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BR112018009071A2 - método para preparar uma amostra, composição homogenizada, métodos para gerar dados, para tratar uma doença, de identificação de um marcador, para determinar o prognóstico de um câncer, para determinar um perfil fenotípico, para armazenar a composição homogenizada, para preparar uma amostra de tecido e preparar a composição homogenizada - Google Patents

método para preparar uma amostra, composição homogenizada, métodos para gerar dados, para tratar uma doença, de identificação de um marcador, para determinar o prognóstico de um câncer, para determinar um perfil fenotípico, para armazenar a composição homogenizada, para preparar uma amostra de tecido e preparar a composição homogenizada

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Publication number
BR112018009071A2
BR112018009071A2 BR112018009071A BR112018009071A BR112018009071A2 BR 112018009071 A2 BR112018009071 A2 BR 112018009071A2 BR 112018009071 A BR112018009071 A BR 112018009071A BR 112018009071 A BR112018009071 A BR 112018009071A BR 112018009071 A2 BR112018009071 A2 BR 112018009071A2
Authority
BR
Brazil
Prior art keywords
sample
homogenized composition
preparing
determining
homogenized
Prior art date
Application number
BR112018009071A
Other languages
English (en)
Other versions
BR112018009071A8 (pt
BR112018009071B1 (pt
Inventor
Barhoumi Aoune
Walk Eric
Roberts Esteban
Leith Katherine
Gallegos Lisa
Day Melinda
Alexander Nelson
Rajkovich Samantha
Stanislaw Stacey
Original Assignee
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Publication of BR112018009071A2 publication Critical patent/BR112018009071A2/pt
Publication of BR112018009071A8 publication Critical patent/BR112018009071A8/pt
Publication of BR112018009071B1 publication Critical patent/BR112018009071B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • A01N1/0226—
    • A01N1/0278—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01—MEASURING; TESTING
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    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N1/36—Embedding or analogous mounting of samples
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
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    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]
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    • G01N2800/00—Detection or diagnosis of diseases
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Abstract

a divulgação geralmente se refere à preparação de amostras representativas de amostras clínicas, por exemplo, tumores (inteiros ou parciais), nódulo linfáticos, metástases, cistos, pólipos ou uma combinação ou porção dos mesmos, usando métodos de dissociação mecânicos e/ ou bioquímicos para homogenizar. amostras intactas ou grandes porções das mesmas. o material homogenizado resultante fornece a capacidade de obter uma amostra representativa correta apesar da heterogeneidade espacial dentro da amostra, aumentando a probabilidade de detecção de subclones de baixa prevalência e é adequado para uso em vários testes diagnósticos, bem como na produção de terapêuticas, especialmente vacinas contra tumores ou terapias baseadas em células imunitárias.
BR112018009071-9A 2015-11-06 2016-11-07 Método in vitro para preparar uma amostra representativa para análise BR112018009071B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562252153P 2015-11-06 2015-11-06
US62/252,153 2015-11-06
US201662279405P 2016-01-15 2016-01-15
US62/279,405 2016-01-15
US201662354622P 2016-06-24 2016-06-24
US62/354,622 2016-06-24
US201662418146P 2016-11-04 2016-11-04
US62/418,146 2016-11-04
PCT/US2016/060861 WO2017079763A1 (en) 2015-11-06 2016-11-07 Representative diagnostics

Publications (3)

Publication Number Publication Date
BR112018009071A2 true BR112018009071A2 (pt) 2018-10-30
BR112018009071A8 BR112018009071A8 (pt) 2019-02-26
BR112018009071B1 BR112018009071B1 (pt) 2021-12-14

Family

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BR112018009071-9A BR112018009071B1 (pt) 2015-11-06 2016-11-07 Método in vitro para preparar uma amostra representativa para análise

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US (2) US11959838B2 (pt)
EP (1) EP3371594A1 (pt)
JP (4) JP7094880B2 (pt)
KR (2) KR102696044B1 (pt)
CN (2) CN114480574A (pt)
AU (2) AU2016349644B2 (pt)
BR (1) BR112018009071B1 (pt)
CA (1) CA3004504A1 (pt)
IL (3) IL298356B2 (pt)
MX (2) MX2018004838A (pt)
RU (1) RU2743169C2 (pt)
WO (1) WO2017079763A1 (pt)
ZA (1) ZA201802493B (pt)

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CN108593380B (zh) * 2018-04-25 2021-05-18 复旦大学附属中山医院 一种组织芯片量产制作方法
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JP7479367B2 (ja) * 2018-11-29 2024-05-08 ヴェンタナ メディカル システムズ， インク． 代表的なＤＮＡシーケンシングによる個別化されたｃｔＤＮＡ疾患のモニタリング
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