Unwinding the twister ribozyme: from structure to mechanism
J Gebetsberger, R Micura - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
The twister ribozyme motif has been identified by bioinformatic means very recently.
Currently, four crystal structures with ordered active sites together with a series of chemical …
Currently, four crystal structures with ordered active sites together with a series of chemical …
Mechanistic debris generated by twister ribozymes
RR Breaker - ACS chemical biology, 2017 - ACS Publications
Twister RNAs represent a recently discovered class of natural ribozymes that promote rapid
cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and …
cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and …
Crystal structure and mechanistic investigation of the twister ribozyme
We present a crystal structure at 2.3-Å resolution of the recently described nucleolytic
ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a …
ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a …
Cleaning up mechanistic debris generated by twister ribozymes using computational RNA enzymology
CS Gaines, TJ Giese, DM York - ACS catalysis, 2019 - ACS Publications
The catalytic properties of RNA have been a subject of fascination and intense research
since their discovery over 30 years ago. Very recently, several classes of nucleolytic …
since their discovery over 30 years ago. Very recently, several classes of nucleolytic …
Pseudoknot formation seeds the twister ribozyme cleavage reaction coordinate
N Vusurovic, RB Altman, DS Terry… - Journal of the …, 2017 - ACS Publications
The twister RNA is a recently discovered nucleolytic ribozyme that is present in both bacteria
and eukarya. While its biological role remains unclear, crystal structure analyses and …
and eukarya. While its biological role remains unclear, crystal structure analyses and …
Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme
D Eiler, J Wang, TA Steitz - Proceedings of the National …, 2014 - National Acad Sciences
Twister is a recently discovered RNA motif that is estimated to have one of the fastest known
catalytic rates of any naturally occurring small self-cleaving ribozyme. We determined the 4.1 …
catalytic rates of any naturally occurring small self-cleaving ribozyme. We determined the 4.1 …
The novel chemical mechanism of the twister ribozyme
TJ Wilson, Y Liu, C Domnick… - Journal of the …, 2016 - ACS Publications
We describe the multifactorial origins of catalysis by the twister ribozyme. We provide
evidence that the adenine immediately 3′ to the scissile phosphate (A1) acts as a general …
evidence that the adenine immediately 3′ to the scissile phosphate (A1) acts as a general …
Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage
The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent
discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal …
discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal …
Molecular Dynamics Study of Twister Ribozyme: Role of Mg2+ Ions and the Hydrogen-Bonding Network in the Active Site
The recently discovered twister ribozyme is thought to utilize general acid–base catalysis in
its self-cleavage mechanism, but the roles of nucleobases and metal ions in the mechanism …
its self-cleavage mechanism, but the roles of nucleobases and metal ions in the mechanism …
In-line alignment and Mg2+ coordination at the cleavage site of the env22 twister ribozyme
A Ren, M Košutić, KR Rajashankar, M Frener… - Nature …, 2014 - nature.com
Small self-cleaving nucleolytic ribozymes contain catalytic domains that accelerate site-
specific cleavage/ligation of phosphodiester backbones. We report on the 2.9-Å crystal …
specific cleavage/ligation of phosphodiester backbones. We report on the 2.9-Å crystal …