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BR9810483A - Forma b de omeprazol-sódico, processos para a preparação daforma b de omeprazol-sódico e de tratamento de distúrbios gastrointestinais formulação farmacêutica, uso da forma b de omeprazol-sódico. - Google Patents

Forma b de omeprazol-sódico, processos para a preparação daforma b de omeprazol-sódico e de tratamento de distúrbios gastrointestinais formulação farmacêutica, uso da forma b de omeprazol-sódico.

Info

Publication number
BR9810483A
BR9810483A BR9810483-7A BR9810483A BR9810483A BR 9810483 A BR9810483 A BR 9810483A BR 9810483 A BR9810483 A BR 9810483A BR 9810483 A BR9810483 A BR 9810483A
Authority
BR
Brazil
Prior art keywords
omeprazole
sodium
processes
preparation
treatment
Prior art date
Application number
BR9810483-7A
Other languages
English (en)
Inventor
Anders Gustavsson
Kristina Kjellbom
Ingvar Ymen
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of BR9810483A publication Critical patent/BR9810483A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"FORMA B DE OMEPRAZOL-SóDICO PROCESSOS PARA A PREPARAçãO DA FORMA B DE OMEPRAZOL-SóDICO E DE TRATAMENTO DE DISTúRBIOS GASTROINTESTINAIS FORMULAçãO FARMACêUTICA, USO DA FORMA B DE OMEPRAZOL-SóDICO". Esta invenção refere-se a uma nova forma de um sal de sódio de 5-metóxi-2-[[(4-metóxi-3,5-dimetil-2-piridinil)-metil]-sulfinil]-1<MU>H<M V>-benzimidazol, conhecida sob o nome genérico de sal de sódio de omeprazol. Esta invenção também se refere aos processos de sua preparação de forma B de omeprazol-sódico que é termodinamicamente estável, bem como às composições farmacêuticas que a contêm e ao seu uso no tratamento de distúrbios gastrointestinais.
BR9810483-7A 1997-06-27 1998-06-11 Forma b de omeprazol-sódico, processos para a preparação daforma b de omeprazol-sódico e de tratamento de distúrbios gastrointestinais formulação farmacêutica, uso da forma b de omeprazol-sódico. BR9810483A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702483A SE510643C2 (sv) 1997-06-27 1997-06-27 Termodynamiskt stabil omeprazol natrium form B
PCT/SE1998/001124 WO1999000380A1 (en) 1997-06-27 1998-06-11 Omeprazole sodium salt

Publications (1)

Publication Number Publication Date
BR9810483A true BR9810483A (pt) 2000-09-12

Family

ID=20407555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810483-7A BR9810483A (pt) 1997-06-27 1998-06-11 Forma b de omeprazol-sódico, processos para a preparação daforma b de omeprazol-sódico e de tratamento de distúrbios gastrointestinais formulação farmacêutica, uso da forma b de omeprazol-sódico.

Country Status (35)

Country Link
US (1) US6207188B1 (pt)
EP (2) EP0991641B1 (pt)
JP (1) JP3377218B2 (pt)
KR (1) KR100580987B1 (pt)
CN (1) CN1134432C (pt)
AR (1) AR013350A1 (pt)
AT (1) ATE233756T1 (pt)
AU (1) AU750239B2 (pt)
BR (1) BR9810483A (pt)
CA (1) CA2294614C (pt)
CZ (1) CZ296723B6 (pt)
DE (1) DE69811892T2 (pt)
DK (1) DK0991641T3 (pt)
EE (1) EE03613B1 (pt)
EG (1) EG24224A (pt)
ES (1) ES2191944T3 (pt)
HK (1) HK1026699A1 (pt)
HU (1) HU227976B1 (pt)
ID (1) ID24829A (pt)
IL (2) IL133559A0 (pt)
IS (1) IS1946B (pt)
MY (1) MY127871A (pt)
NO (1) NO318245B1 (pt)
NZ (1) NZ501929A (pt)
PL (1) PL190869B1 (pt)
PT (1) PT991641E (pt)
RU (1) RU2186778C2 (pt)
SA (1) SA98190410B1 (pt)
SE (1) SE510643C2 (pt)
SK (1) SK283958B6 (pt)
TR (1) TR199903270T2 (pt)
TW (1) TW483758B (pt)
UA (1) UA58556C2 (pt)
WO (1) WO1999000380A1 (pt)
ZA (1) ZA985317B (pt)

