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BR0213739A - Derivados de estaurosporina como inibidores da atividade de receptores flt3 de tirosina cinase - Google Patents

Derivados de estaurosporina como inibidores da atividade de receptores flt3 de tirosina cinase

Info

Publication number
BR0213739A
BR0213739A BR0213739-9A BR0213739A BR0213739A BR 0213739 A BR0213739 A BR 0213739A BR 0213739 A BR0213739 A BR 0213739A BR 0213739 A BR0213739 A BR 0213739A
Authority
BR
Brazil
Prior art keywords
tyrosine kinase
inhibitors
kinase flt3
receptor activity
staurosporine derivatives
Prior art date
Application number
BR0213739-9A
Other languages
English (en)
Other versions
BRPI0213739B1 (pt
BRPI0213739B8 (pt
Inventor
James Douglas Griffin
Paul William Manley
Original Assignee
Novartis Ag
Dana Farber Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26991080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0213739(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Dana Farber Inst Inc filed Critical Novartis Ag
Publication of BR0213739A publication Critical patent/BR0213739A/pt
Publication of BRPI0213739B1 publication Critical patent/BRPI0213739B1/pt
Publication of BRPI0213739B8 publication Critical patent/BRPI0213739B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

"DERIVADOS DE ESTAUROSPORINA COMO INIBIDORES DA ATIVIDADE DE RECEPTORES FLT3 DE TIROSINA CINASE". A presente invenção refere-se ao uso de derivados de estaurosporina para a preparação de uma droga para o tratamento de doenças envolvendo a atividade desregulada de receptores FLT3 de tirosina cinase, especialmente para ao tratamento curativo e/ou profilático de leucemias e síndromes mielodisplásicas, e a um método de tratamento de doenças envolvendo a atividade desregulada de receptores FLT3 de tirosina cinase.
BRPI0213739A 2001-10-30 2002-10-29 derivados de estaurosporina como inibidores da atividade de receptores flt3 de tirosina cinase BRPI0213739B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33903101P 2001-10-30 2001-10-30
US33818501P 2001-12-07 2001-12-07
PCT/EP2002/012076 WO2003037347A1 (en) 2001-10-30 2002-10-29 Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity

Publications (3)

Publication Number Publication Date
BR0213739A true BR0213739A (pt) 2004-10-19
BRPI0213739B1 BRPI0213739B1 (pt) 2020-06-09
BRPI0213739B8 BRPI0213739B8 (pt) 2021-05-25

Family

ID=26991080

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0213739A BRPI0213739B8 (pt) 2001-10-30 2002-10-29 derivados de estaurosporina como inibidores da atividade de receptores flt3 de tirosina cinase

Country Status (26)

Country Link
US (3) US7973031B2 (pt)
EP (1) EP1441737B1 (pt)
JP (1) JP4959918B2 (pt)
KR (2) KR20090087139A (pt)
CN (2) CN101703509A (pt)
AT (1) ATE335490T1 (pt)
AU (1) AU2006249245B2 (pt)
BR (1) BRPI0213739B8 (pt)
CA (1) CA2462657C (pt)
CY (1) CY1106199T1 (pt)
DE (1) DE60213842T2 (pt)
DK (1) DK1441737T3 (pt)
ES (1) ES2269793T3 (pt)
FR (1) FR18C1012I2 (pt)
HK (1) HK1068262A1 (pt)
HU (1) HU230798B1 (pt)
IL (2) IL161156A0 (pt)
MX (1) MXPA04004137A (pt)
NO (1) NO335685B1 (pt)
NZ (1) NZ532136A (pt)
PL (1) PL211461B1 (pt)
PT (1) PT1441737E (pt)
RU (1) RU2337692C3 (pt)
TW (1) TWI302836B (pt)
WO (1) WO2003037347A1 (pt)
ZA (1) ZA200402498B (pt)

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DK1441737T3 (da) 2006-11-13
JP4959918B2 (ja) 2012-06-27
HUP0401642A3 (en) 2008-05-28
EP1441737B1 (en) 2006-08-09
TW200301127A (en) 2003-07-01
US8222244B2 (en) 2012-07-17
PT1441737E (pt) 2006-12-29
KR20090087139A (ko) 2009-08-14
HK1068262A1 (en) 2005-04-29

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