700 سؤال مهم
700 سؤال مهم
700 سؤال مهم
Pearsonvue
Exam of 2014
Pharmacy
2015
ك ن ه في ع ن العبد م دا العبد في ع ن اخيه
س ه ف تجميع هذه المذكره مج نيه ليس ل بيع المق بل ال حيد ه الدع ء لمن تع
المذكره رج ء مراجع الجر ص ح فكرةانش ء هذه المذكره كل فتره لمت بع كل م
ه جديد نظراً ل تحديث الذى يت كل فتره ع اأسئ ه من قبل شرك بيرس ن في رابط
الجر :
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1- antibiotic needed in community acquired pneumonia which need
hospitalization
a-macrolid
b-ceftriaxone +macrolid
c-Doxycyclin
d-Moxifloxacin+vancomycin
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a-Impeniem/cilastatin b-Clindamycin
c-Ceftrisxon d-Amoxicillin
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5- patient with ulcerative colitis ttt on cortison and mesalazin must use
what
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A-FSH B-LH
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Note:
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N.B:
H.pylori treated by triple therapy (( PPI + 2 antibiotics )) usually ((
omeprazole + metronidazole + clarithromycin )) omeprazole alone used for
Gastritis
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Tdap & Dtap are the same vaccines but Tdap is used for adult and
pregnant , Dtap is used for (0-6) years old children
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a-Leucovorin b-naproxen
c-Vit k d-naloxon
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-add water and bulky to stool and soften stool like a jelly
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c-amiloride d-propranalol
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a-anti-inflammatory
b-anti diarrheal
c-antipyretic
d-anitcholergic
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a-propranolol b-metronidazole(flagyl)
c-thiabendazole d-mebendazole
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28- tyramine when taken with MAOIs(monoamine oxidase inhibitor) cause
severe crysis of
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a-iron b-vit.b12
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40-patient with hepatic and renal failure which of the following skeletal
muscle relaxant can be used
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54-amphotericin-b is
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a-naloxone b-methadone
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Qr.....propranolol
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85-clonidine and methyldopa are alpha 2 agonists
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Paracetamol (oral & rectal form) is category B and for (IV formulation) is
category C in pregnancy
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Erythropoietin should not be started until iron status has been evaluated,
and iron supplements should be given first in patients with evidence of
iron deficiency. An adequate response to erythropoietin requires the
maintenance of sufficient iron stores.
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107-neuromusclar blocker block : acetylcholine
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A- 100mg tid
B- 212,5 mg tid
C- 275 mg tid
4- 325 mg bid
If in the question elemental iron: the recommended oral daily dose for
the treatment of iron deficiency in adults is in the range of 150 to
200mg/day of elemental iron"50-65 mg 3 times per day”.
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117-probiotics are bacteria and yeast eaten to provide patient with health
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a-LEVIGATION b-grinding
c-disintegration d-reduction
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a-phenylephrine b- reserpine
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N.B:
During infection or growth →exotoxin
During phagocytosis→endotoxin
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a- decrease C.O.P.
b- Don't induce preiphral vasoconistriction
c- Increase .force of contraction
d- constrict selective dilate renal & mesenteric
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155- Which of following is the drug of choice for treatment of all forms of
Schistosomiasis?
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159-sevelamer used in patients with chronic kidney disease for
a-Hypermagnesmia b-Hyperkalemia c-
Hyperphosphatemia
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a-pharmacokinetics b-pharmacovigilance(safty)
c-pharmacoeconomics(cost) d-pharmacognosy(plants)
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a-exhale , shake the inhaler , put it between your lips then breath slowly
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A-anastrazole
B -tamoxifen
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a-niclosamide b-metronidazole
c-primaquin d-mebendazole
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175-toxidrome is
a-over poison induced syndrome
b-steps involved in treat of toxicity
c-symptoms and signs due to toxicity
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176-a geriatric patient with osteoarthritis mild pain in hip . he has
hypertension and coronary artery disease what is the best drug for pain
a-glucosamine b-paracetamol(acetaminophen)
c-ibubrofen d-aspirin
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177-how many phases applied to drug to be approved by FDA
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183-septic shock patient with normal sodium value with high potassium
and creatine the treatment is : dopamine
Septic shock in this question with normal sodium level and renal failure
(kidney injury)= Dopamine
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a) clopidogrel b) urokinase
c) warfarin d) Abciximab
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a) analgesics b) anti_hypertensive
c) anti- epeleptic d) in chemotherapy
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Flutamide and androcure are anti androgenic drug to treat prostate cancer
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194.
**Drug D is diuretic
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198-A fixed dose of drug that follows 1st order elimination depends on ::
a- dose of drug
b- dosing intervals
c- elimination Half-life
to reach STEADT STATE for drug follows 1st order it depends on rate of
elimination
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a-insulin
b-thiazide diuretic
c- calcium carbonate (may use calcium gluconate or calcium carbonate)
d-spironolactone
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a) patient
b) prescriber
c) medication safety office
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a-allergy from amoxicillin with some one is known that hasn't adverse
effect with any drug
b-tachy cardia with some forgot his dose of anti hypertensive drug and
took 3pills
c-half dose of acetaminophen will cause fever
معني السؤال ايه الح لة الي في ااثر الج نبي غير مممن ع يعني هيحصل هيحصل
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(direct acting)
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215-phenylephrine used in
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a-anastrozole b-tamoxifen
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224--drug interaction between
a-furosemide and osteoporosis (cause hypocalcemia)
b-pirocxicam and heart failure
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225- Effect of aspirin decrease prostaglandin
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226- drug decreases synthesis of cholesterol in liver Simvastatin
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227- Don’t give vaccines to:
A-hypertension patient
b-patients with kidney disease
c- Patients with CD4 < 200
live vaccine c/i with which of the following
choose pt who have CDcount less than 200
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235- Antidote : antagonism of the toxicity of over dose of a drug
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236- The most dangerous adverse effects of Amikacin is: (kidney
disease)
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237-45 year old man his volume of distribution is 35 L what the
interpretation
A-drug is bound to DNA
B-Drug is lipid soluble
C-drug is highly distributed in.plasma
D-low bioavailability of drug
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238-Man came to ER vomiting and dizzy...after he ingested toxic dose of
certain drug Which is the most important step?
