Heneghan 2020
Heneghan 2020
Heneghan 2020
Rationale
The current COVID-19 pandemic has highlighted the risk faced by older adults, who are
more susceptible to complications, including acute respiratory distress syndrome,
usually as a result of pneumonia. Comorbidities, impaired immunity and frailty,
including a reduced ability to cough and to clear secretions from the lungs, can all
contribute to this complication. Older people are therefore more likely to develop
severe pneumonia, suffer from respiratory failure, and die.
Viruses are thought to cause about 50% of cases of pneumonia. Viral pneumonia is
generally less severe than bacterial pneumonia but can act as a precursor to it.
Preventing any pneumonia in older adults is preferable to treating it.
Identification of the early stages of pneumonia in older patients can prove difficult.
Traditional symptoms and signs, including fever, may be absent. Limited evidence
suggests that many tests that are useful in younger patients do not help diagnose
infections in older adults. The onset of pneumonia in elderly people can often be
rapid, and the prognosis is poor in severe pneumonia: as many as one in five will die.
The older you are, the more prevalent severe pneumonia becomes.
Patients in nursing homes appear to fare even worse, as they often have several
comorbidities and poor nutritional status and are often physically inactive. [5] In-
hospital mortality is significantly higher, even after adjusting for age and sex.
Older patients may have polymicrobial infections, which could be a factor in those who
do not respond to initial antimicrobial treatment. Sputum cultures are often not
1
Oxford COVID-19 Evidence Service
Assessment of 12,945 US Medicare in-patients with pneumonia, aged over 65, showed
that initial treatment with a second-generation cephalosporin plus a macrolide, or a
non-antipseudomonal third-generation cephalosporin plus a macrolide, or a
fluoroquinolone alone lowered 30-day mortality. And an analysis of 101 patients aged
> 75 (mean and SD, 82 ± 5.5) admitted to an intensive care unit reported significantly
higher mortality in those who received inadequate antimicrobial therapy (39% versus
4%; P = 0.007).
Amoxicillin with 500 mg 3 times a day (higher doses can be used – see BNF) for 5 days
Alternative oral antibiotics for penicillin allergy, if the pneumonia is of moderate intensity; treatment
should be guided by microbiological results when available
Doxycycline with 200 mg on the first day, then 100 mg once a day for a further 4 days (5-day
course in total)
2
Oxford COVID-19 Evidence Service
The intensity of pneumonia in the community can be assessed using the CRB65 score;
each factor scores one point:
● confusion (abbreviated Mental Test score 8 or less, or new disorientation in
person, place, or time);
● a raised respiratory rate (30 breaths per minute or more);
● a low blood pressure (diastolic 60 mmHg or less, or systolic less than 90
mmHg);
● age 65 years or over.
Score 1 or 2: intermediate risk (1-10% mortality risk).
Score 3 or 4: high risk (more than 10% mortality risk).
NICE recommends that anyone with a score of 2 should be admitted to hospital. NICE’s
approach, however, doesn’t account for the high risk in very elderly people. The
mortality rate from COVID-19 approaches 15% at age 80 (Figure 1).
Current NICE guidance requires starting antibiotic treatment as soon as possible after
establishing a diagnosis of community-acquired pneumonia, and certainly within 4
hours. This strategy is supported by the results of a US multicenter retrospective
cohort study, a medical record review of 14,069 patients aged over 65 years and
hospitalized with pneumonia. A lower 30-day mortality was associated with antibiotic
administration within 8 hours of hospital arrival (odds ratio = 0.85; 95% CI = 0.75-
0.96).
However, this may not be possible within the constraints of an overstretched service in
a pandemic. If antibiotics have to be taken within 4 hours of onset, there needs to be
in place a self-management strategy that permits rapid access to the right
antimicrobial treatment. Nursing homes could hold stocks of antibiotics for rapid
3
Oxford COVID-19 Evidence Service
Examination strategy
The least amount of equipment that is clinically appropriate should be used to assess a
patient who might have COVID-19. This should include a pulse oximeter, a
thermometer, and a stethoscope. The ‘eyeball’ test, incorporating information on
temperature, oxygen saturation, and pulse rate, should be sufficient to assess severity
and cut down significantly on contact time. The absence of any individual chest
examination finding has little effect on the probability of diagnosing pneumonia.
Assessing blood pressure significantly increases contact time and should be considered
only in those in whom it contributes to the decision to admit or not. We recommend
documenting that a ‘limited examination’ was performed.
In assessing patients, carry antibiotics in a pre-sealed bag, to cut down entry and exit
times from the person’s home or nursing home.
4
Oxford COVID-19 Evidence Service
Oxygen
The use of oxygen in pneumonia is based on expert opinion. A Cochrane systematic
review of the effectiveness of oxygen in adults with pneumonia highlights that
the evidence is weak and limited owing to a small number of studies. The British
Thoracic Society suggests that for patients with pneumonia not at risk of hypercapnic
respiratory failure, it is appropriate to aim for an oxygen saturation of 94–98%. Very
elderly patients may tolerate an abnormally low SaO2 at rest when clinically stable;
however, COVID-19 pneumonia may significantly worsen SaO2. Access to oxygen
therapy will be challenging at the height of a pandemic.
Corticosteroids
In the initial phase of pneumonia, elderly patients can present with wheezing and
respiratory distress. It is not uncommon to consider corticosteroids at this stage,
because of their anti-inflammatory effects. Corticosteroids were widely used during
the 2002-3 SARS outbreak. However, in a subsequent systematic review, including 29
low quality studies of steroid use, 25 studies were inconclusive and four reported
possible harm from steroid use. A further evidence review did not support
corticosteroid treatment, reporting no evidence of net benefit with corticosteroids in
“respiratory infection due to RSV, influenza, SARS-CoV, or MERS-CoV”, and that
corticosteroids probably impair clearance of SARS-CoV. In contrast to pneumonia,
corticosteroids show much clearer benefit in patients with sepsis.
Conclusions
Interventions that affect mortality in pneumonia are of great significance for public
health, particularly during the current pandemic. Rescue prescribing strategies,
initiated by the patient at an early stage, could aid effective delivery of antimicrobials,
significantly reduce hospital admissions, and reduce mortality. While reducing
antimicrobial resistance should remain a global priority, the current pandemic
5
Oxford COVID-19 Evidence Service
highlights the need for unprecedented management strategies. For example, in the
current context, it may be entirely appropriate for nursing homes to have routine
stockpiles of antibiotics, allowing rapid and appropriate prescribing decisions that
could minimize morbidity and mortality, as well as reducing the impact of the
pandemic on health services. Rapid interventions like this could be life-saving. A UK
strategy of prospectively self isolating those over 70 is being considered. In this
context, equipping patients with rescue antibiotics may be a legitimate strategy to
consider. In patients with few physiological reserves, there is no room for error, and
providing the right initial treatment, and rapidly, matters.
Disclaimer: the article has not been peer-reviewed; it should not replace individual
clinical judgement and the sources cited should be checked. The views expressed in
this commentary represent the views of the authors and not necessarily those
of the host institution, the NHS, the NIHR, or the Department of Health. The
views are not a substitute for professional medical advice.
Competing Interests
6
Oxford COVID-19 Evidence Service
The views expressed in this commentary represent the views of the authors
and not necessarily those of the host institution, the NHS, the NIHR, or the
Department of Health. The views are not a substitute for professional medical
advice.