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CY1108424T1 - Μεθοδοι για τη βελτιωση της διαμορφωσης πρωτεϊνων με τη βοηθεια αναγωγικων μεσων - Google Patents

Μεθοδοι για τη βελτιωση της διαμορφωσης πρωτεϊνων με τη βοηθεια αναγωγικων μεσων

Info

Publication number
CY1108424T1
CY1108424T1 CY20081101157T CY081101157T CY1108424T1 CY 1108424 T1 CY1108424 T1 CY 1108424T1 CY 20081101157 T CY20081101157 T CY 20081101157T CY 081101157 T CY081101157 T CY 081101157T CY 1108424 T1 CY1108424 T1 CY 1108424T1
Authority
CY
Cyprus
Prior art keywords
recombinant
protein
lysate
purification
assistance
Prior art date
Application number
CY20081101157T
Other languages
English (en)
Inventor
Geert Maertens
Joost Louwagie
Alfons Bosman
Erwin Sablon
Maan Zrein
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8237028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108424(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of CY1108424T1 publication Critical patent/CY1108424T1/el

Links

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο για τον καθαρισμό μίας κυστεΐνης που περιέχει ανασυνδυασμένα εκφρασμένη πρωτεΐνη που περιλαμβάνει τουλάχιστον 2, κατά προτίμηση 3 ή 4 και ακόμη προτιμότερα όλα τα ακόλουθα στάδια: (α) σουλφονίωση ενός λύματος από ανασυνδυασμένα κύτταρα ξενιστή ή λύση ανασυνδυασμένων κυττάρων ξενιστή υπό την παρουσία χλωριούχου γουανιδινίου ακολουθούμενη από μία επακόλουθη σουλφονίωση του κυτταρολύματος, (β) αγωγή μ' ένα απορρυπαντικό επαμφοτερίζοντος ιόντος, κατά προτίμηση μετά από την αφαίρεση των κυτταρικών θρυμμάτων, (γ) καθαρισμό της σουλφονιωμένης έκδοσης της ανασυνδυασμένης πρωτεΐνης ή καθαρισμό της σουλφονιωμένης έκδοσης της ανασυνδυασμένης πρωτεΐνης με ακόλουθη αφαίρεση του απορρυπαντικού επαμφοτερίζοντος ιόντος, όπου ο εν λόγω καθαρισμός είναι κατά προτίμηση χρωματογραφία, ακόμη προτιμότερα μία χρωματογραφία Ni-IMAC με την εν λόγω ανασυνδυασμένη πρωτεΐνη να είναι μία ανασυνδυασμένη πρωτεΐνη με ετικέτα His, (δ) αποσουλφονίωση της σουλφονιωμένης έκδοσης της ανασυνδυασμένης πρωτεΐνης, κατά προτίμηση με μία μοριακή περίσσεια DTT,(ε) αποθήκευση υπό την παρουσία μίας μοριακής περίσσειας DTT. Η παρούσα εφεύρεση αναφέρεται επίσης σε νέες αλληλουχίες HCV NS3 όπως απεικονίζονται στα Σχέδια 1-8.
CY20081101157T 1998-04-17 2008-10-16 Μεθοδοι για τη βελτιωση της διαμορφωσης πρωτεϊνων με τη βοηθεια αναγωγικων μεσων CY1108424T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870087 1998-04-17
EP04103238A EP1471074B1 (en) 1998-04-17 1999-04-15 Methods for improving the conformation of proteins by means of reducing agents

Publications (1)

Publication Number Publication Date
CY1108424T1 true CY1108424T1 (el) 2014-04-09

Family

ID=8237028

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101157T CY1108424T1 (el) 1998-04-17 2008-10-16 Μεθοδοι για τη βελτιωση της διαμορφωσης πρωτεϊνων με τη βοηθεια αναγωγικων μεσων

Country Status (22)

