ATE445586T1 - Terphenylderivate zur alzheimerbehandlung - Google Patents

Terphenylderivate zur alzheimerbehandlung

Info

Publication number: ATE445586T1
Authority: AT; Austria
Prior art keywords: terphenyl derivatives; alzheimer treatment; alzheimer; treatment; terphenyl
Prior art date: 2006-04-21

Application number

AT06112934T

Other languages

English (en)

Inventor

Francis Wilson

Alison Reid

Valerie Reader

Richard Harrison

Mihiro Sunose

Remedios Hernadez-Perni

Jeremy Major

Cyrille Boussard

Kathryn Smelt

Formal Adeline Le

Andrew Cansfield

Svenja Burckhardt

Jess Taylor

Original Assignee

Cellzome Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-21

Filing date

2006-04-21

Publication date

2009-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE445586(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-04-21 Application filed by Cellzome Ltd filed Critical Cellzome Ltd

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE445586T1 publication Critical patent/ATE445586T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT06112934T 2006-04-21 2006-04-21 Terphenylderivate zur alzheimerbehandlung ATE445586T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06112934A EP1847524B1 (de)	2006-04-21	2006-04-21	Terphenylderivate zur Alzheimerbehandlung

Publications (1)

Publication Number	Publication Date
ATE445586T1 true ATE445586T1 (de)	2009-10-15

Family

ID=36293499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06112934T ATE445586T1 (de)	2006-04-21	2006-04-21	Terphenylderivate zur alzheimerbehandlung

Country Status (35)

Country	Link
US (1)	US8106236B2 (de)
EP (2)	EP1847524B1 (de)
JP (1)	JP5422827B2 (de)
KR (1)	KR101494906B1 (de)
CN (1)	CN101484410B (de)
AR (1)	AR060621A1 (de)
AT (1)	ATE445586T1 (de)
AU (1)	AU2007240382B2 (de)
BR (1)	BRPI0710632A2 (de)
CA (1)	CA2649845C (de)
CR (2)	CR10376A (de)
CY (1)	CY1109729T1 (de)
DE (1)	DE602006009764D1 (de)
DK (1)	DK1847524T3 (de)
EA (1)	EA016908B1 (de)
ES (2)	ES2333539T3 (de)
GE (1)	GEP20115211B (de)
HK (1)	HK1134923A1 (de)
IL (2)	IL194853A0 (de)
MA (1)	MA30420B1 (de)
MX (1)	MX2008013447A (de)
MY (1)	MY148988A (de)
NO (1)	NO20084516L (de)
NZ (1)	NZ572999A (de)
PE (1)	PE20080267A1 (de)
PL (1)	PL1847524T3 (de)
PT (1)	PT1847524E (de)
SI (1)	SI1847524T1 (de)
SM (1)	SMP200800062B (de)
TN (1)	TNSN08414A1 (de)
TW (1)	TWI435720B (de)
UA (1)	UA95766C2 (de)
UY (1)	UY30300A1 (de)
WO (1)	WO2007124351A1 (de)
ZA (1)	ZA200809857B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE445586T1 (de)	2006-04-21	2009-10-15	Cellzome Ltd	Terphenylderivate zur alzheimerbehandlung
ATE543799T1 (de)	2007-10-19	2012-02-15	Janssen Pharmaceutica Nv	Piperidinyl- und piperazinylmodulatoren von g- sekretase
KR20100082351A (ko)	2007-10-19	2010-07-16	얀센 파마슈티카 엔.브이.	γ-세크레타아제의 아민 결합된 조절제
CA2702959C (en)	2007-10-19	2016-07-26	Janssen Pharmaceutica Nv	Carbon linked modulators of .gamma.-secretase
CN101903334A (zh) *	2007-10-19	2010-12-01	詹森药业有限公司	Gsm中间体
US20110092554A1 (en) *	2007-11-19	2011-04-21	Richard Chesworth	1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2707492A1 (en) *	2007-12-13	2009-06-18	Amgen Inc.	Gamma secretase modulators
JP2011507909A (ja)	2007-12-20	2011-03-10	エンビボファーマシューティカルズインコーポレイテッド	四置換ベンゼン
MX2010009755A (es) *	2008-03-11	2010-09-30	Neurosearch As	Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.
US7968725B2 (en) *	2008-07-22	2011-06-28	Janssen Pharmaceutica N.V.	Pyridinyl modulators of γ-secretase
ES2583093T3 (es) *	2011-03-03	2016-09-19	Denovamed Inc.	Compuestos antimicrobianos/adyuvantes
CN103012200B (zh) *	2011-09-20	2014-12-17	北京大学	具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en)	2014-01-15	2015-07-23	Forum Pharmaceuticals Inc.	Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en)	2015-06-10	2016-12-15	Forum Pharmceuticals Inc.	Oxadiazine compounds and methods of use thereof
JPWO2022114105A1 (de) *	2020-11-27	2022-06-02

