ATE483711T1 - Spiroindolinonderivate - Google Patents

Spiroindolinonderivate

Info

Publication number: ATE483711T1
Authority: AT; Austria
Prior art keywords: spiroindolinone derivatives; spiroindolinone; derivatives
Prior art date: 2006-03-13

Application number

AT07712430T

Other languages

English (en)

Inventor

Li Chen

Qingjie Ding

Jin-Jun Liu

Song Yang

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-13

Filing date

2007-03-05

Publication date

2010-10-15

2007-03-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE483711T1 publication Critical patent/ATE483711T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT07712430T 2006-03-13 2007-03-05 Spiroindolinonderivate ATE483711T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US78195806P	2006-03-13	2006-03-13
US88175607P	2007-01-22	2007-01-22
PCT/EP2007/052038 WO2007104664A1 (en)	2006-03-13	2007-03-05	Spiroindolinone derivatives

Publications (1)

Publication Number	Publication Date
ATE483711T1 true ATE483711T1 (de)	2010-10-15

Family

ID=38179455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07712430T ATE483711T1 (de)	2006-03-13	2007-03-05	Spiroindolinonderivate

Country Status (15)

Country	Link
US (1)	US20070213341A1 (de)
EP (1)	EP1996590B1 (de)
JP (1)	JP5038337B2 (de)
KR (1)	KR101131031B1 (de)
AR (1)	AR059957A1 (de)
AT (1)	ATE483711T1 (de)
AU (1)	AU2007224505B2 (de)
BR (1)	BRPI0709605A2 (de)
CA (1)	CA2645062A1 (de)
DE (1)	DE602007009650D1 (de)
IL (1)	IL193641A0 (de)
NO (1)	NO20083726L (de)
RU (1)	RU2435771C2 (de)
TW (1)	TW200801000A (de)
WO (1)	WO2007104664A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2320955B1 (es) *	2007-03-02	2010-03-16	Laboratorios Almirall S.A.	Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es)	2007-04-26	2010-09-23	Laboratorios Almirall S.A.	Nuevos derivados de 4,8-difenilpoliazanaftaleno.
US7553833B2 (en) *	2007-05-17	2009-06-30	Hoffmann-La Roche Inc.	3,3-spiroindolinone derivatives
US8134001B2 (en) *	2007-12-14	2012-03-13	Hoffmann-La Roche Inc.	Spiroindolinone derivatives
US7776875B2 (en) *	2007-12-19	2010-08-17	Hoffman-La Roche Inc.	Spiroindolinone derivatives
US7723372B2 (en) *	2008-03-19	2010-05-25	Hoffman-La Roche Inc.	Spiroindolinone derivatives
EP2108641A1 (de)	2008-04-11	2009-10-14	Laboratorios Almirall, S.A.	Neue substituierte Spiro[Cycloalkyl-1,3'-indo]-2'(1'H)-on-Derivate und ihre Verwendung als p38 mitogen-activated Kinase Inhibitoren
EP2113503A1 (de) *	2008-04-28	2009-11-04	Laboratorios Almirall, S.A.	Neue substituierte Indolin-2-on- Derivate und ihre Verwendung als p39 mitogen-activated Kinase Inhibitoren
KR100915320B1 (ko)	2008-09-29	2009-09-03	(주)메디룬	생리통완화를 위한 휴대용 조합자극기
US20100190814A1 (en) *	2009-01-26	2010-07-29	Li Chen	Spiroindolinone derivative prodrugs
US7928233B2 (en) *	2009-02-10	2011-04-19	Hoffmann-La Roche Inc.	Spiroindolinone pyridine derivatives
US8217051B2 (en)	2009-02-17	2012-07-10	Hoffmann-La Roche Inc.	Spiroindolinone derivatives
US8076482B2 (en)	2009-04-23	2011-12-13	Hoffmann-La Roche Inc.	3,3′-spiroindolinone derivatives
BR112012002214B1 (pt)	2009-07-31	2022-01-25	Global Alliance For Tb Drug Development	Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
US8088815B2 (en)	2009-12-02	2012-01-03	Hoffman-La Roche Inc.	Spiroindolinone pyrrolidines
US8288431B2 (en)	2010-02-17	2012-10-16	Hoffmann-La Roche Inc.	Substituted spiroindolinones
US8217044B2 (en)	2010-04-28	2012-07-10	Hoffmann-La Roche Inc.	Spiroindolinone pyrrolidines
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9962459B2 (en) *	2010-07-02	2018-05-08	Basf Se	Ultrathin fluid-absorbent cores
HUE038714T2 (hu)	2011-03-10	2018-11-28	Daiichi Sankyo Co Ltd	Dispiropirrolidin származék
CA2850166C (en)	2011-09-27	2019-12-03	Amgen Inc.	Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
TWI586668B (zh)	2012-09-06	2017-06-11	第一三共股份有限公司	二螺吡咯啶衍生物之結晶
BR112015013611A2 (pt)	2012-12-20	2017-11-14	Merck Sharp & Dohme	composto, e, composição farmacêutica
US11407721B2 (en)	2013-02-19	2022-08-09	Amgen Inc.	CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
JP6266659B2 (ja)	2013-02-28	2018-01-24	アムジエン・インコーポレーテツド	癌の治療のための安息香酸誘導体ｍｄｍ２阻害剤
JP6377123B2 (ja)	2013-03-14	2018-08-22	アムジエン・インコーポレーテツド	癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物
JOP20200296A1 (ar)	2013-06-10	2017-06-16	Amgen Inc	عمليات صنع وأشكال بلورية من mdm2 مثبط
WO2016001376A1 (en)	2014-07-03	2016-01-07	Boehringer Ingelheim International Gmbh	New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
WO2016133194A1 (ja)	2015-02-20	2016-08-25	第一三共株式会社	がんの併用治療法
WO2016167236A1 (ja)	2015-04-13	2016-10-20	第一三共株式会社	Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
RS61936B1 (sr)	2015-10-09	2021-07-30	Boehringer Ingelheim Int	Spiro[3h-indol-3,2´-pirolidin]-2(1h)-on jedinjenja i derivati kao mdm2-p53 inhibitori
CN118436801A (zh)	2016-05-20	2024-08-06	豪夫迈·罗氏有限公司	Protac抗体缀合物及其使用方法
JPWO2018074387A1 (ja)	2016-10-17	2019-08-08	第一三共株式会社	Ｍｄｍ２阻害剤とｄｎａメチルトランスフェラーゼ阻害剤との併用治療法
EP3511334A1 (de) *	2018-01-16	2019-07-17	Adamed sp. z o.o.	1,2,3',5'-tetrahydro-2'h-spiro[indol-3,1'-pyrrolo[3,4-c]pyrrol] -2,3'-dion-verbindungen als therapeutische mittel, die tp53 aktivieren
WO2023056069A1 (en)	2021-09-30	2023-04-06	Angiex, Inc.	Degrader-antibody conjugates and methods of using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1202994B1 (de) *	1999-07-21	2004-04-14	AstraZeneca AB	Verbindungen
JP2009530236A (ja) *	2006-03-13	2009-08-27	エフ．ホフマン−ラロシュアーゲー	スピロインドリノン誘導体

