MCQ Transdermal Drug Delivery
MCQ Transdermal Drug Delivery
MCQ Transdermal Drug Delivery
1.
Trans dermal drug delivery systems systems offer the following advantages, choose the
correct statements from below,
[1]: They produce high peak plasma concentration of the drug
[2]: They produce smooth and non fluctuating plasma concentration of the drug
[3]: They minimise inter individual variations in the achieved plasma drug concentration
[4]: They avoid hepatic first-pass metabolism of the drug
4, 2, 3
Alternative routes of administration like suppository, intravenous, intramuscular, inhalational aerosol, transdermal, and
sublingual avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.
2. Match List-I (Type) with List-II (Method)and select the correct answer using the codes
given below the lists:
List I List II
(e) Causes a slow fall in plasma fentanyl concentrations after its removal, because of skin deposition.
Explanation: The active delivery of fentanyl means that the mean time to peak fentanyl serum
concentration is greatly reduced: being only 39 min in one study. After discontinuation of fentanyl
PCA, plasma concentrations decrease at a rate similar to that following i.v. administration,
suggesting that there is no development of a skin depot. The fentanyl ITS system has been shown to
be superior to placebo in randomized controlled trials. (Power I. Fentanyl HCliontophoretic
transdermal system (ITS): clinical application of iontophoretic technology in the management of
acute postoperative pain. Br J Anaesth 2007; 98: 4–11)