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UA98944C2 - Амиды диазабициклоалканов, селективные относительно ацетилхолинового подтипа никотиновых рецепторов - Google Patents

Амиды диазабициклоалканов, селективные относительно ацетилхолинового подтипа никотиновых рецепторов

Info

Publication number
UA98944C2
UA98944C2 UAA200905474A UAA200905474A UA98944C2 UA 98944 C2 UA98944 C2 UA 98944C2 UA A200905474 A UAA200905474 A UA A200905474A UA A200905474 A UAA200905474 A UA A200905474A UA 98944 C2 UA98944 C2 UA 98944C2
Authority
UA
Ukraine
Prior art keywords
compounds
effects
diazabicycloalkanes
significant
receptorsub
Prior art date
Application number
UAA200905474A
Other languages
English (en)
Ukrainian (uk)
Inventor
Анатолій Мазуров
Лань Мяо
Юнь-де Сяо
Філіп С. Хеммонд
Крейг Х. Міллер
Срінівіса Рао Акіредді
В. Срініваса Мерті
Реджина С. Уітакер
Скотт Р. Брейнінг
Метт С. Мелвін
Original Assignee
Таргасепт, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Таргасепт, Інк. filed Critical Таргасепт, Інк.
Publication of UA98944C2 publication Critical patent/UA98944C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В изобретении раскрыты соединения, фармацевтическая композиция, которая содержит такие соединения, а также применение указанных соединений. Описанные соединения могут быть получены из некоторых гетероарилсодержащих карбоновых кислот и определенных диазабициклоалканов. Данные соединения демонстрируют селективность в отношении нейронных никотиновых рецепторов подтипа α4β2 в центральной нервной системе (ЦНС) и связываются с ними с высокой аффинностью. Описанные соединения и композиции могут применяться для лечения и/или профилактики широкого спектра заболеваний и расстройств, в частности расстройств ЦНС. Соединения могут: (i) изменять количество никотиновых холинергических рецепторов в мозге пациента, (ii) демонстрировать нейрозащитное действие и (iii) при применении в эффективных количествах не приводить к заметным неблагоприятным побочным эффектам (например, таких побочных эффектов, как значительное увеличение кровяного давления и частоты сердцебиения, значительное негативное влияние на желудочно-кишечный тракт и значительное влияние на скелетную мускулатуру).
UAA200905474A 2006-11-02 2007-11-01 Амиды диазабициклоалканов, селективные относительно ацетилхолинового подтипа никотиновых рецепторов UA98944C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85607906P 2006-11-02 2006-11-02

Publications (1)

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UA98944C2 true UA98944C2 (ru) 2012-07-10

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200905474A UA98944C2 (ru) 2006-11-02 2007-11-01 Амиды диазабициклоалканов, селективные относительно ацетилхолинового подтипа никотиновых рецепторов
UAA200912807A UA106718C2 (ru) 2006-11-02 2007-11-01 Амиды диазабициклоалканов, селективные ОТНОСИТЕЛЬНО ацетилхолинового подтипа никотиновых рецепторов

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UAA200912807A UA106718C2 (ru) 2006-11-02 2007-11-01 Амиды диазабициклоалканов, селективные ОТНОСИТЕЛЬНО ацетилхолинового подтипа никотиновых рецепторов

Country Status (33)

Country Link
US (6) US8114889B2 (ru)
EP (2) EP2284171B1 (ru)
JP (2) JP5539723B2 (ru)
KR (2) KR101415705B1 (ru)
CN (4) CN102838605B (ru)
AR (2) AR063451A1 (ru)
AT (2) ATE509022T1 (ru)
AU (2) AU2007317433B2 (ru)
BR (2) BRPI0722387A2 (ru)
CA (1) CA2663925C (ru)
CL (1) CL2007003155A1 (ru)
CO (1) CO6180435A2 (ru)
CY (1) CY1112374T1 (ru)
DK (1) DK2094703T3 (ru)
ES (2) ES2395212T3 (ru)
HK (2) HK1149751A1 (ru)
HR (1) HRP20110570T1 (ru)
IL (2) IL197618A (ru)
MX (1) MX2009004801A (ru)
MY (2) MY156730A (ru)
NO (1) NO20091251L (ru)
NZ (2) NZ587847A (ru)
PE (2) PE20110671A1 (ru)
PL (1) PL2094703T3 (ru)
PT (1) PT2094703E (ru)
RS (1) RS51834B (ru)
RU (2) RU2517693C2 (ru)
SA (1) SA07280584B1 (ru)
SI (1) SI2094703T1 (ru)
TW (3) TWI454262B (ru)
UA (2) UA98944C2 (ru)
UY (1) UY30686A1 (ru)
WO (1) WO2008057938A1 (ru)

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CN102838605B (zh) 2017-04-26
US8114889B2 (en) 2012-02-14
RS51834B (en) 2012-02-29
AU2010219323A1 (en) 2010-09-30
US9580434B2 (en) 2017-02-28
EP2094703A1 (en) 2009-09-02
HK1133260A1 (en) 2010-03-19
CL2007003155A1 (es) 2008-05-16
MX2009004801A (es) 2009-07-31
PE20110671A1 (es) 2011-10-20
CN102020646A (zh) 2011-04-20
CO6180435A2 (es) 2010-07-19
RU2517693C2 (ru) 2014-05-27
AU2010219323B2 (en) 2012-05-03
CN101528745A (zh) 2009-09-09
US20160039833A1 (en) 2016-02-11
AR079840A2 (es) 2012-02-22
UY30686A1 (es) 2009-08-03
US8921410B2 (en) 2014-12-30
MY145602A (en) 2012-03-15
KR20090074051A (ko) 2009-07-03
RU2009120674A (ru) 2010-12-10
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