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239- which of the following cause metallic taste
a-metoformin b-cimetidine c-captopril
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240-Women came to the ER with pointed pupil. With vomiting and
dizziness... Which drug is responsible?
A-Heroin (Heroin because it is opoid agonist and cause miosis)
B-Cocaine (Cocaine ia indirectly sympathomimetic and cause mydriasis)
Note :
cocaine make mydriasis & Heroin miosis as morphine =pin point pupil
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241- The most error that may occur when a patient is transferred from
one unit of facility to another
A-wrong dose
B-wrong drug prescribed
C-Missing drug he was taking
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249- Pregnant woman has UTI (Urinary Tract Infection) which is the drug
of
choice to treat her UTI :
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a-ciprofloxacin b-tetracyclin c-sulphamethoxizole d-
nitrofurantoin
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250- acetylcystiene is
A- Laxative B- mucolytic C- Skeletal muscle relaxant
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251-drug that makes urine red
A- Rifampicin b- nitrofurantoin (brown)
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A-Drugs that make urine red are:
phenazopyridine
senna laxative
rifampicin
Doxorubicin
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253-Drug stored in the body in
a- fat b- protein c- connective tissue d- muscle e-
A&B
If youdon't have "a&b" … the answer will be "fat"
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256- To know the severity of immunodeffiecency in HIV
a-ESR b-LEUCOCYTE COUNT
c-WBC COUNt d- CD4 count
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257-The ethical principle of veracity requires that:
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260- Following the ethical principle of nonmaleficence requires that
pharmacists:
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262- Which one of the following is taken orally
a-Estrogen b- Estrogen gluconate
c- Estrogen malate d- all of the above
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263- The responsibility of pharmacist in hospital is
a- administration of drug b- deal with patient
c- deal with drug interaction d- notice effect of drug
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264- Plasma conc. Of drug in all body is
a- rate of absorption b- rate of distribution
c- rate of binding d- therapeutic volume
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Q.You should keep the prescription of narcotics in the pharmacy for
a- two year
b- three years
c- four years
d- five years
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ش ر36 في السؤال دست ر ااد ية السع د تك ن ااج بة اذا ط
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265-The following statements are wrong about domperidone except
a- anti-emetic without CNS effect
b- anticoagulant
c- anti-emetic with sever CNS effect
d- non of the above
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266- Pka for normal water in room temperature :
A- 7 B- 14 C- 7^10 D- 10^14
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267- drug make urine red other than rifampicin?
phenazopyridine (Pyridium), and laxatives containing senna
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268-syncop may occure with the 1st dose of the folowing
a-digoxin b-salbutamol c-prazosin d-reserpin
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269 -which one is more effective agaienst in traveller diarrhea:
a-amoxiciilin b-ciprofloxacin
c-sulphamethoxasol d-erythromycin
N.B: quinolones have been the drug of choice
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270- antihypertensive produce tackycardia :
a)Hydralazine b)Reserpine c)Methyldopa d)Atenolol
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271- the action of digoxin can reduced with
a- antacid b-verapamil c-hypokalemia
d-hypothirodism e-hyperthyrodism
a & e both are right
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272- the main cause of digitalis toxicity is
a-diabetes milli
b-hypertension
c-hepatitis
d-renal faliure hypokalimai is main cause of digitalis toxicity
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274- which one used in ventricular arrhthmia with heart block Phynetoin
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275-which one is antiarrythmic class 1A
a-phynetoin b-disopyramide c-propranolol d-verapamil
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276-- Anticancer derived from plant origin NOT venca_
Etoposide
- anti cancer derived from venca is_ Vincristine
Plant origin ... Etoposide
Vinca Plant ... Vincristine
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277-which one used to trigeminal neuralgia tegretol(Carbamazepine)
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278- process require CYP450 :
a)Oxidation b)Hydrolysis
c)Glucoronidation d)Deamination
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283-about digitoxin , which is false :
a) Oral bioavaiability 100%
b) Protein binding 95%
c) Half life is 7 days
d) Mainly hepatic metabolism by microsomal
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284-to compare between 2 drugs use:
a) Physical appearance
b) Weightif comparing bioequivalency))
c) Pharmacokinetic parametersif effect
d) Pharmacodynamic parameter
e) Taste
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285- about sid effect of oral contraceptive except :
a) Depressoin b) Hypertension c)constipation
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287- in tolerence
patient need more dose to obtain the same effect
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288- causes of hypo thyrodism :
iodine deficiency , low hypothulmus&pituitary hormons
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289-phenytoin uses other than anti convelcent agent are :
ttt irregular heart beat&ttt painful nerve coduction (neuralgia)
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290- arrhythmia due to :
dysfunction in generate heart pulse or conduction of it abnormal
impulse conduction and abnormal impulse propagation
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291- Hydralazine, vessel relaxation. It dilates arterioles more than veins.
