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BR112017000774A2 - dispositivo e método de distribuição de implante ocular - Google Patents

dispositivo e método de distribuição de implante ocular

Info

Publication number
BR112017000774A2
BR112017000774A2 BR112017000774A BR112017000774A BR112017000774A2 BR 112017000774 A2 BR112017000774 A2 BR 112017000774A2 BR 112017000774 A BR112017000774 A BR 112017000774A BR 112017000774 A BR112017000774 A BR 112017000774A BR 112017000774 A2 BR112017000774 A2 BR 112017000774A2
Authority
BR
Brazil
Prior art keywords
shell
implant
eye
central
distal end
Prior art date
Application number
BR112017000774A
Other languages
English (en)
Other versions
BR112017000774B1 (pt
Inventor
Waitz Ariel
HARTSIG Bill
BIANCHI Keith
Vedrine Lionel
Sponsel Mark
Patel Mukund
Nunn Scott
Original Assignee
Forsight Vision4 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forsight Vision4 Inc filed Critical Forsight Vision4 Inc
Publication of BR112017000774A2 publication Critical patent/BR112017000774A2/pt
Publication of BR112017000774B1 publication Critical patent/BR112017000774B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Prostheses (AREA)

Abstract

a presente invenção refere-se a um sistema de implante ocular incluindo um implante ocular dimensionado e formado para ser inserido pelo menos parcialmente em um olho; um membro transportador com uma casca tendo um canal central se estendendo pelo menos parcialmente através da casca de uma extremidade proximal em direção a uma extremidade distal da casca. uma luva de guia removivelmente fixada dentro de pelo menos uma primeira região do canal central da casca e definindo um orifício proximal para o canal central que é acessível da extremidade proximal da casca. um retentor de implante removivelmente fixado dentro de pelo menos uma segunda região do canal central da casca adjacente a uma extremidade distal da luva de guia e tendo um par de agarradores adaptados para fixar removivelmente o implante em uma extremidade distal do retentor de implante. dispositivos, sistemas e/ou métodos relacionados são descritos.
BR112017000774-6A 2014-07-15 2015-07-15 Sistema de manipulação de implante ocular BR112017000774B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024682P 2014-07-15 2014-07-15
US62/024,682 2014-07-15
PCT/US2015/040633 WO2016011191A1 (en) 2014-07-15 2015-07-15 Ocular implant delivery device and method

Publications (2)

Publication Number Publication Date
BR112017000774A2 true BR112017000774A2 (pt) 2017-11-28
BR112017000774B1 BR112017000774B1 (pt) 2021-12-14

Family

ID=55079028

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017000774-6A BR112017000774B1 (pt) 2014-07-15 2015-07-15 Sistema de manipulação de implante ocular

Country Status (15)

