CR20190417A - Anticuerpos anti-par2 y usos de los mismos referencia cruzada a solicitudes relacionadas - Google Patents
Anticuerpos anti-par2 y usos de los mismos referencia cruzada a solicitudes relacionadasInfo
- Publication number
- CR20190417A CR20190417A CR20190417A CR20190417A CR20190417A CR 20190417 A CR20190417 A CR 20190417A CR 20190417 A CR20190417 A CR 20190417A CR 20190417 A CR20190417 A CR 20190417A CR 20190417 A CR20190417 A CR 20190417A
- Authority
- CR
- Costa Rica
- Prior art keywords
- par2
- antibodies
- antigen
- binding fragments
- binding
- Prior art date
Links
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 239000012634 fragment Substances 0.000 abstract 5
- 101000603877 Homo sapiens Nuclear receptor subfamily 1 group I member 2 Proteins 0.000 abstract 4
- 101001098560 Homo sapiens Proteinase-activated receptor 2 Proteins 0.000 abstract 4
- 101000713170 Homo sapiens Solute carrier family 52, riboflavin transporter, member 1 Proteins 0.000 abstract 4
- 102100036863 Solute carrier family 52, riboflavin transporter, member 1 Human genes 0.000 abstract 4
- 230000001419 dependent effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente divulgación proporciona anticuerpos y fragmentos de unión a antígeno capaces de unirse a PAR2. En algunas realizaciones, los anticuerpos anti-PAR2 o fragmentos de unión a antígeno de los mismos se unen a PAR2 de una manera dependiente del pH. La divulgación proporciona además métodos para preparar y usar los anticuerpos y fragmentos de unión a antígeno.The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472462P | 2017-03-16 | 2017-03-16 | |
| US201862637766P | 2018-03-02 | 2018-03-02 | |
| PCT/EP2018/056776 WO2018167322A1 (en) | 2017-03-16 | 2018-03-16 | Anti-par2 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20190417A true CR20190417A (es) | 2019-12-06 |
Family
ID=61827709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20190417A CR20190417A (es) | 2017-03-16 | 2018-03-16 | Anticuerpos anti-par2 y usos de los mismos referencia cruzada a solicitudes relacionadas |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10836822B2 (es) |
| EP (1) | EP3596125A1 (es) |
| JP (2) | JP7222901B2 (es) |
| KR (1) | KR102711884B1 (es) |
| CN (1) | CN110446720B (es) |
| AU (2) | AU2018235031B2 (es) |
| BR (1) | BR112019018752A2 (es) |
| CA (1) | CA3055251A1 (es) |
| CL (1) | CL2019002626A1 (es) |
| CO (1) | CO2019010975A2 (es) |
| CR (1) | CR20190417A (es) |
| IL (1) | IL269134B2 (es) |
| MA (1) | MA49886A (es) |
| MX (1) | MX2019010802A (es) |
| NZ (1) | NZ757915A (es) |
| PH (1) | PH12019502087A1 (es) |
| SG (1) | SG11201908056QA (es) |
| TW (1) | TWI788332B (es) |
| UA (1) | UA125757C2 (es) |
| WO (1) | WO2018167322A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2275443E (pt) | 2008-04-11 | 2016-03-15 | Chugai Pharmaceutical Co Ltd | Moléculas de ligação ao antigénio capazes de se ligarem, repetidamente, a duas ou mais moléculas de antigénio |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| EP3604330A1 (en) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20180054923A (ko) | 2014-12-19 | 2018-05-24 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| PL3233921T3 (pl) | 2014-12-19 | 2022-01-10 | Chugai Seiyaku Kabushiki Kaisha | Przeciwciała anty-c5 i sposoby ich stosowania |
| CN114773469A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| AU2017305073B2 (en) | 2016-08-05 | 2024-02-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for prevention or treatment of IL-8 related diseases |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| JP2023538379A (ja) * | 2020-08-18 | 2023-09-07 | セファロン エルエルシー | 抗ｐａｒ－２抗体及びそれらの使用方法 |
| GB202204159D0 (en) | 2022-03-24 | 2022-05-11 | Heptares Therapeutics Ltd | Antibodies |
| WO2024156720A1 (en) | 2023-01-25 | 2024-08-02 | Medimmune Limited | Migraine therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2357187A1 (en) | 2000-12-12 | 2011-08-17 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| EP1604207A2 (en) * | 2003-03-11 | 2005-12-14 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with g-protein coupled proteinase activated receptor 2 (par2) |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| WO2006052723A2 (en) * | 2004-11-04 | 2006-05-18 | New England Medical Center Hospitals, Inc. | G protein coupled receptor agonists and antagonists and methods of use |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| CL2008001887A1 (es) * | 2007-06-29 | 2008-10-03 | Amgen Inc | Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende. |
