pt unknown
- 2015-12-21 SI SI201530725T patent/SI3237418T1/sl unknown
- 2015-12-21 JP JP2017533767A patent/JP6736559B2/ja active Active
- 2015-12-21 WO PCT/IB2015/059843 patent/WO2016103155A1/en active Application Filing
- 2015-12-21 EP EP15820637.5A patent/EP3237418B1/en active Active
- 2015-12-21 HU HUE15820637A patent/HUE043060T2/hu unknown
- 2015-12-21 BR BR112017010354A patent/BR112017010354B8/pt active IP Right Grant
- 2015-12-21 US US14/977,273 patent/US9580437B2/en active Active
- 2015-12-21 TN TN2017000204A patent/TN2017000204A1/en unknown
- 2015-12-21 RS RS20190502A patent/RS58679B1/sr unknown
- 2015-12-21 MX MX2017008529A patent/MX2017008529A/es active IP Right Grant
- 2015-12-22 JO JOP/2015/0331A patent/JO3489B1/ar active
- 2015-12-22 TW TW104143216A patent/TWI694076B/zh active
-
2017
- 2017-05-07 IL IL252135A patent/IL252135B/en active IP Right Grant
- 2017-06-01 PH PH12017501016A patent/PH12017501016A1/en unknown
- 2017-06-16 CL CL2017001572A patent/CL2017001572A1/es unknown
- 2017-06-16 CO CONC2017/0005992A patent/CO2017005992A2/es unknown
- 2017-06-21 DO DO2017000149A patent/DOP2017000149A/es unknown
- 2017-06-23 SV SV2017005472A patent/SV2017005472A/es unknown
- 2017-06-23 GT GT201700146A patent/GT201700146A/es unknown
- 2017-07-20 EC ECIEPI201747153A patent/ECSP17047153A/es unknown
-
2019
- 2019-01-11 US US16/246,380 patent/US20190142837A1/en not_active Abandoned
- 2019-04-29 HR HRP20190805TT patent/HRP20190805T1/hr unknown
- 2019-04-30 CY CY20191100456T patent/CY1121901T1/el unknown
-
2020
- 2020-04-30 US US16/863,631 patent/US11207325B2/en active Active
-
2021
- 2021-10-19 US US17/505,271 patent/US11931363B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2722048T3 (es) | Compuestos de triazolopirimidina y usos de los mismos | |
| AR091838A1 (es) | Acidos 5-aminotetrahidroquinolin-2-carboxilicos y su uso | |
| AR094262A1 (es) | Compuestos antivirales para el tratamiento de la hepatitis c | |
| CO6251261A2 (es) | Derivados de 1- 82-amino-2-oxoalquil)-n(1h-indazol-5-il)pirrolidina-3-carboxamida | |
| AR067646A1 (es) | Ariloxazoles sustituidos y su uso | |
| AR077695A1 (es) | Derivados de pirimidina como inhibidores del factor ixa | |
| AR098912A1 (es) | Inhibidores de syk | |
| AR101175A1 (es) | Imidazopiridinas e imidazopirazinas como inhibidores de lsd1 | |
| AR089143A1 (es) | Triazolopiridinas sustituidas con actividad inhibidora de ttk | |
| AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
| CR20160296A (es) | Benzamidas sustituidas y métodos para usarlas | |
| CR20140548A (es) | Derivados de aril-sultamo como moduladores de rorc | |
| AR092505A2 (es) | Compuestos antivirales | |
| AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR103170A1 (es) | Compuestos y composiciones farmacéuticas de los mismos para el tratamiento de desordenes inflamatorios y osteoartritis | |
| AR084277A1 (es) | Compuestos utiles para el tratamiento del sida | |
| AR087311A1 (es) | Quinolinas sustituidas y su uso como medicamentos | |
| CU20160192A7 (es) | Derivados de indano e indolina útiles como activadores de la guanilato ciclasa soluble | |
| AR092809A1 (es) | 3,5-diaminopirazol como inhibidor de quinasa | |
| AR094762A1 (es) | Compuestos de hexahidropirano[3,4-d][1,3]tiazin-2-amina sustituida con heteroarilo | |
| AR086482A1 (es) | Inhibidores de aldosterona sintasa | |
| AR094496A1 (es) | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
| AR103742A1 (es) | Derivados de trifluorometilpropanamida | |
| AR077080A1 (es) | Compuestos de 2,3-dihidro-1h-indeno | |
| AR079050A1 (es) | Compuestos benzoimidazolicos y sus usos |