Country Link
US (3) US10258503B2 (pt)
EP (2) EP3679908B1 (pt)
JP (1) JP6581194B2 (pt)
KR (1) KR102416726B1 (pt)
CN (1) CN106687079B (pt)
AU (1) AU2015289625B2 (pt)
BR (1) BR112017000774B1 (pt)
CA (1) CA2955186C (pt)
ES (1) ES2803102T3 (pt)
IL (1) IL250079B (pt)
MX (1) MX2017000609A (pt)
MY (1) MY182497A (pt)
RU (1) RU2695563C2 (pt)
WO (1) WO2016011191A1 (pt)
ZA (1) ZA201700387B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2391419B1 (en) 2009-01-29 2019-06-12 ForSight Vision4, Inc. Posterior segment drug delivery
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
WO2016011191A1 (en) * 2014-07-15 2016-01-21 Forsight Vision4, Inc. Ocular implant delivery device and method
JP2017522122A (ja) 2014-07-24 2017-08-10 シノプシス サージカル インコーポレイテッドＳｉｎｏｐｓｙｓ Ｓｕｒｇｉｃａｌ，Ｉｎｃ． 副鼻腔アクセスインプラントデバイスおよび関連する製品ならびに方法
RU2017105844A (ru) 2014-08-08 2018-09-11 Форсайт Вижн4, Инк. Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения
KR20170106298A (ko) 2014-11-10 2017-09-20 포사이트 비젼4, 인크. 확장 가능한 약물 전달 장치 및 이용 방법
US11432959B2 (en) 2015-11-20 2022-09-06 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
AU2017246889B2 (en) 2016-04-05 2021-12-16 Forsight Vision4, Inc. Implantable ocular drug delivery devices
JP7408542B2 (ja) * 2017-09-20 2024-01-05 シノプシス サージカル インコーポレイテッド 副鼻腔流体アクセス埋め込み器具、アセンブリ、キット、および方法
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
EP3698758A1 (en) * 2019-02-20 2020-08-26 Leibniz-Institut für Polymerforschung Dresden e.V. Device and assemblies for oriented transport, microscopic investigation and oriented ejection of a tissue graft or implant
CN110507476B (zh) * 2019-09-12 2021-10-26 格劳科斯公司 制造眼部植入物输送装置的方法
HRP20240604T1 (hr) * 2020-02-27 2024-07-19 Istar Medical Sa Paket za držanje i izdavanje sklopa osovine za isporuku implantata
US20220054311A1 (en) * 2020-08-12 2022-02-24 United States Government As Represented By The Department Of Veterans Affairs Eye Drop Dispensing Apparatus
US20220133532A1 (en) 2020-11-04 2022-05-05 Aerie Pharmaceuticals, Inc. Medical implant
CA3232769A1 (en) 2021-09-20 2023-03-23 Mott Corporation Polymer coating for medical devices and method of manufacture thereof
USD1037439S1 (en) 2022-01-17 2024-07-30 EyePoint Pharamaceuticals, Inc. Ocular injector
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
CN114848289A (zh) * 2022-05-06 2022-08-05 海思盖德(苏州)生物医学科技有限公司 一种眼部植入物输送器
CN114983670A (zh) * 2022-05-30 2022-09-02 海思盖德(苏州)生物医学科技有限公司 一种眼内植入物输送器
CN118512302B (zh) * 2024-07-23 2024-10-01 苏州朗目医疗科技有限公司 一种眼用缓释药输送系统