2007
- 2007-03-01 US US11/712,883 patent/US20070213341A1/en not_active Abandoned
- 2007-03-05 RU RU2008140386/04A patent/RU2435771C2/ru not_active IP Right Cessation
- 2007-03-05 CA CA002645062A patent/CA2645062A1/en not_active Abandoned
- 2007-03-05 JP JP2008558774A patent/JP5038337B2/ja not_active Expired - Fee Related
- 2007-03-05 DE DE602007009650T patent/DE602007009650D1/de active Active
- 2007-03-05 AU AU2007224505A patent/AU2007224505B2/en not_active Ceased
- 2007-03-05 BR BRPI0709605-4A patent/BRPI0709605A2/pt not_active IP Right Cessation
- 2007-03-05 WO PCT/EP2007/052038 patent/WO2007104664A1/en active Application Filing
- 2007-03-05 KR KR1020087022284A patent/KR101131031B1/ko not_active IP Right Cessation
- 2007-03-05 EP EP07712430A patent/EP1996590B1/de not_active Not-in-force
- 2007-03-05 AT AT07712430T patent/ATE483711T1/de active
- 2007-03-09 AR ARP070100987A patent/AR059957A1/es not_active Application Discontinuation
- 2007-03-09 TW TW096108227A patent/TW200801000A/zh unknown
2008
- 2008-08-21 IL IL193641A patent/IL193641A0/en unknown
- 2008-08-29 NO NO20083726A patent/NO20083726L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2645062A1 (en)	2007-09-20
DE602007009650D1 (de)	2010-11-18
EP1996590A1 (de)	2008-12-03
EP1996590B1 (de)	2010-10-06
AR059957A1 (es)	2008-05-14
WO2007104664A1 (en)	2007-09-20
JP5038337B2 (ja)	2012-10-03
US20070213341A1 (en)	2007-09-13
JP2009529566A (ja)	2009-08-20
KR20080095279A (ko)	2008-10-28
RU2435771C2 (ru)	2011-12-10
NO20083726L (no)	2008-11-25
AU2007224505A1 (en)	2007-09-20
BRPI0709605A2 (pt)	2011-07-19
TW200801000A (en)	2008-01-01
RU2008140386A (ru)	2010-04-20
IL193641A0 (en)	2009-05-04
KR101131031B1 (ko)	2012-04-12
AU2007224505B2 (en)	2012-05-03

Publication	Publication Date	Title
ATE475662T1 (de)	2010-08-15	Dihydropyrazolopyrimidinonderivate
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
DK2035394T3 (da)	2009-10-05	2-pyrazincarboxamidderivater
DK2164844T3 (da)	2012-08-20	Pyrimidinyl-pyridazinonderivater
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
DE602006004717D1 (de)	2009-02-26	Kapselperforationsmodul
DE602006020192D1 (de)	2011-03-31	Riemenscheibenanorndung
DE602007000258D1 (de)	2009-01-02	Kassetteneinspannmechanismus
AT504580A3 (de)	2008-07-15	Scan-einrichtung
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
DE602007001280D1 (de)	2009-07-30	Getränkeextraktor
ATE518837T1 (de)	2011-08-15	Indazolamidderivate
DE602006019150D1 (de)	2011-02-03	Riemenscheibenanorndung
BRPI0717939A2 (pt)	2013-12-03	Aminometil-4-imidazóis
DE502007000218D1 (de)	2008-12-18	nsetzungen
DE502007002453D1 (de)	2010-02-11	Kunstoffverdichtergehäuse
DE602007000501D1 (de)	2009-03-12	Breitbandrichtkoppler
DK2152370T3 (da)	2011-08-15	Aryletherpyridazinonderivater
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate
DE602006016174D1 (de)	2010-09-23	Blisterverpackungsverfahren
DE502007001629D1 (de)	2009-11-12	Rfahren
DE502007000361D1 (de)	2009-02-26	Stanznieteinheit
ATE519760T1 (de)	2011-08-15	Isoxazolimidazolderivate

Legal Events

Date	Code	Title	Description
2011-05-15	UEP	Publication of translation of european patent specification	Ref document number: 1996590 Country of ref document: EP

Date

Code

Title

Description

2011-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1996590

Country of ref document: EP