ATE545646T1 - Amide von diazabicycloalkanen die selektiv sind für acetylcholin receptor untergruppen - Google Patents

Amide von diazabicycloalkanen die selektiv sind für acetylcholin receptor untergruppen

Info

Publication number: ATE545646T1
Authority: AT; Austria
Prior art keywords: diazabicycloalkanes; amides; selective; acetylcholine receptor; receptor subgroups
Prior art date: 2006-11-02

Application number

AT10075738T

Other languages

English (en)

Inventor

Anatoly Mazurov

Lan Miao

Yun-De Xiao

Philip S Hammond

Craig H Miller

Srinivasa Rao Akireddy

V Srinivasa Murthy

Regina C Whitaker

Scott R Breining

Matt S Melvin

Original Assignee

Targacept Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-02

Filing date

2007-11-01

Publication date

2012-03-15

2007-11-01 Application filed by Targacept Inc filed Critical Targacept Inc

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE545646T1 publication Critical patent/ATE545646T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT10075738T 2006-11-02 2007-11-01 Amide von diazabicycloalkanen die selektiv sind für acetylcholin receptor untergruppen ATE545646T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US85607906P	2006-11-02	2006-11-02

Publications (1)

Publication Number	Publication Date
ATE545646T1 true ATE545646T1 (de)	2012-03-15

Family

ID=39233054

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT07863786T ATE509022T1 (de)	2006-11-02	2007-11-01	Nikotin-acetylcholin-rezeptorsubtyp-selektive diazabicycloalkanamide
AT10075738T ATE545646T1 (de)	2006-11-02	2007-11-01	Amide von diazabicycloalkanen die selektiv sind für acetylcholin receptor untergruppen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT07863786T ATE509022T1 (de)	2006-11-02	2007-11-01	Nikotin-acetylcholin-rezeptorsubtyp-selektive diazabicycloalkanamide

Country Status (33)