Family Cites Families (366)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2585815A (en) 1947-01-16 1952-02-12 Mclintock Duncan Menzies Injection syringe
US2564977A (en) 1949-01-19 1951-08-21 Hu Quang Hsi Medical injecting apparatus
US3232117A (en) 1962-09-14 1966-02-01 Roger Gilmont Instr Inc Micrometer buret
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3641237A (en) 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3995635A (en) 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3902495A (en) 1974-01-28 1975-09-02 Cavitron Corp Flow control system
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949748A (en) 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US3977404A (en) 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4014333A (en) 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4220152A (en) 1978-05-08 1980-09-02 Pfizer Inc. Delivery system
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4309776A (en) 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4712550A (en) 1985-04-08 1987-12-15 Sinnett Kevin B Retinal tack
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
US4693886A (en) 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
EP0201611A1 (de) 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
EP0228185B1 (en) 1985-11-27 1990-07-25 Thomas C. White Tissue-implantable fluid-dissipating device
US4781675A (en) 1985-11-27 1988-11-01 White Thomas C Infusion cannula
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
DE3751871D1 (de) 1986-12-23 1996-09-19 Liposome Co Inc Guanidinaminoglycosid enthaltende Liposome
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5174999A (en) 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
WO1990007575A1 (en) 1988-12-30 1990-07-12 Anderson David M Stabilized microporous materials and hydrogel materials
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5084021A (en) 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5334189A (en) 1991-06-03 1994-08-02 Wade Stephen E Device for controlled diffusion of a chemical substance
US5282829A (en) 1991-08-15 1994-02-01 United States Surgical Corporation Hollow body implants
FR2682090B1 (fr) 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5681572A (en) 1991-10-18 1997-10-28 Seare, Jr.; William J. Porous material product and process
US5178622A (en) 1991-11-01 1993-01-12 Lehner Ii Robert H Instrument for implanting a soft intraocular lens
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
DK0788351T3 (da) 1994-11-10 2003-05-26 Univ Kentucky Res Found Implanterbar, genopfyldelig anordning til hastighedsreguleret lægemiddeladministration direkte til en indre del af kroppen
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5554132A (en) 1995-03-30 1996-09-10 Abbott Laboratories Hand grip for use with syringe
JP3670291B2 (ja) 1995-05-14 2005-07-13 オプトノール リミティド 眼内移植片、導入装置
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB2310149A (en) 1996-02-15 1997-08-20 Nomix Chipman Ltd Spray gun
US20090005864A1 (en) 1996-03-18 2009-01-01 Eggleston Harry C Modular intraocular implant
US5951512A (en) 1996-05-28 1999-09-14 Horizon Medical Products, Inc. Infusion port with modified drug reservoir
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
AU7533696A (en) 1996-12-13 1998-06-18 Ciba-Geigy Ag New materials
PT973499E (pt) 1997-03-31 2003-12-31 Alza Corp Sistema de administracao difusor implantavel
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6039712A (en) 1997-11-04 2000-03-21 Terence M. Fogarty Implantable injection port
US8313454B2 (en) * 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
DK1187617T3 (da) 1999-06-18 2004-04-13 Alcon Mfg Ltd Fremgangsmåde til at vælge koncentrationen af et amfipatisk antihistaminlægemiddel ved at bestemme lægemidlets overfladeaktivitetsmåltal
US6638263B1 (en) 1999-10-12 2003-10-28 Durect Corporation Regulation of drug delivery through flow diversion
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
CN1292721C (zh) 1999-10-21 2007-01-03 爱尔康公司 药物释放装置
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
NZ520099A (en) 2000-01-12 2005-03-24 Becton Dickinson Co Systems and methods for reducing intraocular pressure
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
EP1186439A4 (en) 2000-03-13 2004-12-08 Seiko Epson Corp SURFACE TREATMENT METHOD, SURFACE TREATED ARTICLE AND SURFACE TREATMENT DEVICE
US7141152B2 (en) 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6478800B1 (en) 2000-05-08 2002-11-12 Depuy Acromed, Inc. Medical installation tool
CA2420038C (en) 2000-08-30 2010-11-09 John Hopkins University Devices for intraocular drug delivery
ATE380042T1 (de) 2000-09-06 2007-12-15 Alcon Inc Beschichtungsmittel mit veränderbarer klebrigkeit für augenimplantate
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
CA2434156A1 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
CA2432225C (en) 2001-01-03 2008-01-15 Michael J. Brubaker Sustained release drug delivery devices with prefabricated permeable plugs
