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DE69318136D1 - Sulfonsaeurederivate zur behandlung von viruserkrankungen - Google Patents

Sulfonsaeurederivate zur behandlung von viruserkrankungen

Info

Publication number
DE69318136D1
DE69318136D1 DE69318136T DE69318136T DE69318136D1 DE 69318136 D1 DE69318136 D1 DE 69318136D1 DE 69318136 T DE69318136 T DE 69318136T DE 69318136 T DE69318136 T DE 69318136T DE 69318136 D1 DE69318136 D1 DE 69318136D1
Authority
DE
Germany
Prior art keywords
acid derivatives
sulphonic acid
virus diseases
treating virus
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69318136T
Other languages
English (en)
Other versions
DE69318136T2 (de
Inventor
Alan Cardin
Norton Peet
Nelsen Lentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69318136D1 publication Critical patent/DE69318136D1/de
Application granted granted Critical
Publication of DE69318136T2 publication Critical patent/DE69318136T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/40Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02Monothiocarbonic acids; Derivatives thereof
    • C07C329/04Esters of monothiocarbonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12Dithiocarbonic acids; Derivatives thereof
    • C07C329/14Esters of dithiocarbonic acids
    • C07C329/20Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02Monothiocarbamic acids; Derivatives thereof
    • C07C333/08Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/18Esters of dithiocarbamic acids
    • C07C333/24Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69318136T 1992-02-20 1993-01-22 Sulfonsaeurederivate zur behandlung von viruserkrankungen Expired - Lifetime DE69318136T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83863992A 1992-02-20 1992-02-20
PCT/US1993/000564 WO1993016992A1 (en) 1992-02-20 1993-01-22 Sulfonic acid derivatives in the treatment of viral diseases

Publications (2)

Publication Number Publication Date
DE69318136D1 true DE69318136D1 (de) 1998-05-28
DE69318136T2 DE69318136T2 (de) 1998-10-22

Family

ID=25277670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69318136T Expired - Lifetime DE69318136T2 (de) 1992-02-20 1993-01-22 Sulfonsaeurederivate zur behandlung von viruserkrankungen

Country Status (15)

Country Link
US (1) US5359131A (de)
EP (1) EP0626945B1 (de)
JP (1) JP3309104B2 (de)
KR (1) KR100275843B1 (de)
AT (1) ATE165345T1 (de)
AU (1) AU663925B2 (de)
CA (1) CA2130360C (de)
DE (1) DE69318136T2 (de)
ES (1) ES2115756T3 (de)
IL (1) IL104780A (de)
MX (1) MX9300836A (de)
NZ (1) NZ249032A (de)
TW (1) TW224968B (de)
WO (1) WO1993016992A1 (de)
ZA (1) ZA931035B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670144A (en) * 1990-07-09 1997-09-23 Merrell Pharmaceuticals Inc. Anti-herpes virus and cytomegalovirus polyester oligomers
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
US5424063A (en) * 1992-01-09 1995-06-13 The Dow Chemical Company Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
IL112174A (en) * 1994-01-03 1999-05-09 Merrell Dow Pharma Oligomers of polythioureas pharmaceutical compositions containing them and a process for their preparation
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
EP0809492A4 (de) * 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 rezeptor antagonisten
IL124733A0 (en) * 1995-12-15 1999-01-26 Cryopreservation Tech Cc Composition for organ cryopreservation and treatment of viral and bacterial infections
US5852015A (en) * 1997-01-27 1998-12-22 American Cyanamid Company Triazine containing anionic compounds useful as antiviral agents
CN1163401A (zh) * 1996-02-13 1997-10-29 李占元 全自动血球计数仪试剂及配制方法
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
HUP9903922A3 (en) 1996-06-27 2001-12-28 Smithkline Beecham Corp Il-8 receptor antagonists
IL127666A0 (en) * 1996-06-27 1999-10-28 Smithkline Beecham Corp IL-8 receptor antagonists
ZA984649B (en) * 1997-06-13 1999-12-17 Cryopreservation Tech Cc "Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes".
GB9928418D0 (en) * 1999-12-01 2000-01-26 Novartis Ag Organic compounds
US6806366B2 (en) 2001-02-02 2004-10-19 Wyeth Preparation and purification of antiviral disulfonic acid disodium salt
AU2005210594A1 (en) * 2004-02-04 2005-08-18 Active Biotech Ab Diurea derivatives
WO2008001368A2 (en) * 2006-06-27 2008-01-03 Hadasit Medical Research Services And Development Ltd. Use of stilbene derivatives for treatment and prevention of aquatic mold infections
EP2117601A2 (de) * 2006-12-22 2009-11-18 The Regents of the University of California Makromolekulare konjugate von zystische-fibrose-transmembran-leitwert-regulatorprotein-inhibitoren und verwendungen davon
WO2010148177A2 (en) * 2009-06-17 2010-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods of synthesis, and methods of treatment
TW201702218A (zh) * 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
JP2022514195A (ja) * 2018-11-22 2022-02-10 ユニバーシテ デ ナンテス 増殖性疾患の処置で使用するためのジスルホナートスチルベン

