S Wikipedije, slobodne enciklopedije
Histon H2B tip 3-Bprotein koji je kod ljudi kodiran genom HIST3H2BB sa hromosoma 1 .[ 5] [ 6]
Dužina polipeptidnog lanca je 126 aminokiselina , a molekulska težina 13.908 Da .[ 7]
10 20 30 40 50 MPDPSKSAPA PKKGSKKAVT KAQKKDGKKR KRGRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIASEASR LAHYNKRSTI TSREVQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK
Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota . Nukleosomi se sastoje od približno 146 baznih parova (bp) DNK omotanih oko histonskog oktamera sastavljenog od parova svakog od četiri jezgra histona (H2A , H2B , H3 i H4 ). Hromatinsko vlakno se dalje sabija interakcijom linkera histona, H1 , sa DNK između nukleosoma, kako bi se formirale strukture hromatina višeg reda. Ovaj gen je bezintronski i kodira člana histonske porodice H2B. Transkripti ovog gena sadrže palindromski terminski element.[ 6]
^ a b c ENSG00000285449 GRCh38: Ensembl release 89: ENSG00000196890, ENSG00000285449 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080712 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b "Entrez Gene: HIST3H2BB histone cluster 3, H2bb" .^ "UniProt, Q8N257" (jezik: en.). Pristupljeno 12. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
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