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292- guanthedin SE are all
a-prevent ejaculation
b-orthostatic hypotension
c- diarrhea
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293- not from WBC
a- reticleucyte
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294- about minoxidil
a - it decrease myocardium contractility
b - dilate arteries only
c- cause bradycardia
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295- mizolastine used as
a- antibiotic b- anticoagulant
c - anti platlet d- ) non sedating –
antihistaminic
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296- all these drugs are anti metabolite execept
Cisplatin
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297- about digioxin what is not true ?
taken only orally
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298- Captopril and Enalapril do all the following except:
a- Increaserennin concentration in blood
b- Inhibit an enzyme
c- Competively blocks Angiotensin II at it’s receptors
d- Raises the blood Potassium concentration
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299- Various opiates may be used as all of the following except:
a- Analgesics
b- Anti-inflammatories
c- Antidiarreals
d- Aids to anesthesia
e- Antitussive
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307-Ultra-short acting barbiturates are used primarily as
a- Sedatives b- Hypnotics
c- Anti-parkinsonian agent d- Preanesthetic agents
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308-for a 4 year old child, the maximum daily dose of paracetamol is
a- 240mg b- 480 mg c- 1 g d- 2 g
N.B. Dose for children of paracetamol:
Four years old child should take 240 mg paracetamol per dose,
repeated every four hours, Maximum: 5 doses daily>>>>> so, 5 x
240mg= 1200 mg =1.2g choice: 1g (as age based dose)
For (age based dose): 10 to 15 mg/kg/dose every 4 to 6 hours as
needed; do not exceed 5 doses in 24 hours; maximum daily dose: 75
mg/kg/day
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309- To supply the myocardium with O2 shortly after myocardial
infarction we give
a-anticoagulant b-fibrinolytic c-aspirin d-ACEI
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310-Which one of the following cannot be dispensed without prescription:
a- Ibuprofen b- Doxycycline
c- Aspirin d- Bisacodyl
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311-The aim in the management of uncomplicated hypertension:
a- > 90\65 b- > 130\80 c- > 150\95 d- >
180\110
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312- A hospital on formulating drugs, Efficacy, Work overload, and Costs
are taken in concern. A, B, C, D, and E are antifungal drugs available in
the market. All have the same efficacy. The hospital was using drug E for
a period of time. According to the following data which drug is best to be
used by the hospital:
DRUG COST FREQUENCY DURATION
A-3.25 BID 14 DAYS B-2.25 ONCE DAILY 14 DAYS
C-5.5 BID 7 DAYS D-2.25 BID 7 DAYS
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313- Solid dosage forms are better than Solution dosage form because:
a- Accurate dose b- Easy to handle c- More
stable
d- Faster action e- a&b and c
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314- Tolerance is a problem when using Nitroglycerin, which of the
following is true:
a- Tolerance doesn't occur in young patient
b- Over 50 years patient doesn't develop tolerance
c- Dosing schedule may affect tolerance
d- Isosorbide dinitrate doesn't develop tolerance
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315- arranging the electro magnetic waves alpha,,, beta,,,gamma in an
increase ranking in air will be
a-alpha,beta,gamma
b-beta,gamma, alpha
c-gamma,,alpha,,beta
d-alpha,,beta negative,,,gamma,,,beta positive
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316-indapemide used in
Pulmonary eodema
Essential hypertension
if we have choice both of them this choice is correct or if not have both we
must choice essential hypertension
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317- one of the followimg not related to heparin
a-prevent blood clotting
b-decrease antithrombine time
c-prevent formation of factor VII
d-used in pulmonary empolie
Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX,X) ,
whereas heparin and related compounds increase the action of
antithrombin on thrombin and factor Xa
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318-Which not effect of caffiene-:
a)preiphral vasoconistriction b)cardiac stimulation
c)dieresis
d)skeletal muscle relaxant e)stimulation of C.N.S
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323- At 25° C, benzoic acid is much more soluble in benzene (C6H6) than it
is in water. In this situation benzoic acid could be considered to be:
A- Hydrophilic B- Colloidal
C- Non-polar D- Polar
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324- The following properties are similar for both solutions and
suspensions:
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326- In the treatment of the osteoporosis, which of the following is not
correct:
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a-tachycardia b-diuresis
c-hyperglycemia d-hyperuricemia
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333-thiopental is ?
a ) short acting barbiturates b ) long acting barbiturates
c ) spinal anaesthesia d ) antihistaminic
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334- which of the following is NOT macrolide antibiotic?
