ATE234838T1 - Purinederivate mit antipoliferativer wirkung und ihre biologischen eigenschaften - Google Patents
Purinederivate mit antipoliferativer wirkung und ihre biologischen eigenschaftenInfo
- Publication number
- ATE234838T1 ATE234838T1 AT96941088T AT96941088T ATE234838T1 AT E234838 T1 ATE234838 T1 AT E234838T1 AT 96941088 T AT96941088 T AT 96941088T AT 96941088 T AT96941088 T AT 96941088T AT E234838 T1 ATE234838 T1 AT E234838T1
- Authority
- AT
- Austria
- Prior art keywords
- purine derivatives
- antipoliferative
- rnh
- cyclin
- effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9514237A FR2741881B1 (fr) | 1995-12-01 | 1995-12-01 | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
PCT/FR1996/001905 WO1997020842A1 (fr) | 1995-12-01 | 1996-11-29 | Nouveaux derives de purine possedant notamment des proprietes anti-proliferatives et leurs applications biologiques |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234838T1 true ATE234838T1 (de) | 2003-04-15 |
Family
ID=9485066
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96941088T ATE234838T1 (de) | 1995-12-01 | 1996-11-29 | Purinederivate mit antipoliferativer wirkung und ihre biologischen eigenschaften |
AT02293256T ATE500255T1 (de) | 1995-12-01 | 1996-11-29 | Purin-derivat zur anwendung in der behandlung einer proliferativen erkrankung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02293256T ATE500255T1 (de) | 1995-12-01 | 1996-11-29 | Purin-derivat zur anwendung in der behandlung einer proliferativen erkrankung |
Country Status (11)
Country | Link |
---|---|
US (6) | US6316456B1 (de) |
EP (2) | EP1308447B1 (de) |
JP (1) | JP4340796B2 (de) |
AT (2) | ATE234838T1 (de) |
CA (1) | CA2238843C (de) |
DE (2) | DE69638337D1 (de) |
DK (2) | DK0874847T3 (de) |
ES (2) | ES2195027T3 (de) |
FR (1) | FR2741881B1 (de) |
PT (2) | PT874847E (de) |
WO (1) | WO1997020842A1 (de) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69627195T2 (de) | 1995-11-01 | 2004-01-29 | Novartis Ag | Purinderivate und verfahren zu ihrer herstellung |
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
US6794390B2 (en) * | 1996-08-02 | 2004-09-21 | Cv Therapeutics, Inc. | Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha |
US6790958B2 (en) * | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
CA2287531A1 (en) * | 1997-03-03 | 1998-09-11 | Board Of Regents, The University Of Texas System | Supression of cyclin kinase 2 activity for prevention and treatment of dna viral infections |
EP1003746A1 (de) * | 1997-08-07 | 2000-05-31 | The Regents Of The University Of California | Purin inhibitoren der protein kinasen, g proteine und polymerasen |
JP2001515722A (ja) * | 1997-09-05 | 2001-09-25 | クロップデザイン エヌ.ブイ. | 植物細胞周期蛋白質を調節する方法および手段ならびに植物細胞増殖の制御におけるそれらの使用 |
US7265267B1 (en) | 1997-09-16 | 2007-09-04 | Cropdesign N.V. | Cyclin-dependent kinase inhibitors and uses thereof |
AU754803B2 (en) * | 1997-09-16 | 2002-11-28 | Cropdesign N.V. | Cyclin-dependent kinase inhibitors and uses thereof |
US6710227B1 (en) | 1998-09-16 | 2004-03-23 | Cropdesign N.V. | Cyclin-dependent kinase inhibitors and uses thereof |
EP0911634A1 (de) * | 1997-10-24 | 1999-04-28 | Het Nederlands Kanker Instituut | Pharmazeutische Verwendungen von Regulatoren der CDK-2 |
CA2307171A1 (en) * | 1997-10-24 | 1999-05-06 | Cropdesign N.V. | A novel mitogenic cyclin and uses thereof |
US6642231B2 (en) * | 1998-02-26 | 2003-11-04 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
PT1056744E (pt) * | 1998-02-26 | 2004-03-31 | Aventis Pharma Inc | 2-¬trans-(4-aminociclo-hexil)amino|purinas 6,9-dissubstituidas |
CN1128149C (zh) * | 1998-02-26 | 2003-11-19 | 阿旺蒂斯制药公司 | 6,9-二取代的2-[反-(4-氨基环己基)氨基]嘌呤 |
US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