EP1404295B1 (en) 2001-01-03 2007-10-10 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
DE60137542D1 (de) 2001-01-03 2009-03-12 Bausch & Lomb Wirkstoffabgabevorrichtungen mit verzögerter freisetzung mehrere stoffe enthaltend
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
CA2433528A1 (en) 2001-01-26 2002-08-01 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20020133168A1 (en) 2001-03-16 2002-09-19 Smedley Gregory T. Applicator and methods for placing a trabecular shunt for glaucoma treatment
EP2316394B1 (en) 2001-06-12 2016-11-23 The Johns Hopkins University Reservoir device for intraocular drug delivery
IL159715A0 (en) 2001-07-10 2004-06-20 Teva Pharma Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
CA2446741C (en) 2001-07-23 2009-09-29 Alcon, Inc. Ophthalmic drug delivery device
JP4261343B2 (ja) 2001-07-23 2009-04-30 アルコン，インコーポレイティド 眼薬投与装置
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
ES2393101T3 (es) 2001-08-29 2012-12-18 Ricardo A. P. De Carvalho Sistema implantable y sellable para la administración unidireccional de agentes terapéuticos a tejidos diana
US20030118649A1 (en) 2001-10-04 2003-06-26 Jinming Gao Drug delivery devices and methods
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20030119177A1 (en) 2001-11-15 2003-06-26 Lewis Gruber Sample chip
GB2399753B (en) 2002-01-18 2006-04-19 Michael E Snyder Method of making a sustained release ophthalmological device
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
RU2322233C2 (ru) 2002-03-11 2008-04-20 Алькон, Инк. Имплантируемая система для доставки лекарственных средств
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
ATE424187T1 (de) 2002-07-15 2009-03-15 Alcon Inc Bioerodierbare folie zur abgabe eines ophthalmischen arzneimittels
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20040019325A1 (en) 2002-07-29 2004-01-29 Medrip Ltd. Syringe Pump
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
TWI282271B (en) 2002-09-18 2007-06-11 Allergan Inc Apparatus for delivery of ocular implants
WO2004028477A2 (en) 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US20060258000A1 (en) 2003-02-26 2006-11-16 Allen Jared W Use of steady-state oxygen gradients to modulate animal cell functions
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US20050074497A1 (en) 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
EP1671624B1 (en) 2003-05-02 2010-08-11 SurModics, Inc. Delivery device for a controlled drug release of an active agent into the posterior section of the eye
JP4824549B2 (ja) 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
US8403941B2 (en) 2003-06-02 2013-03-26 Abbott Medical Optics Inc. Intraocular lens and cartridge packaging with lens-loading function
EP1635876A4 (en) 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
WO2004112653A2 (en) 2003-06-18 2004-12-29 D-Crown Ltd. Devices and methods for delivering and forming single and multiple stenting structures in situ
US20040260380A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices for delivering multiple stenting structures in situ
US20040260381A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices and methods for forming stenting structures in situ
US8367410B2 (en) 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
EP1684669A4 (en) 2003-07-10 2008-01-02 Alcon Inc DEVICE FOR RELEASING AN OPHTHALMIC MEDICINAL PRODUCT
FI120333B (fi) 2003-08-20 2009-09-30 Bioretec Oy Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi
US7252673B2 (en) * 2003-09-10 2007-08-07 Warsaw Orthopedic, Inc. Devices and methods for inserting spinal implants
CA2539324A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
EP1675636A4 (en) 2003-09-24 2009-12-23 Medi Stream Pty Ltd MEDICATION HOLDER
AU2006225241B2 (en) 2003-09-24 2008-07-17 Tianda Pharmaceuticals (Australia) Pty Limited Medication Holder
WO2005033798A2 (en) 2003-10-03 2005-04-14 University Of Washington Electrochemical micromanufacturing system and method
US7211272B2 (en) 2003-12-22 2007-05-01 Bausch & Lomb Incorporated Drug delivery device
AU2005214040B2 (en) 2004-02-12 2011-03-31 Neo Vista, Inc. Methods and apparatus for intraocular brachytherapy
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
WO2005091922A2 (en) 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
ES2349954T3 (es) * 2004-04-22 2011-01-13 Advanced Vision Science, Inc. Dispositivo para la implantación de unas lentes intraoculares deformables.
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20060182783A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
WO2006014484A2 (en) 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
AU2005267734A1 (en) 2004-08-06 2006-02-09 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006023530A2 (en) 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US20060052754A1 (en) 2004-09-04 2006-03-09 Fields Douglas W Thumb trigger syringe pole
