PHF21A

PHF21A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PUY, 2YQL
Identifiers
Aliases	PHF21A, BHC80, BM-006, PHD finger protein 21A, NEDMS, IDDBCS
External IDs	OMIM: 608325; MGI: 2384756; HomoloGene: 9597; GeneCards: PHF21A; OMA:PHF21A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,121,454 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,364,666 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; blood; ; epithelium of colon; ; ganglionic eminence; ; monocyte; ; buccal mucosa cell; ; sural nerve; ; granulocyte; ; ventricular zone; ; Achilles tendon;
	Top expressed in
	genital tubercle; ; tail of embryo; ; Rostral migratory stream; ; spermatocyte; ; ventricular zone; ; medulla of thymus; ; granulocyte; ; aortic valve; ; ascending aorta; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; histone binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; transcription coregulator activity; protein binding; metal ion binding; histone deacetylase activity;
Cellular component	histone deacetylase complex; DNA repair complex; nucleus; nucleoplasm;
Biological process	blood coagulation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; histone deacetylation; regulation of transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51317
	192285
	ENSG00000135365
	ENSMUSG00000058318
	Q96BD5
	Q6ZPK0
NM_001101802; NM_016621; NM_001352025; NM_001352026; NM_001352027;
	NM_001352028; NM_001352029; NM_001352030; NM_001352031; NM_001352032
NM_001109690; NM_001109691; NM_138755; NM_001346704; NM_001362829;
	NM_001362830; NM_001362831; NM_001362832; NM_001362833
NP_001095272; NP_057705; NP_001338954; NP_001338955; NP_001338956;
	NP_001338957; NP_001338958; NP_001338959; NP_001338960; NP_001338961
NP_001103160; NP_001103161; NP_001333633; NP_620094; NP_001349758;
	NP_001349759; NP_001349760; NP_001349761; NP_001349762
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.^[5]^[6]^[7]

Function

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM]^[7]

Interactions

PHF21A has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135365 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
^ ^a ^b ^c ^d ^e Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
^ ^a ^b "Entrez Gene: PHF21A PHD finger protein 21A".
^ ^a ^b ^c ^d Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
^ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

External links

PHF21A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135365 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11214970-5] Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.

[pmid12032298-6] Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.

[entrez-7] "Entrez Gene: PHF21A PHD finger protein 21A".

[pmid15325272-8] Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

[pmid12493763-9] Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

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Function

Interactions

References

Further reading

External links