US6703395B2 (en) * | 1998-03-04 | 2004-03-09 | Institute Of Experimental Botany Of The Academy Of Sciences Of The Czech Republic | Cyclin dependent kinase inhibitor |
US6221873B1 (en) * | 1998-03-04 | 2001-04-24 | Institute Of Experimental Botany Of The Academy Of Sciences Of The Czech Republic | Cyclin dependent kinase inhibitor |
GB9806739D0 (en) * | 1998-03-28 | 1998-05-27 | Univ Newcastle Ventures Ltd | Cyclin dependent kinase inhibitors |
US6664439B1 (en) | 1998-04-28 | 2003-12-16 | The Procter & Gamble Company | Absorbent articles with distribution materials positioned underneath storage material |
WO2000021550A2 (en) * | 1998-10-13 | 2000-04-20 | President And Fellows Of Harvard College | Methods and compositions for treating neurodegenerative diseases |
AU1559400A (en) * | 1998-12-04 | 2000-06-26 | Cropdesign N.V. | Method to identify regulators of cdk activity |
CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
DK1150982T3 (da) * | 1999-02-01 | 2005-12-27 | Cv Therapeutics Inc | Purininhibitorer af cylkineafhængig kinase 2 og 1kB-alfa |
AU2004200192B2 (en) * | 1999-02-01 | 2006-11-16 | Gilead Palo Alto, Inc. | Purine inhibitors of cyclin dependent kinase 2 and 1k-Aa |
EP1026251A3 (de) * | 1999-02-03 | 2000-09-06 | Pfizer Products Inc. | Transgene Tiere welche das menschliche p25 Gen exprimieren |
GB9903762D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
US6627633B2 (en) * | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
US6969720B2 (en) | 1999-03-17 | 2005-11-29 | Amr Technology, Inc. | Biaryl substituted purine derivatives as potent antiproliferative agents |
FR2793794B1 (fr) * | 1999-05-21 | 2001-07-27 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
US20030187261A1 (en) * | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
WO2001055148A1 (en) * | 2000-01-27 | 2001-08-02 | Warner-Lambert Company | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease |
FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
US20040254094A1 (en) * | 2000-10-11 | 2004-12-16 | The Trustees Of University Of Pennsylvania And Board Of Regents | Suppression of cyclin kinase activity for prevention and treatment of infections |
US6861524B2 (en) | 2000-10-31 | 2005-03-01 | Aventis Pharmaceuticals Inc. | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
FR2818642B1 (fr) | 2000-12-26 | 2005-07-15 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion |
DE60205376T2 (de) * | 2001-06-27 | 2006-04-06 | Cyclacel Ltd. | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
US6667311B2 (en) | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
US6812232B2 (en) | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
US7176312B2 (en) * | 2001-10-12 | 2007-02-13 | The Scripps Research Institute | Kinase inhibitor scaffolds and methods for their preparation |
US20050222054A1 (en) * | 2002-03-27 | 2005-10-06 | Cyclacel Limited | Combination comprising a CDK inhibitor and doxorubicin |
CA2488562A1 (en) * | 2002-06-27 | 2004-01-08 | F. Hoffmann-La Roche Ag | Synthesis of purine derivatives |
GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
GB0219746D0 (en) * | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
US20050226879A1 (en) * | 2002-09-17 | 2005-10-13 | Ulmann Katharine S | Methods and compositions related to inhibiting nuclear envelope breakdown |
AU2003276467A1 (en) * | 2002-11-06 | 2004-06-07 | Cyclacel Limited | Combination comprising docetaxel and a cdk inhibitor |
MXPA05004920A (es) * | 2002-11-06 | 2005-08-18 | Cyclacel Ltd | Combinacion que comprende un inhibidor cdk y cisplatin. |
GB0225873D0 (en) * | 2002-11-06 | 2002-12-11 | Cyclacel Ltd | Combination |
