AR051792A1 - Compuestos de aminobenzofenona triazol sustituidos - Google Patents
Compuestos de aminobenzofenona triazol sustituidosInfo
- Publication number
- AR051792A1 AR051792A1 ARP050105193A ARP050105193A AR051792A1 AR 051792 A1 AR051792 A1 AR 051792A1 AR P050105193 A ARP050105193 A AR P050105193A AR P050105193 A ARP050105193 A AR P050105193A AR 051792 A1 AR051792 A1 AR 051792A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- hydroxyalkyl
- hydroxy
- alkyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Composicion farmacéutica y uso para preparar medicamentos para tratar trastornos inflamatorios u oftálmicos, cáncer, asma, alergia, artritis, entre otras enfermedades. Reivindicacion 1: Una compuesto de la formula general (1) o (2); en las cuales: R1 es metilo, cloro, bromo, o metoxi; R2 es cloro o metilo; R3 representa alquilo C1-6, alquenilo C2-6, alquinilo C2-6, hidroxialquilo C1-6, haloalquilo C1-6, alcoxi C1-6, alcoxicarbonilo, C1-6, amino C1-6 ureido, tioureido, alquilcarboniloxi C1-6, alquilcarbonilo C1-6, alcoxicarboniloxi C1-6, alcoxisulfoniloxi C1-6, alcoxicarbamoilo C1-6, o aminocarbonilo C1-6; cada uno de los cuales está opcionalmente sustituido con uno o más, sustituyentes iguales o diferentes seleccionados del grupo que consiste en halogeno, hidroxi mercapto, trifluormetilo, ciano, carboxi, CONH2, nitro, oxo, -S(O)2NH2, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, hidroxialquilo C1-4, haloalquilo C1-6, alcoxi C1-4, alcoxicarbonilo C1-4, ureido, tiureido, alquilcarboniloxi C1-4, alcoxicarboniloxi C1-4, alcoxisulfoniloxi C1-4, alcoxicarbamoilo C1-4, aminocarbonilo C1-4, alquiltio C1-4, cicloalquilo C3-6, cicloalquenilo C3-6, amino, imino, aminosulfonilo C1-4, aminocarboniloxi C1-4, alquilsulfonilamino C1-4, alcoxiimino C1-4, alquilcarbonilamino C1-4, alquilsulfonilo C1-4, heteroarilo C1-6, heterocicloalquilo C1-6, o heterocicloalquenilo C2-6; donde dicho alquilo C1-4, alquenilo C2-4, alquinilo C2-4, hidroxialquilo C1-4, haloalquilo C1-6, alcoxi C1-4, alcoxicarbonilo C1-4, ureido, tiureido, alquilcarboniloxi C1-4, alcoxicarboniloxi C1-4, alcoxisulfoniloxi C1-4, alcoxicarbamoilo C1-4, aminocarbonilo C1-4, alquiltio C1-4, cicloalquilo C3-6, cicloalquenilo C3-6, amino, imino, aminosulfonilo C1- 4, aminocarboniloxi C1-4, alquilsulfonilamino C1-4, alcoxiimino C1-4, alquilcarbonilamino C1-4, alquilsulfonilo C1-4, heteroarilo C1-6, heterocicloalquilo C1-6, o heterocicloalquenilo C2-6; están opcionalmente adicionalmente sustituidos con uno o más sustituyentes iguales o diferentes seleccionados del grupo que consiste en halogeno, hidroxi, -NH2, mercapto, trifluormetilo, ciano, carboxi, CONH2, nitro, oxo, -S(O)2NH2, alquilo C1-4, o hidroxialquilo C1-4; o R3 representa hidrogeno, hidroxi o carboxi; R4, R5, R6, R7, y R8 independientemente uno del otro representan cada uno hidrogeno, halogeno, NH2, hidroxi, trifluormetilo, metoxi, etoxi, ciano, acetilo, acetamido, metilo o etilo; con la condicion de que el compuesto no sea [4-(2- aminofenil)amino)-2-clorofenil]-[2-metil-5-[1-2-[(tetrahidro-2H-piran-2-il)oxi]etil]-1H-1,2,3-triazol-4-il]-fenil]-metanona o [4-[(2-aminofenil)amino]-2-clorofenil]-[5-[1-(2-hidroxietil)-1H-1,2,3-triazol-4-il]-2-metilfenil]-metanona; o una sal, solvato o éster del mismo farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63500004P | 2004-12-13 | 2004-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051792A1 true AR051792A1 (es) | 2007-02-07 |
Family