Country Link
US (1) US7935490B2 (el)
EP (2) EP1471074B1 (el)
JP (2) JP2002512370A (el)
KR (1) KR20010042807A (el)
CN (1) CN1305589A (el)
AT (2) ATE278960T1 (el)
AU (1) AU751362B2 (el)
BR (1) BRPI9909678B8 (el)
CA (2) CA2324970C (el)
CY (1) CY1108424T1 (el)
CZ (1) CZ298268B6 (el)
DE (2) DE69939132D1 (el)
DK (2) DK1471074T3 (el)
ES (2) ES2230851T5 (el)
HK (1) HK1036653A1 (el)
HU (1) HUP0101719A3 (el)
IL (1) IL138791A0 (el)
PL (1) PL343469A1 (el)
PT (2) PT1071955E (el)
TR (4) TR200202213T2 (el)
WO (1) WO1999054735A1 (el)
ZA (1) ZA200005445B (el)

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JP2004108914A (ja) * 2002-09-18 2004-04-08 Kudo Norio コラーゲンの測定方法
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CN109870581B (zh) * 2017-12-04 2021-05-04 厦门万泰凯瑞生物技术有限公司 一种定量检测HBsAg的试剂盒及方法
CN109678954B (zh) * 2018-12-29 2022-01-07 山东莱博生物科技有限公司 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用
CN110988362B (zh) * 2019-12-20 2023-11-14 迈克生物股份有限公司 抗组蛋白抗体测定试剂、试剂盒及其使用方法
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CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN113219169B (zh) * 2021-05-22 2021-12-17 北京金诺百泰生物技术有限公司 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒
CN115112897B (zh) * 2021-12-10 2024-11-01 中山大学附属第八医院（深圳福田） 一种用于鉴别抗体检测生物学假阳性的方法

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Also Published As

Publication number Publication date
AU3817199A (en) 1999-11-08
TR200202213T2 (tr) 2002-11-21
ES2230851T3 (es) 2005-05-01
ZA200005445B (en) 2003-01-06
HUP0101719A2 (hu) 2001-09-28
ATE401340T1 (de) 2008-08-15
ES2310701T3 (es) 2009-01-16
ATE278960T1 (de) 2004-10-15
BR9909678A (pt) 2000-12-19
US20060263854A1 (en) 2006-11-23
KR20010042807A (ko) 2001-05-25
EP1471074A2 (en) 2004-10-27
DE69939132D1 (de) 2008-08-28
BRPI9909678B8 (pt) 2021-05-25
WO1999054735A1 (en) 1999-10-28
EP1071955B1 (en) 2004-10-06
TR200101647T2 (tr) 2002-06-21
US7935490B2 (en) 2011-05-03
AU751362B2 (en) 2002-08-15
TR200101648T2 (tr) 2002-06-21
CZ298268B6 (cs) 2007-08-08
PT1071955E (pt) 2005-02-28
CA2324970C (en) 2009-06-30
EP1071955B2 (en) 2009-02-18
DK1071955T3 (da) 2005-02-07
HUP0101719A3 (en) 2006-05-29
CA2324970A1 (en) 1999-10-28
EP1471074B1 (en) 2008-07-16
DE69920895T2 (de) 2005-10-13
IL138791A0 (en) 2001-10-31
DE69920895T3 (de) 2009-09-03
EP1071955A1 (en) 2001-01-31
CN1305589A (zh) 2001-07-25
JP3974620B2 (ja) 2007-09-12
PT1471074E (pt) 2008-10-23
CA2658218C (en) 2014-10-28
EP1471074A3 (en) 2004-11-10
BR9909678B1 (pt) 2013-11-12
HK1036653A1 (en) 2002-01-11
PL343469A1 (en) 2001-08-13
ES2230851T5 (es) 2009-06-25
DE69920895D1 (de) 2004-11-11
CZ20003819A3 (cs) 2001-10-17
TR200003024T2 (tr) 2000-12-21
DK1471074T3 (da) 2008-11-17
CA2658218A1 (en) 1999-10-28
DK1071955T4 (da) 2009-06-15
JP2002512370A (ja) 2002-04-23
JP2005185285A (ja) 2005-07-14

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