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EA200000204A1 - Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов - Google Patents

Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов

Info

Publication number
EA200000204A1
EA200000204A1 EA200000204A EA200000204A EA200000204A1 EA 200000204 A1 EA200000204 A1 EA 200000204A1 EA 200000204 A EA200000204 A EA 200000204A EA 200000204 A EA200000204 A EA 200000204A EA 200000204 A1 EA200000204 A1 EA 200000204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolopyrlonone
elastasis
neutrophils
inhibitors
derivatives
Prior art date
Application number
EA200000204A
Other languages
English (en)
Inventor
Джеффри Дюк Эдуард Кларк
Майкл Деннис Даул
Гарри Финч
Ли Эндрю Харрисон
Грэм Джордж Адам Инглис
Мартин Редпат Джонсон
Саймон Джон Фосетт Макдоналд
Прайтом Ша
Робин Эндрю Смит
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200000204A1 publication Critical patent/EA200000204A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Согласно настоящему изобретению предложены соединения формулы (I), где R, Rи Rявляются такими, как определено в описании. Соединения формулы (I) полезны, в частности, при лечении воспалительных расстройств дыхательных путей.Отчет о международном поиске был опубликован 1999.05.27.
EA200000204A 1997-09-09 1998-09-07 Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов EA200000204A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number Publication Date
EA200000204A1 true EA200000204A1 (ru) 2000-10-30

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000204A EA200000204A1 (ru) 1997-09-09 1998-09-07 Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов

Country Status (24)

Country Link
EP (1) EP1003748A2 (ru)
JP (1) JP2001515904A (ru)
KR (1) KR20010023766A (ru)
CN (1) CN1278820A (ru)
AP (1) AP2000001761A0 (ru)
AR (1) AR017072A1 (ru)
AU (1) AU9741298A (ru)
BR (1) BR9812062A (ru)
CA (1) CA2303176A1 (ru)
CO (1) CO4970719A1 (ru)
EA (1) EA200000204A1 (ru)
EE (1) EE200000138A (ru)
HU (1) HUP0004644A3 (ru)
ID (1) ID24452A (ru)
IL (1) IL134791A0 (ru)
IS (1) IS5391A (ru)
MA (1) MA26543A1 (ru)
NO (1) NO20001198L (ru)
NZ (1) NZ503130A (ru)
PE (1) PE107899A1 (ru)
PL (1) PL339176A1 (ru)
SK (1) SK3192000A3 (ru)
TR (1) TR200000907T2 (ru)
WO (1) WO1999012933A2 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
CN1960981A (zh) 2004-03-31 2007-05-09 詹森药业有限公司 作为组胺h3受体调节剂的非咪唑杂环化合物
DE102004024772A1 (de) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AU2005308575A1 (en) 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
JP4999920B2 (ja) 2006-05-04 2012-08-15 プルマジェン セラピューティクス （インフラメーション） リミテッド テトラヒドロピロロピリミジンジオン類およびヒト好中球エラスターゼ阻害薬としてのそれらの使用
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
KR20220079527A (ko) 2019-09-17 2022-06-13 메레오 바이오파마 4 리미티드 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
AU726649B2 (en) * 1996-03-28 2000-11-16 Glaxo Group Limited Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Also Published As

Publication number Publication date
PL339176A1 (en) 2000-12-04
JP2001515904A (ja) 2001-09-25
BR9812062A (pt) 2000-09-26
NO20001198L (no) 2000-05-08
EE200000138A (et) 2001-02-15
ID24452A (id) 2000-07-20
WO1999012933A2 (en) 1999-03-18
IL134791A0 (en) 2001-04-30
NO20001198D0 (no) 2000-03-08
KR20010023766A (ko) 2001-03-26
EP1003748A2 (en) 2000-05-31
HUP0004644A3 (en) 2002-01-28
PE107899A1 (es) 1999-11-17
AU9741298A (en) 1999-03-29
CN1278820A (zh) 2001-01-03
AP2000001761A0 (en) 2000-03-31
MA26543A1 (fr) 2004-12-20
NZ503130A (en) 2001-08-31
CO4970719A1 (es) 2000-11-07
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
AR017072A1 (es) 2001-08-22
TR200000907T2 (tr) 2000-11-21
HUP0004644A2 (hu) 2001-09-28
CA2303176A1 (en) 1999-03-18
IS5391A (is) 2000-02-29

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