Pharmaceutics Exam 2 - This Semester
Pharmaceutics Exam 2 - This Semester
Pharmaceutics Exam 2 - This Semester
5. Which of the following theories of emulsification predicts that an emulsifier molecule having
a greater hydrophilic than hydrophobic character will promote an o/w emulsion
a. Surface tension theory
b. Oriented wedge theory
c. Platic theory
d. Interfacial film theory
e. Percolation theory
8. Using cocoa butter as the base, how much cocoa butter is neeed to prep 12 suppositories
contanign phenoarbital 150mg/each? Using the same mold, a cocoa butte blank suppo weight 2
g. the esnity of coaoe butter is 0.9 g/mL. the ensity of phenol is 1.08 g/mL
ANS. 22.5 g
9. Prepare suppositories of a drug using cocoa butter: each contains 10% w/w of the drug with a
cocoa butter dosage replacement factor (f) of 0.3. The mold can prepare blank cocoa butter
suppository of 2.0 g. How much cocoa butter should be added to each medication suppository?
ANS. 1.94 g.
11. A satisfactory suppository base must meet all of the following criteria except:
a. it should melt or dissolve at body temp
b. it should dissolve or melt rapidly in body cavity
c. it should be nonirritating and nonsensitizing
d. it should have low viscosity after melt or dissolved
e. it should be inert
12. The following factors can significanctly affect drug absoprotion from a rectal supp, except:
a. rectal mucus condition
b. rectal wall motility
c. rectal glui volume
d. rectal ph of fluid
e. position of sup in rectum
15. During the drug release and systemic absorption of a hydrophobic drug from a PEG based
suppository, the following processes are critical, EXCEPT
a. Melting
b. Sediment
c. Wetting
d. Dissolving
e. Partition
17. When evaporated to dryness, Purified Water USP must not yield more than
a. 1% of solid residue
b. 0.1% of solid residue
c. 0.01% of solid residue
d. 0.001% of solid residue
e. 0.0001% of solid residue
19. The following water purification methods can prepare Water for Injections, USP EXCEPT
a. Distillation
b. Ion exchange
c. Reverse Osmosis
d. Double step distillation
e. Multi step distillation
21. Which of the following dosage forms is used for external only?
a. Collodion
b. Aromatic water
c. Diluted acid
d. Tincture
e. Syrup
23. For adult, the ethanol content limit for oral OTC solution products is:
a. 0.05%
b. 0.5%
c. 1.5%
d. 5%
e. 10%
25. A 3/8 inch long, 25 guage needle is the most suitable for:
a. Intradermal injection
b. Intramuscular injection
c. Intravenous injection
d. Intrathecal injection
e. Intraspinal injection
32. The following in solution/vehicle can be use for neonates, EXCEPT: bacteriostatic NaCl inj,
USP
33. The following are antibacterial agents for parenteral preparation, EXCEPT:
a. Phenylmercuric nitrate
b. Butylated hydroxyanisole
c. Thimerosal
d.Benzethonium chloride
e.Chlorobutanol
34. Which of the following areas has the cleanest air? Certified federal class 100 clean room in a
hospital pharmacy
36. Which of the following procedures has the correct sequence to prep a thermal stable inj
solution? Dissolve in water for inj, filtration, filling to vials, sterilization, pyrogen particle, and
sterile testing.
37. Which of the following modification of insulin injection can increase the absorption rate and
decrease the duration of action?
a. Change the protein structure by a single substitute at the Pro28 (the position of praline)
on the B chain by Asp28 (aspartic acid)
b. Change the formulation by adding certain amounts or protamine
c. Adjust pH value close to 7.2
d. Change the dosage form from solution to suspension
e. Increase the crystal size in a suspension preparation
38. Ringer’s in, USP contaisn the following ions, except? Phosphate.
39. A central venous route such as superior vena cava must be used for total parenteral nutrition
administration, when:
a. the osmolarity of a intravenous solution is higher than 1000 mOsm/L
b. the volume of the solution is larger than 1 liter
c. the dextrose concentration is higher than 0.9% (w/v)
d. the solution contains more than 5% of lactose (w/v)
e. the solution contains particles
40. If another pharmaceutical company produce a new insulin product that is similar to Humulin
N an approvde by FDA. It can be called as follow on protein