a ) erythromycin b ) spiramycin
c ) chloramphenicol d ) clarithromycin
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335- Digoxin action except :-
a-+ve inotropic
b-shorten refractory period in atrial and ventricular myocardial
c-increase conduction velocity in AV node
d-contraction of myocardial muscle
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Q-All of the following to decrease the exposure to the radiation except
a-increase the distance from radiation source
b-out from the place of radiation
c-put shelves
e-decrease the activity of radiation person
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336- Milironin has following except :
a-+ve inotropic
b-vasodilator
c-increase ca intercellular C....as it increase ca intracellular not
intercellular
d-phosphodiasterase inhibitor
e-potantiate the effect of CAMP
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337- Very small molecule(1 part ) soluble in more than 10,000 part of water
a- fairly soluble b- slightly soluble C-immiscible
d- miscible e- insoluble
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340-protect from light" in usp means :
a- air tight container
b- plastic container
c- Light resistant container
d- Amber glass
e- Amber plastic
N.B: if the ques. asked about "InUSP " … the answer is Amber glass
if not … the answer is " Light resistant container"
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340-drugs have different crystal structures so different in
a-polymorphism b-solubility c-crystalitis d-drug form
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342-most potent anti-inflammatory corticosteroid systemically is :
a-cortisone b-hydrocortisone
c-triamcinolone d-prednisone e- dexmethasone
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343-suspension eye drop differ than ophthalmic solution in:
a-less commonly used b- decrease contact time of drug with
eye
c- used for insoluble drugs d- a&c
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344-cushing - like syndrome is due to
a) adrenal hyperplasia b) adrenal hyporplasia
c) Hypothyroidism d) hyperthyroidism
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345- Morphine causes respiratory depression by
a) depression of respiratory center in brain
b) activation of respiratory center in brain
c) depression of CTZ receptors center in brain
d) activation of CTZ receptors center in brain
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346-Calcium-channel blockers mode of action
a) increase the inward calcium to cells
b) decrease the inward calcium to cells
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347-which is (are) electromagnetic waves??
a)X-ray b) Beta- ray c) Gama- ray d)a+c
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348-Phenylepherine
a- used in nasal decongestant
b-in high doses stimulate b adrenergic receptor
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A -tubocurarine.
B - Vecuronium.
C -pancuronium.
D -gallamine.
E – atracurim
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350- enzyme kinetics law:
A - Michaelis–Menten law. B -henry s law.
C -franks law .D - Henderson hasselbach law.
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357- all these drugs used in ameobic dysentery exept
a-metronidazole b-diloxanid
c-gentamycin d-tetracyclin
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358-Example of pathological toxicity:
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359- Allopurinol
a- uricosuric b- Anti-inflammatory
N.b:
1- uricosuric drugs are substances that increase the excretion of uric acid
in the urine, thus reducing the concentration of uric acid in blood plasma
(probenecid is a uricosuric.)
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note:
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Food may decrease the rate but not the extent of oral absorption of aspirin.
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a- omeprazole
d- H2 receptor antagonist
neutralize acidity>>antacids
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N.B:
Sucralfate (aluminum sucrose sulfate) , H2 blocker and PPI are effective in ttt
NSAIDs induced ulcer
The most effective is PPI
prostaglandin analogue (misoprostol ) (cytotec®), gastric mucous barrier is
prophylaxis , can’t treat the ulcer
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375- Sodium bicarbonate antacid makes an out elimination of )
A-pka=1.2, weak acid
B-pka=5.1, weak acid
C-pka=7.8, weak base
D-pka= 9 , weak bas
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376- a pregnant woman at 43 week pregnancy She began labor actions for
12 hrs. The contractions were strong at first but after some while became
very weak
Which of the following could be useful in her case :
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N.B:
Dyslipidemia: A disorder of lipoprotein metabolism, including lipoprotein
overproduction or deficiency.
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378-Side effect of albuterol
a-Tachycardia. b- bradycardia c-hypotension
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379-Drug of choice in absence seizures .. ethosuximide
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380- DOC tape worms
a-thiabendazole b-mebendazol c- Niclosamide
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381- A diabetic old patient with hyperlipidemia complains of erectile
dysfunction so DOC
A) sildenafil B) testosterone patch
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382- a drug increases the effect of highly bound to plasma protein
a- digoxin b-phenobarbiton c-valporic acid
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383-Rapid relief of acidity:
a- omeprazole b- Al hydroxide c- alginic acid
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384-Anemic patient refuses to take injection so DOC:
a- Iron sucrose b-Ferrous gluconate c-Vit. b12
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386- Drug that increases paracetamol toxicity
a-Alcohol ( ethanol ) b-phenobarbitone
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386- Dopamine is used in cardiac shock as ..
a-don't induce peripheral vaso construction
b-decrease c.o.p
c-dec. force of contraction
d-selective dilate renal and mesenteric(vasodilation) -
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a) take alendronate 1/2 hour before breakfast and stand upright for 1/2
hour
c) take alendronate 1/2 hour before breakfast with water and stand upright
for 1/2 hour
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391-which drug will be more absorbed in presence of ranitidine
a-warfarin b-aspirin c-triazolam d-naproxen
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It occurs when the kidney leaks small amounts of albumin into the urine
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394-Pregnant woman have hepatitis B when deliver we must give for baby?
A. Hepatitis B vaccine only
B. Hepatitis B vaccine with interferon
C. Hepatitis B vaccine with immunoglobulin hepatitis.
D-Hepatitis B immunoglobulin with lamivudine
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395- According to FDA the most dangerous abbreviation that shouldn’t be
written on prescription is???
a-Ac b- pc c- prn d- pe
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396- 85 years man have pain in joint .. what the most dangours abbreviation
put in prescription ?
a-Qid b-P.R.N c-pe d-OD
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A-Multivitamins B-Paracetamol
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N.B:
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399-12 years old boy has diabetes type1 which drug can take?
A.metformin B. glipizide C. Pioglitazone D. glibenclamide
Note :
if " insulin" is an option .. choose it .