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08325182A (ja) *	1995-05-31	1996-12-10	Fuji Yakuhin Kogyo Kk	置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) *	1997-08-21	1999-11-12	Cird Galderma	Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
WO2000069823A1 (en)	1999-05-12	2000-11-23	Neurosearch A/S	Ion channel modulating agents
JP2003530437A (ja)	2000-04-13	2003-10-14	マヨファウンデーションフォーメディカルエデュケーションアンドリサーチ	Ａβ４２低下物質
CA2405170A1 (en) *	2000-04-24	2001-11-01	Merck Frosst Canada & Co.	Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
WO2002066552A1 (en) *	2001-02-20	2002-08-29	Isis Innovation Limited	Metal-containing dendrimers
FR2838439B1 (fr) *	2002-04-11	2005-05-20	Sanofi Synthelabo	Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
CA2506114A1 (en) *	2002-12-05	2004-06-24	Axys Pharmaceuticals, Inc.	Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en)	2003-03-14	2003-04-23	Glaxo Group Ltd	Novel compounds
WO2004096220A1 (en) *	2003-04-30	2004-11-11	Merck Frosst Canada Ltd.	8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) *	2004-05-19	2005-11-24	Cellzome Ag	(biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en)	2004-07-23	2004-08-25	Merck Sharp & Dohme	Therapeutic agents
CA2618340C (en) *	2005-08-15	2013-11-19	F.Hoffmann-La Roche Ag	Piperidine and piperazine derivatives as p2x3 antagonists
WO2007039736A1 (en)	2005-10-06	2007-04-12	Astrazeneca Ab	Novel compounds
ATE445586T1 (de)	2006-04-21	2009-10-15	Cellzome Ltd	Terphenylderivate zur alzheimerbehandlung

2006
- 2006-04-21 AT AT06112934T patent/ATE445586T1/de active
- 2006-04-21 EP EP06112934A patent/EP1847524B1/de not_active Not-in-force
- 2006-04-21 DK DK06112934T patent/DK1847524T3/da active
- 2006-04-21 SI SI200630509T patent/SI1847524T1/sl unknown
- 2006-04-21 PT PT06112934T patent/PT1847524E/pt unknown
- 2006-04-21 ES ES06112934T patent/ES2333539T3/es active Active
- 2006-04-21 DE DE602006009764T patent/DE602006009764D1/de active Active
- 2006-04-21 PL PL06112934T patent/PL1847524T3/pl unknown
2007
- 2007-04-19 NZ NZ572999A patent/NZ572999A/en not_active IP Right Cessation
- 2007-04-19 MX MX2008013447A patent/MX2008013447A/es active IP Right Grant
- 2007-04-19 CA CA2649845A patent/CA2649845C/en not_active Expired - Fee Related
- 2007-04-19 US US11/737,475 patent/US8106236B2/en not_active Expired - Fee Related
- 2007-04-19 WO PCT/US2007/066951 patent/WO2007124351A1/en active Application Filing
- 2007-04-19 MY MYPI20084202A patent/MY148988A/en unknown
- 2007-04-19 AU AU2007240382A patent/AU2007240382B2/en not_active Ceased
- 2007-04-19 EA EA200802173A patent/EA016908B1/ru not_active IP Right Cessation
- 2007-04-19 CN CN2007800184982A patent/CN101484410B/zh not_active Expired - Fee Related
- 2007-04-19 UA UAA200813475A patent/UA95766C2/ru unknown
- 2007-04-19 SM SM200800062T patent/SMP200800062B/it unknown
- 2007-04-19 BR BRPI0710632-7A patent/BRPI0710632A2/pt not_active IP Right Cessation
- 2007-04-19 EP EP07760900A patent/EP2016039B1/de active Active
- 2007-04-19 GE GEAP200710984A patent/GEP20115211B/en unknown
- 2007-04-19 JP JP2009506772A patent/JP5422827B2/ja not_active Expired - Fee Related
- 2007-04-19 ES ES07760900T patent/ES2392352T3/es active Active
- 2007-04-19 KR KR1020087028470A patent/KR101494906B1/ko not_active IP Right Cessation
- 2007-04-20 PE PE2007000497A patent/PE20080267A1/es not_active Application Discontinuation
- 2007-04-20 AR ARP070101724A patent/AR060621A1/es not_active Application Discontinuation
- 2007-04-20 TW TW096114164A patent/TWI435720B/zh not_active IP Right Cessation
- 2007-04-20 UY UY30300A patent/UY30300A1/es unknown
2008
- 2008-10-17 TN TNP2008000414A patent/TNSN08414A1/en unknown
- 2008-10-17 CR CR10376A patent/CR10376A/es not_active Application Discontinuation
- 2008-10-22 IL IL194853A patent/IL194853A0/en unknown
- 2008-10-22 IL IL194789A patent/IL194789A0/en not_active IP Right Cessation
- 2008-10-27 NO NO20084516A patent/NO20084516L/no not_active Application Discontinuation
- 2008-11-19 ZA ZA200809857A patent/ZA200809857B/xx unknown
- 2008-11-20 MA MA31394A patent/MA30420B1/fr unknown
- 2008-11-21 CR CR10452A patent/CR10452A/es unknown
2009
- 2009-12-23 HK HK09112111.0A patent/HK1134923A1/xx not_active IP Right Cessation
2010
- 2010-01-14 CY CY20101100039T patent/CY1109729T1/el unknown

