ZA200706029B - Tricyclic &-opioid domulators - Google Patents

Tricyclic &-opioid domulators

Info

Publication number: ZA200706029B
Authority: ZA; South Africa
Prior art keywords: tricyclic; opioid; domulators; modulators; pharmaceutical
Prior art date: 2004-12-22

Application number

ZA200706029A

Other languages

English (en)

Inventor

Steven J Coats

Decorte Bart

Mcdonnell Mark

Scott L Dax

Liu Li

James J Mcnally

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-22

Filing date

2007-07-20

Publication date

2008-12-31

2007-07-20 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2008-12-31 Publication of ZA200706029B publication Critical patent/ZA200706029B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lock And Its Accessories (AREA)
Credit Cards Or The Like (AREA)
Electroluminescent Light Sources (AREA)
Semiconductor Lasers (AREA)
Oscillators With Electromechanical Resonators (AREA)

ZA200706029A 2004-12-22 2007-07-20 Tricyclic &-opioid domulators ZA200706029B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63831504P	2004-12-22	2004-12-22

Publications (1)

Publication Number	Publication Date
ZA200706029B true ZA200706029B (en)	2008-12-31

Family

ID=36481352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200706029A ZA200706029B (en)	2004-12-22	2007-07-20	Tricyclic &-opioid domulators

Country Status (17)

Country	Link
US (3)	US7439239B2 (es)
EP (1)	EP1833826B1 (es)
JP (1)	JP2008525482A (es)
KR (1)	KR20070092293A (es)
CN (1)	CN101115751A (es)
AT (1)	ATE432279T1 (es)
AU (1)	AU2005319060A1 (es)
BR (1)	BRPI0518563A2 (es)
CA (1)	CA2591963A1 (es)
DE (1)	DE602005014671D1 (es)
EA (1)	EA011674B1 (es)
IL (1)	IL184064A0 (es)
MX (1)	MX2007007626A (es)
NI (1)	NI200700163A (es)
NO (1)	NO20073776L (es)
WO (1)	WO2006069276A2 (es)
ZA (1)	ZA200706029B (es)

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UA86024C2 (ru)	2003-06-27	2009-03-25	Янссен Фармацевтика Н.В.	Трициклические дельта-опиоидные модуляторы
WO2007030089A1 (en) *	2004-08-05	2007-03-15	Janssen Pharmaceutica N.V.	Tricyclic delta- opioid modulators
BRPI0519201A2 (pt) *	2004-12-22	2008-12-30	Janssen Pharmaceutica Nv	moduladores de delta-opiàide tricÍclico
CA2592462A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
CA2591963A1 (en)	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic o-opioid modulators
CN101128460A (zh) *	2005-01-06	2008-02-20	詹森药业有限公司	三环的δ-阿片样物质调节剂
AU2006259273A1 (en) *	2005-06-16	2006-12-28	Janssen Pharmaceutica N.V.	Tricyclic opioid modulators
EP1924559B1 (en)	2005-07-21	2014-04-16	Rensselaer Polytechnic Institute	8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents
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CA2779108C (en) *	2009-10-30	2018-01-02	Janssen Pharmaceutica Nv	4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
IT1396951B1 (it) *	2009-12-18	2012-12-20	Neuroscienze Pharmaness S C A R L	Composti farmaceutici
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US10836757B1 (en)	2020-04-02	2020-11-17	Neurogastrx, Inc.	Polymorphic forms of metopimazine
CN114236024B (zh) *	2021-12-07	2023-12-29	江苏宝众宝达药业股份有限公司	一种同时测定4-氟-3-硝基苯腈及其异构体含量的方法
CN114334022B (zh) *	2021-12-31	2022-11-18	杭州剂泰医药科技有限责任公司	一种化合物分子的溶解度预测模型及应用

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UA86024C2 (ru) *	2003-06-27	2009-03-25	Янссен Фармацевтика Н.В.	Трициклические дельта-опиоидные модуляторы
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WO2007030089A1 (en)	2004-08-05	2007-03-15	Janssen Pharmaceutica N.V.	Tricyclic delta- opioid modulators
DE102004055057A1 (de) *	2004-11-15	2006-05-24	Infineon Technologies Ag	Ausgangsschaltung
CA2592462A1 (en)	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
BRPI0519201A2 (pt)	2004-12-22	2008-12-30	Janssen Pharmaceutica Nv	moduladores de delta-opiàide tricÍclico
CA2591963A1 (en)	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic o-opioid modulators
CN101128460A (zh)	2005-01-06	2008-02-20	詹森药业有限公司	三环的δ-阿片样物质调节剂
AU2006259273A1 (en)	2005-06-16	2006-12-28	Janssen Pharmaceutica N.V.	Tricyclic opioid modulators

