CDCA7
Izgled
CDCA7 | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||||||||||||||||||
Aliasi | CDCA7 | ||||||||||||||||||||||||
Vanjski ID-jevi | OMIM: 609937 MGI: 1914203 HomoloGene: 49970 GeneCards: CDCA7 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Ortolozi | |||||||||||||||||||||||||
Vrste | Čovjek | Miš | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNK) | |||||||||||||||||||||||||
RefSeq (bjelančevina) | |||||||||||||||||||||||||
Lokacija (UCSC) | Chr 2: 173.35 – 173.37 Mb | Chr 2: 72.31 – 72.32 Mb | |||||||||||||||||||||||
PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
Wikipodaci | |||||||||||||||||||||||||
|
Protein 7 vezan za ćelijski ciklus jest protein koji je kod ljudi kodiran genom CDCA7 sa hromosoma 2.[5][6][7]
Amiokiselininska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 371 aminokiselina, a molekulska težina 42.573 Da.[8]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MDARRVPQKD | LRVKKNLKKF | RYVKLISMET | SSSSDDSCDS | FASDNFANTR | ||||
LQSVREGCRT | RSQCRHSGPL | RVAMKFPARS | TRGATNKKAE | SRQPSENSVT | ||||
DSNSDSEDES | GMNFLEKRAL | NIKQNKAMLA | KLMSELESFP | GSFRGRHPLP | ||||
GSDSQSRRPR | RRTFPGVASR | RNPERRARPL | TRSRSRILGS | LDALPMEEEE | ||||
EEDKYMLVRK | RKTVDGYMNE | DDLPRSRRSR | SSVTLPHIIR | PVEEITEEEL | ||||
ENVCSNSREK | IYNRSLGSTC | HQCRQKTIDT | KTNCRNPDCW | GVRGQFCGPC | ||||
LRNRYGEEVR | DALLDPNWHC | PPCRGICNCS | FCRQRDGRCA | TGVLVYLAKY | ||||
HGFGNVHAYL | KSLKQEFEMQ | A |
Funkcija
[uredi | uredi izvor]Ovaj gen je identificiran kao c-Myc gen koji reagira i ponaša se kao direktan c-Myc ciljni gen. Utvrđeno je da prekomjerna ekspresija ovog gena pojačava transformaciju limfoblastoidnih ćelija i nadopunjuje transformacijski defektni Myc kutijski mutant II, sugerirajući njegovu uključenost u c-Myc posredovanu transformaciju ćelija. Prijavljene su dvije alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[7]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000144354 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055612 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.
- ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
- ^ a b "Entrez Gene: CDCA7 cell division cycle associated 7".
- ^ "UniProt, Q9BWT1" (jezik: engleski). Pristupljeno 16. 11. 2021.
Dopunska literatura
[uredi | uredi izvor]- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Osthus RC, Karim B, Prescott JE, et al. (2005). "The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo". Cancer Res. 65 (13): 5620–7. doi:10.1158/0008-5472.CAN-05-0536. PMC 1224734. PMID 15994934.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Goto Y, Hayashi R, Muramatsu T, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity". Biochim. Biophys. Acta. 1759 (1–2): 60–8. doi:10.1016/j.bbaexp.2006.02.004. PMID 16580749.
Vanjski linkovi
[uredi | uredi izvor]- Lokacija ljudskog genoma CDCA7 i stranica sa detaljima o genu CDCA7 u UCSC Genome Browseru.