Nothing Special   »   [go: up one dir, main page]

ATE377076T1 - Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen - Google Patents

Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen

Info

Publication number
ATE377076T1
ATE377076T1 AT00916164T AT00916164T ATE377076T1 AT E377076 T1 ATE377076 T1 AT E377076T1 AT 00916164 T AT00916164 T AT 00916164T AT 00916164 T AT00916164 T AT 00916164T AT E377076 T1 ATE377076 T1 AT E377076T1
Authority
AT
Austria
Prior art keywords
ligand
polypeptide
human cytokine
zalpha
receptor
Prior art date
Application number
AT00916164T
Other languages
English (en)
Inventor
Julie Novak
Scott Presnell
Cindy Sprecher
Donald Foster
Richard Holly
Jane Gross
Janet Johnston
Andrew Nelson
Stacey Dillon
Angela Hammond
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27385745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE377076(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE377076T1 publication Critical patent/ATE377076T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00916164T 1999-03-09 2000-03-09 Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen ATE377076T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26490899A 1999-03-09 1999-03-09
US26599299A 1999-03-11 1999-03-11
US14201399P 1999-07-01 1999-07-01

Publications (1)

Publication Number Publication Date
ATE377076T1 true ATE377076T1 (de) 2007-11-15

Family

ID=27385745

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00916164T ATE377076T1 (de) 1999-03-09 2000-03-09 Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen

Country Status (23)

