CR20210165A - Formas cristalinas de un inhibidor de fosfoinositida 3-quinasa (pi3k) campo técnico - Google Patents
Formas cristalinas de un inhibidor de fosfoinositida 3-quinasa (pi3k) campo técnicoInfo
- Publication number
- CR20210165A CR20210165A CR20210165A CR20210165A CR20210165A CR 20210165 A CR20210165 A CR 20210165A CR 20210165 A CR20210165 A CR 20210165A CR 20210165 A CR20210165 A CR 20210165A CR 20210165 A CR20210165 A CR 20210165A
- Authority
- CR
- Costa Rica
- Prior art keywords
- crystalline forms
- pi3k
- phosphoinositide
- kinase
- inhibitor
- Prior art date
Links
- 108091007960 PI3Ks Proteins 0.000 title 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- VHMODILVAAVUJY-UHFFFAOYSA-N 8-amino-N-(2-hydroxy-2-methylpropyl)-3-[2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound NC=1C=2N(C=C(N=1)C(=O)NCC(C)(C)O)C(=CN=2)C1=C(C=CC(=C1)C(C(F)(F)F)(C)O)C VHMODILVAAVUJY-UHFFFAOYSA-N 0.000 abstract 2
- AIJMGQDXUVKDIN-UHFFFAOYSA-N 2-[3-[8-amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl]-4-methylphenyl]-3,3,3-trifluoro-2-hydroxypropanamide Chemical compound NC=1C=2N(C=C(N=1)C(F)(F)F)C(=CN=2)C=1C=C(C=CC=1C)C(C(=O)N)(C(F)(F)F)O AIJMGQDXUVKDIN-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000012828 PI3K inhibitor Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a sales y formas cristalinas de 2–(3–(8–amino–6–(trifluorometil)imidazo[1,2–a]pirazin–3–il)–4–metilfenil) 3,3,3–trifluoro–2–hidroxipropanamida, formas cristalinas de 8–amino–N–(2–hidroxi–2–metilpropil)–3–(2–metil–5–(1,1,1–trifluoro–2 hidroxipropan–2–il)fenil)imidazo[1,2–a]pirazin–6–carboxamida y formas cristalinas de 8–amino–N–(2–hidroxi–2–metilpropil)–3–(2–(metil–d3)–5–(1,1,1–trifluoro–2–hidroxipropan–2–il)fenil)imidazo[1,2–a]pirazin–6–carboxamida, que son inhibidores de PI3K de utilidad en el tratamiento de cáncer y otras enfermedades
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862727321P | 2018-09-05 | 2018-09-05 | |
| US201862727339P | 2018-09-05 | 2018-09-05 | |
| US201862727328P | 2018-09-05 | 2018-09-05 | |
| US201862746928P | 2018-10-17 | 2018-10-17 | |
| PCT/US2019/049419 WO2020051169A1 (en) | 2018-09-05 | 2019-09-04 | Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210165A true CR20210165A (es) | 2021-10-01 |
Family
ID=69642051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210165A CR20210165A (es) | 2018-09-05 | 2019-09-04 | Formas cristalinas de un inhibidor de fosfoinositida 3-quinasa (pi3k) campo técnico |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11186580B2 (es) |
| EP (2) | EP4338801A3 (es) |
| JP (1) | JP2021535182A (es) |
| KR (1) | KR20210091121A (es) |
| CN (1) | CN113677683A (es) |
| AU (2) | AU2019336675B2 (es) |
| BR (1) | BR112021004094A2 (es) |
| CA (1) | CA3111629A1 (es) |
| CL (1) | CL2021000539A1 (es) |
| CO (1) | CO2021004061A2 (es) |
| CR (1) | CR20210165A (es) |
| DK (1) | DK3847175T3 (es) |
| EC (1) | ECSP21022719A (es) |
| ES (1) | ES2976576T3 (es) |
| FI (1) | FI3847175T3 (es) |
| HR (1) | HRP20240252T1 (es) |
| HU (1) | HUE066111T2 (es) |
| IL (2) | IL309869A (es) |
| LT (1) | LT3847175T (es) |
| MA (1) | MA53561A (es) |
| MD (1) | MD3847175T2 (es) |
| MX (2) | MX2021002551A (es) |
| PE (1) | PE20211815A1 (es) |
| PH (1) | PH12021550472A1 (es) |
| PL (1) | PL3847175T3 (es) |
| PT (1) | PT3847175T (es) |
| RS (1) | RS65334B1 (es) |
| SG (1) | SG11202102224UA (es) |
| SI (1) | SI3847175T1 (es) |
| TW (1) | TWI833796B (es) |
| WO (1) | WO2020051169A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3697789T (pt) | 2017-10-18 | 2021-12-31 | Incyte Corp | Derivados de imidazol condensados substituídos por grupos hidróxi terciários como inibidores de pi3kgama |
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