WO2006031532A2 (en) 2004-09-10 2006-03-23 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
EP2452670A1 (en) 2004-10-01 2012-05-16 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US20080207502A1 (en) 2004-10-14 2008-08-28 Sopherion Therapeutics, Inc. Anti-Angiogenic Peptides and Methods of Use Thereof
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060154981A1 (en) 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
WO2006082588A2 (en) 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
US20060257450A1 (en) 2005-03-21 2006-11-16 Sreenivasu Mudumba Drug delivery systems for treatment of diseases or conditions
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US20070077270A1 (en) 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
JP4937997B2 (ja) 2005-03-30 2012-05-23 ニューレンズ・リミテッド 調節型眼内レンズ（ａｉｏｌ）アセンブリおよびそのための個別の構成要素
EP1875560A4 (en) 2005-04-05 2011-02-09 Univ Ohio State DIFFUSION DELIVERY SYSTEM AND METHODS OF MAKING
US20100168535A1 (en) 2006-04-12 2010-07-01 Mark Ries Robinson Methods and apparatuses related to blood analyte measurement system
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
EP1895957A1 (en) 2005-05-18 2008-03-12 SurModics, Inc. Insertion instrument for non-linear medical devices
US20070088414A1 (en) 2005-05-25 2007-04-19 Campbell Robert L Particulate formulations for intradermal delivery of biologically active agents
US20060276738A1 (en) 2005-06-06 2006-12-07 Becker Bruce B Lacrimal drainage bypass device and method
TW200716140A (en) 2005-06-17 2007-05-01 Dynamis Therapeutics Inc Treatment of inflammatory conditions
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
WO2007035621A1 (en) 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
WO2007038453A2 (en) 2005-09-26 2007-04-05 Advanced Ocular Systems Limited Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation
US20080003219A1 (en) 2005-09-26 2008-01-03 Minu, L.L.C. Delivery of an ocular agent
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
US20070072933A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an ocular agent
US20070071756A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation
TW200732347A (en) 2005-10-06 2007-09-01 Trophogen Inc VEGF analogs and methods of use
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
US20090043253A1 (en) 2005-10-11 2009-02-12 Blake Podaima Smart medical compliance method and system
BRPI0617414A2 (pt) 2005-10-14 2011-07-26 Alcon Inc mÉtodo para tratamento de formas primÁrias e secundÁrias de glaucoma
US20080125406A1 (en) 2005-10-14 2008-05-29 Robin Alan L Method for Treating Primary and Secondary Forms of Glaucoma
JP4721425B2 (ja) 2005-12-01 2011-07-13 キヤノン株式会社 流体移動方法および流体移動装置
CN101336315B (zh) 2005-12-07 2012-12-19 特拉维夫大学拉莫特有限公司 药物递送复合结构
US20070131611A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based article and associated method
US20070131610A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based apparatus and associated method
ES2762239T3 (es) 2006-01-17 2020-05-22 Alcon Inc Dispositivo de tratamiento del glaucoma
EP3338743A1 (en) 2006-01-17 2018-06-27 Novartis Ag Drug delivery treatment device
US20080216736A1 (en) 2006-01-19 2008-09-11 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
US8979770B2 (en) 2006-02-24 2015-03-17 Merck Sharp & Dohme Corp. Extraction and diagnostic fluid devices, systems and methods of use
US7625927B2 (en) 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
US20100297046A1 (en) 2006-03-31 2010-11-25 Dynamis Therapeutics, Inc. Compositions and Methods Related to Fructosamine-3-Kinase Inhibitors
WO2007115259A2 (en) 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
JP4889789B2 (ja) 2006-04-18 2012-03-07 チョンシャン ボータイ ファーマシューティック インストゥルメンツ カンパニーリミテッド 無菌混合薬剤注射器
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US7918814B2 (en) 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US20080124372A1 (en) 2006-06-06 2008-05-29 Hossainy Syed F A Morphology profiles for control of agent release rates from polymer matrices
JP2009542710A (ja) 2006-06-28 2009-12-03 サーモディクス，インコーポレイティド 活性剤送達用分解性及び非分解性マトリックスの併用
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
AU2007269259B2 (en) * 2006-06-30 2012-05-31 Aquesys Inc. Methods, systems and apparatus for relieving pressure in an organ
WO2008009120A2 (en) 2006-07-19 2008-01-24 Noab Biodiscoveries Inc. Method and device to extract components contained in a fluid
US20080152694A1 (en) 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
WO2008016712A2 (en) 2006-08-02 2008-02-07 Inframat Corporation Medical devices and methods of making and using
US9039761B2 (en) * 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
JP2008054521A (ja) 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
US8821943B2 (en) 2006-09-12 2014-09-02 Board Of Regents Of The University Of Nebraska Methods and compositions for targeted delivery of therapeutic agents
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
JP5694664B2 (ja) 2006-09-29 2015-04-01 サーモディクス，インコーポレイティド 生分解性眼用インプラント及び眼の病気を治療する方法
