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TR200101647T2 - İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. - Google Patents

İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller.

Info

Publication number
TR200101647T2
TR200101647T2 TR2001/01647T TR200101647T TR200101647T2 TR 200101647 T2 TR200101647 T2 TR 200101647T2 TR 2001/01647 T TR2001/01647 T TR 2001/01647T TR 200101647 T TR200101647 T TR 200101647T TR 200101647 T2 TR200101647 T2 TR 200101647T2
Authority
TR
Turkey
Prior art keywords
sulfonated
reducing agents
purification
solid phase
immunodiagnostic assays
Prior art date
Application number
TR2001/01647T
Other languages
English (en)
Inventor
Maertens Geert
Louwagie Joost
Bosman Alfons
Sablon Erwin
Zrein Maan
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8237028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200101647(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of TR200101647T2 publication Critical patent/TR200101647T2/tr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Mevcut bulus, kati faz bagisiklik tahlili (immünoassay) ile ilgili olup, bahsedilen kati faz üzerinde, indirgeyici bir ajanin varliginda, bir antijenden olusmaktadir. Bunun yaninda, mevcut bulus; sistein içeren, rekombinant olarak tanimlanan bir proteini saflastirmak için bir metot ile ilgili olup, asagidaki basamaklarin en az 2, tercihen 3 veya 4'ü ve hatta daha çok da, tercihen tümünden olusmaktadir: (a) bir lisatin rekombinant tasiyici canli hücrelerinden sülfonasyonu veya guanidinyum klorürün varliginda, rekombinant tasiyici canli hücrelerinin belirtilerinin giderek kaybolmasi (lisis), arkasindan da hücre lisatinin sülfonasyonu, (b) tercihen, hücre kalintilarinin uzaklastirilmasindan sonra, bir zvitteryonik deterjan ile muamele, (c) rekombinant proteinin sülfonasyonlu versiyonunun saflastirilmasi veya ardisik olarak gerçeklestirilen zvitteryonik deterjanin uzaklastirilmasi ile, sülfonasyonlu rekombinant proteinin saflastirilmasi olup (DEVAMI VAR)
TR2001/01647T 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. TR200101647T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98870087 1998-04-17

Publications (1)

Publication Number Publication Date
TR200101647T2 true TR200101647T2 (tr) 2002-06-21

Family

ID=8237028

Family Applications (4)

Application Number Title Priority Date Filing Date
TR2002/02213T TR200202213T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller
TR2001/01647T TR200101647T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller.
TR2001/01648T TR200101648T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller
TR2000/03024T TR200003024T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2002/02213T TR200202213T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2001/01648T TR200101648T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller
TR2000/03024T TR200003024T2 (tr) 1998-04-17 1999-04-15 İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller.

Country Status (22)

Country Link
US (1) US7935490B2 (tr)
EP (2) EP1471074B1 (tr)
JP (2) JP2002512370A (tr)
KR (1) KR20010042807A (tr)
CN (1) CN1305589A (tr)
AT (2) ATE278960T1 (tr)
AU (1) AU751362B2 (tr)
BR (1) BRPI9909678B8 (tr)
CA (2) CA2324970C (tr)
CY (1) CY1108424T1 (tr)
CZ (1) CZ298268B6 (tr)
DE (2) DE69939132D1 (tr)
DK (2) DK1471074T3 (tr)
ES (2) ES2230851T5 (tr)
HK (1) HK1036653A1 (tr)
HU (1) HUP0101719A3 (tr)
IL (1) IL138791A0 (tr)
PL (1) PL343469A1 (tr)
PT (2) PT1071955E (tr)
TR (4) TR200202213T2 (tr)
WO (1) WO1999054735A1 (tr)
ZA (1) ZA200005445B (tr)

