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AR037491A1 - Bromuro de (1alfa,2beta,4beta,5alfa,7beta,)-7-[(hidroxi-di-2tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azoniatriciclo.[3.3.1.0 /2,4]-nonano cristalino en la forma anhidra (bromuro de tiotropio cristalino anhidro) , un procedimiento para su preparacion , su utilizacion para la preparacion de un medicamen - Google Patents

Bromuro de (1alfa,2beta,4beta,5alfa,7beta,)-7-[(hidroxi-di-2tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azoniatriciclo.[3.3.1.0 /2,4]-nonano cristalino en la forma anhidra (bromuro de tiotropio cristalino anhidro) , un procedimiento para su preparacion , su utilizacion para la preparacion de un medicamen

Info

Publication number
AR037491A1
AR037491A1 ARP020102337A ARP020102337A AR037491A1 AR 037491 A1 AR037491 A1 AR 037491A1 AR P020102337 A ARP020102337 A AR P020102337A AR P020102337 A ARP020102337 A AR P020102337A AR 037491 A1 AR037491 A1 AR 037491A1
Authority
AR
Argentina
Prior art keywords
preparation
crystal
bromide
tiotropium bromide
oxa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased/Invalidation/Refusal/Rejection/Nullification
Application number
ARP020102337A
Other languages
English (en)
Inventor
Sieger Peter Dr
Ulrike Werthmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR037491A1 publication Critical patent/AR037491A1/es
Ceased/Invalidation/Refusal/Rejection/Nullification legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Bromuro de (1a,2b,4b,5a,7b)-7-[(hidroxi-di-2-tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azoniatriciclo- [3.3.1.02,4]-nonano cristalino en la forma anhidra (bromuro de tiotropio cristalino anhidro), de fórmula (1). Está modificación cristalina anhidra del bromuro de tiotropio no tiene tendencia a la formación de polimorfos, es uniforme y claramente definida. Es un agente anticolinérgico muy eficaz y, por lo tanto, es útil en la terapia del asma o de la COPD ( enfermedad pulmonar obstructiva crónica). También se describe un procedimiento para preparar el bromuro de tiotropio cristalino anhidro por desecación del monohidrato de bromuro de tiotropio cristalino, la utilización del bromuro de tiotropio cristalino anhidro para preparar un medicamento destinado al tratamiento de enfermedades en las que la aplicación de un agente anticolinérgico puede desarrollar una utilidad terapéutica, y un medicamento, en particular un polvo inhalable, que contiene bromuro de tiotropio anhidro cristalino.
ARP020102337A 2001-06-22 2002-06-21 Bromuro de (1alfa,2beta,4beta,5alfa,7beta,)-7-[(hidroxi-di-2tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azoniatriciclo.[3.3.1.0 /2,4]-nonano cristalino en la forma anhidra (bromuro de tiotropio cristalino anhidro) , un procedimiento para su preparacion , su utilizacion para la preparacion de un medicamen Ceased/Invalidation/Refusal/Rejection/Nullification AR037491A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08

Publications (1)

Publication Number Publication Date
AR037491A1 true AR037491A1 (es) 2004-11-17

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102337A Ceased/Invalidation/Refusal/Rejection/Nullification AR037491A1 (es) 2001-06-22 2002-06-21 Bromuro de (1alfa,2beta,4beta,5alfa,7beta,)-7-[(hidroxi-di-2tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azoniatriciclo.[3.3.1.0 /2,4]-nonano cristalino en la forma anhidra (bromuro de tiotropio cristalino anhidro) , un procedimiento para su preparacion , su utilizacion para la preparacion de un medicamen

Country Status (38)

