CY2008017I2 - Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4 - Google Patents
Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4Info
- Publication number
- CY2008017I2 CY2008017I2 CY2008017C CY2008017C CY2008017I2 CY 2008017 I2 CY2008017 I2 CY 2008017I2 CY 2008017 C CY2008017 C CY 2008017C CY 2008017 C CY2008017 C CY 2008017C CY 2008017 I2 CY2008017 I2 CY 2008017I2
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- therapeutic treatment
- rheumatic diseases
- soluble ctla4
- ctla4 molecule
- Prior art date
Links
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 title 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 title 1
- 208000025747 Rheumatic disease Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21591300P | 2000-07-03 | 2000-07-03 | |
PCT/US2001/021204 WO2002002638A2 (en) | 2000-07-03 | 2001-07-02 | Methods for treating rheumatic diseases using a soluble ctla4 molecule |
Publications (2)
Publication Number | Publication Date |
---|---|
CY2008017I1 CY2008017I1 (el) | 2009-11-04 |
CY2008017I2 true CY2008017I2 (el) | 2016-08-31 |
Family
ID=22804919
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101167T CY1109786T1 (el) | 2000-07-03 | 2008-10-21 | Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4 |
CY2008017C CY2008017I2 (el) | 2000-07-03 | 2008-11-05 | Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4 |
CY20181100546T CY1120577T1 (el) | 2000-07-03 | 2018-05-23 | Χρησεις διαλυτων μοριων ctla4 μεταλλακτικης παραλλαγης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101167T CY1109786T1 (el) | 2000-07-03 | 2008-10-21 | Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100546T CY1120577T1 (el) | 2000-07-03 | 2018-05-23 | Χρησεις διαλυτων μοριων ctla4 μεταλλακτικης παραλλαγης |
Country Status (39)
Country | Link |
---|---|
US (1) | US7455835B2 (el) |
EP (4) | EP2281568A3 (el) |
JP (1) | JP2004517806A (el) |
KR (3) | KR20030017606A (el) |
CN (1) | CN1318086C (el) |
AR (2) | AR035037A1 (el) |
AT (1) | ATE401909T1 (el) |
AU (2) | AU2001273174B2 (el) |
BG (2) | BG66024B1 (el) |
BR (1) | BR0112104A (el) |
CA (2) | CA2630062C (el) |
CY (3) | CY1109786T1 (el) |
CZ (1) | CZ303959B6 (el) |
DE (1) | DE60135029D1 (el) |
DK (2) | DK1935427T3 (el) |
EE (1) | EE05378B1 (el) |
ES (2) | ES2310557T3 (el) |
HK (1) | HK1058486A1 (el) |
HR (1) | HRP20030071B1 (el) |
HU (3) | HU226847B1 (el) |
IL (2) | IL153593A0 (el) |
IS (1) | IS2834B (el) |
LT (2) | LT1935427T (el) |
LV (1) | LV12993B (el) |
MX (1) | MXPA02012603A (el) |
MY (1) | MY137552A (el) |
NO (3) | NO20026264L (el) |
PE (1) | PE20020772A1 (el) |
PL (2) | PL212205B1 (el) |
PT (2) | PT1372696E (el) |
RS (1) | RS50811B (el) |
RU (1) | RU2287340C2 (el) |
SI (3) | SI1372696T1 (el) |
SK (1) | SK287940B6 (el) |
TR (1) | TR201807700T4 (el) |
TW (2) | TWI322153B (el) |
UY (1) | UY26815A1 (el) |
WO (1) | WO2002002638A2 (el) |
ZA (1) | ZA200210058B (el) |
Families Citing this family (65)
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US6887471B1 (en) | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
EP0892643B2 (en) * | 1996-03-20 | 2009-09-02 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
TWI319405B (en) * | 2000-05-26 | 2010-01-11 | Bristol Myers Squibb Co | Soluble ctla4 mutant molecules and uses thereof |
