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UY30641A1 - Derivados de 2-[1h-pirazol-5-il] y de 2-[2h-pirazol-3-il]tieno[3,2-c]piridinas sustituidas, sus sales farmaceuticamente aceptables y aplicaciones - Google Patents

Derivados de 2-[1h-pirazol-5-il] y de 2-[2h-pirazol-3-il]tieno[3,2-c]piridinas sustituidas, sus sales farmaceuticamente aceptables y aplicaciones

Info

Publication number
UY30641A1
UY30641A1 UY30641A UY30641A UY30641A1 UY 30641 A1 UY30641 A1 UY 30641A1 UY 30641 A UY30641 A UY 30641A UY 30641 A UY30641 A UY 30641A UY 30641 A1 UY30641 A1 UY 30641A1
Authority
UY
Uruguay
Prior art keywords
pirazol
pharmaceutically acceptable
acceptable salts
pyridins
derivatives
Prior art date
Application number
UY30641A
Other languages
English (en)
Inventor
Huifen Chen
Stephen Douglas Barrett
Kramer James Bernard
Mark Laurence Boys
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY30641A1 publication Critical patent/UY30641A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion proprciona compuestos de formula I, y sus sales farmacéuticamente aceptables, en la que R1, R2,R3, R4, R5, R6, y R7 tienen cualquiera de los valores definidos para ellos en la memoria descriptiva, y sus sales farmacéuticamente aceptables, que son utiles como agentes terapeuticos en el tratamiento de trastornos mediados por TGFB, incluyendo el cáncer y trastornos fibroticos. También se proporcionan composiciones farmacéuticas que comprenden uno o más compuestos de formula I.
UY30641A 2006-10-16 2007-10-12 Derivados de 2-[1h-pirazol-5-il] y de 2-[2h-pirazol-3-il]tieno[3,2-c]piridinas sustituidas, sus sales farmaceuticamente aceptables y aplicaciones UY30641A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85198206P 2006-10-16 2006-10-16

Publications (1)

Publication Number Publication Date
UY30641A1 true UY30641A1 (es) 2008-05-31

Family

ID=38962671

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30641A UY30641A1 (es) 2006-10-16 2007-10-12 Derivados de 2-[1h-pirazol-5-il] y de 2-[2h-pirazol-3-il]tieno[3,2-c]piridinas sustituidas, sus sales farmaceuticamente aceptables y aplicaciones

Country Status (16)

Country Link
US (5) US7964612B2 (es)
EP (2) EP2527345B1 (es)
JP (1) JP5443988B2 (es)
KR (1) KR20090066297A (es)
CN (1) CN101528752A (es)
AR (1) AR063318A1 (es)
AU (1) AU2007311560B2 (es)
CA (1) CA2666603C (es)
CL (1) CL2007002916A1 (es)
ES (2) ES2435430T3 (es)
IL (1) IL197750A0 (es)
MX (1) MX2009003157A (es)
NO (1) NO20091247L (es)
TW (1) TW200825094A (es)
UY (1) UY30641A1 (es)
WO (1) WO2008047198A1 (es)