TW200817039A (en) 2006-10-06 2008-04-16 Dynamis Therapeutics Inc Compositions and methods for skin lightening
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
CA2667614A1 (en) 2006-10-25 2008-09-25 Revalesio Corporation Method of wound care and treatment
AU2007308840C1 (en) 2006-10-25 2014-09-25 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
CA2668954C (en) 2006-11-10 2020-09-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080111282A1 (en) 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
US20100286791A1 (en) 2006-11-21 2010-11-11 Goldsmith David S Integrated system for the ballistic and nonballistic infixion and retrieval of implants
US20090263346A1 (en) 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
EP2101745A4 (en) 2006-12-05 2009-12-30 Landec Corp DISTRIBUTION OF MEDICINAL PRODUCTS
US20080154241A1 (en) 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
AR063619A1 (es) 2006-12-18 2009-02-04 Alcon Res Ltd Dispositivos y metodos para la administraicion de un farmaco oftalmico
EP2097044A4 (en) 2006-12-26 2012-10-10 Quadra Logic Tech Inc DRUG RELIEF IMPLANTS FOR INHIBITING OPTICAL DEFECTS
DK2124856T3 (en) 2007-01-09 2019-02-11 Fovea Pharmaceuticals DEVICE FOR INTRAOCULAR INJECTION
AU2008206953A1 (en) 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US7905888B2 (en) 2007-02-16 2011-03-15 Brown David C Apparatus for inserting flexible medical implant
WO2008116165A2 (en) 2007-03-21 2008-09-25 Next Safety, Inc. Methods and systems of delivering medication via inhalation
US20080249501A1 (en) 2007-04-09 2008-10-09 Medtronic Vascular, Inc. Methods for Simultaneous Injection and Aspiration of Fluids During a Medical Procedure
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2688344C (en) 2007-05-29 2019-09-03 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US9808557B2 (en) 2007-08-10 2017-11-07 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US20090105749A1 (en) 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Insertion and extraction tools for lacrimal implants
BRPI0817074A2 (pt) 2007-09-07 2015-03-24 Qlt Plug Delivery Inc Aparelho, método para tratar uma desordem ocular, dispositivo de detecção e sistema de detecção
NZ583678A (en) 2007-09-07 2012-03-30 Quadra Logic Tech Inc Silicone matrix drug cores for sustained release of therapeutic agents
US8308755B2 (en) 2007-09-24 2012-11-13 Ethicon Endo-Surgery, Inc. Elliptical retractor
US20090214601A1 (en) 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
RU2475282C2 (ru) 2007-10-05 2013-02-20 Тико Хелскеа Груп Лп Герметизирующий фиксатор для использования при хирургических операциях
US20100310665A1 (en) 2007-10-25 2010-12-09 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
WO2009055620A1 (en) 2007-10-25 2009-04-30 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090263495A1 (en) 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20100303918A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100009008A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
WO2010062628A1 (en) 2008-10-27 2010-06-03 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US20100303917A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100004189A1 (en) 2007-10-25 2010-01-07 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100008997A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
CA2703000C (en) 2007-11-05 2013-08-06 Bausch & Lomb Incorporated Water-immiscible materials as vehicles for drug delivery
US8114883B2 (en) 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
US20100305514A1 (en) 2008-01-10 2010-12-02 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009094466A2 (en) 2008-01-22 2009-07-30 University Of Florida Research Foundation, Inc. Contact lenses for extended release of bioactive agents containing diffusion attenuators
US8201752B2 (en) 2008-03-10 2012-06-19 Vapore, Inc. Low energy vaporization of liquids: apparatus and methods
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
WO2009117112A2 (en) 2008-03-21 2009-09-24 Novartis Ag Powder dispersion apparatus, method of making and using the apparatus, components that can be used on the apparatus and other devices, and various active agents
KR101771629B1 (ko) 2008-03-31 2017-08-25 닛토덴코 가부시키가이샤 침투제 전달 시스템 및 그의 사용방법
DK2285439T3 (en) 2008-04-04 2014-03-24 Nektar Therapeutics Aerosoliseringsanorning
WO2009128932A1 (en) 2008-04-15 2009-10-22 Sarcode Corporation Delivery of lfa-1 antagonists to the gastrointestinal system
EP2280676A2 (en) * 2008-04-25 2011-02-09 The Regents of the University of California Device to store and inject corneal graft
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
US8980325B2 (en) 2008-05-01 2015-03-17 Revalesio Corporation Compositions and methods for treating digestive disorders
US7846124B2 (en) 2008-05-07 2010-12-07 Becker Bruce B Punctal anchor for lacrimal stent, introducer tool and method
EP2320972B1 (en) 2008-05-08 2020-07-01 MiniPumps, LLC Implantable drug-delivery devices