Country	Link
US (6)	US8114889B2 (de)
EP (2)	EP2284171B1 (de)
JP (2)	JP5539723B2 (de)
KR (2)	KR101415705B1 (de)
CN (4)	CN102838605B (de)
AR (2)	AR063451A1 (de)
AT (2)	ATE509022T1 (de)
AU (2)	AU2007317433B2 (de)
BR (2)	BRPI0722387A2 (de)
CA (1)	CA2663925C (de)
CL (1)	CL2007003155A1 (de)
CO (1)	CO6180435A2 (de)
CY (1)	CY1112374T1 (de)
DK (1)	DK2094703T3 (de)
ES (2)	ES2395212T3 (de)
HK (2)	HK1149751A1 (de)
HR (1)	HRP20110570T1 (de)
IL (2)	IL197618A (de)
MX (1)	MX2009004801A (de)
MY (2)	MY156730A (de)
NO (1)	NO20091251L (de)
NZ (2)	NZ587847A (de)
PE (2)	PE20110671A1 (de)
PL (1)	PL2094703T3 (de)
PT (1)	PT2094703E (de)
RS (1)	RS51834B (de)
RU (2)	RU2517693C2 (de)
SA (1)	SA07280584B1 (de)
SI (1)	SI2094703T1 (de)
TW (3)	TWI454262B (de)
UA (2)	UA98944C2 (de)
UY (1)	UY30686A1 (de)
WO (1)	WO2008057938A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI454262B (zh) *	2006-11-02	2014-10-01	Targacept Inc	菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
MX2010009727A (es) *	2008-03-05	2010-09-28	Targacept Inc	Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos.
WO2009113950A1 (en) *	2008-03-10	2009-09-17	Astrazeneca Ab	Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist
US8658635B2 (en)	2008-06-05	2014-02-25	Glaxosmithkline Intellectual Property Development Limited	Benzpyrazol derivatives as inhibitors of PI3 kinases
JP5502077B2 (ja)	2008-06-05	2014-05-28	グラクソグループリミテッド	新規な化合物
EP2280705B1 (de)	2008-06-05	2014-10-08	Glaxo Group Limited	Neue verbindungen
US20110263629A1 (en) *	2008-09-05	2011-10-27	Targacept, Inc.	Amides of diazabicyclooctanes and uses thereof
WO2010028011A1 (en) *	2008-09-05	2010-03-11	Targacept, Inc.	Amides of diazabicyclononanes and uses thereof
WO2010080757A2 (en)	2009-01-07	2010-07-15	Astrazeneca Ab	Combinations with an alpha-4beta-2 nicotinic agonist
JP5656880B2 (ja)	2009-03-09	2015-01-21	グラクソグループリミテッドＧｌａｘｏＧｒｏｕｐＬｉｍｉｔｅｄ	Ｐｉ３キナーゼの阻害剤としての４−オキサジアゾール−２−イル−インダゾール
CA2759476C (en)	2009-04-30	2018-10-09	Julie Nicole Hamblin	Novel compounds
RU2417082C2 (ru) *	2009-07-14	2011-04-27	Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран)	Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения
MX2012005637A (es)	2009-11-18	2012-06-13	Suven Life Sciences Ltd	COMPUESTOS BICICLICOS COMO LIGANDOS DEL RECEPTOR NICOTINICO DE ACETILCOLINA A4 ß2.
DK2519514T3 (en)	2009-12-29	2015-11-16	Suven Life Sciences Ltd	Neuronal nicotinic alpha4beta2-acetylcholine receptor ligands
GB201018124D0 (en)	2010-10-27	2010-12-08	Glaxo Group Ltd	Polymorphs and salts
AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
WO2015078803A1 (en)	2013-11-26	2015-06-04	F. Hoffmann-La Roche Ag	NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL
AU2015238537B2 (en)	2014-03-26	2019-08-01	F. Hoffmann-La Roche Ag	Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
SG11201703135XA (en)	2014-10-20	2017-05-30	Oyster Point Pharma Inc	Methods of treating ocular conditions
CA2992889A1 (en)	2015-09-04	2017-03-09	F. Hoffmann-La Roche Ag	Phenoxymethyl derivatives
BR112018006024A2 (pt)	2015-09-24	2020-05-12	F. Hoffmann-La Roche Ag	Compostos bicíclicos como inibidores de atx
CR20180143A (es)	2015-09-24	2018-05-03	Hoffmann La Roche	Nuevos compuestos biciclicos como inhibidores duales de atx/ca
CA2991612A1 (en)	2015-09-24	2017-03-30	F. Hoffmann-La Roche Ag	New bicyclic compounds as dual atx/ca inhibitors
BR112018006034A2 (pt)	2015-09-24	2018-10-09	Hoffmann La Roche	compostos bicíclicos como inibidores de atx
EP3970724A1 (de)	2016-04-07	2022-03-23	Oyster Point Pharma, Inc.	Verfahren zur behandlung von augenleiden
CN110392679B (zh)	2017-03-16	2023-04-07	豪夫迈·罗氏有限公司	可用作双重atx/ca抑制剂的杂环化合物
JP7090099B2 (ja)	2017-03-16	2022-06-23	エフ．ホフマン－ラロシュアーゲー	Ａｔｘインヒビターとしての新規二環式化合物
LT3448859T (lt) *	2017-03-20	2019-10-25	Forma Therapeutics Inc	Pirolpirolo kompozicijos, kaip piruvato kinazės (pkr) aktyvatoriai
US11001588B2 (en)	2018-09-19	2021-05-11	Forma Therapeutics, Inc.	Activating pyruvate kinase R and mutants thereof
US12053458B2 (en)	2018-09-19	2024-08-06	Novo Nordisk Health Care Ag	Treating sickle cell disease with a pyruvate kinase R activating compound
AU2020349555A1 (en)	2019-09-19	2022-04-07	Forma Therapeutics, Inc.	Activating Pyruvate Kinase R
US12128035B2 (en)	2021-03-19	2024-10-29	Novo Nordisk Health Care Ag	Activating pyruvate kinase R