ATE409484T1 (de) * | 2002-12-17 | 2008-10-15 | Centre Nat Rech Scient | Verwendung von purinderivaten zur induktion der differenzierung überzähliger haarzellen und deiter-zellen im entwickelnden corti-organ zur behandlung von taubheit |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
EP1444982A1 (de) * | 2003-02-06 | 2004-08-11 | Merckle Gmbh | Verwendung von Purinderivaten als selektive Kinase-Inhibitoren |
GB0307640D0 (en) * | 2003-04-02 | 2003-05-07 | Cyclacel Ltd | Markers |
GB0315259D0 (en) * | 2003-06-30 | 2003-08-06 | Cyclacel Ltd | Use |
US20070287718A1 (en) * | 2003-11-06 | 2007-12-13 | Green Simon R | Methods for the Treatment of Multiple Myeloma Using Roscovitine |
EP2277595A3 (de) | 2004-06-24 | 2011-09-28 | Novartis Vaccines and Diagnostics, Inc. | Verbindungen zur Immunopotenzierung |
CA2576159A1 (en) * | 2004-08-27 | 2006-03-02 | Cyclacel Limited | Purine and pyrimidine cdk inhibitors and their use for the treatment of autoimmune diseases |
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FR2876583B1 (fr) * | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de derives de purines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
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KR20110010813A (ko) * | 2005-10-14 | 2011-02-07 | 에프. 호프만-라 로슈 아게 | 5-(2-클로로페닐)-1,2-디히드로-7-플루오로-8-메톡시-3-메틸-피라졸로[3,4-b][1,4] 벤조디아제핀의 투여 섭생 |
US20070110751A1 (en) * | 2005-10-25 | 2007-05-17 | Maclellan Robb | Compositions and methods for reducing infarct size |
JP5486808B2 (ja) | 2005-11-30 | 2014-05-07 | アッヴィ・インコーポレイテッド | アミロイドベータタンパク質に対するモノクローナル抗体及びその使用 |
EP2289909B1 (de) | 2005-11-30 | 2014-10-29 | AbbVie Inc. | Screeningsverfahren, Verfahren zur Reinigung von nicht-diffundierenden Beta-Oligomeren, selektive Antikörper gegen genannten nichtdiffundierende Beta-Oligomere und Verfahren zur Herstellung von genannten Antikörpern |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
FR2899107B1 (fr) * | 2006-03-30 | 2008-06-13 | Neurokin Entpr Unipersonnelle | Utilisation de la (s)-roscovitine pour la fabrication d'un medicament |
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UA93548C2 (uk) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073803B1 (de) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmazeutische kombinationen |
DK2076268T3 (da) * | 2006-10-19 | 2013-04-22 | Genzyme Corp | Roscovitin til behandling af visse cystiske sygdomme |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
EP2142545A1 (de) | 2007-03-28 | 2010-01-13 | NeuroSearch A/S | Purinylderivate und ihre verwendung als kaliumkanalmodulatoren |
NZ579248A (en) * | 2007-03-28 | 2011-08-26 | Neurosearch As | Purinyl derivatives and their use as potassium channel modulators |
GB0706633D0 (en) | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
GB0706632D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | New purine derivatives |
CZ300774B6 (cs) * | 2007-10-05 | 2009-08-05 | Univerzita Palackého | Substituované 6-(alkylbenzylamino)purinové deriváty pro použití jako antagonisté cytokininových receptoru a prípravky obsahující tyto slouceniny |
BRPI0820722A2 (pt) | 2007-12-20 | 2015-06-16 | Novartis Ag | Derivados de tiazol usados como inibidores de pi 3 cinases |
JP2011207764A (ja) * | 2008-07-29 | 2011-10-20 | Univ Of Tokyo | Cdk阻害剤によるc型肝炎ウイルスの複製抑制 |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
CZ302122B6 (cs) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující |
CZ302623B6 (cs) * | 2009-04-22 | 2011-08-03 | Univerzita Palackého | Oxalátokomplexy platiny s deriváty N6-benzyladeninu, zpusob jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
FR2945747A1 (fr) | 2009-05-25 | 2010-11-26 | Centre Nat Rech Scient | Composition pharmaceutique antitumorale comprenant un inhibiteur de cdks et un inhibiteur de la croissance cellulaire |