KR20030007899A (ko) * | 2000-06-09 | 2003-01-23 | 브리스톨-마이어스스퀴브컴파니 | 림프구성 신호의 차단 및 lfa-1 매개 접착의 차단을통한 세포-매개 면역 반응의 조절 방법 |
US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
HU226847B1 (en) * | 2000-07-03 | 2009-12-28 | Bristol Myers Squibb Co | Use of soluble ctla4 molecules for treating of rheumatoid arthritis |
EP1368059A1 (en) * | 2001-01-26 | 2003-12-10 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
CZ305380B6 (cs) | 2001-05-23 | 2015-08-26 | Bristol-Myers Squibb Company | Léčivo pro inhibici rejekce transplantovaných buněk ostrůvků slinivky břišní |
WO2003088991A1 (en) * | 2002-04-19 | 2003-10-30 | Bristol-Myers Squibb Company | Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid |
CN101044239B (zh) * | 2002-12-23 | 2010-12-08 | 布里斯托尔-迈尔斯斯奎布公司 | 用于蛋白质生产的哺乳动物细胞培养方法 |
TWI328614B (en) * | 2002-12-23 | 2010-08-11 | Bristol Myers Squibb Co | Product quality enhancement in mammalian cell culture processes for protein production |
MXPA05007019A (es) | 2002-12-30 | 2005-08-18 | Amgen Inc | Terapia de combinacion con factores co-estimuladores. |
RU2353384C2 (ru) * | 2003-08-04 | 2009-04-27 | Бристол-Маерс Сквибб Компани | Способ лечения сердечно-сосудистого заболевания с применением растворимого ctla4 |
WO2005044188A2 (en) | 2003-10-27 | 2005-05-19 | Amgen Inc. | Compositions and methods to modulate an immune response to an immunogenic therapeutic agent |
US7815765B2 (en) * | 2004-04-01 | 2010-10-19 | Swei Mu Wang | Method for forming laminated synthetic leather |
US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
PL1962886T6 (pl) * | 2005-12-20 | 2023-03-13 | Bristol-Myers Squibb Company | Stabilne formulacje białkowe |
TWI423986B (zh) * | 2005-12-20 | 2014-01-21 | 必治妥美雅史谷比公司 | 組合物及製造組合物之方法 |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
US7528111B2 (en) * | 2006-05-12 | 2009-05-05 | Bristol-Myers Squibb Company | Method of vaccinating subjects receiving immune modulating therapy |
GB0620934D0 (en) * | 2006-10-20 | 2006-11-29 | Cambridge Antibody Tech | Protein variants |
AU2012202324B2 (en) * | 2007-11-01 | 2014-08-28 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
PT2612868T (pt) * | 2007-11-01 | 2018-10-24 | Astellas Pharma Inc | Ácidos nucleicos e polipéptidos imunosupressores |
AU2014250683B2 (en) * | 2007-11-01 | 2015-11-26 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US7915222B2 (en) | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
WO2010033878A2 (en) | 2008-09-19 | 2010-03-25 | David Brown | Solute concentration measurement device and related methods |
US8475790B2 (en) | 2008-10-06 | 2013-07-02 | Bristol-Myers Squibb Company | Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases |
WO2010049935A1 (en) * | 2008-10-30 | 2010-05-06 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
EP2932994B1 (en) | 2009-07-30 | 2017-11-08 | Tandem Diabetes Care, Inc. | New o-ring seal, and delivery mechanism and portable infusion pump system related thereto |
CN102030828B (zh) * | 2009-09-25 | 2014-10-29 | 上海抗体药物国家工程研究中心有限公司 | 一种高亲和力的CTLA4-Ig融合蛋白突变体 |
CN106432473B (zh) * | 2010-02-19 | 2021-04-02 | Xencor公司 | 新颖ctla4-ig免疫粘附素 |
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