ID=37715934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105193A AR051792A1 (es) | 2004-12-13 | 2005-12-12 | Compuestos de aminobenzofenona triazol sustituidos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8293772B2 (es) |
| EP (1) | EP1828148B1 (es) |
| JP (1) | JP5015005B2 (es) |
| KR (1) | KR101260236B1 (es) |
| CN (1) | CN101115728B (es) |
| AR (1) | AR051792A1 (es) |
| AT (1) | ATE455768T1 (es) |
| AU (1) | AU2005316034B2 (es) |
| BR (1) | BRPI0518993A2 (es) |
| CA (1) | CA2590479A1 (es) |
| DE (1) | DE602005019093D1 (es) |
| DK (1) | DK1828148T3 (es) |
| ES (1) | ES2341473T3 (es) |
| HR (1) | HRP20100225T1 (es) |
| IL (1) | IL183513A0 (es) |
| MX (1) | MX2007006739A (es) |
| NO (1) | NO20073574L (es) |
| PL (1) | PL1828148T3 (es) |
| PT (1) | PT1828148E (es) |
| RU (1) | RU2394818C2 (es) |
| UA (1) | UA90698C2 (es) |
| WO (1) | WO2006063585A1 (es) |
| ZA (1) | ZA200704809B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101048279B1 (ko) | 2002-05-30 | 2011-07-13 | 더 스크립스 리서치 인스티튜트 | 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션 |
| JP2009541286A (ja) * | 2006-06-21 | 2009-11-26 | ハマースミス・イメイネット・リミテッド | 化学的方法及び装置 |
| US8080540B2 (en) | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| KR100932093B1 (ko) * | 2006-09-27 | 2009-12-16 | 주식회사종근당 | 미세소관 형성 저해제로서 유용한 벤조페논 유도체 |
| US8288367B2 (en) | 2006-11-30 | 2012-10-16 | Solvay Pharmaceuticals Gmbh | Substituted estratriene derivatives as 17BETA HSD inhibitors |
| CA2706839C (en) * | 2007-12-18 | 2015-10-20 | Actelion Pharmaceuticals Ltd | Aminotriazole derivatives as alx agonists |
| DK2272845T3 (en) * | 2008-03-26 | 2015-05-04 | Chong Kun Dang Pharm Corp | Benzophenone Thiazole Derivatives for Inhibiting Microtubule Formation and Method for Preparation thereof |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| KR20110022672A (ko) | 2008-06-16 | 2011-03-07 | 유니버시티 오브 테네시 리서치 파운데이션 | 암 치료용 화합물 |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US20130023501A1 (en) | 2009-12-22 | 2013-01-24 | Leo Pharma A/S | Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue |
| MX2012007229A (es) | 2009-12-22 | 2012-07-30 | Leo Pharma As | Composicion cutanea que comprende analogo de vitamina d y mezcla de solvente y tensioactivos. |
| CA2785253A1 (en) | 2009-12-22 | 2011-06-30 | Leo Pharma A/S | Calcipotriol monohydrate nanocrystals |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| CA2791738C (en) | 2010-03-01 | 2020-06-09 | Gtx, Inc. | Aryl imidazolyl compounds for the treatment of cancer |
| KR101666759B1 (ko) * | 2015-08-06 | 2016-10-18 | 경북대학교 산학협력단 | 1-벤조피란메틸-1h-1,2,3-트리아졸 유도체 및 이의 용도 |
| CN106632285B (zh) * | 2016-11-23 | 2019-11-01 | 河南师范大学 | 一种齐多夫定-1,2,3-三氮唑类化合物的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9701453D0 (en) | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
| JP2003505362A (ja) | 1999-07-16 | 2003-02-12 | レオ・ファーマ・アクティーゼルスカブ | ＩＬ−１βおよびＴＮＦ−αの抑制剤としてのアミノベンゾフェノン |
| PL353645A1 (en) | 1999-07-16 | 2003-12-01 | Leo Pharma A/Sleo Pharma A/S | Novel aminobenzophenones |
| PT1202957E (pt) | 1999-07-16 | 2005-01-31 | Leo Pharma As | Aminobenzofenonas como inibidoras de il-1beta e tnf-alpha |
| CZ200283A3 (cs) | 1999-07-16 | 2002-06-12 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemis | Aminobenzofenony jako inhibitory IL-1beta a TNF-alfa |
| DK1210325T3 (da) | 1999-07-16 | 2005-01-31 | Leo Pharma As | Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa |
| AU776395B2 (en) * | 1999-12-06 | 2004-09-09 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha |
| EP1289958A2 (en) | 2000-05-22 | 2003-03-12 | Leo Pharma A/S | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) |
| GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
| US20030073832A1 (en) | 2001-04-10 | 2003-04-17 | Havez Sophie Elisabeth | Novel aminophenyl ketone derivatives |
| RU2361855C2 (ru) | 2001-08-28 | 2009-07-20 | Лео Фарма А/С | Аминобензофеноны |
| RU2005122951A (ru) | 2002-12-20 | 2006-01-27 | Лео Фарма А/С (Dk) | Новые аминобензофеноновые соединения |
| AU2004259264B2 (en) * | 2003-07-24 | 2011-01-06 | Leo Pharma A/S | Novel aminobenzophenone compounds |
| US20090313239A1 (en) | 2008-06-16 | 2009-12-17 | Microsoft Corporation | Adaptive Visual Similarity for Text-Based Image Search Results Re-ranking |
-
2005
- 2005-11-28 CN CN2005800480385A patent/CN101115728B/zh not_active Expired - Fee Related
- 2005-11-28 ZA ZA200704809A patent/ZA200704809B/xx unknown
- 2005-11-28 AT AT05804019T patent/ATE455768T1/de active
- 2005-11-28 DK DK05804019.7T patent/DK1828148T3/da active
- 2005-11-28 RU RU2007126648/04A patent/RU2394818C2/ru not_active IP Right Cessation
- 2005-11-28 CA CA002590479A patent/CA2590479A1/en not_active Abandoned
- 2005-11-28 AU AU2005316034A patent/AU2005316034B2/en not_active Ceased
- 2005-11-28 DE DE602005019093T patent/DE602005019093D1/de active Active
- 2005-11-28 PT PT05804019T patent/PT1828148E/pt unknown
- 2005-11-28 ES ES05804019T patent/ES2341473T3/es active Active
- 2005-11-28 MX MX2007006739A patent/MX2007006739A/es active IP Right Grant
- 2005-11-28 JP JP2007545836A patent/JP5015005B2/ja not_active Expired - Fee Related
- 2005-11-28 PL PL05804019T patent/PL1828148T3/pl unknown
- 2005-11-28 EP EP05804019A patent/EP1828148B1/en active Active
- 2005-11-28 BR BRPI0518993-4A patent/BRPI0518993A2/pt not_active IP Right Cessation
- 2005-11-28 UA UAA200707890A patent/UA90698C2/ru unknown
- 2005-11-28 WO PCT/DK2005/000757 patent/WO2006063585A1/en active Application Filing
- 2005-11-28 KR KR1020077015959A patent/KR101260236B1/ko not_active IP Right Cessation
- 2005-12-02 US US11/292,064 patent/US8293772B2/en not_active Expired - Fee Related
- 2005-12-12 AR ARP050105193A patent/AR051792A1/es not_active Application Discontinuation
-
2007
- 2007-05-29 IL IL183513A patent/IL183513A0/en unknown
- 2007-07-10 NO NO20073574A patent/NO20073574L/no not_active Application Discontinuation
-
2010
- 2010-04-19 HR HR20100225T patent/HRP20100225T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007006739A (es) | 2007-08-02 |
| WO2006063585A1 (en) | 2006-06-22 |
| EP1828148B1 (en) | 2010-01-20 |
| AU2005316034A1 (en) | 2006-06-22 |
| CN101115728B (zh) | 2012-12-19 |
| AU2005316034B2 (en) | 2012-01-19 |
| RU2394818C2 (ru) | 2010-07-20 |
| KR101260236B1 (ko) | 2013-05-06 |
| ES2341473T3 (es) | 2010-06-21 |
| US20060128766A1 (en) | 2006-06-15 |
| IL183513A0 (en) | 2007-09-20 |
| US8293772B2 (en) | 2012-10-23 |
| CA2590479A1 (en) | 2006-06-22 |
| JP5015005B2 (ja) | 2012-08-29 |
| DE602005019093D1 (de) | 2010-03-11 |
| HRP20100225T1 (hr) | 2010-07-31 |
| NO20073574L (no) | 2007-07-10 |
| RU2007126648A (ru) | 2009-01-20 |
| ATE455768T1 (de) | 2010-02-15 |
| PT1828148E (pt) | 2010-05-04 |
| ZA200704809B (en) | 2008-08-27 |
| DK1828148T3 (da) | 2010-05-17 |
| EP1828148A1 (en) | 2007-09-05 |
| JP2008523115A (ja) | 2008-07-03 |
| PL1828148T3 (pl) | 2010-08-31 |
| UA90698C2 (en) | 2010-05-25 |
| BRPI0518993A2 (pt) | 2008-12-23 |
| CN101115728A (zh) | 2008-01-30 |
| KR20070095945A (ko) | 2007-10-01 |
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