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400- Megaloplastic anemia folic acid /cyanocoblamin……..i.e (vitb9+vitb12)
N.B: Pernicious anemia. Deficiency of vit b12 ..Only
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401-Indapamide used in
Indapamide used in hypertension or for swelling " salt and water retention
due to congestive heart failure
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402- ethosuximide is antiepileptic used in absence (petit mal) seizure
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403-A Child with otitis media ,,, high dose amoxicillin
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404- hormone is released from adrenal cortex Adrenocorticotropic
a-oxytocin b-progesteron
Hormone released from posterior gland Vasopressin and oxytocin.
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406-A pregnant women in her 35 week has a headache she should take
a- ergotamine b- acetaminophen(= Paracetamol)
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Used with caution = generally safe in short term use with least possible
effective dose
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408-A drug for hyperthyroidism associated with a agranulocytosis is
propyl thiouracil
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409- Bioavailability refers to the extent and rate at which the active moiety
(drug or metabolite) enters:
a- systemic circulation ( the site of action) b- intestine
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410- Hb1Vgenotybe hepatic patient for ttt take ?
a.interferon and ribavirin b- First ribavirin then interferon
c-only interferon d-only ribavirin
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411-A pregnant women with syphilis should take
a- ampicillin B-amoxicillin c- clavulanate b- ciprofloxacin
N.B:
Deferoxamine acts by binding free iron in the bloodstream and enhancing
its elimination in the urine
**
414-Anti-inflammatory MOC
a-increase prostaglandin b.decrease prostaglandin c-
leukotriene inhibition
**
415- The concomitant administration of H2 blockers may increase the
dissolution rate of enteric-coated naproxen
**
416-which one has narrow therapeutic index:
a) nifedipine b) digoxin c) sildenafil
**
417-symptoms of digitalis toxicity include whitch one of the following :
a- Ototoxicity b- arrhythmia
**
**
**
420-deltiazem used in hypertension to inhibit calcium influx
**
a-A drug that shows promising results for life-threatening disease with
other drugs available can treat it
**
422-A Drug Increases of benign prostate hypertrophy (BPH)
Chlorpheniramine
**
423-Essential element thought which Thiazide produces its
pharmacological action (diuretics effect):
A-sodium b- Potassium C-Bicarbonate D-phosphate
**
424-long long term treatment with thiazide requires
a- K b- Na c- Ca d- CO3
**
425-The drug is most commonly used in the selective COX2 inhibitors:
A. Rifocoxib B. Etidolac C. Celecoxib
**
**
427- A Drug that may cause arrhythmia Digoxin
**
428-drug need to monitor its plasma level Gentamycin
**
429-drug make complex with dairy product Ciprofloxacin
**
430- Drugs that make complex with antacids?
(tetracyclines and fluoroquinolones)
**
431-Drug makes complex with antacid
A-Warfarin b-propranolol c-Doxycycline
**
432- Antiarrhythmic drug class 1A Disopyramide
**
434-in ovulation phase, Which hormone predominate?
a-FSH b-LH C) GnRH
**
**
**
N.B: Aspirin replace heparin in plasma protein bind Increase the effects of
heparin. And risk of bleeding
**
**
**
**
The label must contain the pt. name due to no other pt. take this
drug
**
a-increase the distance from radiation source b-out from the place of
radiation
**
c-glomerular filtration
**
a- drowsiness b- diarrhea
**
**
**
unfractionated heparin
**
Doses qusetions
Adult...600iu
**
452- A Drug causes sodium and water retention
A.indomethacin
B.verapamil
C.atenolol
D.ACEI drugs
Indomethacin if there is no Minoxidil in choices
**
453-Which of the following induce diarrhea Indomethacin
**
**
**
456-Vitamin k is antidote of
A-warfarin B-Digoxin C-heparin
**
457-Antidote of heparin is
a- vitamin k b-Protamine sulfate
c-propranolol d-desferoxamine
**
**
458-Atropine is
a- Muscarinic agonist
b- Muscarinic antagonist
c- Nicotinic agonist
D-nicotinic antagonist
**
459-Benefits of using the unit- dose system:
To decrease medication errors (dose errors)
**
460- MOA of cromolyn ( cromolyn sodium)
a- anti-leukotriene b- mast cell stabilizers c- pg modifier
**
461- Treatment of patient with chronic wheezing and cough:
A-corticosteroid B-beta 2 agonist
**
462-which of the following prevents Neural tube defects ( birth defects)
Folic acid (vit. B9)
**
463- Category X
Category X
Studies in animals or humans have demonstrated fetal abnormalities
and/or there is positive evidence of human fetal risk based on adverse
reaction data from investigational or marketing experience, and the
risks involved in use of the drug in pregnant women clearly outweigh
potential benefits.