Country Link
EP (1) EP1401445B1 (es)
JP (1) JP2005504015A (es)
KR (2) KR100971616B1 (es)
CN (1) CN100586948C (es)
AR (1) AR037491A1 (es)
AT (1) ATE337006T1 (es)
AU (1) AU2002345016B2 (es)
BG (1) BG66303B1 (es)
BR (1) BR0210537A (es)
CA (1) CA2450961C (es)
CO (1) CO5550423A2 (es)
CY (1) CY1105223T1 (es)
CZ (1) CZ302786B6 (es)
DE (1) DE50207943D1 (es)
DK (1) DK1401445T3 (es)
EA (1) EA005813B1 (es)
EE (1) EE05316B1 (es)
EG (1) EG24851A (es)
ES (1) ES2271280T3 (es)
HK (1) HK1068540A1 (es)
HR (1) HRP20031066B1 (es)
HU (1) HUP0400333A3 (es)
IL (2) IL159238A0 (es)
ME (1) ME00412B (es)
MX (1) MXPA03011718A (es)
MY (1) MY122779A (es)
NO (1) NO334301B1 (es)
NZ (1) NZ530690A (es)
PE (2) PE20081305A1 (es)
PL (1) PL208137B1 (es)
PT (1) PT1401445E (es)
RS (1) RS50441B (es)
SA (1) SA02230255B1 (es)
SI (1) SI1401445T1 (es)
SK (1) SK287262B6 (es)
TW (2) TW200617007A (es)
UY (1) UY27342A1 (es)
WO (1) WO2003000265A1 (es)

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Also Published As

Publication number Publication date
EP1401445B1 (de) 2006-08-23
PE20081305A1 (es) 2008-10-01
MEP62008A (en) 2011-05-10
CZ302786B6 (cs) 2011-11-09
EP1401445A1 (de) 2004-03-31
PL364489A1 (en) 2004-12-13
EE05316B1 (et) 2010-08-16
BG66303B1 (bg) 2013-03-29
ATE337006T1 (de) 2006-09-15
HUP0400333A3 (en) 2012-10-29
CA2450961C (en) 2010-03-30
YU99703A (sh) 2006-05-25
CZ2004120A3 (cs) 2004-05-12
MY122779A (en) 2006-05-31
NO20035696D0 (no) 2003-12-19
NZ530690A (en) 2005-05-27
CO5550423A2 (es) 2005-08-31
TW200617007A (en) 2006-06-01
TWI261589B (en) 2006-09-11
JP2005504015A (ja) 2005-02-10
BG108440A (en) 2004-08-31
KR20040018285A (ko) 2004-03-02
IL159238A0 (en) 2004-06-01
HUP0400333A2 (hu) 2004-12-28
HRP20031066B1 (en) 2011-10-31
EE200400029A (et) 2004-04-15
KR20090031638A (ko) 2009-03-26
PE20030130A1 (es) 2003-04-02
HRP20031066A2 (en) 2004-04-30
PT1401445E (pt) 2006-10-31
SI1401445T1 (sl) 2007-02-28
RS50441B (sr) 2010-03-02
DE50207943D1 (de) 2006-10-05
BR0210537A (pt) 2004-06-22
SK287262B6 (sk) 2010-04-07
CA2450961A1 (en) 2003-01-03
EA005813B1 (ru) 2005-06-30
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
WO2003000265A1 (de) 2003-01-03
KR101011353B1 (ko) 2011-01-28
CN100586948C (zh) 2010-02-03
KR100971616B1 (ko) 2010-07-22
MXPA03011718A (es) 2004-12-06
EG24851A (en) 2010-10-27
NO334301B1 (no) 2014-02-03
ME00412B (me) 2011-10-10
HK1068540A1 (en) 2005-04-29
IL159238A (en) 2010-04-15
UY27342A1 (es) 2003-02-28
DK1401445T3 (da) 2006-11-27
SA02230255B1 (ar) 2006-10-31
EA200301293A1 (ru) 2004-08-26
AU2002345016B2 (en) 2008-04-17
SK522004A3 (en) 2004-06-08
CN1520294A (zh) 2004-08-11
ES2271280T3 (es) 2007-04-16

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