LYL1

LYL1
Identifiers
Aliases	LYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDs	OMIM: 151440; MGI: 96891; HomoloGene: 4078; GeneCards: LYL1; OMA:LYL1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	13,103,161 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,431,569 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; monocyte; ; trabecular bone; ; bone marrow; ; spleen; ; bone marrow cells; ; vena cava; ; superficial temporal artery; ; lymph node;
	Top expressed in
	granulocyte; ; spleen; ; bone marrow; ; tibiofemoral joint; ; stroma of bone marrow; ; fetal liver hematopoietic progenitor cell; ; blood; ; mesenteric lymph nodes; ; interventricular septum; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	positive regulation of transcription, DNA-templated; B cell differentiation; definitive hemopoiesis; regulation of transcription, DNA-templated; transcription, DNA-templated; blood vessel maturation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4066
	17095
	ENSG00000104903
	ENSMUSG00000034041
	P12980
	P27792
	NM_005583
	NM_008535
	NP_005574
	NP_032561
	Wikidata
View/Edit Human	View/Edit Mouse

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.^[5]^[6]

Interactions

LYL1 has been shown to interact with TCF3^[7] and NFKB1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034041 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.
^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
^ Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
^ Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

External links

LYL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034041 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2752424-5] Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.

[entrez-6] "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".

[pmid8628307-7] Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.

[pmid10023675-8] Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

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Interactions

References

Further reading

External links