Example drugs: atorvastatin, simvastatin, warfarin, methotrexate,
finasteride
**
**
Change to ethosuximide
**
Granisetron (Kytril)
**
**
**
Hemorrhage
**
A-1,25-dihydroxycholecalciferol( Calcitriol)
B-D3
C-D2
**
C-hypocalcaemia D- hypercalcemia
**
**
**
A – Angina B - Asthma
**
A.dialysis
**
**
**
**
**
488- Drugs induced cough Except
.Losartan (angiotensin II receptor antagonists)
**
489-MOA of. spironolactone (Adverse effect of Spironolactone (
a-hypokalemia b-hyperkalemia c-hypnetermia
**
490.ACEI contraindication ?
a- HTN . b- angina.
c- arrhythmia. d- renal failure
**
491. Diltiazem actin? CCB cacuim channel blocker
**
492. LDL indicate ? Arteriosclerosis
**
493- cholestyramin use in ? .ttt hypercholesterolemia
**
494. Used in hyperlipidemic? simvastatin
**
495. Benzodiazepine is used in treatment of ? note:( Anxiolytic and
anticonvulsant)
**
497. Pt. with Low creatinine clearance= high serum creatinine=kidney
injury contraindicated? Gentamycin
**
**
499Treatment of Diabetic patient with Glycated hb 9 as initial ttt:
a- Metformin b-glipzide
c-insulin d-another choice
**
500-Use of combination OCs(Oral contraceptives) contraindicated in
case of
DVT(Deep vien thrombosis)
**
501-A woman had DVT and was treated a year ago ,now she wants to
use oral contraceptive pills
the most suitable ocs for her
a-Levonorgestrel (or l-norgestrel or D-norgestrel)
b-ethinyle estradiol
**
502-pregnant hypertensive woman take
a-prazosine b-methyldopa c-propanolo
**
503-Iron deficiency anemia treated with.......》iron
**
**
**
**
**
**
**
A-Decrase
B- increase
C- no effect
D- increase then decrase
**
A/ shift to phenytoin
B/ shift to carbamazepine
C/ take clozapine
D/ keep using oxycarbamazipine
**
A/ estrogen B/ progesterone
**
**
**
515-Definition of half-life(t1/2)
Time it takes for the plasma concentration or the amount of drug in the
body to be reduced نصف الفترة من بعد اإمتص صby 50%
**
**
517- patient take 4 drugs .. he did kidney function test and the result
was high serum cr and high BUN ( blood urea nitrogen)and high
potassium serum level so which drug should be stopped
**
d.do nothing
**
**
**
522-Influenza vaccine in pregnancy is?
Safe
(IIV) Inactivated influenza vaccine is safe for pregnant
**
clonidin or probranolol
**
524 - An elderly man around 60 years old , complain from polyuria , dry
mouth .. there is no family history of diabetes .. he has done a lab tests
and the results were positive for disbetes .. initial treatment should be !
metformin
**
Note :
Erythropoietin treat anemia induced by CRF by increasing the number of
new red blood cells your body .
**
526- Patients with ulcerative colitis ttt on cortisone and mesalazin must
use what?
if Colitis & Cortison …………….>> the answer is Ca
if Colitis only………..>> the answer is vit b12
**
**
528- month-old baby with a history of premature birth and chronic lung
disease is admitted to the pediatric intensive care unit with respiratory
distress requiring intubation; fever; and a 3-day history of cold-like
symptoms. A nasal swab is positive for RSV. Which one of the following
is the best intervention?
A. Palivizumab.
B. Corticosteroids.
C. Cefuroxime.
D. Intravenous fluids and supportive care
529 - Pregnant woman with G6PD deficiency has G-ve. M.o. and UTI,
which is the drug of choice to treat her UTI:
A-vancomycine B-nitrofurantoin
C-cefuroxime D-sulphamethoxazole
**
**
**
a-b12 b- b9 c - b6 d - b1
**
**
**
**
**
**
**
552- daily dose of iron in iron defficency anemia is .......... 100 mg 3 times
daily
**
553- mechanism of action of domperidone & doxazocin
Domperidone has peripheral dopamine receptor blocking properties
(dopamine antagonist) and does not readily cross the blood-brain
barrier.
Doxazosin Competitively inhibits postsynaptic alpha1-adrenergic
receptors.
**
554- BPH is worsen by ...................... anticholinergic drugs
**
555- mechanism of action of benzodiazepine..............GABA agonist
**
556- drugs that physician should care when using it .........
a-low safty drugs b- low therapeutic index
**
557- First-Pass Effect
a. Blood that perfuses virtually all the gastrointestinal tissues passes
through the liver by means of the
hepatic portal vein.
b. Fifty percent of the rectal blood supply bypasses the liver (middle and
**
**
561-.toxiderm meaning:
A.the toxin that cause syndrome
B.the signs and symptoms of toxcity syndrome
C.the causes of the syndrome made by toxin
D.the syndromes caused by toxin
**
**
A.Betaxolo
B.timolol
C- acebutalol
D-propranolol
Copyright https://www.facebook.com/groups/pearsonvue.questions Page 87
•Betaxolol selective Beta-1 blocker
•Timolol is non selective Beta blocker
**
A .1/k
B . 0.693 k
**
**
2.decrease c.o.p
**
a) decrease C.O.P.
**
a) take alendronate 1/2 hour before breakfast and stand upright for 1/2
hour
c) take alendronate 1/2 hour before breakfast with water and stand
upright for 1/2 hour
**
569-A 39 years old what is oral birth control pills appropriate for her
A-Levonorgestrel
B-Ethinyl estradiol/lnestrenol
C- lynestrenol/norethisterone
D-medroxyprogesterone (depot contraceptive)
**
**
573- If a drug is eliminated by first order elimination, what determines
when will it reach steady state?
a) Dose interval b) Elimination rate c) Drug dose D) t(1/2)
half life
**
574-A drug induces Water retention
a.indomethacin b-Verapamil c-Atenolol
**
575-Bioavailbility Area under the curve
**
576-MOA of Fluoxetine selective serotonin reuptake inhibitor (SSRI)
**
577- Relief pain due to MI (Myocardial Infarction)
A.Morphine B. Ibuprofen C- Benzodiazepine
Copyright https://www.facebook.com/groups/pearsonvue.questions Page 90
**
578- Which of the following show penicillinase resistance
a-Penicillin v b-Flucloxacillin (floxacillin)
c-amoxicillin d- Augmentin
**
579-the recommended maximum adult daily dose of paracetamol
A-2500 mg B- 3500 mg C-4000mg
**
580- Pregnant woman has vaginal discharge and has Candida albicans
what's the drug of choice?