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JP2013523182A (ja) | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
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AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
CN105348387B (zh) | 2010-08-14 | 2020-08-25 | Abbvie 公司 | β淀粉样蛋白结合蛋白 |
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WO2012142029A2 (en) | 2011-04-10 | 2012-10-18 | Florida A&M University | Serms for the treatment of estrogen receptor-mediated disorders |
EP2561867A1 (de) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | CDK9-Hemmer zur Behandlung eines Mittellinienkarzinoms |
EP2562265A1 (de) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | Empfindlichkeit auf selektive CDK9-Inhibitoren |
PT2771342T (pt) | 2011-10-28 | 2016-08-17 | Novartis Ag | Derivados de purina e o seu uso no tratamento de doença |
WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
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HUE057092T2 (hu) | 2013-12-06 | 2022-04-28 | Novartis Ag | Alfa-izoformára szelektív foszfatidilinozitol-3-kináz-inhibitor adagolási rendje |
EP2907514B1 (de) | 2014-02-17 | 2019-10-23 | Manros Therapeutics | Purinderivatverbindungen zur medizinischen Verwendung |
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CN108472289A (zh) | 2015-11-02 | 2018-08-31 | 诺华股份有限公司 | 磷脂酰肌醇3-激酶抑制剂的给药方案 |
WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
US10729692B2 (en) * | 2017-02-26 | 2020-08-04 | Institute For Cancer Research | Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death |
EP3606536A4 (de) * | 2017-04-04 | 2020-12-16 | University of Miami | Biomarker für prostatakrebs und behandlung davon |
BR112021011894A2 (pt) | 2018-12-21 | 2021-09-08 | Daiichi Sankyo Company, Limited | Composição farmacêutica |
CN112794852B (zh) * | 2021-01-12 | 2021-11-30 | 江汉大学 | 一种含硒有机化合物及其制备方法与应用 |
CN112794853B (zh) * | 2021-01-12 | 2021-11-30 | 江汉大学 | 一种有机硒化合物及其制备方法与应用 |
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US2844577A (en) * | 1958-07-22 | Certificate of correction | ||
US2691654A (en) * | 1952-06-11 | 1954-10-12 | Buroughs Wellcome & Co U S A I | Amino heterocycles and method of making |
US2830053A (en) * | 1955-03-25 | 1958-04-08 | Burroughs Wellcome Co | 6-substituted purine compounds and method of making |
US2966488A (en) * | 1956-07-30 | 1960-12-27 | Shive William | Substituted alkylaminopurines |
US3213095A (en) * | 1963-04-04 | 1965-10-19 | American Cyanamid Co | N-benzylation of adenine |
US3930005A (en) * | 1973-06-15 | 1975-12-30 | Squibb & Sons Inc | Antiinflammatory agents and their use |
US3862189A (en) * | 1973-08-14 | 1975-01-21 | Warner Lambert Co | Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents |
DE2355536A1 (de) * | 1973-11-07 | 1975-05-22 | Merck Patent Gmbh | Adeninderivate und verfahren zu ihrer herstellung |
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
DE2550000A1 (de) * | 1975-11-07 | 1977-05-12 | Boehringer Mannheim Gmbh | Neue purin-derivate und verfahren zu ihrer herstellung |
GB1544419A (en) * | 1975-11-19 | 1979-04-19 | Science Union & Cie | Purines and pyrazolo-pyrimidines a process for their preparation and pharmaceutical compositions containing them |
US4189485A (en) * | 1977-08-23 | 1980-02-19 | Takeda Chemical Industries, Ltd. | Purine derivatives |
DE2804416A1 (de) * | 1978-02-02 | 1979-08-09 | Boehringer Mannheim Gmbh | Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
EP0363320A3 (de) * | 1988-10-06 | 1991-11-21 | Ciba-Geigy Ag | Substituierte 9H-Purine |
ZA902280B (en) * | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