Country Link
EP (3) EP1881070B1 (de)
JP (1) JP4405686B2 (de)
KR (1) KR100743640B1 (de)
CN (5) CN102406937A (de)
AT (1) ATE377076T1 (de)
AU (2) AU777842B2 (de)
BR (1) BR0008772B1 (de)
CA (1) CA2366921C (de)
CZ (1) CZ302921B6 (de)
DE (1) DE60036930T2 (de)
DK (1) DK1165791T3 (de)
ES (1) ES2295019T3 (de)
HU (1) HU229148B1 (de)
IL (5) IL145288A0 (de)
MX (1) MXPA01009074A (de)
NO (2) NO331551B1 (de)
NZ (1) NZ514708A (de)
PL (1) PL207350B1 (de)
PT (1) PT1165791E (de)
RU (1) RU2346951C2 (de)
UA (1) UA84387C2 (de)
WO (1) WO2000053761A2 (de)
ZA (1) ZA017370B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
ATE377076T1 (de) * 1999-03-09 2007-11-15 Zymogenetics Inc Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen
WO2003028630A2 (en) * 2001-10-04 2003-04-10 Genetics Institute Llc. Methods and compositions for modulating interleukin-21 receptor activity
DK1451322T3 (da) * 2001-11-05 2010-02-01 Zymogenetics Inc Il-21-antagonister
CA2487133A1 (en) * 2002-06-07 2003-12-18 Zymogenetics, Inc. Use of il-21 in cancer and other therapeutic applications
EA011686B1 (ru) 2002-07-15 2009-04-28 Уайт Способ модуляции развития и функций т-клеток-хелперов
EP1731163A2 (de) * 2002-10-11 2006-12-13 Novo Nordisk A/S Behandlung von allergischen Zuständen durch Verwendung von IL-21
WO2004032953A1 (en) * 2002-10-11 2004-04-22 Novo Nordisk A/S Treatment of allergic conditions by use of il 21
BR0317243A (pt) * 2002-12-13 2005-11-01 Zymogenetics Inc Vetor de expressão, célula hospedeira, métodos para produzir proteìnas il-21 e para isolar proteìna il-21 insolúvel, e, composição
NZ542306A (en) 2003-03-14 2008-04-30 Wyeth Corp Antibodies against human IL-21 receptor and uses therefor
CA2529520A1 (en) * 2003-06-19 2004-12-29 Centocor, Inc. Interleukin-21 analogs
DK1944318T3 (da) * 2003-07-21 2011-06-14 Transgene Sa Multifunktionelle cytokiner
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
WO2005030196A2 (en) * 2003-09-25 2005-04-07 Zymogenetics, Inc. Methods of treating autoimmune diseases using il-21
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
ATE481420T1 (de) 2003-10-10 2010-10-15 Novo Nordisk As Il-21-derivate
EP2633866A3 (de) 2003-10-17 2013-12-18 Novo Nordisk A/S Kombinationstherapie
JP2007522109A (ja) * 2004-01-15 2007-08-09 ノボ　ノルディスク　アクティーゼルスカブ 自己免疫疾患の治療およびｉｌ−２１での同種異系移植片拒絶反応
CN1909930B (zh) 2004-01-21 2015-12-16 诺和诺德医疗保健公司 转谷氨酰胺酶介导的肽的接合
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
DE602006020032D1 (de) 2005-04-18 2011-03-24 Novo Nordisk As Il-21-varianten
ES2491118T3 (es) * 2005-11-28 2014-09-05 Zymogenetics, Inc. Antagonistas de IL-21
EP2091968A2 (de) 2006-10-26 2009-08-26 Novo Nordisk A/S Il-21-varianten
US8211420B2 (en) 2006-12-21 2012-07-03 Novo Nordisk A/S Interleukin-21 variants with altered binding to the IL-21 receptor
CN103772502B (zh) 2007-12-07 2017-03-29 津莫吉尼蒂克斯公司 抗人il‑21单克隆抗体
AR071885A1 (es) 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
BRPI0912998A2 (pt) 2008-05-23 2015-10-13 Wyeth Llc métodos de tratamento que utilizam proteínas de ligação do receptor para a interleucina-21
CA2739357A1 (en) 2008-09-23 2010-04-08 Wyeth Llc Methods for predicting production of activating signals by cross-linked binding proteins
CN102021196B (zh) * 2009-11-20 2013-06-26 上海杰隆生物工程股份有限公司 毕赤酵母生产重组人白细胞介素21的方法
IN2015KN00073A (de) 2012-06-27 2015-07-31 Univ Rutgers
WO2015110930A1 (en) 2014-01-24 2015-07-30 Pfizer Inc. Modified interleukin 21 receptor proteins
EP2982693A1 (de) * 2014-08-07 2016-02-10 Affimed Therapeutics AG CD3 Bindungsdomäne
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK368882A (da) 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US4486533A (en) 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4977092A (en) 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US5139936A (en) 1983-02-28 1992-08-18 Collaborative Research, Inc. Use of the GAL1 yeast promoter
US4661454A (en) 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
CA1280080C (en) 1984-12-06 1991-02-12 Jacques Oberto Promoters for the expression of foreign genes in yeast, plasmids comprising them, and uses thereof for the production of polypeptides
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5063154A (en) 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
EP0325224B1 (de) 1988-01-22 1996-07-31 ZymoGenetics, Inc. Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5162228A (en) 1988-12-28 1992-11-10 Takeda Chemical Industries, Ltd. Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5298418A (en) 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
AU5103293A (en) 1992-09-14 1994-04-12 Oklahoma State University Immortalized cells and uses therefor
EP0711354A1 (de) 1993-07-30 1996-05-15 University Of Medicine & Dentistry Of New Jersey Effiziente gentransfer in primäre maus-lymphozyten ohne den gebrauch einer arzneimittelselektion
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
JP2000500015A (ja) 1995-11-09 2000-01-11 ザイモジェネティクス，インコーポレイティド メチロトロープ性酵母におけるｇａｄ６５の生成
AU708572B2 (en) 1996-07-17 1999-08-05 Zymogenetics Inc. Preparation of (pichia methanolica) auxotrophic mutants
IL128073A0 (en) 1996-07-17 1999-11-30 Zymogenetics Inc Transformation of pichia methanolica
DK0942968T3 (da) 1996-12-03 2008-06-23 Amgen Fremont Inc Fuldt humane antistoffer, der binder EGFR
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
US6057128A (en) * 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
ATE377076T1 (de) * 1999-03-09 2007-11-15 Zymogenetics Inc Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen
US9418201B1 (en) 2015-11-19 2016-08-16 International Business Machines Corporation Integration of functional analysis and common path pessimism removal in static timing analysis