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU482990A1 (ru) *	1973-09-03	1978-04-15	Предприятие П/Я Г-4059	Способ получени 1,4-диазабицикло(2,2,2)-октана
US4922901A (en)	1988-09-08	1990-05-08	R. J. Reynolds Tobacco Company	Drug delivery articles utilizing electrical energy
IL107184A (en)	1992-10-09	1997-08-14	Abbott Lab	Heterocyclic ether compounds that enhance cognitive function
US5852041A (en)	1993-04-07	1998-12-22	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en)	1993-10-25	1996-02-20	Organix, Inc.	Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5468858A (en)	1993-10-28	1995-11-21	The Board Of Regents Of Oklahoma State University Physical Sciences	N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
EP0737194B1 (de) *	1993-12-29	1999-03-03	Pfizer Inc.	Diazabicyclische neurokinin antagonisten
US5457121A (en)	1994-09-02	1995-10-10	Eli Lilly And Company	Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
US5604231A (en)	1995-01-06	1997-02-18	Smith; Carr J.	Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5597919A (en)	1995-01-06	1997-01-28	Dull; Gary M.	Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en)	1995-04-07	1996-12-17	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en)	1995-05-17	1996-12-10	Bencherif; Merouane	Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en)	1995-06-07	2006-10-05	Abbott Lab	Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5616716A (en)	1996-01-06	1997-04-01	Dull; Gary M.	(3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv) *	1996-02-23	1996-02-23	Astra Ab	Azabicyclic esters of carbamic acids useful in therapy
US5663356A (en)	1996-04-23	1997-09-02	Ruecroft; Graham	Method for preparation of aryl substituted alefinic secondary amino compounds
US5726189A (en)	1996-05-03	1998-03-10	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
US5952339A (en)	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
JP2003516988A (ja) *	1999-12-14	2003-05-20	ニューロサーチ、アクティーゼルスカブ	新規ヘテロアリール−ジアザビシクロアルカン類
US6809105B2 (en) *	2000-04-27	2004-10-26	Abbott Laboratories	Diazabicyclic central nervous system active agents
EP1368354A1 (de)	2001-03-07	2003-12-10	Pfizer Products Inc.	Modulatoren der aktivität von chemokin-rezeptoren
JP2004532899A (ja) *	2001-07-06	2004-10-28	ニューロサーチ、アクティーゼルスカブ	新規化合物、その製造方法及びその使用方法
SE0202430D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New Compounds
SE0202465D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New compounds
MXPA05006861A (es) *	2003-02-27	2005-12-12	Neurosearch As	Derivados arildiazabiciclicos novedosos.
CN1317280C (zh) *	2003-02-27	2007-05-23	神经研究公司	新的二氮杂双环芳基衍生物
US7399765B2 (en) *	2003-09-19	2008-07-15	Abbott Laboratories	Substituted diazabicycloalkane derivatives
US7365193B2 (en) *	2004-02-04	2008-04-29	Abbott Laboratories	Amino-substituted tricyclic derivatives and methods of use
ES2297727T3 (es) *	2004-06-09	2008-05-01	F. Hoffmann-La Roche Ag	Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos.
CA2574301C (en)	2004-07-22	2013-09-10	Cumbre Pharmaceuticals Inc.	(r/s) rifamycin derivatives, their preparation and pharmaceutical compositions
CN101193635A (zh) *	2005-05-13	2008-06-04	莱西肯医药有限公司	多环化合物及其使用方法
TWI454262B (zh) *	2006-11-02	2014-10-01	Targacept Inc	菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺

2007
- 2007-10-19 TW TW101139986A patent/TWI454262B/zh not_active IP Right Cessation
- 2007-10-19 TW TW096139391A patent/TWI405763B/zh not_active IP Right Cessation
- 2007-10-19 TW TW099135628A patent/TWI404532B/zh not_active IP Right Cessation
- 2007-10-30 SA SA07280584A patent/SA07280584B1/ar unknown
- 2007-10-31 PE PE2011000136A patent/PE20110671A1/es not_active Application Discontinuation
- 2007-10-31 CL CL200703155A patent/CL2007003155A1/es unknown
- 2007-10-31 PE PE2007001487A patent/PE20081441A1/es not_active Application Discontinuation
- 2007-11-01 MY MYPI2011004927A patent/MY156730A/en unknown
- 2007-11-01 CN CN201210291637.1A patent/CN102838605B/zh not_active Expired - Fee Related
- 2007-11-01 UA UAA200905474A patent/UA98944C2/ru unknown
- 2007-11-01 DK DK07863786.5T patent/DK2094703T3/da active
- 2007-11-01 RU RU2009138600/04A patent/RU2517693C2/ru not_active IP Right Cessation
- 2007-11-01 UA UAA200912807A patent/UA106718C2/uk unknown
- 2007-11-01 RS RS20110339A patent/RS51834B/en unknown
- 2007-11-01 RU RU2009120674/04A patent/RU2448969C2/ru not_active IP Right Cessation
- 2007-11-01 EP EP10075738A patent/EP2284171B1/de active Active
- 2007-11-01 JP JP2009535465A patent/JP5539723B2/ja active Active
- 2007-11-01 MX MX2009004801A patent/MX2009004801A/es active IP Right Grant
- 2007-11-01 MY MYPI20091569A patent/MY145602A/en unknown
- 2007-11-01 CN CN2007800402281A patent/CN101528745B/zh not_active Expired - Fee Related
- 2007-11-01 AR ARP070104876A patent/AR063451A1/es not_active Application Discontinuation
- 2007-11-01 WO PCT/US2007/083330 patent/WO2008057938A1/en active Application Filing
- 2007-11-01 EP EP07863786A patent/EP2094703B1/de active Active
- 2007-11-01 CA CA2663925A patent/CA2663925C/en not_active Expired - Fee Related
- 2007-11-01 BR BRPI0722387-0A patent/BRPI0722387A2/pt not_active Application Discontinuation
- 2007-11-01 BR BRPI0717930-8A patent/BRPI0717930A2/pt not_active IP Right Cessation
- 2007-11-01 NZ NZ587847A patent/NZ587847A/en not_active IP Right Cessation
- 2007-11-01 CN CN201210401679.6A patent/CN102942569B/zh not_active Expired - Fee Related
- 2007-11-01 KR KR1020097008122A patent/KR101415705B1/ko active IP Right Grant
- 2007-11-01 KR KR1020107025973A patent/KR20100124356A/ko active IP Right Grant
- 2007-11-01 CN CN2010105367790A patent/CN102020646B/zh not_active Expired - Fee Related
- 2007-11-01 AT AT07863786T patent/ATE509022T1/de active
- 2007-11-01 PT PT07863786T patent/PT2094703E/pt unknown
- 2007-11-01 SI SI200730628T patent/SI2094703T1/sl unknown
- 2007-11-01 NZ NZ575557A patent/NZ575557A/en not_active IP Right Cessation
- 2007-11-01 AU AU2007317433A patent/AU2007317433B2/en not_active Ceased
- 2007-11-01 ES ES07863786T patent/ES2395212T3/es active Active
- 2007-11-01 US US12/447,850 patent/US8114889B2/en not_active Expired - Fee Related
- 2007-11-01 ES ES10075738T patent/ES2395157T3/es active Active
- 2007-11-01 AT AT10075738T patent/ATE545646T1/de active
- 2007-11-01 UY UY30686A patent/UY30686A1/es not_active Application Discontinuation
- 2007-11-01 PL PL07863786T patent/PL2094703T3/pl unknown
2009
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- 2009-03-26 NO NO20091251A patent/NO20091251L/no not_active Application Discontinuation
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2010
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- 2010-01-20 HK HK10100570.6A patent/HK1133260A1/xx not_active IP Right Cessation
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2011
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- 2011-07-20 CY CY20111100706T patent/CY1112374T1/el unknown
- 2011-08-02 HR HR20110570T patent/HRP20110570T1/hr unknown
2012
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- 2012-11-19 JP JP2012253103A patent/JP5739398B2/ja active Active
2014
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2015
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Also Published As