Also Published As

Publication number	Publication date
TW200810746A (en)	2008-03-01
CR10376A (es)	2009-02-26
CN101484410A (zh)	2009-07-15
MY148988A (en)	2013-06-28
EA200802173A1 (ru)	2009-06-30
AU2007240382A1 (en)	2007-11-01
TWI435720B (zh)	2014-05-01
ES2392352T3 (es)	2012-12-10
EP1847524A1 (de)	2007-10-24
ES2333539T3 (es)	2010-02-23
KR101494906B1 (ko)	2015-02-24
WO2007124351A1 (en)	2007-11-01
HK1134923A1 (en)	2010-05-20
IL194853A0 (en)	2009-08-03
AU2007240382B2 (en)	2013-05-02
SMP200800062B (it)	2009-07-14
KR20090024678A (ko)	2009-03-09
CR10452A (es)	2009-02-23
PT1847524E (pt)	2009-12-18
PL1847524T3 (pl)	2010-03-31
EA016908B1 (ru)	2012-08-30
ZA200809857B (en)	2009-08-26
DK1847524T3 (da)	2010-01-11
US20070254957A1 (en)	2007-11-01
US8106236B2 (en)	2012-01-31
NO20084516L (no)	2009-01-13
NZ572999A (en)	2012-06-29
EP2016039A1 (de)	2009-01-21
CA2649845C (en)	2014-09-16
CA2649845A1 (en)	2007-11-01
IL194789A0 (en)	2009-08-03
AR060621A1 (es)	2008-07-02
UA95766C2 (ru)	2011-08-25
EP2016039B1 (de)	2012-08-01
EP1847524B1 (de)	2009-10-14
DE602006009764D1 (de)	2009-11-26
JP2009538275A (ja)	2009-11-05
SI1847524T1 (sl)	2010-01-29
SMAP200800062A (it)	2008-11-19
TNSN08414A1 (en)	2010-04-14
UY30300A1 (es)	2007-08-31
MA30420B1 (fr)	2009-05-04
CY1109729T1 (el)	2014-09-10
PE20080267A1 (es)	2008-05-16
JP5422827B2 (ja)	2014-02-19
CN101484410B (zh)	2013-08-21
GEP20115211B (en)	2011-04-26
BRPI0710632A2 (pt)	2011-08-23
MX2008013447A (es)	2009-03-10

Publication	Publication Date	Title
ATE445586T1 (de)	2009-10-15	Terphenylderivate zur alzheimerbehandlung
LTC2004635I2 (lt)	2021-05-25	Pakeistieji enaminokarbonilo junginiai
DK2047098T3 (da)	2013-08-19	Kalibreringsfremgangsmåde
FR2898073B3 (fr)	2008-02-01	Jante
CR10831A (es)	2009-06-18	INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
DK2016080T3 (da)	2010-11-22	Dihydropyrazolopyrimidinon-derivater
DE602007012130D1 (de)	2011-03-03	Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
ATE524477T1 (de)	2011-09-15	Aziridinylepothilonverbindungen
DK2035394T3 (da)	2009-10-05	2-pyrazincarboxamidderivater
DE602007007219D1 (de)	2010-07-29	Selements zur zeitmessung
NO20085127L (no)	2009-01-08	Leptomycinderivater
DE602007009461D1 (de)	2010-11-11	Tonwiedergabegerät
BRPI0716528A2 (pt)	2013-09-17	mÉtodo de estabilizaÇço
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate
DK2173831T3 (da)	2012-09-17	Brøndbehandling
BRPI0718145A2 (pt)	2013-11-05	Método de micronização
DE602007001593D1 (de)	2009-08-27	Aryl-/alkylvinylsulfon-hyaluronsäurederivate
LU93092I2 (de)	2016-08-01	Alemtuzumab
DE602007013310D1 (de)	2011-05-05	Hochfrequenzbehandlungsinstrument
DE602007002163D1 (de)	2009-10-08	Weichspülmittel
DE602006021493D1 (de)	2011-06-01	Einrichtung
ATE473994T1 (de)	2010-07-15	Avermectinderivate

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