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US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE510643C2 (sv) 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
WO2000071122A1 (en) * 1999-05-20 2000-11-30 Par Pharmaceutical, Inc. Stabilized composition based on pyridinyl-sulfinyl-benzimidazoles and process
SE9903831D0 (sv) 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
BR0110926A (pt) * 2000-05-15 2004-02-17 Ranbaxy Lab Ltd Novas formas amorfas de sais de omeprazol e processo de preparação dos mesmos
WO2002012225A1 (fr) 2000-08-04 2002-02-14 Takeda Chemical Industries, Ltd. Sels de composé à base de benzimidazole et leurs applications
US7396841B2 (en) 2000-08-18 2008-07-08 Takeda Pharmaceutical Company Limited Injections
EP1411900B2 (en) * 2001-06-01 2013-12-04 Pozen, Inc. PHARMACEUTICAL COMPOSITIONS FOR THE COORDINATED DELIVERY OF NSAIDs
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
KR100433735B1 (ko) * 2001-06-27 2004-06-04 주식회사 씨트리 결정형 ⅰ을 갖는 란소프라졸의 제조방법
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
EA200500673A1 (ru) * 2002-10-22 2005-12-29 Рэнбакси Лабораториз Лимитед Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе
EP1633736A1 (en) 2003-05-05 2006-03-15 Ranbaxy Laboratories Limited Barium salt of benzimidazole derivative
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
FR2871800B1 (fr) * 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
KR20130038949A (ko) * 2004-06-24 2013-04-18 아스트라제네카 아베 에소메프라졸 나트륨염의 제조에서 사용하기 위한 결정 변형의 제조를 위한 신규한 방법
WO2006073779A1 (en) * 2004-12-30 2006-07-13 Transform Phamaceuticals, Inc. Novel omeprazole forms and related methods
JP2008545768A (ja) * 2005-06-08 2008-12-18 レツク・フアーマシユーテイカルズ・デー・デー オメプラゾールナトリウムの結晶性溶媒和物
KR20110079641A (ko) 2008-09-09 2011-07-07 아스트라제네카 아베 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법
CN101412710B (zh) * 2008-12-16 2010-04-21 海南百那医药发展有限公司 一种奥美拉唑钠化合物及其制法
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
US20110008432A1 (en) * 2009-06-25 2011-01-13 Pozen Inc. Method for Treating a Patient in Need of Aspirin Therapy
CN102351846B (zh) * 2011-09-07 2012-08-22 周晓东 一种新的奥美拉唑钠化合物及其药物组合物
CN102319223B (zh) * 2011-09-21 2013-06-19 石药集团欧意药业有限公司 一种埃索美拉唑冻干制剂及其制备方法
CN102512380B (zh) * 2011-12-20 2013-04-17 海南锦瑞制药股份有限公司 一种以奥美拉唑钠为活性成分的冻干粉针剂及其制备方法
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid
CN102827147B (zh) * 2012-09-13 2013-08-07 山东罗欣药业股份有限公司 一种奥美拉唑钠晶体化合物及含有该晶体化合物的药物组合物
CN102871973A (zh) * 2012-10-16 2013-01-16 浙江亚太药业股份有限公司 一种奥美拉唑钠冻干制剂及其制备方法
CN103012371B (zh) * 2013-01-05 2014-02-12 宁辉 奥美拉唑钠结晶化合物、其制备方法及其药物组合物
CN103570687B (zh) * 2013-11-15 2015-01-07 悦康药业集团有限公司 一种奥美拉唑钠晶体化合物
CN104788426B (zh) * 2015-04-02 2015-12-30 天津大学 一种奥美拉唑钠半水合物及其制备方法
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification
CN116041325A (zh) * 2022-12-09 2023-05-02 山东北大高科华泰制药有限公司 稳定化质子泵抑制剂的方法

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Also Published As

Publication number Publication date
AR013350A1 (es) 2000-12-27
CA2294614C (en) 2002-01-08
SE9702483L (sv) 1998-12-28
EG24224A (en) 2008-11-10
PL337735A1 (en) 2000-08-28
ZA985317B (en) 1999-01-11
CZ296723B6 (cs) 2006-05-17
WO1999000380A1 (en) 1999-01-07
JP3377218B2 (ja) 2003-02-17
IL133559A (en) 2006-04-10
ATE233756T1 (de) 2003-03-15
IL133559A0 (en) 2001-04-30
AU8135398A (en) 1999-01-19
KR100580987B1 (ko) 2006-05-17
EP1186602A2 (en) 2002-03-13
RU2186778C2 (ru) 2002-08-10
HK1026699A1 (en) 2000-12-22
NZ501929A (en) 2001-06-29
NO996440D0 (no) 1999-12-23
DE69811892D1 (de) 2003-04-10
HUP0003017A2 (hu) 2001-06-28
TW483758B (en) 2002-04-21
SE9702483D0 (sv) 1997-06-27
ID24829A (id) 2000-08-24
SK283958B6 (sk) 2004-06-08
AU750239B2 (en) 2002-07-11
PT991641E (pt) 2003-06-30
SE510643C2 (sv) 1999-06-14
KR20010014165A (ko) 2001-02-26
HU227976B1 (en) 2012-07-30
CN1134432C (zh) 2004-01-14
SA98190410B1 (ar) 2006-06-10
DE69811892T2 (de) 2004-03-04
MY127871A (en) 2006-12-29
IS5314A (is) 1999-12-21
NO996440L (no) 2000-02-08
TR199903270T2 (xx) 2000-07-21
IS1946B (is) 2004-10-13
SK172999A3 (en) 2000-07-11
EE9900593A (et) 2000-08-15
NO318245B1 (no) 2005-02-21
PL190869B1 (pl) 2006-02-28
CZ469999A3 (cs) 2000-08-16
UA58556C2 (uk) 2003-08-15
JP2001508805A (ja) 2001-07-03
EP0991641B1 (en) 2003-03-05
CN1261362A (zh) 2000-07-26
ES2191944T3 (es) 2003-09-16
EP1186602A3 (en) 2002-03-27
HUP0003017A3 (en) 2002-01-28
CA2294614A1 (en) 1999-01-07
EP0991641A1 (en) 2000-04-12
DK0991641T3 (da) 2003-05-19
EE03613B1 (et) 2002-02-15
US6207188B1 (en) 2001-03-27

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O,11,13 E 24 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]