| AR070911A1 (es) | 2008-03-19 | 2010-05-12 | Regeneron Pharma | Uso de antagonistas del receptor par2 activado con proteasa |
| PT2275443E (pt) | 2008-04-11 | 2016-03-15 | Chugai Pharmaceutical Co Ltd | Moléculas de ligação ao antigénio capazes de se ligarem, repetidamente, a duas ou mais moléculas de antigénio |
| WO2009139822A1 (en) | 2008-05-01 | 2009-11-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| JP2011530515A (ja) | 2008-08-05 | 2011-12-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐａｒ−２活性化のエフェクターおよび炎症の調節におけるその使用 |
| JO3246B1 (ar) * | 2009-09-09 | 2018-03-08 | Regeneron Pharma | اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري |
| PE20130393A1 (es) | 2010-03-11 | 2013-04-07 | Rinat Neuroscience Corp | Anticuerpos con union de antigenos dependiente de ph |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| KR20150041662A (ko) * | 2012-08-13 | 2015-04-16 | 리제너론 파아마슈티컬스, 인크. | Ｐｈ-의존적 결합 특성을 갖는 항-ｐｃｓｋ9 항체 |
| JP7037885B2 (ja) * | 2014-06-30 | 2022-03-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ｐＨ依存性抗原結合を示す抗ＴＮＦａ抗体 |
-
2018
- 2018-03-16 UA UAA201910275A patent/UA125757C2/uk unknown
- 2018-03-16 NZ NZ757915A patent/NZ757915A/en unknown
- 2018-03-16 BR BR112019018752A patent/BR112019018752A2/pt unknown
- 2018-03-16 AU AU2018235031A patent/AU2018235031B2/en active Active
- 2018-03-16 TW TW107109179A patent/TWI788332B/zh active
- 2018-03-16 US US15/923,374 patent/US10836822B2/en active Active
- 2018-03-16 EP EP18714185.8A patent/EP3596125A1/en active Pending
- 2018-03-16 MA MA049886A patent/MA49886A/fr unknown
- 2018-03-16 KR KR1020197030092A patent/KR102711884B1/ko active IP Right Grant
- 2018-03-16 CA CA3055251A patent/CA3055251A1/en active Pending
- 2018-03-16 JP JP2019549512A patent/JP7222901B2/ja active Active
- 2018-03-16 MX MX2019010802A patent/MX2019010802A/es unknown
- 2018-03-16 SG SG11201908056QA patent/SG11201908056QA/en unknown
- 2018-03-16 CN CN201880018128.7A patent/CN110446720B/zh active Active
- 2018-03-16 WO PCT/EP2018/056776 patent/WO2018167322A1/en active Application Filing
- 2018-03-16 IL IL269134A patent/IL269134B2/en unknown
- 2018-03-16 CR CR20190417A patent/CR20190417A/es unknown
-
2019
- 2019-09-13 CL CL2019002626A patent/CL2019002626A1/es unknown
- 2019-09-13 PH PH12019502087A patent/PH12019502087A1/en unknown
- 2019-10-03 CO CONC2019/0010975A patent/CO2019010975A2/es unknown
-
2020
- 2020-09-29 US US17/035,956 patent/US11591389B2/en active Active
-
2021
- 2021-10-27 AU AU2021257983A patent/AU2021257983A1/en active Pending
-
2023
- 2023-02-03 JP JP2023015469A patent/JP2023055895A/ja active Pending
- 2023-02-07 US US18/165,614 patent/US20230242639A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL269134B2 (en) | 2024-07-01 |
| US20230242639A1 (en) | 2023-08-03 |
| AU2018235031B2 (en) | 2021-08-12 |
| US20210061905A1 (en) | 2021-03-04 |
| IL269134A (en) | 2019-11-28 |
| AU2018235031A1 (en) | 2019-10-31 |
| US11591389B2 (en) | 2023-02-28 |
| TW201843176A (zh) | 2018-12-16 |
| MA49886A (fr) | 2020-06-24 |
| CA3055251A1 (en) | 2018-09-20 |
| EP3596125A1 (en) | 2020-01-22 |
| KR102711884B1 (ko) | 2024-10-02 |
| NZ757915A (en) | 2023-05-26 |
| JP2023055895A (ja) | 2023-04-18 |
| UA125757C2 (uk) | 2022-06-01 |
| CO2019010975A2 (es) | 2019-10-21 |
| US20180305450A1 (en) | 2018-10-25 |
| JP7222901B2 (ja) | 2023-02-15 |
| JP2020509762A (ja) | 2020-04-02 |
| BR112019018752A2 (pt) | 2020-05-05 |
| IL269134B1 (en) | 2024-03-01 |
| CN110446720B (zh) | 2023-09-12 |
| CL2019002626A1 (es) | 2019-12-06 |
| AU2021257983A1 (en) | 2021-11-25 |
| KR20190129925A (ko) | 2019-11-20 |
| MX2019010802A (es) | 2019-10-30 |
| WO2018167322A1 (en) | 2018-09-20 |
| PH12019502087A1 (en) | 2020-03-09 |
| US10836822B2 (en) | 2020-11-17 |
| TWI788332B (zh) | 2023-01-01 |
| SG11201908056QA (en) | 2019-09-27 |
| CN110446720A (zh) | 2019-11-12 |
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