Also Published As

Publication number Publication date
IL145288A (en) 2010-11-30
CN1378595A (zh) 2002-11-06
HUP0200418A3 (en) 2003-12-29
BR0008772A (pt) 2002-05-07
BR0008772B1 (pt) 2011-11-01
ES2295019T3 (es) 2008-04-16
PT1165791E (pt) 2008-01-16
IL207424A (en) 2013-04-30
MXPA01009074A (es) 2002-03-27
CN102406937A (zh) 2012-04-11
KR20010103794A (ko) 2001-11-23
RU2346951C2 (ru) 2009-02-20
EP1165791B1 (de) 2007-10-31
EP2295577A3 (de) 2012-08-08
WO2000053761A2 (en) 2000-09-14
IL195713A (en) 2010-11-30
PL207350B1 (pl) 2010-12-31
CN1827639A (zh) 2006-09-06
DK1165791T3 (da) 2008-02-11
CN101575377A (zh) 2009-11-11
CN1927883A (zh) 2007-03-14
NO20111085L (no) 2001-11-09
NO20014364D0 (no) 2001-09-07
NO20014364L (no) 2001-11-09
CZ20013184A3 (cs) 2002-04-17
IL145288A0 (en) 2002-06-30
HUP0200418A2 (hu) 2002-05-29
EP1881070A2 (de) 2008-01-23
JP4405686B2 (ja) 2010-01-27
RU2004126135A (ru) 2006-02-10
JP2002537839A (ja) 2002-11-12
UA84387C2 (ru) 2008-10-27
CA2366921C (en) 2013-12-17
CZ302921B6 (cs) 2012-01-18
EP1881070A3 (de) 2008-03-05
EP2295577A2 (de) 2011-03-16
NO331551B1 (no) 2012-01-23
WO2000053761A3 (en) 2000-12-21
KR100743640B1 (ko) 2007-07-27
DE60036930D1 (de) 2007-12-13
CA2366921A1 (en) 2000-09-14
CN1927883B (zh) 2011-09-21
AU3731200A (en) 2000-09-28
CN101575377B (zh) 2012-12-26
NZ514708A (en) 2005-01-28
IL207403A (en) 2012-03-29
EP1165791A2 (de) 2002-01-02
EP1881070B1 (de) 2012-10-03
ZA017370B (en) 2002-06-26
DE60036930T2 (de) 2008-10-09
PL351160A1 (en) 2003-03-24
AU2005200240A1 (en) 2005-02-17
CN100500846C (zh) 2009-06-17
AU777842B2 (en) 2004-11-04
HU229148B1 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
ATE377076T1 (de) Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen
DK0751992T3 (da) Karendotelvækstfaktor 2
DK0759067T3 (da) Transformerende vækstfaktor alfa-H1
TR199501182A2 (tr) Pestisid özellikte yeni proteinler ve suslar.
NO20043419L (no) Nytt cytokin, zcytor17-ligand
DK1015587T3 (da) DcR3 polypeptid, en TNFR-homolog
WO2003020932A1 (fr) Nouvelles proteines de secretion et adn associe
IL141869A0 (en) Mammalian transforming growth factor beta-9 (ztgfss9)
EP0967283A4 (de) Gene, die für proteine mit transglykolysierungsaktivität kodieren.
DE69734596D1 (de) "smoothened" proteine aus wirbeltieren
IL142709A0 (en) Novel amino acid sequences, dna encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof
KR950700988A (ko) 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
DK1030867T3 (da) Vækstfaktor af mælk fra pattedyr
AU6722498A (en) Disubstituted biphenyloxazolines
EP1295943A4 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
WO2000070015A3 (fr) Cultures de cellules d'insecte se multipliant a 37°c, leur p rocede d'obtention, et leurs utilisations
NZ509284A (en) Tumour antigen peptide derived from SART-that binds to HLA-A24 antigen thereby facilitating recognition by a T call
UA29770A (uk) Спосіб пригнічення репродукції вірусу імунодефіциту людини
FR2678636B1 (de)
NZ606260A (en) Novel polypeptides involved in immune response
ITRM940091A0 (it) Procedimento per la preparazione di colture cellulari di eisenia foetida (anellidi, oligocheti).