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CR10376A - Derivados de terfenil para el tratamiento de la enfermedad de alzheimer - Google Patents

Derivados de terfenil para el tratamiento de la enfermedad de alzheimer

Info

Publication number
CR10376A
CR10376A CR10376A CR10376A CR10376A CR 10376 A CR10376 A CR 10376A CR 10376 A CR10376 A CR 10376A CR 10376 A CR10376 A CR 10376A CR 10376 A CR10376 A CR 10376A
Authority
CR
Costa Rica
Prior art keywords
alzheimer
disease
treatment
terfenil
derivatives
Prior art date
Application number
CR10376A
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernandez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Adeline Leformal
Andrew Cansfield
Svenja Burckhardt
Yan Zhang
Chih Yung Ho
Original Assignee
Cellzome Ltd
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10376(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Ltd, Ortho Mcneil Janssen Pharm filed Critical Cellzome Ltd
Publication of CR10376A publication Critical patent/CR10376A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invencion se relaciona con compuestos que tienen la formula general (I) con las definiciones de X, Y, R1, R2, R3, R4, R9, R10, que se detallan a continuacion y solvatos, hidratos, esteres y sales farmaceuticamente aceptables de los mismos. Ademas, la invencion se refiere al uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y su uso para la modulacion de la actividad de la y-secretasa.
CR10376A 2006-04-21 2008-10-17 Derivados de terfenil para el tratamiento de la enfermedad de alzheimer CR10376A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number Publication Date
CR10376A true CR10376A (es) 2009-02-26

Family

ID=36293499

Family Applications (2)

Application Number Title Priority Date Filing Date
CR10376A CR10376A (es) 2006-04-21 2008-10-17 Derivados de terfenil para el tratamiento de la enfermedad de alzheimer
CR10452A CR10452A (es) 2006-04-21 2008-11-21 Derivados de terfenilo para el tratamiento de enfermedad de alzheimer

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR10452A CR10452A (es) 2006-04-21 2008-11-21 Derivados de terfenilo para el tratamiento de enfermedad de alzheimer

Country Status (35)

Country Link
US (1) US8106236B2 (es)
EP (2) EP1847524B1 (es)
JP (1) JP5422827B2 (es)
KR (1) KR101494906B1 (es)
CN (1) CN101484410B (es)
AR (1) AR060621A1 (es)
AT (1) ATE445586T1 (es)
AU (1) AU2007240382B2 (es)
BR (1) BRPI0710632A2 (es)
CA (1) CA2649845C (es)
CR (2) CR10376A (es)
CY (1) CY1109729T1 (es)
DE (1) DE602006009764D1 (es)
DK (1) DK1847524T3 (es)
EA (1) EA016908B1 (es)
ES (2) ES2333539T3 (es)
GE (1) GEP20115211B (es)
HK (1) HK1134923A1 (es)
IL (2) IL194853A0 (es)
MA (1) MA30420B1 (es)
MX (1) MX2008013447A (es)
MY (1) MY148988A (es)
NO (1) NO20084516L (es)
NZ (1) NZ572999A (es)
PE (1) PE20080267A1 (es)
PL (1) PL1847524T3 (es)
PT (1) PT1847524E (es)
SI (1) SI1847524T1 (es)
SM (1) SMP200800062B (es)
TN (1) TNSN08414A1 (es)
TW (1) TWI435720B (es)
UA (1) UA95766C2 (es)
UY (1) UY30300A1 (es)
WO (1) WO2007124351A1 (es)
ZA (1) ZA200809857B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE445586T1 (de) 2006-04-21 2009-10-15 Cellzome Ltd Terphenylderivate zur alzheimerbehandlung
ATE543799T1 (de) 2007-10-19 2012-02-15 Janssen Pharmaceutica Nv Piperidinyl- und piperazinylmodulatoren von g- sekretase
KR20100082351A (ko) 2007-10-19 2010-07-16 얀센 파마슈티카 엔.브이. γ-세크레타아제의 아민 결합된 조절제
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
CN101903334A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 Gsm中间体
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2707492A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
MX2010009755A (es) * 2008-03-11 2010-09-30 Neurosearch As Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
ES2583093T3 (es) * 2011-03-03 2016-09-19 Denovamed Inc. Compuestos antimicrobianos/adyuvantes
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof
JPWO2022114105A1 (es) * 2020-11-27 2022-06-02

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
WO2000069823A1 (en) 1999-05-12 2000-11-23 Neurosearch A/S Ion channel modulating agents
JP2003530437A (ja) 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Ａβ４２低下物質
CA2405170A1 (en) * 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
WO2002066552A1 (en) * 2001-02-20 2002-08-29 Isis Innovation Limited Metal-containing dendrimers
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
CA2506114A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2004096220A1 (en) * 2003-04-30 2004-11-11 Merck Frosst Canada Ltd. 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
CA2618340C (en) * 2005-08-15 2013-11-19 F.Hoffmann-La Roche Ag Piperidine and piperazine derivatives as p2x3 antagonists
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
ATE445586T1 (de) 2006-04-21 2009-10-15 Cellzome Ltd Terphenylderivate zur alzheimerbehandlung

Also Published As

Publication number Publication date
TW200810746A (en) 2008-03-01
CN101484410A (zh) 2009-07-15
MY148988A (en) 2013-06-28
EA200802173A1 (ru) 2009-06-30
AU2007240382A1 (en) 2007-11-01
TWI435720B (zh) 2014-05-01
ES2392352T3 (es) 2012-12-10
EP1847524A1 (en) 2007-10-24
ES2333539T3 (es) 2010-02-23
KR101494906B1 (ko) 2015-02-24
WO2007124351A1 (en) 2007-11-01
HK1134923A1 (en) 2010-05-20
IL194853A0 (en) 2009-08-03
AU2007240382B2 (en) 2013-05-02
SMP200800062B (it) 2009-07-14
KR20090024678A (ko) 2009-03-09
CR10452A (es) 2009-02-23
PT1847524E (pt) 2009-12-18
ATE445586T1 (de) 2009-10-15
PL1847524T3 (pl) 2010-03-31
EA016908B1 (ru) 2012-08-30
ZA200809857B (en) 2009-08-26
DK1847524T3 (da) 2010-01-11
US20070254957A1 (en) 2007-11-01
US8106236B2 (en) 2012-01-31
NO20084516L (no) 2009-01-13
NZ572999A (en) 2012-06-29
EP2016039A1 (en) 2009-01-21
CA2649845C (en) 2014-09-16
CA2649845A1 (en) 2007-11-01
IL194789A0 (en) 2009-08-03
AR060621A1 (es) 2008-07-02
UA95766C2 (ru) 2011-08-25
EP2016039B1 (en) 2012-08-01
EP1847524B1 (en) 2009-10-14
DE602006009764D1 (de) 2009-11-26
JP2009538275A (ja) 2009-11-05
SI1847524T1 (sl) 2010-01-29
SMAP200800062A (it) 2008-11-19
TNSN08414A1 (en) 2010-04-14
UY30300A1 (es) 2007-08-31
MA30420B1 (fr) 2009-05-04
CY1109729T1 (el) 2014-09-10
PE20080267A1 (es) 2008-05-16
JP5422827B2 (ja) 2014-02-19
CN101484410B (zh) 2013-08-21
GEP20115211B (en) 2011-04-26
BRPI0710632A2 (pt) 2011-08-23
MX2008013447A (es) 2009-03-10

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)