A-Acyclovir b-Clotrimazole c-Tetracycline d-
Fluconazole
**
581-Low denisty lipoprotein(LDL)act as:
A- carrier cholesterol in plasma
B-transport fatty acid
C- good lipoprotein
**
**
582-A drug with narrow therapeutic index
A -Quinidine B-Procainamide C-Phenytoin
**
583- Which of the following drugs are considered drugs dependence in
normal dose???
a- Valproate b-phenytoin
c-fluxetine (Prozac) d-quindine
**
585- A patient with iron deficiency anemia refused to take any parenteral
drugs
give him
a-ferrous gluconate b- Iron sucrose c–Other
choices
**
586-which drug has the rapid effective action in esophageal burn and
acidity
A-omeprazole
B- magnesium/aluminum hydroxide
c - Other choices
**
587- Studies in which data collected from different studies
A-double blind B-systematic review C-other choices
**
**
Note :
**
a- Anxiolytic b-Antiepileptic
c- Ant Parkinsonism d-anti-psychotic
**
**
592-A patient who is taking sevelamer drug means that he/she suffers
from
a-hyper phosphatemia
b--hyper calcemia
c-hyper magnesiumea
**
593-Mg antacid for patient with renal failure the antacid will cause
Copyright https://www.facebook.com/groups/pearsonvue.questions Page 93
a- .increase the absorption of Mg
b- decrease the abs of Mg
c-Increase the Elimination of Mg
d- decrease the Elimination Of Mg
**
a-Hemorrhage
b- Helicobacter pylori(H. pylori)
c-gastric ulcer
d-gastritis
**
a-warfarin
b-Heparin
c-onaxprine
d-streptokinase
**
**
a- chlorpheniramine b-metformin
c-reserpine d-clonidine
**
**
599-Dopamine causes:
**
A-taste
B-weight
C-physical appearance
D-Pharmacokinetic parameters
N.B: pharmacokinetics: It is the way that body deal with the drug
**
A-Mg hydroxide
B-Ca sulfate
C-Ca hydroxide
**
**
**
**
A.cephalosporin
b-Tetracycline
c-.neomycin
d-.erythromycin
**
**
N.B: Probiotics are live bacteria and yeasts that are good for health
**
**
**
**
A-shift to ethoxsumide
B-shift to topiramate
**
**
614-MOA of Labetalol
**
615-MOA of :(Isoprenaline)
Sympathomimetic
Bronchodilator Agents
Cardio tonic Agents
Adrenergic beta-Agonists
**
616- A drug Treats Bph by relaxation of bladder neck?
A-Terazocin
B-metolol
**
617- Decreases effect of phenytoin?
A-Isoniazid
b- Alcohol
**
618-Normal water is used for which of these preparations?
A-Ophthalmic
b- Oral solutions
c- Parenteral solutions
d- External preparations
**
619-Hydralazine acts on heart by:
a-relax cardiac muscle
b- Relax smooth muscle
N.B: hydralazine is a vasodilator (direct-acting) smooth muscle relaxant
works by relaxing blood vessels (arterioles more than venues) and
increasing the supply of blood and oxygen to the heart while reducing its
workload
**
620-Anti metabolite anti-cancer
A-vindesin(Vindesine is an anti-mitotic vinca alkaloid used in
chemotherapy )
B-Cyclophosphamide(an alkylating agent)
c-flurouracil
**
621- When taking MAOIs avoid food containing -- tyramine
**
622- A patient has megaloblastic anemia should receive?
B12 cobalt and b9 folic acid
**
623-A women takes estrogen and she made hysterectomy should take ?
A-testosterone
b-hydroxyprogestrone
**
**
625-the aminoglycoside? Antibiotic
**
626-which of the following true?
ACEi cause dry cough
**
627-Aspartame is added to some preparation as
a-Nutrients
B-sweeting agent
C-flavor
D-preservative
**
628- Drug of choice for hemolytic anemia?
a-Enoxaprin-
B-Cortisone
c-antibiotic
**
629- Toxidrome meaning:
A-poison induced toxicity syndromes
B- physical signs and symptoms due to specific toxicity syndrome
C-the causes of the syndrome made by toxin
**
630-.rapid relief of acidity...Al hydroxide
**
631-.case has pain and solid tumor... Oral contraceptives
N.B:
- hormone therapy " e.g . oral contraceptive pills" are used to treat
endometriosis-associated pain and they are effective.
- Danazol can be used but it isn't the first choice because it can cause
serious side effects and can be harmful to the baby if the patient become
pregnant while taking this medication.
- Progestins have a more favorable side effect profile than danazol.