US5117830A (en) * | 1990-11-08 | 1992-06-02 | Whitby Research, Inc. | Method of determining viability of tissue |
DE69627195T2 (de) | 1995-11-01 | 2004-01-29 | Novartis Ag | Purinderivate und verfahren zu ihrer herstellung |
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
EP1003746A1 (de) * | 1997-08-07 | 2000-05-31 | The Regents Of The University Of California | Purin inhibitoren der protein kinasen, g proteine und polymerasen |
DE60205376T2 (de) * | 2001-06-27 | 2006-04-06 | Cyclacel Ltd. | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
CA2488562A1 (en) * | 2002-06-27 | 2004-01-08 | F. Hoffmann-La Roche Ag | Synthesis of purine derivatives |
GB0219054D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
GB0219052D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
WO2004035132A2 (en) * | 2002-10-15 | 2004-04-29 | Irm Llc | Compositions and methods for inducing osteogenesis |
US7960397B2 (en) * | 2007-12-28 | 2011-06-14 | Institute Of Experimental Botany, Academy Of Sciences Of The Czech Republic | 6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions |
-
1995
- 1995-12-01 FR FR9514237A patent/FR2741881B1/fr not_active Expired - Lifetime
-
1996
- 1996-11-29 PT PT96941088T patent/PT874847E/pt unknown
- 1996-11-29 AT AT96941088T patent/ATE234838T1/de active
- 1996-11-29 EP EP02293256A patent/EP1308447B1/de not_active Expired - Lifetime
- 1996-11-29 ES ES96941088T patent/ES2195027T3/es not_active Expired - Lifetime
- 1996-11-29 DE DE69638337T patent/DE69638337D1/de not_active Expired - Lifetime
- 1996-11-29 AT AT02293256T patent/ATE500255T1/de active
- 1996-11-29 ES ES02293256T patent/ES2364722T3/es not_active Expired - Lifetime
- 1996-11-29 CA CA2238843A patent/CA2238843C/fr not_active Expired - Lifetime
- 1996-11-29 DK DK96941088T patent/DK0874847T3/da active
- 1996-11-29 JP JP52103497A patent/JP4340796B2/ja not_active Expired - Lifetime
- 1996-11-29 DK DK02293256.0T patent/DK1308447T3/da active
- 1996-11-29 US US09/077,470 patent/US6316456B1/en not_active Expired - Lifetime
- 1996-11-29 DE DE69626855T patent/DE69626855T2/de not_active Expired - Lifetime
- 1996-11-29 WO PCT/FR1996/001905 patent/WO1997020842A1/fr active IP Right Grant
- 1996-11-29 EP EP96941088A patent/EP0874847B1/de not_active Expired - Lifetime
- 1996-11-29 PT PT02293256T patent/PT1308447E/pt unknown
-
2001
- 2001-11-08 US US09/986,329 patent/US20020049218A1/en not_active Abandoned
-
2003
- 2003-02-25 US US10/372,670 patent/US20030186999A1/en not_active Abandoned
-
2004
- 2004-03-08 US US10/793,941 patent/US20040235868A1/en not_active Abandoned
-
2007
- 2007-05-30 US US11/755,576 patent/US20090030019A1/en not_active Abandoned
-
2009
- 2009-12-23 US US12/646,778 patent/US8163762B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2238843C (fr) | 2012-04-10 |
US20090030019A1 (en) | 2009-01-29 |
EP0874847B1 (de) | 2003-03-19 |
US20100273802A1 (en) | 2010-10-28 |
CA2238843A1 (fr) | 1997-06-12 |
EP1308447A1 (de) | 2003-05-07 |
US20020049218A1 (en) | 2002-04-25 |
ES2364722T3 (es) | 2011-09-13 |
DE69626855T2 (de) | 2003-12-24 |
US20030186999A1 (en) | 2003-10-02 |
PT874847E (pt) | 2003-08-29 |
US6316456B1 (en) | 2001-11-13 |
EP0874847A1 (de) | 1998-11-04 |
US8163762B2 (en) | 2012-04-24 |
PT1308447E (pt) | 2011-06-07 |
FR2741881A1 (fr) | 1997-06-06 |
DK1308447T3 (da) | 2011-06-20 |
FR2741881B1 (fr) | 1999-07-30 |
EP1308447B1 (de) | 2011-03-02 |
JP2000501408A (ja) | 2000-02-08 |
US20040235868A1 (en) | 2004-11-25 |
WO1997020842A1 (fr) | 1997-06-12 |
DK0874847T3 (da) | 2003-07-14 |
ES2195027T3 (es) | 2003-12-01 |
JP4340796B2 (ja) | 2009-10-07 |
DE69626855D1 (de) | 2003-04-24 |
DE69638337D1 (de) | 2011-04-14 |
ATE500255T1 (de) | 2011-03-15 |
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