CA2769307C (en) 2008-07-11 2017-12-12 Intellicyt Corporation Multi-sample particle analyzer system and method for high throughput screening
AU2009274127A1 (en) 2008-07-21 2010-01-28 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
US20100022943A1 (en) 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Hydrodynamic Thrombectomy Catheter
US20100023033A1 (en) 2008-07-25 2010-01-28 Medtronic Vescular, Inc. Hydrodynamic Thrombectomy Catheter
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
TW201026300A (en) 2009-01-02 2010-07-16 Alcon Res Ltd In-situ refillable ophthalmic implant
US8235932B2 (en) 2009-01-09 2012-08-07 Becker Bruce B Side-by-side lacrimal intubation threader and method
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
EP2391419B1 (en) 2009-01-29 2019-06-12 ForSight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
US8287494B2 (en) 2009-03-23 2012-10-16 Colin Ma Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye
EP2424507A4 (en) 2009-04-27 2012-10-24 Revalesio Corp COMPOSITIONS AND METHODS FOR THE TREATMENT OF INSULIN AND DIABETES RESISTANCE
WO2010125416A1 (en) 2009-04-27 2010-11-04 Raouf Rekik Drug delivery to the anterior and posterior segments of the eye
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
WO2010132835A1 (en) 2009-05-15 2010-11-18 Arstasis, Inc. Devices, methods and kits for forming tracts in tissue
CA3186189A1 (en) 2009-05-18 2010-11-25 Dose Medical Corporation Drug eluting ocular implant
CN102596097B (zh) 2009-06-03 2015-05-20 弗赛特实验室有限责任公司 一种眼插入件
US9005649B2 (en) 2009-07-14 2015-04-14 Board Of Regents, The University Of Texas System Methods for making controlled delivery devices having zero order kinetics
US20110033933A1 (en) 2009-07-15 2011-02-10 Morteza Gharib Method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves
AU2010282282A1 (en) 2009-08-14 2012-03-01 Genentech, Inc. Biological markers for monitoring patient response to VEGF antagonists
WO2011028850A1 (en) 2009-09-01 2011-03-10 Northwestern University Delivery of therapeutic agents using oligonucleotide-modified nanoparticles as carriers
EP2480270A4 (en) 2009-09-21 2015-07-08 Harvard Apparatus Regenerative Technology Inc METHODS AND APPARATUSES FOR INTRODUCING CELLS INTO A TISSUE SITE
US20120245505A1 (en) * 2009-12-16 2012-09-27 Robinson Michael R Intracameral devices for sustained delivery
CA2785468A1 (en) 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
US8430853B2 (en) 2010-02-05 2013-04-30 Johnson & Johnson Vision Care, Inc. Implantation instruments, system, and kit for punctal implants
JP5511530B2 (ja) * 2010-06-10 2014-06-04 Ｈｏｙａ株式会社 眼内レンズ挿入装置
CN103209733B (zh) 2010-08-05 2015-12-16 弗赛特影像4股份有限公司 用于药物输送的注入器装置和方法
ES2894940T3 (es) 2010-08-05 2022-02-16 Forsight Vision4 Inc Aparato para tratar un ojo
EP2600876B1 (en) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
WO2012019047A2 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Subconjunctival implant for posterior segment drug delivery
US20140033800A1 (en) 2010-11-11 2014-02-06 Forsight Vision4, Inc. Methods and apparatus to determine diffusion properties of porous structures for drug delivery
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059A3 (en) 2011-06-28 2023-11-29 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE
FR2980102B1 (fr) * 2011-09-16 2014-10-31 Medicontur Orvostechnikai Korlatolt Felelossegu Tarsasag Dispositif pour injecter une lentille intraoculaire dans un œil
US9883968B2 (en) 2011-09-16 2018-02-06 Forsight Vision4, Inc. Fluid exchange apparatus and methods
SG11201402794YA (en) * 2011-12-02 2014-11-27 Bioceptive Inc Methods and apparatus for inserting a device or pharmaceutical into a uterus
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
MX349226B (es) * 2012-06-04 2017-07-19 Alcon Pharmaceuticals Ltd Insertador de lentes intraoculares.
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
CA2896106C (en) * 2013-04-03 2021-05-04 Novartis Ag Automated intraocular lens injector device
US9987163B2 (en) * 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
US20160302965A1 (en) 2013-12-06 2016-10-20 Forsight Vision4, Inc. Implantable therapeutic devices
WO2016011191A1 (en) 2014-07-15 2016-01-21 Forsight Vision4, Inc. Ocular implant delivery device and method
RU2017105844A (ru) 2014-08-08 2018-09-11 Форсайт Вижн4, Инк. Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения
KR20170106298A (ko) 2014-11-10 2017-09-20 포사이트 비젼4, 인크. 확장 가능한 약물 전달 장치 및 이용 방법
US11432959B2 (en) 2015-11-20 2022-09-06 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
AU2017246889B2 (en) 2016-04-05 2021-12-16 Forsight Vision4, Inc. Implantable ocular drug delivery devices

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US10258503B2 (en) 2019-04-16
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KR20170034396A (ko) 2017-03-28
US20170165108A1 (en) 2017-06-15

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