- surgery is the last resort and is recommended if the patient planning for
pregnancy
**
**
634-case 12_years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethoxsumide B-shift to topiramate
**
635- a pregnant woman in her third week she take levothyroxine 100 mcg
, you advise her :
a) stop the medication immediately
b) increase the dose of levothyroxine
c) ask the prescriber to change the medication
d) continue using the medication as prescribed
**
636) The lowest in potency
a)Dexamethasone b)Triamcinolon c)Hydrocortisone
d)Betamethasone
**
637-The ability of liquid to dissolve in another liquid is called
A- Solubility equilibrium
**
638-ACEI role in CHF
A.alpha 1 blocker
B.block ca influx to cells
C.prevent ventricular remodeling
D.cannot remember but wasnot related to angiotensin
**
639-.dispyramide as anti arrhythmia:
A.dec. phase 0
B.inc. phase 0
C.dec. phase 3
D.inc phase 3
**
640-.drug interact with statin:
A . aspirin
B Ketoconazole
C-Carvedilol
**
641-. vitamins prevent fetus abnormalities. .
A.iron
B.ca
C.vit a
D.vit b9
**
642-antiestrogen cause abortion..>> anastrozole
- antiesterogen used in breast cancer>> .. tamoxifen
**
643-.Antiprogesterone cause abortion.. Mifepristone
**
644-.Drug known to cause kidney injury
A.Thiazide
B. Aminoglycoside
N.B:
1-The most common medicines known to cause drug-induced lupus are:
• Isoniazid.
• Hydralazine.
• Procainamide.
2- lupus is any of various diseases or conditions marked by inflammation
of the skin, especially lupus vulgaris or lupus erythematosus
**
**
a-increase LDL
b-decrease HDL
c- Increase efficiency of lipoprotein removal
d-decrease LDL
a- nicotinamide
b_ fibrate ( Fenofibrates (gemfebrozil) acts on Triglycerides
**
A.benzodiazepenes
B.fluxetin
**
**
A . clopidogril
B.streptokinas
C.altepase
D.enoxaprin
**
**
Copyright https://www.facebook.com/groups/pearsonvue.questions Page 103
655- beta blocker used in angina because ...
**
**
**
A-bumetanide
B-hydrochlorothiazide
**
**
**
**
a- vit. A
b- vit. D
c- vit. C
d- vit. B12
**
**
**
a- hydrochlorothiazide
b- ramipril
c- nifidipine
**
**
**
**
A-Decrase
B- increase
C- no effect
D- increase then decrase
**
A-Decrase
B- increase
C- no effect
D- increase then decrase
**
a)Hypokalemia
b)Hyperkalemia
c)Hypocalcemia
**
**
**
**
**
**
a-increase gaba
b-increase reuptake of amine at synaptic
c-decrease reuptake of amine at synaptic
**
690-uses of promethazine:
**
a- hydrochlorothiazide
b-bumetamide
c-triamterene
**
**
**
**
**
**
A-kcl
B-one of h1 blocker,
C-don’t remember
**
1-low temperature
2-weight gain
3-cushing syndrome
**
•LPL is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG)
core of circulating TG-rich lipoproteins, chylomicrons, and very low-
density lipoproteins (VLDL).
Low density lipoproteins (LDLs) carry cholesterol from the liver to body
cells.
**
1-omeprazole
2-pantoprazole
3-esomprazole
**
A-sterile
B-purified
d- isotonic
**
**
a.Ciprofloxacin
b.Rituximab
**
a.phenytoin
b.lidocaine
c.procainamide
**
a- Paracetamol.
b- Ketoconazole.
c- Rifampicin.
d- Quinolones.
Important Notes :
A, aa., or aa = of each
dil = dilute
ad = to, up to
D.C.,dc, or disc. = discontinue
a.d. = right ear
a.s. = left ear
a.u. = each ear, both ears
o.d. = right eye
o.I. or o.s. = left eye
o.u. = each eye, both eye
disp. = dispense
ad lib = At pleasure freely
div. = divide, to be divided
d.t.d. = give of such doses
aq. = water
DW= distilled water
D5W= dextrose% in water
asa = aspirin
e.m.p. = as directed
et = and
ex aq. = in water
BP = British pharmacopeia
BSA = body surface area
c.or c = with
ft = make
amp. = ampoule
cap or caps = capsule
Inj. = injection
IM =intramuscular
Copyright https://www.facebook.com/groups/pearsonvue.questions Page 112
IV = intervenes
Pulv. = powder
Gtt or gtt = drop, drops
elix = elixir
comp. = compound, compounded
g or GM =gram
gr or gr = grain
gal = gallon
Cc or cc. cubic centimeter
oz. = ounce
M2 or m2 = square meter
μl or μL = microlitre
Mcg, mcg or μg = microgram
I or L = liter
Lb = pound
mEq = milliequivalent
mg = milligram
ml or Ml = milliliter
fl or fld = fluid
fl oz = fluid ounce
dl or dL = deciliter
cp = chest pain
D.A.W. described as written
GI = gastrointestinal
Non rep. = do not repeat
H = hypodermic
NPO = nothing by mouth
N.S., NS = normal saline
½ NS = half-strength normal saline
O = pint
IVP = intervenous push
IVPB = intervenous piggyback
OTC = over the counter
K =POTASSIUM
PDR = Physicians, Desk Reference
μ = Greek mu
M = mix
Ppt = precipitated
p.o. = by mouth
Pr = for rectum
Pv = vagenal use
Prn or p.r.n. = as needed
Pt. = pint
N & V = nausea & vomiting
N.F. = National formulary
**
Don’t Forget to Study the other Files (Cases &Calculations)
GOOD LUCK