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FR2949468B1 (fr) * 2009-08-28 2011-09-30 Sanofi Aventis Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique
DK2382215T3 (da) * 2008-12-29 2014-10-27 Sanofi Sa Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf
PT2382205E (pt) 2008-12-29 2014-07-28 Sanofi Sa Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, sua preparação e sua aplicação terapêutica como activadores de hif
FR2940652B1 (fr) * 2008-12-29 2011-02-11 Sanofi Aventis Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique
CA2758071C (en) * 2009-04-06 2018-01-09 Agios Pharmaceuticals, Inc. Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use
ES2618630T3 (es) 2009-06-29 2017-06-21 Agios Pharmaceuticals, Inc. Composiciones terapéuticas y métodos de uso relacionados
AR077292A1 (es) 2009-06-29 2011-08-17 Agios Pharmaceuticals Inc Derivados de piperazin - quinolin sulfonamidas y composiciones farmaceuticas
KR20130038224A (ko) * 2010-03-15 2013-04-17 가부시키가이샤 구라레 티에노피리딘 유도체 및 그 제조 방법, 그리고 그것을 사용한 유기 반도체 디바이스
JP5743418B2 (ja) * 2010-04-09 2015-07-01 Ｏａｔアグリオ株式会社 新規なピラゾール化合物、その製造方法及び有害生物防除剤
ES2770575T3 (es) 2010-10-28 2020-07-02 Pacira Pharmaceuticals Inc Formulación de liberación sostenida de un fármaco antiinflamatorio no esteroideo
PT2651951E (pt) 2010-12-16 2015-01-14 Hoffmann La Roche Compostos tricíclicos do inibidor pi3k e processos para a sua utilização
CA2821975A1 (en) 2010-12-17 2012-06-21 Shunqi Yan N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators
EP2655350B1 (en) 2010-12-21 2016-03-09 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
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PL3406251T3 (pl) 2011-05-03 2024-04-29 Agios Pharmaceuticals, Inc. Aktywatory kinazy pirogronianowej do stosowania w terapii
WO2012151440A1 (en) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
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CN102660253B (zh) * 2012-03-07 2014-05-21 泰山医学院 一种吡唑啉衍生物类Ni2+荧光探针及其应用
CA2894399A1 (en) 2012-12-06 2014-06-12 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
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WO2014202599A1 (en) * 2013-06-20 2014-12-24 Basf Se Process for preparing pyridylpyrazole compounds and derivatives thereof from pyridylhydrazine
EP4344703A1 (en) 2015-06-11 2024-04-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
US11541149B2 (en) 2015-12-11 2023-01-03 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patient specific tissue engineering vascular grafts
KR102434226B1 (ko) * 2016-06-30 2022-08-19 한미약품 주식회사 Alk5 억제제로서의 신규 피라졸 유도체 및 이의 용도
MX2019003684A (es) * 2016-09-30 2019-08-05 Intercept Pharmaceuticals Inc Formas cristalinas de un derivado de acido biliar.
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US20230303562A1 (en) * 2020-09-28 2023-09-28 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pyrazole compound and preparation method therefor and use thereof
IL308129A (en) * 2021-05-03 2023-12-01 Thirona Bio Inc Methods for treating lung disease with an ALK-5 inhibitor (TGF BETA R1)
WO2023212063A1 (en) * 2022-04-29 2023-11-02 Freeman John J Method and composition for treating lung diseases

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GB0102672D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
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Also Published As

Publication number Publication date
KR20090066297A (ko) 2009-06-23
NO20091247L (no) 2009-04-23
EP2527345A1 (en) 2012-11-28
US9260450B2 (en) 2016-02-16
US20080090861A1 (en) 2008-04-17
ES2559521T3 (es) 2016-02-12
US20160200735A1 (en) 2016-07-14
US7964612B2 (en) 2011-06-21
US20110224251A1 (en) 2011-09-15
WO2008047198A1 (en) 2008-04-24
US20140031385A1 (en) 2014-01-30
ES2435430T3 (es) 2013-12-19
IL197750A0 (en) 2009-12-24
CL2007002916A1 (es) 2008-04-18
EP2074128A1 (en) 2009-07-01
CN101528752A (zh) 2009-09-09
EP2074128B1 (en) 2013-08-14
JP2010506895A (ja) 2010-03-04
TW200825094A (en) 2008-06-16
US8455512B2 (en) 2013-06-04
CA2666603C (en) 2013-08-06
EP2527345B1 (en) 2015-12-16
JP5443988B2 (ja) 2014-03-19
AU2007311560B2 (en) 2011-04-21
US9938289B2 (en) 2018-04-10
CA2666603A1 (en) 2008-04-24
AU2007311560A1 (en) 2008-04-24
US20150175624A1 (en) 2015-06-25
AR063318A1 (es) 2009-01-21
MX2009003157A (es) 2009-04-03
US9090625B2 (en) 2015-07-28

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20170727