2005
- 2005-12-21 CA CA002591963A patent/CA2591963A1/en not_active Abandoned
- 2005-12-21 AT AT05855276T patent/ATE432279T1/de not_active IP Right Cessation
- 2005-12-21 US US11/313,635 patent/US7439239B2/en not_active Expired - Fee Related
- 2005-12-21 DE DE602005014671T patent/DE602005014671D1/de active Active
- 2005-12-21 AU AU2005319060A patent/AU2005319060A1/en not_active Abandoned
- 2005-12-21 EP EP05855276A patent/EP1833826B1/en active Active
- 2005-12-21 EA EA200701355A patent/EA011674B1/ru not_active IP Right Cessation
- 2005-12-21 WO PCT/US2005/046691 patent/WO2006069276A2/en active Application Filing
- 2005-12-21 BR BRPI0518563-7A patent/BRPI0518563A2/pt not_active IP Right Cessation
- 2005-12-21 JP JP2007548493A patent/JP2008525482A/ja not_active Withdrawn
- 2005-12-21 MX MX2007007626A patent/MX2007007626A/es unknown
- 2005-12-21 KR KR1020077016697A patent/KR20070092293A/ko not_active Application Discontinuation
- 2005-12-21 CN CNA2005800479922A patent/CN101115751A/zh active Pending
2007
- 2007-06-19 IL IL184064A patent/IL184064A0/en unknown
- 2007-06-22 NI NI200700163A patent/NI200700163A/es unknown
- 2007-07-19 NO NO20073776A patent/NO20073776L/no not_active Application Discontinuation
- 2007-07-20 ZA ZA200706029A patent/ZA200706029B/xx unknown
2008
- 2008-10-09 US US12/248,150 patent/US7652005B2/en not_active Expired - Fee Related
2009
- 2009-11-20 US US12/622,548 patent/US20100093709A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090042871A1 (en)	2009-02-12
EP1833826B1 (en)	2009-05-27
US7652005B2 (en)	2010-01-26
CA2591963A1 (en)	2006-06-29
MX2007007626A (es)	2008-01-28
KR20070092293A (ko)	2007-09-12
WO2006069276A2 (en)	2006-06-29
BRPI0518563A2 (pt)	2008-11-25
EP1833826A2 (en)	2007-09-19
ATE432279T1 (de)	2009-06-15
IL184064A0 (en)	2007-10-31
US20060135763A1 (en)	2006-06-22
US7439239B2 (en)	2008-10-21
WO2006069276A3 (en)	2006-08-10
NI200700163A (es)	2008-02-04
US20100093709A1 (en)	2010-04-15
AU2005319060A1 (en)	2006-06-29
EA011674B1 (ru)	2009-04-28
NO20073776L (no)	2007-09-21
EA200701355A1 (ru)	2008-02-28
JP2008525482A (ja)	2008-07-17
CN101115751A (zh)	2008-01-30
DE602005014671D1 (de)	2009-07-09

Publication	Publication Date	Title
ZA200706029B (en)	2008-12-31	Tricyclic &-opioid domulators
TW200716134A (en)	2007-05-01	Tricyclic opioid modulators
UA86024C2 (ru)	2009-03-25	Трициклические дельта-опиоидные модуляторы
TW200716546A (en)	2007-05-01	Oxindole compounds and their uses as therapeutic agents
GEP20074197B (en)	2007-09-10	5ht2c receptor modulators
TW200724543A (en)	2007-07-01	Heterocyclic compounds and their uses as therapeutic agents
TW200608979A (en)	2006-03-16	Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2005004818A3 (en)	2005-05-06	Heterocyclic compounds and their use as anticancer agents
TW200800976A (en)	2008-01-01	New compounds for the treatment of neurological, psychiatric or pain disorders
TW200531689A (en)	2005-10-01	Therapeutic agents
TNSN06403A1 (en)	2008-02-22	3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
EA200601212A1 (ru)	2006-10-27	Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
TW200608960A (en)	2006-03-16	3-aminocyclopentanecarboxamides as modulators of chemokine receptors
MXPA06003363A (es)	2006-06-08	Derivados de fenil-piperazina como moduladores de receptores muscarinicos.
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