Publication number	Publication date
CN102838605B (zh)	2017-04-26
US8114889B2 (en)	2012-02-14
RS51834B (en)	2012-02-29
AU2010219323A1 (en)	2010-09-30
US9580434B2 (en)	2017-02-28
EP2094703A1 (de)	2009-09-02
HK1133260A1 (en)	2010-03-19
CL2007003155A1 (es)	2008-05-16
MX2009004801A (es)	2009-07-31
PE20110671A1 (es)	2011-10-20
CN102020646A (zh)	2011-04-20
CO6180435A2 (es)	2010-07-19
RU2517693C2 (ru)	2014-05-27
AU2010219323B2 (en)	2012-05-03
CN101528745A (zh)	2009-09-09
US20160039833A1 (en)	2016-02-11
AR079840A2 (es)	2012-02-22
UY30686A1 (es)	2009-08-03
US8921410B2 (en)	2014-12-30
MY145602A (en)	2012-03-15
KR20090074051A (ko)	2009-07-03
RU2009120674A (ru)	2010-12-10
CA2663925C (en)	2015-04-21
NZ575557A (en)	2011-01-28
TWI404532B (zh)	2013-08-11
US8268860B2 (en)	2012-09-18
JP5739398B2 (ja)	2015-06-24
WO2008057938A1 (en)	2008-05-15
UA98944C2 (ru)	2012-07-10
PL2094703T3 (pl)	2011-10-31
HRP20110570T1 (hr)	2011-09-30
TW200826935A (en)	2008-07-01
US8859609B2 (en)	2014-10-14
KR20100124356A (ko)	2010-11-26
KR101415705B1 (ko)	2014-07-04
JP2013056919A (ja)	2013-03-28
EP2284171B1 (de)	2012-02-15
EP2094703B1 (de)	2011-05-11
CN102942569A (zh)	2013-02-27
ATE509022T1 (de)	2011-05-15
EP2284171A1 (de)	2011-02-16
AU2007317433B2 (en)	2012-05-10
NZ587847A (en)	2011-09-30
NO20091251L (no)	2009-05-28
CN102020646B (zh)	2013-11-13
AU2007317433A1 (en)	2008-05-15
MY156730A (en)	2016-03-15
CN102838605A (zh)	2012-12-26
PT2094703E (pt)	2011-07-22
US20150080576A1 (en)	2015-03-19
CA2663925A1 (en)	2008-05-15
BRPI0717930A2 (pt)	2011-05-10
DK2094703T3 (da)	2011-08-29
TWI454262B (zh)	2014-10-01
ES2395157T3 (es)	2013-02-08
IL197618A (en)	2013-09-30
US20100173932A1 (en)	2010-07-08
PE20081441A1 (es)	2008-10-30
SA07280584B1 (ar)	2010-11-02
SI2094703T1 (sl)	2011-07-29
JP5539723B2 (ja)	2014-07-02
RU2009138600A (ru)	2011-04-27
ES2395212T3 (es)	2013-02-11
CN101528745B (zh)	2011-09-14
HK1149751A1 (en)	2011-10-14
JP2010509230A (ja)	2010-03-25
TWI405763B (zh)	2013-08-21
RU2448969C2 (ru)	2012-04-27
AR063451A1 (es)	2009-01-28
CY1112374T1 (el)	2015-12-09
US20100081683A1 (en)	2010-04-01
BRPI0722387A2 (pt)	2023-02-23
CN102942569B (zh)	2015-10-28
IL209026A (en)	2014-03-31
US20120289572A1 (en)	2012-11-15
IL209026A0 (en)	2011-01-31
US20130005789A1 (en)	2013-01-03
TW201305176A (zh)	2013-02-01
IL197618A0 (en)	2009-12-24
UA106718C2 (uk)	2014-10-10
TW201114424A (en)	2011-05-01

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