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD39717A (de) *
US2676982A (en) * 1951-06-08 1954-04-27 Gen Aniline & Film Corp Fluorescent agents
BE660945A (de) * 1964-03-12 1965-07-01
US4107202A (en) * 1977-03-28 1978-08-15 American Cyanamid Company Substituted 4,4'-biphenylylene bis(2-thioureylene)di-naphthalenetrisulfonic acids and salts thereof
US4328244A (en) * 1980-05-21 1982-05-04 The Dow Chemical Company Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids and pharmaceutically-acceptable salts thereof
US4349568A (en) * 1980-06-12 1982-09-14 The Dow Chemical Company Sulfur-substituted diphenyl ethers having antiviral activity
US4435394A (en) * 1981-12-17 1984-03-06 Shionogi & Co., Ltd. 3-Sulfonamido-benzophenonimine derivatives useful for treating virus infections
DE3600046A1 (de) * 1985-08-13 1987-07-09 Barthell Eduard Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung
DE3528992A1 (de) * 1985-08-13 1987-02-26 Barthell Eduard Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung
DE3530718A1 (de) * 1985-08-28 1987-03-12 Madaus & Co Dr Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten
EP0221021B1 (de) * 1985-10-16 1989-11-08 Ciba-Geigy Ag Bechamp-Reduktion von DNS zu DAS mit H2SO4 und Spuren von HOAc
DE3626309A1 (de) * 1986-08-02 1988-02-18 Stockhausen Chem Fab Gmbh Antivirusmittel
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE69106493T2 (de) * 1991-02-05 1995-06-29 Merrell Dow Pharma Sulfonische Stilbenderivate zur Behandlung von Viruserkrankungen.

Also Published As

Publication number Publication date
TW224968B (de) 1994-06-11
JPH07504190A (ja) 1995-05-11
WO1993016992A1 (en) 1993-09-02
CA2130360A1 (en) 1993-08-21
NZ249032A (en) 1996-09-25
AU663925B2 (en) 1995-10-26
KR100275843B1 (ko) 2000-12-15
JP3309104B2 (ja) 2002-07-29
ES2115756T3 (es) 1998-07-01
AU3481893A (en) 1993-09-13
DE69318136T2 (de) 1998-10-22
IL104780A0 (en) 1993-06-10
CA2130360C (en) 1998-06-09
IL104780A (en) 1998-10-30
EP0626945B1 (de) 1998-04-22
MX9300836A (es) 1993-09-01
ZA931035B (en) 1993-09-17
KR950700245A (ko) 1995-01-16
ATE165345T1 (de) 1998-05-15
US5359131A (en) 1994-10-25
EP0626945A1 (de) 1994-12-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US

R071 Expiry of right

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