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ES2237115T5 (es) * 1998-06-24 2008-05-16 Innogenetics N.V. Particulas de proteinas de la envoltura del hcv: uso para la vacunacion.
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
PL360990A1 (en) * 2000-08-17 2004-09-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
NZ529324A (en) 2001-04-24 2005-08-26 Innogenetics N Core-glycosylated HCV envelope proteins made in yeast cells
JP2004108914A (ja) * 2002-09-18 2004-04-08 Kudo Norio コラーゲンの測定方法
WO2004041853A2 (en) * 2002-11-08 2004-05-21 Innogenetics N.V. Hcv vaccine compositions comprising e1 and ns3 peptides
US20050014136A1 (en) * 2003-05-28 2005-01-20 Innogenetics N.V. Modified HCV NS5
CN101892199A (zh) 2003-10-28 2010-11-24 株式会社先端生命科学研究所 丙型肝炎病毒的检测方法
JP2009543099A (ja) * 2006-07-07 2009-12-03 ポール・コーポレーション 親和性捕捉中の変性剤の使用
EP2178363A4 (en) * 2007-07-16 2010-07-21 Pfizer METHOD FOR IMPROVING A GENOMMARKER INDEX OF MILK PRODUCTS AND PRODUCTS
WO2009035560A1 (en) * 2007-09-12 2009-03-19 Pfizer, Inc. Methods of using genetic markers and related epistatic interactions
BRPI0818300A2 (pt) * 2007-10-03 2017-05-09 Pfizer marcadores genéticos para gado com chifres e sem chifres e processos relacionados
WO2009085689A2 (en) * 2007-12-17 2009-07-09 Pfizer Inc. Methods of improving genetic profiles of dairy animals and products
JP5476376B2 (ja) * 2008-07-16 2014-04-23 ラジオメーター・メディカル・アー・ペー・エス 高性能固相
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
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EP3213083B1 (en) 2014-10-29 2020-08-19 Abbott Laboratories Subject anti-hcv antibody detection assays employing ns3 capture peptides
CN109870581B (zh) * 2017-12-04 2021-05-04 厦门万泰凯瑞生物技术有限公司 一种定量检测HBsAg的试剂盒及方法
CN109678954B (zh) * 2018-12-29 2022-01-07 山东莱博生物科技有限公司 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用
CN110988362B (zh) * 2019-12-20 2023-11-14 迈克生物股份有限公司 抗组蛋白抗体测定试剂、试剂盒及其使用方法
CN112225783B (zh) * 2020-09-16 2021-08-31 东莞市朋志生物科技有限公司 Hcv重组抗原及其突变体
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN113219169B (zh) * 2021-05-22 2021-12-17 北京金诺百泰生物技术有限公司 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒
CN115112897B (zh) * 2021-12-10 2024-11-01 中山大学附属第八医院（深圳福田） 一种用于鉴别抗体检测生物学假阳性的方法

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Also Published As

Publication number Publication date
AU3817199A (en) 1999-11-08
TR200202213T2 (tr) 2002-11-21
ES2230851T3 (es) 2005-05-01
ZA200005445B (en) 2003-01-06
HUP0101719A2 (hu) 2001-09-28
ATE401340T1 (de) 2008-08-15
ES2310701T3 (es) 2009-01-16
ATE278960T1 (de) 2004-10-15
BR9909678A (pt) 2000-12-19
US20060263854A1 (en) 2006-11-23
KR20010042807A (ko) 2001-05-25
EP1471074A2 (en) 2004-10-27
DE69939132D1 (de) 2008-08-28
BRPI9909678B8 (pt) 2021-05-25
WO1999054735A1 (en) 1999-10-28
EP1071955B1 (en) 2004-10-06
US7935490B2 (en) 2011-05-03
AU751362B2 (en) 2002-08-15
TR200101648T2 (tr) 2002-06-21
CZ298268B6 (cs) 2007-08-08
PT1071955E (pt) 2005-02-28
CA2324970C (en) 2009-06-30
EP1071955B2 (en) 2009-02-18
DK1071955T3 (da) 2005-02-07
HUP0101719A3 (en) 2006-05-29
CA2324970A1 (en) 1999-10-28
EP1471074B1 (en) 2008-07-16
DE69920895T2 (de) 2005-10-13
IL138791A0 (en) 2001-10-31
CY1108424T1 (el) 2014-04-09
DE69920895T3 (de) 2009-09-03
EP1071955A1 (en) 2001-01-31
CN1305589A (zh) 2001-07-25
JP3974620B2 (ja) 2007-09-12
PT1471074E (pt) 2008-10-23
CA2658218C (en) 2014-10-28
EP1471074A3 (en) 2004-11-10
BR9909678B1 (pt) 2013-11-12
HK1036653A1 (en) 2002-01-11
PL343469A1 (en) 2001-08-13
ES2230851T5 (es) 2009-06-25
DE69920895D1 (de) 2004-11-11
CZ20003819A3 (cs) 2001-10-17
TR200003024T2 (tr) 2000-12-21
DK1471074T3 (da) 2008-11-17
CA2658218A1 (en) 1999-10-28
DK1071955T4 (da) 2009-06-15
JP2002512370A (ja) 2002-04-23
JP2005185285A (ja) 2005-07-14

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