RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes
R Micura, C Höbartner - Chemical Society Reviews, 2020 - pubs.rsc.org
This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
ZX Liu, S Zhang, HZ Zhu, ZH Chen, Y Yang, LQ Li… - Science, 2024 - science.org
Ribozymes are catalytic RNAs with diverse functions including self-splicing and
polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and …
polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and …
Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes
Highlights•Small self-cleaving ribozymes are essential for rolling-circle-based replication of
satellite and pathogenic RNAs.•Structure–function research on active site alignments and …
satellite and pathogenic RNAs.•Structure–function research on active site alignments and …
High‐throughput mutational analysis of a twister ribozyme
S Kobori, Y Yokobayashi - Angewandte Chemie International …, 2016 - Wiley Online Library
Recent discoveries of new classes of self‐cleaving ribozymes in diverse organisms have
triggered renewed interest in the chemistry and biology of ribozymes. Functional analysis …
triggered renewed interest in the chemistry and biology of ribozymes. Functional analysis …
1-Deazaguanosine-modified RNA: The missing piece for functional RNA atomic mutagenesis
R Bereiter, E Renard, K Breuker, C Kreutz… - Journal of the …, 2022 - ACS Publications
Atomic mutagenesis is the key to advance our understanding of RNA recognition and RNA
catalysis. To this end, deazanucleosides are utilized to evaluate the participation of specific …
catalysis. To this end, deazanucleosides are utilized to evaluate the participation of specific …
Elucidation of catalytic strategies of small nucleolytic ribozymes from comparative analysis of active sites
DD Seith, JL Bingaman, AJ Veenis, AC Button… - ACS …, 2018 - ACS Publications
A number of small, self-cleaving ribozyme classes have been identified including the
hammerhead, hairpin, hepatitis delta virus (HDV), Varkud satellite (VS), glmS, twister …
hammerhead, hairpin, hepatitis delta virus (HDV), Varkud satellite (VS), glmS, twister …
Metals induce transient folding and activation of the twister ribozyme
Twister is a small ribozyme present in almost all kingdoms of life that rapidly self-cleaves in
variety of divalent metal ions. We used activity assays, bulk FRET and single-molecule FRET …
variety of divalent metal ions. We used activity assays, bulk FRET and single-molecule FRET …
Structural and biochemical properties of novel self-cleaving ribozymes
KY Lee, BJ Lee - Molecules, 2017 - mdpi.com
Fourteen well-defined ribozyme classes have been identified to date, among which nine are
site-specific self-cleaving ribozymes. Very recently, small self-cleaving ribozymes have …
site-specific self-cleaving ribozymes. Very recently, small self-cleaving ribozymes have …
Unwinding the twister ribozyme: from structure to mechanism
J Gebetsberger, R Micura - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
The twister ribozyme motif has been identified by bioinformatic means very recently.
Currently, four crystal structures with ordered active sites together with a series of chemical …
Currently, four crystal structures with ordered active sites together with a series of chemical …