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ME00768B - Derivati supstituisanih benzol sulfonamida kao pro-lekovi cox-2 inhibitora - Google Patents

Derivati supstituisanih benzol sulfonamida kao pro-lekovi cox-2 inhibitora

Info

Publication number
ME00768B
ME00768B MEP-1998-443A MEP1998443A ME00768B ME 00768 B ME00768 B ME 00768B ME P1998443 A MEP1998443 A ME P1998443A ME 00768 B ME00768 B ME 00768B
Authority
ME
Montenegro
Prior art keywords
prodrugs
cox
inhibitors
benzenesulfonamide derivatives
substituted benzenesulfonamide
Prior art date
Application number
MEP-1998-443A
Other languages
English (en)
Inventor
John J Talley
James W Malecha
Stephen Bertenshaw
Matthew J Graneto
Jeffrey Carter
Jinglin Li
Srinivasan Nagarajan
David L Brown
Donald J Rogier Jr
Thomas D Penning
Ish K Khanna
Xiangdong Xu
Richard M Weier
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Publication of ME00768B publication Critical patent/ME00768B/me

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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Abstract

Ovaj pronalazakse odnosi na pro-lekove jedinjenja sledeće formule I Ovaj pronalazakse odnosi na pro-lekove jedinjenja sledeće formule I         u kojoj A, R1,R2 i R3 imaju značenje data u 1. patentnom zahtevu, akoji selektivno sprečavaju ciklooksigens-2.Ova jedinjenja su opisana kao korisna pri lečenju zapaljenja kao i poremećaja povezanihsa zapaljenjima. u kojoj A, R 1 ,R 2 i R 3 imaju značenje data u 1. patentnom zahtevu, akoji selektivno  sprečavaju ciklooksigens-2.Ova jedinjenja su opisana kao korisna pri lečenju zapaljenja  kao i poremećaja povezanihsa zapaljenjima.
MEP-1998-443A 1996-04-12 1997-04-11 Derivati supstituisanih benzol sulfonamida kao pro-lekovi cox-2 inhibitora ME00768B (me)

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